Welcome to the Holiday Inn Express Chillicothe! We are located in historic Chillicothe, Ohio, in the foothills of the majestic Appalachian Mountains, in Ohio's first capital city. Chillicothe, home to Ohio University-Chillicothe and Daymar College, is rich in both history and nature. While visiting, you can tour Adena Mansion & Garden, home of Thomas Worthington, catch a show at the 152 year old Majestic Theatre, see a home-run at a Chillicothe Paints baseball game, and stroll and shop in historic downtown Chillicothe; just make sure you save time to see the epic outdoor drama Tecumseh! Convenient to both the Veterans Affair Medical Center and Adena Hospital, consider the Holiday Inn Express, Chillicothe when visiting friends and family. For business travelers Chillicothe is home to the Petland Corporate Headquarters, Mead Corporation-Chillicothe Operations, Kenworth Truck Manufacturing and YSK Corporation. No matter what brings you to town, you'll be sure to find what you're looking for at the Holiday Inn Express Chillicothe!