The Econo Lodge hotel in Hannibal, MO is an easy stop on the road. Our hotel is close to attractions like the Mark Twain Boyhood Home and Museum, Rockcliffe Mansion, Historic Main Street, Hannibal-LaGrange University and the Mark Twain Cave Complex. Amenities include free Easy Starts continental breakfast, free WiFi and copy, print and fax services. Guest rooms include TVs, while select rooms come with microwaves, a hot tubs and refrigerators. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program. Do not request non-smoking rooms.