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Find Flight Deals from United States to Des Moines

Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights to Des Moines

(Round-trip)
Depart: Wed Feb 18 2015 Return: Fri Feb 20 2015 Trip spans 3 days
Frontier
Frontier
DEN
3:34a
DSM
5:06a
1h 32m
nonstop
DSM
6:46a
DEN
8:40a
1h 54m
nonstop
Depart: Thu Jan 8 2015 Return: Sat Jan 10 2015 Trip spans 3 days
American Airlines
American Airlines
ORD
6:10a
DSM
7:24a
1h 14m
nonstop
DSM
11:35a
ORD
12:58p
1h 23m
nonstop
Depart: Sun Jan 18 2015 Return: Fri Jan 23 2015 Trip spans 6 days
Allegiant Air
Allegiant Air
LAS
1:42a
DSM
4:32a
2h 50m
nonstop
DSM
7:20a
LAS
10:28a
3h 08m
nonstop
Depart: Wed Jan 14 2015 Return: Wed Jan 21 2015 Trip spans 8 days
Frontier
Frontier
DFW
1:05a
DSM
6:06a
5h 01m
1 stop
DSM
6:46a
DFW
1:23p
6h 37m
1 stop
Depart: Fri Jan 23 2015 Return: Mon Jan 26 2015 Trip spans 4 days
Frontier
Frontier
SLC
1:15a
DSM
5:06a
3h 51m
1 stop
DSM
6:46a
SLC
10:32a
3h 46m
1 stop
Depart: Thu Jan 22 2015 Return: Mon Jan 26 2015 Trip spans 5 days
United
United
MSY
11:57a
DSM
6:16p
6h 19m
1 stop
DSM
12:30a
MSY
6:27a
5h 57m
1 stop
Depart: Sat Jan 24 2015 Return: Mon Jan 26 2015 Trip spans 3 days
Multiple Airlines
Multiple Airlines
DCA
9:40a
DSM
12:35p
2h 55m
nonstop
DSM
8:03a
DCA
12:02p
3h 59m
1 stop
Depart: Tue Feb 10 2015 Return: Tue Feb 17 2015 Trip spans 8 days
American Airlines
American Airlines
MSP
12:43a
DSM
7:24a
6h 41m
1 stop
DSM
12:46a
MSP
6:17a
5h 31m
1 stop
Depart: Thu Feb 5 2015 Return: Sat Feb 7 2015 Trip spans 3 days
United
United
AUS
2:16p
DSM
6:16p
4h 00m
1 stop
DSM
8:50a
AUS
4:02p
7h 12m
1 stop
Depart: Fri Jun 12 2015 Return: Fri Jun 26 2015 Trip spans 15 days
Allegiant Air
Allegiant Air
LAX
4:15a
DSM
7:33a
3h 18m
nonstop
DSM
10:33a
LAX
2:07p
3h 34m
nonstop
Depart: Mon Feb 9 2015 Return: Thu Feb 12 2015 Trip spans 4 days
Delta
Delta
IAD
2:25a
DSM
10:09a
7h 44m
1 stop
DSM
1:30a
IAD
5:54a
4h 24m
1 stop
Depart: Sun Feb 1 2015 Return: Mon Feb 2 2015 Trip spans 2 days
Delta
Delta
MCO
1:20a
DSM
7:25a
6h 05m
1 stop
DSM
12:20p
MCO
5:28p
5h 08m
1 stop
Depart: Tue Feb 3 2015 Return: Sat Feb 7 2015 Trip spans 5 days
Delta
Delta
PHX
7:45p
DSM
5:25a
9h 40m
1 stop
DSM
9:30a
PHX
7:02p
9h 32m
1 stop
Depart: Tue May 5 2015 Return: Sat May 9 2015 Trip spans 5 days
Delta
Delta
CLT
3:00a
DSM
8:11a
5h 11m
1 stop
DSM
12:45p
CLT
7:10p
6h 25m
1 stop
Depart: Mon Feb 2 2015 Return: Thu Feb 5 2015 Trip spans 4 days
American Airlines
American Airlines
BOS
9:11a
DSM
3:00p
5h 49m
1 stop
DSM
11:35a
BOS
3:49p
4h 14m
1 stop
Depart: Wed Feb 11 2015 Return: Mon Feb 16 2015 Trip spans 6 days
Multiple Airlines
Multiple Airlines
SEA
12:30a
DSM
5:53a
5h 23m
1 stop
DSM
6:46a
SEA
4:05p
9h 19m
1 stop
Depart: Sat Feb 21 2015 Return: Tue Mar 3 2015 Trip spans 11 days
Delta
Delta
PDX
2:00a
DSM
7:33a
5h 33m
1 stop
DSM
3:15a
PDX
9:57a
6h 42m
1 stop
Depart: Sun Feb 8 2015 Return: Fri Feb 13 2015 Trip spans 6 days
Frontier
Frontier
HOU
2:19p
DSM
6:06a
15h 47m
1 stop
DSM
6:46a
HOU
5:31p
10h 45m
1 stop
Depart: Fri Dec 26 2014 Return: Sat Dec 27 2014 Trip spans 2 days
Delta
Delta
MDW
12:07p
DSM
3:48p
3h 41m
1 stop
DSM
12:00p
MDW
4:44p
4h 44m
1 stop
Depart: Mon Apr 13 2015 Return: Tue Apr 21 2015 Trip spans 9 days
Delta
Delta
BWI
12:45p
DSM
5:27p
4h 42m
1 stop
DSM
4:15a
BWI
8:30a
4h 15m
1 stop
Change your search
Airports
Origin

Charlotte
$266
Portland
$322
Seattle
$281
Chicago
only $155
only $330
Austin
$246
Washington
only $259
only $245
Baltimore
$337
Minneapolis
$245
Orlando
$263
New Orleans
$225
Phoenix
$264
Salt Lake City
$198
Los Angeles
$254
Denver
$125
Dallas
$198
Las Vegas
$165
Houston
$327
Boston
$276
Destination

Des Moines
$125