DSM - SYR

$259 Find Cheap Flights from Des Moines to Syracuse

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Syracuse departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Syracuse

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Syracuse, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Syracuse, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$259
Overall average: $383
United Airlines
Sun 11/23Sat 11/29
DSM - SYR • 1 stop
Cheapest one-way
$271
American Airlines
Tue 4/21
DSM - SYR • 1 stop
Top airlines
United Airlines
Cheapest • from $259 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 30% price drop
November
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Syracuse!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Syracuse (DSM-SYR)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Syracuse that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Syracuse

Sun, Nov 23 - Sat, Nov 29
United Airlines Logo
1:05 pm - 9:02 pmDSM-SYR
6h 57m1 stop
United Airlines Logo
9:46 pm - 1:42 amSYR-DSM
4h 56m1 stop
$259United Airlines
Find Deal
Mon, Nov 24 - Tue, Dec 2
United Airlines Logo
11:26 am - 11:13 pmDSM-SYR
10h 47m2 stops
United Airlines Logo
1:05 pm - 5:24 pmSYR-DSM
5h 19m1 stop
$264United Airlines
Find Deal
Fri, Jan 16 - Thu, Jan 22
Delta Logo
5:16 pm - 11:59 pmDSM-SYR
5h 43m1 stop
Delta Logo
6:00 am - 9:41 amSYR-DSM
4h 41m1 stop
$279Delta
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Sat, Jan 17 - Fri, Jan 23
Delta Logo
10:16 am - 6:50 pmDSM-SYR
7h 34m1 stop
Delta Logo
6:00 am - 9:41 amSYR-DSM
4h 41m1 stop
$299Delta
Find Deal
Sat, Nov 15 - Tue, Nov 18
American Airlines Logo
9:02 am - 5:17 pmDSM-SYR
7h 15m1 stop
American Airlines Logo
2:41 pm - 10:02 pmSYR-DSM
8h 21m2 stops
$314American Airlines
Find Deal
Sun, Jan 18 - Wed, Jan 21
Allegiant Air Logo
3:53 pm - 6:56 pmDSM-SYR
26h 03m1 stop
Allegiant Air Logo
12:14 pm - 2:08 pmSYR-DSM
26h 54m1 stop
$325Allegiant Air
Find Deal
Mon, Jan 19 - Wed, Jan 21
Allegiant Air Logo
7:30 am - 6:56 pmDSM-SYR
10h 26m1 stop
Allegiant Air Logo
12:14 pm - 2:08 pmSYR-DSM
26h 54m1 stop
$328Allegiant Air
Find Deal
Thu, Jan 15 - Wed, Jan 21
American Airlines Logo
6:00 am - 11:26 amDSM-SYR
4h 26m1 stop
American Airlines Logo
3:56 pm - 11:08 pmSYR-DSM
8h 12m1 stop
$329American Airlines
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Mon, Dec 15 - Mon, Dec 22
Multiple Airlines Logo
6:35 am - 12:05 pmDSM-SYR
28h 30m2 stops
Multiple Airlines Logo
6:50 pm - 10:13 pmSYR-DSM
28h 23m1 stop
$391Multiple Airlines
Find Deal
Wed, Jan 21 - Thu, Jan 22
Multiple Airlines Logo
6:14 pm - 10:18 amDSM-SYR
15h 04m1 stop
Multiple Airlines Logo
8:04 pm - 3:40 pmSYR-DSM
20h 36m2 stops
$404Multiple Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Des Moines to Syracuse flights

Get data-powered insights and trends into flights from Des Moines to Syracuse to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to Syracuse?

The average price of all round-trip flights from Des Moines to Syracuse clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Syracuse on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Des Moines to Syracuse. For your return ticket, we recommend flying on a Wednesday and avoiding Mondays for the best deals.

What is the cheapest month to fly from Des Moines to Syracuse?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Syracuse, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Syracuse is September, where tickets cost $258 (return) on average. On the other hand, the most expensive months are March and June, where the average cost of round-trip tickets is $618 and $467 respectively.

Good to know

Low seasonSeptember
Cheapest flight$259
Best time to beat the crowds with an average 30% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from Des Moines to Syracuse

When to book flights from Des Moines to Syracuse

Are your dates flexible? Find out the best times to travel from Des Moines to Syracuse based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Syracuse

  • What is the cheapest flight from Des Moines to Syracuse?

    In the last 3 days, the lowest price for a flight from Des Moines to Syracuse was $271 for a one-way ticket and $259 for a round-trip.

  • Do I need a passport to fly between Des Moines and Syracuse?

    No

  • Which airports will I be using when flying from Des Moines to Syracuse?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Syracuse, also known as Syracuse Hancock Intl.

  • Which aircraft models fly most regularly from Des Moines to Syracuse?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Syracuse?

    SkyTeam, and oneworld are the airline alliances operating flights between Des Moines and Syracuse, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Syracuse, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Syracuse are Delta and American Airlines. With an average price for the route of $328 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $376 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Des Moines to Syracuse?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Syracuse.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Syracuse?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Syracuse from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Syracuse?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Syracuse with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and SYR can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Syracuse?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Syracuse from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Syracuse

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Syracuse. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Syracuse? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7997 reviews
8.2Boarding
8.5Crew
7.9Comfort
7.9Entertainment
7.3Food
Airline reviews

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

6.0 GoodDavid, Oct 2025LAX - JFK
Read more Delta reviews

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

Delta made it easy, comfortable and timely. The crew was fantastic.

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

De planning was an absolute mess. We were never told that we weren’t at the gate and that we had to go down unstable stairs and then hop on a bus. People were falling, we couldn’t tell who was in charge. Overall terrible communication that ended up leaving a bad impression at the very end of the experience.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Did not know my son and I had different seating arrangements. He was fine, but it was disappointing.

My flight was canceled after being rescheduled for four days canceling my trip. Kayak and everyone affiliated with it I.e the airlines, and just fly have been excruciating to deal with. My trip to visit family had to be canceled as there was no way to make it. I am furious at all of you.

They delayed our flight because of bad weather in NY which was completely understandable. Then they cancelled our flight and a later flight that evening. The earliest we could fly was the next morning. We ended up buying last minute tickets on another airline and made it home slightly delayed but safely that evening. Delta kept saying it was weather related but if that was the case how did we make it back on another airline? The weather in NY was cloudy but not bad.

I like for how they process during check in. It was very smoothly.

There was no TV's on the plane? I tried to activated the WiFi multiple times before the plane took off but it wasn't work well.

Air Marco’s fleet of airplanes are old and pathetic. The seats are torn and stained. The monitors don’t work properly. If this wasn’t a business trip and I had control of booking the flight, I would not travel on this carrier.

Flight was cancelled 3 hrs AFTER etd. Thetefore Missed connection from JFK to New Zealand . No accommodation provided… This cost ne aporox 1000 USD in extra expenses and turned whst should have been a 24 hr trip ftom Boston - New Zealand into a VERY expensive , late 70+ hr nightmare … Complete nonsense!!!

Overall fine, but the delay was annoying and the reasons for the delay were not communicated. The crew on board were phenomenal!

Whenever a passenger purchase a ticket his advantage number should automatically to his information. It's not everyone remember the number. You request for your number and American airline agent say they will email it....and they never email anything and you loose your mileage just because you don't remember your number. It should automatically go your information and associate with your email account at all times

In flight connectivity (via T-Mobile) was often not working.

Boarding took forever, the plane was cramped and cold, and the seatbelt song came on constantly throughout the red eye flight with a loud pre-recorded message playing each time

Cabin felt crammed Snacks are lame But crew was super efficient getting us out on time despite delay

Flight was empty so had a whole row to myself. Still had to wait to get the bag due to the negligence at Palm Springs departure.

I flew out of Reagan National. My flight was delayed, delayed, delayed, and then canceled ...THREE TIMES over TWO DAYS. Staff were seemingly not empowered to provide information on why the flights were screwed up. A real nightmare.

Everything you need to know for your flight from Des Moines to Syracuse

Information on your arrival and departure airports

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