CLO - GYE

$236 Find Cheap Flights from Cali to Guayaquil - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$376
Typical prices: $323-$414
Copa Airlines
Mon 11/26Tue 1/9
CLO - GYE • 1 stop
Cheapest one-way
$236
Typical prices: $182-$239
LATAM Airlines
Mon 11/26
CLO - GYE • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Cali and Guayaquil. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
13 weeks
in advance
Our data shows that travelers who book at least 13 weeks in advance save around 11% compared to booking last minute.
Insights
Insights
When to travel
February
Cheapest • 22% price drop
December
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Bogotá El Dorado (BOG)
Cheapest • Avg $376 (round-trip)
Medellín Jose Maria Cordova Intl (MDE)
Shortest trip • 5h 06m (one-way)
Insights
Insights
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Cali to Guayaquil (CLO-GYE)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Cali to Guayaquil

Thu, Nov 26 - Sat, Jan 9
Copa Airlines Logo
3:01 pm - 8:56 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
5h 55m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:22 pm - 11:00 amGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
22h 38m1 stop Panama City Tocumen Intl
$376Copa Airlines
Mon, Nov 23 - Wed, Jan 27
Copa Airlines Logo
12:05 pm - 11:18 amCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
23h 13m1 stop Panama City Tocumen Intl
Copa Airlines Logo
8:25 am - 5:34 pmGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
9h 09m1 stop Panama City Tocumen Intl
$376Copa Airlines
Wed, Nov 25 - Mon, Jan 11
Copa Airlines Logo
6:14 pm - 5:35 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
23h 21m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:34 pm - 5:34 pmGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
23h 00m1 stop Panama City Tocumen Intl
$376Copa Airlines
Mon, Dec 7 - Thu, Dec 24
Copa Airlines Logo
8:40 am - 1:42 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
5h 02m1 stop Panama City Tocumen Intl
Copa Airlines Logo
8:25 am - 5:33 pmGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
9h 08m1 stop Panama City Tocumen Intl
$376Copa Airlines
Wed, Nov 25 - Mon, Jan 11
Copa Airlines Logo
12:05 pm - 8:56 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
8h 51m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:34 pm - 11:00 amGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
16h 26m1 stop Panama City Tocumen Intl
$376Copa Airlines
Tue, Nov 24 - Mon, Jan 25
Copa Airlines Logo
3:01 pm - 11:18 amCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
20h 17m1 stop Panama City Tocumen Intl
Copa Airlines Logo
2:44 pm - 11:00 amGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
20h 16m1 stop Panama City Tocumen Intl
$376Copa Airlines
Thu, Nov 19 - Mon, Nov 23
Copa Airlines Logo
6:14 pm - 11:18 amCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
17h 04m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:38 pm - 10:57 amGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
16h 19m1 stop Panama City Tocumen Intl
$376Copa Airlines
Mon, Dec 7 - Sun, Jan 24
Copa Airlines Logo
3:12 pm - 1:42 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
22h 30m1 stop Panama City Tocumen Intl
Copa Airlines Logo
8:25 am - 5:34 pmGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
9h 09m1 stop Panama City Tocumen Intl
$376Copa Airlines
Tue, Dec 1 - Thu, Dec 10
Avianca Logo
12:15 pm - 6:25 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
6h 10m1 stop Bogotá El Dorado
Avianca Logo
3:30 am - 9:45 amGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
6h 15m1 stop Bogotá El Dorado
$381Avianca
Tue, Dec 1 - Fri, Dec 11
Avianca Logo
8:00 am - 3:10 pmCLO  Cali Alfonso B. Aragon Intl-GYE Guayaquil Jose Joaquin de Olmedo
7h 10m1 stop Bogotá El Dorado
Avianca Logo
4:20 pm - 11:05 pmGYE  Guayaquil Jose Joaquin de Olmedo-CLO Cali Alfonso B. Aragon Intl
6h 45m1 stop Bogotá El Dorado
$381Avianca
Booking Insights

Price, demand and travel trends for Cali to Guayaquil flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Cali to Guayaquil?

Round-trip flights from Cali to Guayaquil typically range from $323 to $414. The lowest price found in the past 5 days was $376, on Copa Airlines.

What's the cheapest day of the week to fly from Cali to Guayaquil?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Cali to Guayaquil. It’s 4% cheaper than the average day, while Wednesday is the most expensive, with prices 1% higher.

What’s the cheapest month to fly from Cali to Guayaquil?

•February is the cheapest month to fly from Cali to Guayaquil at $298 round-trip.
•April ($413) and September ($389) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 38% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from Cali to Guayaquil the cheapest?

Flights from Cali to Guayaquil are cheapest 13 weeks before departure. Booking in this window typically costs about 11% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

Find deals

Key details for Cali to Guayaquil flights

Low season

September

Cheapest flight

$236
Beat the crowds with an average 31% drop in travelers.
The most popular month to fly with an average 35% increase in travelers.
One-way flight from Cali to Guayaquil

When to book flights from Cali to Guayaquil

Are your dates flexible? Find out the best times to travel from Cali to Guayaquil based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Cali to Guayaquil flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Cali to Guayaquil?

    Only Economy Class is available on flights from Cali to Guayaquil.

  • How long is a flight from Cali to Guayaquil?

    A nonstop flight from Cali to Guayaquil takes 00m, covering 462 miles.

  • Do I need a passport to fly from Cali to Guayaquil?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Cali to Guayaquil flight?

    Round-trip flights from Cali to Guayaquil range from $323 to $414, with an average of $382 over the past 12 months. Anything below $323 counts as a good deal.

  • How expensive are last-minute Cali to Guayaquil flights?

    Last-minute fares on this route (booked within two weeks of departure) are 2% below the route average of $382. Booking late can sometimes save you money, but inventory is limited.

  • Have flight prices from Cali to Guayaquil changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $376 to $529. That means the highest observed fare was about 40% higher than the lowest one.

  • How are flight prices from Cali to Guayaquil looking right now?

    One-way fares from Cali to Guayaquil are currently higher than usual. Average one-way flight prices are about $301, which is 41% above the typical average for this route.

  • What car rental options are available at Guayaquil Jose Joaquin de Olmedo Airport (GYE)?

    Guayaquil Jose Joaquin de Olmedo Airport (GYE) hosts 5 major car rental companies, with daily rates averaging $37 for economy cars. Top options include:

    • Europcar
    • Fox
    • Sixt
    • Alamo
    • keddy by Europcar

  • Which airports can I use when flying from Cali to Guayaquil?

    Flights from Cali to Guayaquil usually depart from Cali Alfonso B. Aragon Intl (CLO) and arrive at Guayaquil Jose Joaquin de Olmedo (GYE).

  • Which airports do connecting flights from Cali to Guayaquil pass through?

    One-stop flights from Cali to Guayaquil most commonly connect through:

    • Bogotá El Dorado (BOG) - 72% of one-stop connections
    • Panama City Tocumen Intl (PTY) - 28% of one-stop connections
    • Medellín Jose Maria Cordova Intl (MDE) - 0% of one-stop connections

  • Can I save money by using flexible dates for flights from Cali to Guayaquil?

    Yes. Flexible dates can save you up to 5% on flights from Cali to Guayaquil. Thursday is the cheapest departure day at $370 round-trip on average, while Wednesday is the most expensive at $387, a difference of $17.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Cali to Guayaquil?

    Flying via Bogotá El Dorado (BOG) gives the shortest average 1-stop total travel time at 4h 52m, compared with 5h 06m via Medellín Jose Maria Cordova Intl (MDE) and 5h 32m via Panama City Tocumen Intl (PTY).

Your guide to booking Cali to Guayaquil flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Thursday departure and avoid flying on Wednesday. On this route, Thursday flights average $370, about $17 less than Wednesday fares (4% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 13 weeks before you fly. On this route, that window historically saves about 11% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your Cali to Guayaquil trip for February. Fares historically average $298 round-trip in that month - typically $115 less than the most expensive month, which is April (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Guayaquil Jose Joaquin de Olmedo Airport.

    • Radisson Hotel Guayaquil
    • Wyndham Guayaquil Puerto Santa Ana
    • Hilton Colon Guayaquil

More options for your flight from Cali to Guayaquil

Complete your trip to Guayaquil with a hotel stay or car rental

Car rentals in Guayaquil
Hotels in Guayaquil