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Find cheap flights from Panama City to Santa Cruz de la Sierra from $427

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Santa Cruz de la Sierra departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sat 4/27
Sat 5/4

Search hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
In the last 7 days travelers have searched 46,342,885 times on KAYAK, and here is why:

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Cheap flight deals from Panama City to Santa Cruz de la Sierra

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
5:40 pm - 2:00 amPTY-VVI
7h 20m1 stop
3:05 am - 8:45 pmVVI-PTY
18h 40m1 stop
$427Avianca
Find Deal
Thu, Sep 5 - Fri, Sep 13
3:50 pm - 9:53 pmPTY-VVI
5h 03mnonstop
12:52 am - 4:41 amVVI-PTY
4h 49mnonstop
$534Copa Airlines
Find Deal
Sat, Apr 20 - Mon, Apr 22
9:43 pm - 3:34 amPTY-VVI
4h 51mnonstop
12:46 am - 4:41 amVVI-PTY
4h 55mnonstop
$571Copa Airlines
Find Deal
Wed, May 1 - Thu, May 30
3:50 pm - 9:53 pmPTY-VVI
5h 03mnonstop
12:52 am - 4:41 amVVI-PTY
4h 49mnonstop
$598Copa Airlines
Find Deal
Tue, Apr 23 - Thu, Apr 25
3:50 pm - 9:46 pmPTY-VVI
4h 56mnonstop
12:46 am - 4:41 amVVI-PTY
4h 55mnonstop
$646Copa Airlines
Find Deal
Thu, Jun 20 - Sat, Jun 29
9:40 pm - 9:15 pmPTY-VVI
22h 35m2 stops
3:05 am - 8:45 pmVVI-PTY
18h 40m1 stop
Thu, Sep 5 - Fri, Sep 13
5:40 pm - 2:00 amPTY-VVI
7h 20m1 stop
6:30 pm - 8:45 pmVVI-PTY
27h 15m2 stops
Thu, Sep 5 - Sat, Sep 14
12:05 pm - 4:10 amPTY-VVI
15h 05m1 stop
6:30 pm - 6:28 amVVI-PTY
12h 58m1 stop
Thu, Sep 5 - Sat, Sep 14
9:40 pm - 9:15 pmPTY-VVI
22h 35m2 stops
6:40 pm - 10:25 amVVI-PTY
16h 45m2 stops
Thu, Sep 5 - Sat, Sep 14
3:47 pm - 11:50 amPTY-VVI
19h 03m2 stops
3:05 am - 2:45 pmVVI-PTY
36h 40m2 stops
$1,425
Find Deal
Thu, Sep 5 - Fri, Sep 13

Flights from Panama City to Santa Cruz de la Sierra - Travel Insights & Trends

Get data-powered insights and trends into flights from Panama City to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Panama City to Santa Cruz de la Sierra?

The average price of all flights from Panama City to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.
When flying from Panama City to Santa Cruz de la Sierra, you should consider leaving on a Sunday and avoid Mondays if you are looking for the best rates. For your return to Panama City, you’ll find the best rates on Tuesdays and the most expensive ones on Fridays.

What is the cheapest month to fly from Panama City to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Panama City to Santa Cruz de la Sierra is April, where tickets cost $489 on average. On the other hand, the most expensive months are January and December, where the average cost of tickets is $679 and $629 respectively.

How far in advance should I book a flight from Panama City to Santa Cruz de la Sierra?

To calculate daily average prices, KAYAK takes all prices for each day before departure over the last year for flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the average of all the values for each month.
To get a below average price on the flight from Panama City to Santa Cruz de la Sierra, you should book around 1 day before departure. For the absolute cheapest price, our data suggests you should book 42 days before departure.

Which airlines fly non-stop between Panama City and Santa Cruz de la Sierra?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for flights from Panama City to Santa Cruz de la Sierra.
There is just one airline that flies from Panama City to Santa Cruz de la Sierra direct and that is Copa Airlines. The best one-way deal found from Copa Airlines for the route is $465.

How many flights are there between Panama City and Santa Cruz de la Sierra per day?

Each day, there are between 1 and 2 nonstop flights that take off from Panama City and land in Santa Cruz de la Sierra, with an average flight time of 5h 01m. The most common departure time is 3:00 pm and most flights take off in the afternoon. Each week, there are 11 flights. The most frequent day of departure is Friday, when 18% of all weekly flights depart. The fewest flights depart on a Thursday.

Which cabin class options are there for flights between Panama City and Santa Cruz de la Sierra?

The average price of flights for each cabin class for the route found by users searching on KAYAK over the last 2 weeks.
There is only one cabin class option available for the route, which is Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

How long does a flight from Panama City to Santa Cruz de la Sierra take?

Direct flights cover the 2,152 miles separating Panama City to Santa Cruz de la Sierra in about 4h 51m.

What’s the earliest departure time from Panama City to Santa Cruz de la Sierra?

Early birds can take the earliest flight from Panama City at 3:50 pm and will be landing in Santa Cruz de la Sierra at 9:53 pm.

What’s the latest departure time from Panama City to Santa Cruz de la Sierra?

If you prefer to fly at night, the latest flight from Panama City to Santa Cruz de la Sierra jets off at 9:43 pm and lands at 3:42 am.

Good to know

Low season

July

High season

November

Cheapest flight

$427
Best time to beat the crowds but there is an average 10% increase in price.
Most popular time to fly and prices are also 8% lower on average.
Flight from Panama City to Santa Cruz de la Sierra

When to book flights from Panama City to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from Panama City to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Santa Cruz de la Sierra

  • What is the cheapest flight from Panama City to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from Panama City to Santa Cruz de la Sierra was $427 for a round-trip ticket.

  • Do I need a passport to fly between Panama City and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from Panama City.

  • Which aircraft models fly most regularly from Panama City to Santa Cruz de la Sierra?

    The Boeing 737-800 is the aircraft model that flies most regularly on the Panama City to Santa Cruz de la Sierra flight route.

  • Which airline alliances offer flights from Panama City to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between Panama City and Santa Cruz de la Sierra.

  • On which days can I fly direct from Panama City to Santa Cruz de la Sierra?

    There are nonstop flights from Panama City to Santa Cruz de la Sierra on a daily basis.

  • How does KAYAK find such low prices on flights from Panama City to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to Panama City with another airline. Booking your flights between Panama City and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Prefer to fly non-stop from Panama City to Santa Cruz de la Sierra?

Find which airlines fly direct from Tocumen Intl to Viru Viru Intl, which days they fly and book direct flights.

Nonstop departures

Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl

Monday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Tuesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Wednesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Thursday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Friday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Saturday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Sunday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

See more direct flights

Nonstop returns

Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl

Monday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Tuesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Wednesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Thursday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Friday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Saturday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Sunday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

See more direct flights
See more direct flights

Top airline flying from Panama City to Santa Cruz de la Sierra

Need help choosing which airline to fly with from Panama City to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to KAYAK reviews.
7.8
Copa AirlinesOverall score based on 3095 reviews
81boarding
80overall
73entertainment
78comfort
74food
83crew
Airline reviews

landed in panama it was in terminal one. We had to take a bus to terminal two for customs. Then back to terminal one. It was very frustrating. Then, on the way back from panama it was the same situation. We had to go back and forth between terminals to check in and drop our bags and then to board. When we were leaving, we had to wait in line for the boarding area and go through another gate security process. They told the bottles of water and coffee were bought while in line in the airport after we passed the main security. Ridiculous (and expensive). A much better communication system is needed.

Read more about Copa Airlines

landed in panama it was in terminal one. We had to take a bus to terminal two for customs. Then back to terminal one. It was very frustrating. Then, on the way back from panama it was the same situation. We had to go back and forth between terminals to check in and drop our bags and then to board. When we were leaving, we had to wait in line for the boarding area and go through another gate security process. They told the bottles of water and coffee were bought while in line in the airport after we passed the main security. Ridiculous (and expensive). A much better communication system is needed.

This was my first time flying Copa but I'll definitely be back! Great service, professional agents, and delicious food for a fair price. Thanks for a great trip!

No boarding announcements leading to the usual confusion and people trying to board before their group number.

Horrible experience from start to end. Copa costumer service is non existent. They treat you bad. Everybody tells you different information. We didn’t received our luggage in the 1 day stop we did even we they said if was not going to be a problem. They didn’t respect the seats that we had and spread our family leaving in between of two big people who didn’t leave any space for me and crush me from side to side. I’ll never recommend Copa to anybody.

No cumpli mencionado trayecto por reasignacion de Copa Pero extraviaron mis maletas por su culpa

As usual, the flight with normal legroom was not very comfortable, but the second flight was much better because we had paid for extra legroom. It was very nice to check our bags without an extra fee.

other than a slight delay in takeoff from Panama , the flights were excellent ..... we will continue to use Copa whenever possible for flights to and from Central and South America ....

I was fortunate enough to have an entire row to myself and that was the highlight. Unfortunately, the flight was really turbulent which had no impact on how effective the crew was. However, I am disabled and should have boarded the flight first, but that wasn't the case. They also decided to take my bag at the gate because I had one too many and upon my picking it up at JFK it along with my rollator had been damaged. I am a vegan so the didn't have a proper meal for me and I was unable to view the entertainment because I didn't receive a set of headphones and if I needed to supply my own I wasn't made aware of that either. The crew was great, but overall everything was pretty lackluster.

Pros: "The flight was very calm. The crew was friendly all the time."
Cons: "The food"
Pros: "Boarding was organized"
Cons: "They didn’t turn on AC until we landed in Lima, during bording they were hurrying people to get on their seats fast"

Last minute flights from Panama City to Santa Cruz de la Sierra

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Panama City to Santa Cruz de la Sierra that are departing in the next 10 days.
4/2Tue
nonstopCopa Airlines
5h 03mPTY-VVI
4/6Sat
nonstopCopa Airlines
4h 53mVVI-PTY
$726
4/2Tue
nonstopCopa Airlines
5h 03mPTY-VVI
4/8Mon
nonstopCopa Airlines
4h 53mVVI-PTY
$1,406

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Panama City - Santa Cruz de la Sierra Flights

Departure:

Panama City (PTY)Panama

Destination:

Santa Cruz de la Sierra (VVI)Bolivia

Return flight deals:

Santa Cruz de la Sierra - Panama City

Cabin classes:

$2,590
$513

Browse origins:

  • Flights » 
  • Panama City

Browse destinations:

  • Flights » 
  • Worldwide » 
  • Santa Cruz de la Sierra