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DSM - TYS

Find cheap flights from Des Moines to Knoxville from $136

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Thu 5/23
Thu 5/30

Search hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
In the last 7 days travelers have searched 44,632,927 times on KAYAK, and here is why:

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Cheap flight deals from Des Moines to Knoxville (DSM-TYS)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
5:17 pm - 9:56 amDSM-TYS
15h 39m1 stop
9:02 pm - 8:33 pmTYS-DSM
24h 31m1 stop
$136Frontier
Find Deal
Fri, May 10 - Fri, May 17
6:40 am - 2:13 pmDSM-TYS
6h 33m1 stop
5:19 am - 11:38 amTYS-DSM
7h 19m1 stop
$240American Airlines
Find Deal
Tue, May 7 - Tue, May 14
5:48 pm - 12:18 amDSM-TYS
5h 30m1 stop
7:01 am - 11:38 amTYS-DSM
5h 37m1 stop
$241American Airlines
Find Deal
Wed, May 8 - Wed, May 15
2:11 pm - 8:51 pmDSM-TYS
5h 40m1 stop
11:50 am - 7:04 pmTYS-DSM
8h 14m1 stop
$243Delta
Find Deal
Mon, May 6 - Wed, May 15
6:04 am - 2:13 pmDSM-TYS
7h 09m2 stops
7:01 am - 11:38 amTYS-DSM
5h 37m1 stop
$246American Airlines
Find Deal
Tue, May 7 - Tue, May 14
6:09 pm - 11:55 pmDSM-TYS
4h 46m1 stop
7:30 am - 10:51 amTYS-DSM
4h 21m1 stop
$258Delta
Find Deal
Mon, May 6 - Sat, May 11
8:00 am - 1:22 pmDSM-TYS
4h 22m1 stop
7:00 am - 10:34 amTYS-DSM
4h 34m1 stop
$353United Airlines
Find Deal
Sun, May 5 - Sun, May 12
4:23 pm - 2:02 pmDSM-TYS
20h 39m2 stops
6:00 am - 11:05 pmTYS-DSM
18h 05m2 stops
Fri, May 3 - Sun, May 5
11:37 am - 4:50 pmDSM-TYS
4h 13m1 stop
10:51 am - 11:38 pmTYS-DSM
13h 47m2 stops
$427United Airlines
Find Deal
Tue, May 7 - Sat, May 11
9:00 am - 1:00 pmDSM-TYS
27h 00m3 stops
9:00 am - 4:29 pmTYS-DSM
8h 29m1 stop
Sun, May 19 - Sat, May 25

Flights from Des Moines to Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to Knoxville?

The average price of all flights from Des Moines to Knoxville clicked on KAYAK for each day over the last 12 months.
Your flight ticket price will generally be cheaper if you fly to Knoxville on a Saturday and more expensive on a Sunday. On your return trip to Des Moines, you should consider flying back on a Sunday, and avoid Mondays for better deals.

What is the cheapest month to fly from Des Moines to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Des Moines to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Des Moines to Knoxville is September, where tickets cost $364 on average. On the other hand, the most expensive months are May and July, where the average cost of tickets is $553 and $545 respectively.

How far in advance should I book a flight from Des Moines to Knoxville?

To calculate daily average prices, KAYAK takes all prices for each day before departure over the last year for flights from Des Moines to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each month.
To get a below average price on the flight from Des Moines to Knoxville, you should book around 2 weeks before departure. For the absolute cheapest price, our data suggests you should book 31 days before departure.

Which airlines provide the cheapest flights from Des Moines to Knoxville?

The cheapest price for the route for each airline clicked by KAYAK users in the last 72 hours.
In the last 72 hours, the cheapest one-way ticket from Des Moines to Knoxville found on KAYAK was with Allegiant Air for $219. Frontier proposed a round-trip connection from $136 and American Airlines from $240.

Good to know

Low season

January

High season

November

Cheapest flight

$136
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Des Moines to Knoxville

When to book flights from Des Moines to Knoxville

Are your dates flexible? Find out the best times to travel from Des Moines to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Knoxville

  • What is the cheapest flight from Des Moines to Knoxville?

    In the last 3 days, the lowest price for a flight from Des Moines to Knoxville was $219 for a one-way ticket and $136 for a round-trip.

  • Do I need a passport to fly between Des Moines and Knoxville?

    No

  • Which airports will I be using when flying from Des Moines to Knoxville?

    On your way to Knoxville, you’ll fly out from Des Moines. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Des Moines to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Knoxville?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Des Moines and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Knoxville are Delta and United Airlines. With an average price for the route of $422 and an overall rating of 8.0, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $418 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top 4 airlines serving from Des Moines to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 11028 reviews
8.2boarding
7.9comfort
7.5food
8.0entertainment
8.6crew
Airline reviews

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

2.0 MediocreMarisol, Apr 2024DFW - ATL
Read more about Delta reviews

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive.

They did a fine job. Can't wait to use Delta in the future.

There was a loud squeaky sound the whole time we were flying.

Had a broken tray in business class. Crew just shrugged it off.

Seat back monitors and outlets were dead and not working.

Everything was great except for the seat. The backrest would not stay in the upright position.

I usually have a positive experience with Delta. Complimentary upgrades are always nice!

Flight delayed about 2 hrs so it made it a VERY late night

It was a crowded flight. They did the best they could.

The net issue I had was with the gate agent. We had added a carryon to our boarding pass when we checked bags. When I got to the boarding gate the agent was rude asking why I had a backpack - I said I added it - even had an orange tag on it. She ripped my tag off and swung her monitor around to show me how she was right- saying it isn’t wasn’t listed - only a checked bag. I explained again that I wasn’t sure what the issue was but I wouldn’t have an orange tag if I hadn’t added it. Then she finally checked my husband’s boarding pass and found that the agent at checkin had added my carryon to his boarding pass instead of mine. She sent me on my way without my orange tag. Was a bit embarrassing for me the tone she used with me assuming I was trying to get away with something.

Gate agent asked if I could switch seats so a family could sit together. Agent moved me to a seat in the front of the plane, no charge. It was easy. The agent did a great job.

Great seat space. However food and drink prices outrageous. Jabbing to pay for a carry on bag or stuck paying at the gate too much.

Every Allegiant Air flight I've ever taken has been delayed. This flight was delayed a full 2 hours. It was excuse after excuse after excuse. It was a flight from southern Florida. They made us board the plane on time, but made us wait for 2 hours on the tarmac. Because the engines were kept shut off, so was the air conditioning. One can only imagine how hot the air was in the cabin over those 2 hours on the tarmac, while in the hot Florida sun. Just terrible.

Actually, for the price, I'm willing to put up with a little discomfort (upright chairs) and at times inconveniences (like any airline), lack of entertainment (I can bring my own). My flight was non stop and smooth. I would fly this route again.

The flight was delayed 6 hours and we were only offered an $8 food credit. My husband stood in line to get the credit for 45 minutes and when he got close to the end of the line the computers went down.

Worst ever! Flight cancelled supposedly for weather even though we k ow of many others who flew into Bangor same time no problem. At the airport there was no customer service at all just refund and no possibility of rebook for 3-4 days. Aweful won’t fly with them again!!

It’s a budget airline so adjust expectations accordingly. Nothing is without a fee but such is necessary for tickets to remain so affordable.

No complaints. It’s a budget airline so can’t expect any frills.

My TSA number was missing from my ticket which shouldn’t have happened since it’s in my file. The on board flight attendant who was a male, did not want to help me put my luggage in the overhead bin and made a very rude comment and was very unpleasant. The good… the woman who fixed my ticket with the TSA number was excellent and I had extra legroom which was perfect.

Flight delayed from Cape Town to Washington then got diverted to miami and in miami we had to fend for ourselves , im still trying to get to Shreveport now

delay several times and wait extra long to board. no entertainment service because there are problem for some rows. always encounter some delays for the last flight of the day.

I just wrote a text which was supposed to be for the flight from Denver to spokane not Frankfurt to Denver.

On time every leg of the journey and exceptional staff at counter, gate, and on board. I haven’t travelled in US for a long time and was genuinely surprised how pleasant this was.

The delays (5 hrs) were a comedy of errors, and the multiple safety issues encountered were very concerning.

flight delays, staff only communicating when pushed, food service lasting a grand total of 7 minutes, stuck in seat from 45mins into flight until landing

Crew was great and did their best to make us comfortable and captain came out at the beginning to announce why the flight was delayed, weather situation up ahead, and kept us updated throughout the flight.

they made me check my carryon. There was space in the overhead bins.

Nice flight, nice crew but no cookie or napkin with my seltzer.

Trip was smooth bumpy from the wind but no issues at all the crew attendant was very pleasant and had great customer service

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

The Flight attendant had an attitude and didn't allow anyone any time to prepare for landing despite being absent throughout the entire trip

Flight boarded without pilots. Sat on plane for 3 hrs. after over an hour late boarding. Plane never took off. Had to deplane near midnight. Line for rebooking was 3 hours + long. I had to leave.

The flight was great but board was a nightmare. The gate was changed 4 times during the layover period

The experience was great and much better than the flight going out. of course I was in first class but the service was excellent

Cold air blew constantly on my legs almost making me numb.

Missed the flight because of them and up geting a rental car

Delayd flight out of atl as always miss my conection in dfw no flight untill next day

Comfort of seats, ease of boarding. Food selection could be better

i suspect i caught flu on this flight as i could hear someone coughing a few rows back and ended up with flu a few days later. also tiresome to have to watch movies on my device by holding up smartphone screen, would have liked to have in seat display.

Book cheap flights from Des Moines to Knoxville

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Des Moines to Knoxville found on KAYAK in the last 72 hours.
5/5Sun
1 stopAllegiant Air
11h 25mDSM-TYS
$219
5/5Sun
2 stopsAllegiant Air
23h 51mDSM-TYS
$227
5/4Sat
1 stopUnited Airlines
28h 08mDSM-TYS
$359
5/4Sat
2 stopsUnited Airlines
21h 26mDSM-TYS
$364
5/5Sun
3 stops
20h 50mDSM-TYS
$375

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Last minute flights from Des Moines to Knoxville

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Des Moines to Knoxville that are departing in the next 10 days.
4/24Wed
multi-stopAmerican Airlines
7h 52mDSM-TYS
4/28Sun
multi-stopAmerican Airlines
7h 53mTYS-DSM
$551
4/24Wed
multi-stopAmerican Airlines
4h 05mDSM-TYS
4/28Sun
multi-stopAmerican Airlines
7h 13mTYS-DSM
$556
4/24Wed
multi-stopAmerican Airlines
10h 54mDSM-TYS
4/28Sun
multi-stopAmerican Airlines
12h 34mTYS-DSM
$577

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Des Moines - Knoxville Flights

Departure:

Des Moines (DSM)United States

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - Des Moines

Cabin classes: