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TYS - STL

$131 Find cheap flights from Knoxville to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to St. Louis departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sat 5/25
Sat 6/1

Search hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to St. Louis, as well as popular online travel agencies
In the last 7 days travelers have searched 45,119,101 times on KAYAK, and here is why:

Save 22% or moreCompare multiple travel sites with one search.

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Cheap flight deals from Knoxville to St. Louis (TYS-STL)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
6:31 pm - 10:59 pmTYS-STL
5h 28m1 stop
5:08 pm - 10:20 pmSTL-TYS
4h 12m1 stop
$221American Airlines
Find Deal
Sat, May 25 - Sun, May 26
5:35 am - 8:52 amTYS-STL
4h 17m1 stop
7:15 pm - 11:57 pmSTL-TYS
3h 42m1 stop
$228Delta
Find Deal
Thu, Aug 8 - Sun, Aug 11
5:20 am - 9:06 amTYS-STL
4h 46m1 stop
7:06 pm - 11:53 pmSTL-TYS
3h 47m1 stop
$233Delta
Find Deal
Fri, Jul 19 - Sun, Jul 21
5:30 am - 9:05 amTYS-STL
4h 35m1 stop
6:30 pm - 11:55 pmSTL-TYS
4h 25m1 stop
$238Delta
Find Deal
Sat, May 11 - Tue, May 14
5:19 am - 9:53 amTYS-STL
5h 34m1 stop
5:38 pm - 11:58 pmSTL-TYS
5h 20m1 stop
$330American Airlines
Find Deal
Sat, Jun 1 - Sat, Jun 8
5:19 am - 9:53 amTYS-STL
5h 34m1 stop
5:04 am - 10:37 amSTL-TYS
4h 33m1 stop
$435American Airlines
Find Deal
Fri, May 10 - Sun, May 12
5:10 am - 8:30 amTYS-STL
4h 20m1 stop
5:46 pm - 11:57 pmSTL-TYS
5h 11m1 stop
$475American Airlines
Find Deal
Sun, Jul 21 - Sun, Jul 28
10:51 am - 2:23 pmTYS-STL
4h 32m1 stop
5:25 pm - 9:08 pmSTL-TYS
26h 43m1 stop
$552United Airlines
Find Deal
Wed, May 15 - Fri, May 17
10:51 am - 3:46 pmTYS-STL
5h 55m1 stop
11:10 am - 7:24 pmSTL-TYS
7h 14m2 stops
$582United Airlines
Find Deal
Sat, May 11 - Tue, May 14
10:51 am - 3:46 pmTYS-STL
5h 55m1 stop
5:25 pm - 2:51 pmSTL-TYS
20h 26m2 stops
$687United Airlines
Find Deal
Sun, May 5 - Tue, May 7

Flights from Knoxville to St. Louis - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Knoxville to St. Louis?

The average price of all flights from Knoxville to St. Louis clicked on KAYAK for each day over the last 12 months.
If you are looking for a flight deal from Knoxville to St. Louis, look for departures on Wednesdays and avoid leaving on a Monday, as it's usually the priciest day. When flying back from St. Louis, Wednesday is the cheapest day to fly and Sunday is the most expensive.

What is the cheapest month to fly from Knoxville to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Knoxville to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Knoxville to St. Louis is November, where tickets cost $304 on average. On the other hand, the most expensive months are June and March, where the average cost of tickets is $595 and $488 respectively.

How far in advance should I book a flight from Knoxville to St. Louis?

To calculate daily average prices, KAYAK takes all prices for each day before departure over the last year for flights from Knoxville to St. Louis, removes the top 0.1% to account for outliers, and then takes the average of all the values for each month.
To get a below average price on the flight from Knoxville to St. Louis, you should book around 4 days before departure. For the absolute cheapest price, our data suggests you should book 73 days before departure.

Which airlines provide the cheapest flights from Knoxville to St. Louis?

The cheapest price for the route for each airline clicked by KAYAK users in the last 72 hours.
In the last 3 days, Frontier offered the best one-way deal for that route, at $131. KAYAK users also found Knoxville to St. Louis round-trip flights on American Airlines from $221 and on Delta from $228.

Good to know

Low season

January

High season

September

Cheapest flight

$131
Best time to beat the crowds with an average 8% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Knoxville to St. Louis

When to book flights from Knoxville to St. Louis

Are your dates flexible? Find out the best times to travel from Knoxville to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to St. Louis

  • What is the cheapest flight from Knoxville to St. Louis?

    In the last 3 days, the lowest price for a flight from Knoxville to St. Louis was $131 for a one-way ticket and $221 for a round-trip.

  • Do I need a passport to fly between Knoxville and St. Louis?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Knoxville to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to St. Louis?

    oneworld, SkyTeam, and Star Alliance are the airline alliances operating flights between Knoxville and St. Louis, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to St. Louis, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to St. Louis are Delta and American Airlines. With an average price for the route of $376 and an overall rating of 8.0, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $299 and an overall rating of 7.3.

  • How does KAYAK find such low prices on flights from Knoxville to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top airlines flying from Knoxville to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10975 reviews
8.2boarding
7.9comfort
8.0entertainment
8.6crew
7.4food
Airline reviews

I'm a larger, athletic guy (6'2", 260lbs powerlifter) and I found the seats incredibly uncomfortable with minimal leg room, especially in a window seat. Now, I full understand that being smaller may change my view but even if I was 80lbs less, my legs would be the same size and I was sandwiched between my seat and the seat in front of me.

6.0 GoodDan, Apr 2024LGA - DEN
Read more about Delta reviews

I'm a larger, athletic guy (6'2", 260lbs powerlifter) and I found the seats incredibly uncomfortable with minimal leg room, especially in a window seat. Now, I full understand that being smaller may change my view but even if I was 80lbs less, my legs would be the same size and I was sandwiched between my seat and the seat in front of me.

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

This flight was ridiculous. I had to have a connecting flight from New York to orlando Florida??? The flight left late and because it was a short flight there was no first class amenities. I had one alcohol drink. The flight crew was fine, but it sure did not feel like first class. Delta to me dropped the ball by giving me a connecting flight. By the time we got to Raleigh we would have missed the next flight. Lucky for me the flight never came so now I was stuck waiting for a later flight that came in late also.

Our flight was delayed in Atlanta. The staff could have gave us an explanation for the delay and how long it would be.

I liked the ease of checking in, luggage check in, wheel chair assistance, boarding and flight.

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive.

They did a fine job. Can't wait to use Delta in the future.

There was a loud squeaky sound the whole time we were flying.

Had a broken tray in business class. Crew just shrugged it off.

This flight is frequently delayed. The connections seemingly are more frequently delayed. I’ve missed connections as a result twice on the same route to charlotte then Charleston. Final destination arrival has been the next day, twice in a row. No pilots, no crew. Too many excuses. Unfortunately, my days with American are over.

Entertainment was okay not because anything was wrong but it is a short flight so having no wifi is annoying but understandable. Crew was outstanding as usual

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

The Flight attendant had an attitude and didn't allow anyone any time to prepare for landing despite being absent throughout the entire trip

Flight boarded without pilots. Sat on plane for 3 hrs. after over an hour late boarding. Plane never took off. Had to deplane near midnight. Line for rebooking was 3 hours + long. I had to leave.

The flight was great but board was a nightmare. The gate was changed 4 times during the layover period

The experience was great and much better than the flight going out. of course I was in first class but the service was excellent

Cold air blew constantly on my legs almost making me numb.

Missed the flight because of them and up geting a rental car

Delayd flight out of atl as always miss my conection in dfw no flight untill next day

Book cheap flights from Knoxville to St. Louis

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Knoxville to St. Louis found on KAYAK in the last 72 hours.
5/16Thu
1 stopFrontier
10h 13mTYS-STL
$131
5/8Wed
1 stopFrontier
24h 47mTYS-STL
$249
5/16Thu
2 stopsAmerican Airlines
7h 34mTYS-STL
$259
5/8Wed
2 stopsAmerican Airlines
10h 09mTYS-STL
$343
5/7Tue
1 stopAmerican Airlines
3h 52mTYS-STL
$368
5/7Tue
2 stopsAmerican Airlines
7h 21mTYS-STL
$373

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Last minute flights from Knoxville to St. Louis

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Knoxville to St. Louis that are departing in the next 10 days.
4/27Sat
multi-stopAmerican Airlines
5h 24mTYS-STL
4/28Sun
multi-stopAmerican Airlines
6h 04mSTL-TYS
$261
4/26Fri
multi-stopAmerican Airlines
5h 35mTYS-STL
4/28Sun
multi-stopAmerican Airlines
4h 29mSTL-TYS
$262
4/26Fri
multi-stopDelta
6h 29mTYS-STL
4/29Mon
multi-stopDelta
3h 52mSTL-TYS
$264
4/26Fri
multi-stopAmerican Airlines
8h 19mTYS-STL
4/28Sun
multi-stopAmerican Airlines
5h 55mSTL-TYS
$520
4/26Fri
multi-stopAmerican Airlines
8h 19mTYS-STL
4/28Sun
multi-stopAmerican Airlines
7h 09mSTL-TYS
$525
4/27Sat
multi-stopUnited Airlines
12h 49mTYS-STL
4/30Tue
multi-stopUnited Airlines
4h 18mSTL-TYS
$561
4/26Fri
multi-stopUnited Airlines
4h 23mTYS-STL
4/26Fri
multi-stopUnited Airlines
15h 54mSTL-TYS
$747
4/27Sat
multi-stopDelta
4h 29mTYS-STL
4/27Sat
multi-stopDelta
15h 43mSTL-TYS
$762
4/26Fri
multi-stopDelta
5h 56mTYS-STL
4/27Sat
multi-stopDelta
12h 10mSTL-TYS
$776
4/26Fri
multi-stopDelta
6h 26mTYS-STL
4/26Fri
multi-stopDelta
16h 01mSTL-TYS
$835

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Knoxville - St. Louis Flights

Departure:

Knoxville (TYS)United States

Destination:

St. Louis (STL)United States

Return flight deals:

St. Louis - Knoxville

Cabin classes: