TYS - ECP

$119 Find Cheap Flights from Knoxville to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$237
Typical prices: $298-$449
American Airlines
Sat 7/18Wed 7/22
TYS - ECP • 1 stop
Cheapest one-way
$119
Southwest
Wed 8/5
TYS - ECP • 1 stop
Top airlines
Cheapest • from $237 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Panama City. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $364 (round-trip)
Shortest trip • 3h 32m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 21% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama City

Sat, Jul 18 - Wed, Jul 22
American Airlines Logo
8:05 pm - 11:37 pm
TYS
-
ECP
4h 32m
1 stop
American Airlines Logo
6:54 pm - 11:51 pm
ECP
-
TYS
3h 57m
1 stop
$237American Airlines
Tue, Jul 21 - Tue, Jul 28
Southwest Logo
7:10 am - 9:30 am
TYS
-
ECP
3h 20m
1 stop
Southwest Logo
7:40 am - 5:00 pm
ECP
-
TYS
8h 20m
2 stops
$242Southwest
Wed, Aug 12 - Wed, Aug 19
Southwest Logo
7:00 am - 5:00 pm
TYS
-
ECP
11h 00m
2 stops
Southwest Logo
9:10 am - 7:50 pm
ECP
-
TYS
9h 40m
2 stops
$247Southwest
Tue, Jul 28 - Sat, Aug 1
Southwest Logo
8:10 am - 7:45 pm
TYS
-
ECP
12h 35m
2 stops
Southwest Logo
6:35 am - 12:55 pm
ECP
-
TYS
5h 20m
1 stop
$248Southwest
Tue, Jul 21 - Tue, Jul 28
Southwest Logo
7:10 am - 4:45 pm
TYS
-
ECP
10h 35m
2 stops
Southwest Logo
7:40 am - 5:00 pm
ECP
-
TYS
8h 20m
2 stops
$253Southwest
Sat, Jul 18 - Wed, Jul 22
Southwest Logo
1:35 pm - 10:00 pm
TYS
-
ECP
9h 25m
2 stops
Southwest Logo
7:40 am - 12:05 pm
ECP
-
TYS
3h 25m
1 stop
$258Southwest
Sat, Sep 12 - Sat, Sep 19
Southwest Logo
6:50 am - 11:05 am
TYS
-
ECP
5h 15m
1 stop
Southwest Logo
7:45 am - 11:55 am
ECP
-
TYS
3h 10m
1 stop
$259Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
6:50 am - 11:05 am
TYS
-
ECP
5h 15m
1 stop
Southwest Logo
7:45 am - 11:55 am
ECP
-
TYS
3h 10m
1 stop
$264Southwest
Wed, Jul 22 - Mon, Jul 27
American Airlines Logo
8:05 pm - 11:37 pm
TYS
-
ECP
4h 32m
1 stop
American Airlines Logo
6:54 pm - 11:51 pm
ECP
-
TYS
3h 57m
1 stop
$268American Airlines
Mon, Aug 24 - Sat, Aug 29
Southwest Logo
7:10 am - 3:45 pm
TYS
-
ECP
9h 35m
2 stops
Southwest Logo
10:40 am - 5:40 pm
ECP
-
TYS
6h 00m
1 stop
$269Southwest
Booking Insights

KAYAK's insights & trends for Knoxville to Panama City flights

Get data-powered insights and trends into flights from Knoxville to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to Panama City, Florida?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to Panama City, Florida departing in July.

What is the cheapest month to fly from Knoxville to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama City is May, where tickets cost $312 (return) on average. On the other hand, the most expensive months are December and April, where the average cost of round-trip tickets is $720 and $442 respectively.

Good to know

Low seasonDecember
Cheapest flight$119
Best time to beat the crowds but there is an average 84% increase in price.
Most popular time to fly with an average 1% increase in price.
Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Panama City

  • What is the cheapest flight from Knoxville to Panama City?

    In the last 5 days, the lowest price for a flight from Knoxville to Panama City was $119 for a one-way ticket and $237 for a round-trip.

  • Do I need a passport to fly between Knoxville and Panama City?

    No, a passport isn't needed to fly from Knoxville to Panama City. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from Knoxville to Panama City?

    On your way to Panama City, you’ll fly out from Knoxville McGhee Tyson. You’ll be landing at Panama City NW Florida Beaches.

  • Which aircraft models fly most regularly from Knoxville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Panama City?

    oneworld, and SkyTeam are the airline alliances operating flights between Knoxville and Panama City, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Knoxville to Panama City are Southwest and Delta. With an average price for the route of $335 and an overall rating of 7.9, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $380 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from Knoxville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4241 reviews
8.0Comfort
7.5Entertainment
7.0Food
8.1Boarding
8.6Crew
Airline reviews

Flight was constantly delayed with significant changes in time, it was supposed to get to Colorado Springs at 8:30 PM but it got there after midnight.

2.0 MediocreMarcela, Jun 2026
DAL - COS
Read more Southwest reviews

Flight was constantly delayed with significant changes in time, it was supposed to get to Colorado Springs at 8:30 PM but it got there after midnight.

Over a 3 hour flight. The turbulence was almost imperceptible except for 2 short periods which were not bad and over quickly. The attendants claimed "Safety first" and sat looking at their phones for 3 hours with no drink or snack service. This isn't the first time with Southwest. I thinkit may be there new plan of operation. Oh, and it was June 18, Southwest's Birthday which offered free drinks. NOT.

Flight was delayed, full flight and I had to change gates. Southwest flights are always late later in the day.

Flight was delayed over 3 hours. Planes were dirty. Staff indifferent. And they serve vegan pretzels as snacks.

I'm glad it wasn't only 75% full because I could get a good seat

We waited in the airplane for over 45 min for a southwest employee to make the flight. This cause over half the plane to miss their connecting flight in Denver. When we confronted the desk upon arrival, they told us the only flight they had was the next day leaving at 8:50 pm!!! Or they offered to get us to Burbank or LA, but after that we were on our own to get back to Santa Barbara. I paid for a flight from sba to bna bna to sba. My re entry into mom mode has been 💯 rough because of southwest mistake with my flight. And now I’m leaving to Reno tomorrow for a vballl tournament and just discovered that my leg in Vegas has me and my 3 kids on a stand by flight even though I had booked these ticket last year November!! Do better southwest!

The flight was okay. The pilots did an amazing job and kept us updated on the flight. The flight attendants were okay. They found time to be chatty with each other rather than focus on the guests. One of the attendants was a little less warm when asking about my bag I had on my lap that I was using during latter part of the mid- flight. Mind you, it was not the departure descent. I’m respectful to each and every attendant, it was the tone in her voice reminding me to place my carryon bag on the floor. I hope to have a better experience next time.

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was canceled. Supposedly weather. But there was no snow in Baltimore. At least we found out before driving to airport

Still need to work out the kinks on the new assigned seating boarding process. Otherwise, a very good flight.

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Definitely a southern flavor. Cordiality was evident even though no drinks or snacks were served.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

I continue to be satisfied with Delta’s excellent service out of LGA. The digit id works well and gets me through security in no time. Whenever possible, I choose Delta.

Was revoked with Jet Blue due to delay from Kenya Air

Overall Good! The weather delayed our takeoff from Atlanta and our arrival in Miami! If Mother Nature can mess up a flight she will do it every time!

N Everything was perfect from boarding to assistance to baggage in Tampa

Snacks and included beverages were appreciated. Boarding went smoothly. Plenty of overhead bin space. Seats get very uncomfortable after a couple of hours. After waiting 10 painful minutes for my walker, a very nice Delta guest agent pushed me in a wheelchair to the gate. It was finally delivered to me after another 15 minutes . Our checked bag was on the carousel long b4 I was able to retrieve it. Fortunately it was still there but somewhere along the way the straps we used to secure it were removed and and were not reattached. Wish I had made note of the agents name.

The whole experience was excellent. As it most often is with Delta

We waited an hour on the runway to get a gate in Orlando

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

We sat on plane at gate delayed without communication as to why we were just sitting there

Flight was delayed by 6 hours... the level of incompetence was truly astounding. I won't be flying American Airlines again. I don't care if AA is direct and there is a layover with another airline, I'll take the layover.

Little time between flight from Dallas to flight to Gainesville. We chose this one, 43 minutes between, because the price for a connection with at least an hour between, was so much higher. Had to ask passengers on the Dallas flight to please allow us to deplane ahead of them. The economy passengers allowed this. We had to walk very fast to the next gate, 35 gates away. Thankfully all in the same terminal. Getting to the small Gainesville plane was a little confusing as you enter an area that is boarding many small planes at the same time. We stood in the wrong line for about 15 seconds before realizing it was not our Gainesville flight. Since I had boarded at this gate in the past, I knew to check the signs carefully so we weren’t lost. The first class seat experience was wonderful. I really enjoyed the upgrade. We were offered an alcohol drink as soon as we sat down. I got something different but it was a great gesture especially since we really had to hurry to make the flight. We had packed expecting we might miss this connection, but made it. Our luggage didn’t miss the flight. American Airlines delivered our bags to our home the next day. That was very convenient!

The plane was large, not full, but one with 3 seats near each window and 4 in a row in the middle of the plane. There were screens on the backs of the seats for entertainment and information. To use the entertainment one needs ear plugs that physically plug into the screen. My husband had some he let me use as I only had blue tooth type. The stewards gave out some headphones to some, but when my neighbor asked for some, the steward said no. So maybe they ran out? Idk. Bring the old kind of headphones or earbuds if you want entertainment in case this is the type of entertainment offered. We had a very tight connection in Miami. 43 minutes. The other economy passengers allowed us to get ahead of them because I asked if we could since we were near boarding time for our next flight and 35 gates away. They were extremely kind. First class wasn’t going to allow us to pass through. We did make the next flight. Our baggage didn’t, but they were delivered to us the next day and we were prepared with essentials in our carry on packs.

Flight left on time. Captain provided relevant announcements. We had to wait 45 minutes to desembark due to the ramp closed because of lightening.

So overall the flight was just average and nothing special. They overbooked some of the flights and they ended up running out of overhead storage space so we had to check our carry-ons which wasn't terrible but we were inconvenienced because of the second connecting flight with a long layover we couldn't get our bags until the final destination. Most of the flight attendants were pretty good and overall the meals were not that great because the chicken was dry and overcooked. They also didn't provide butter or any kind of spread with the bread which is cheap and concerning. The American airlines staff at the check-in counter was kind of unprofessional because this lady just started singing in the middle of checking us in and that's weird. The worst part of the flights was the terrible conditions of the bathrooms which were unclean and did not have toilet paper or toilet tissue available which is kind of insane for a 14-hour and 8 and 1/2 hour flight.

Cancelled BOYH legs of our flight home 30 min before initial boarding

Flight left early and arrived 30 MINUTES early at the destination. Smooth trip.

I was able to get the AA customer Service desk to put me on an earlier flight without any issues.

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports