TYS - ECP

$130 Find Cheap Flights from Knoxville to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama City

Sat, Dec 6 - Tue, Dec 9
Delta Logo
5:30 am - 9:03 amTYS-ECP
4h 33m1 stop
Delta Logo
2:00 pm - 6:13 pmECP-TYS
3h 13m1 stop
$259Delta
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Thu, Sep 25 - Sat, Sep 27
Delta Logo
4:13 pm - 7:30 pmTYS-ECP
4h 17m1 stop
Delta Logo
6:00 am - 10:25 amECP-TYS
3h 25m1 stop
$283Delta
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Sat, Sep 6 - Sat, Sep 13
Delta Logo
4:19 pm - 7:48 pmTYS-ECP
4h 29m1 stop
Delta Logo
6:00 am - 10:25 amECP-TYS
3h 25m1 stop
$293Delta
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Thu, Sep 25 - Sun, Sep 28
Delta Logo
5:45 am - 9:55 amTYS-ECP
5h 10m1 stop
Delta Logo
6:54 pm - 11:44 pmECP-TYS
3h 50m1 stop
$307Delta
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Fri, Nov 7 - Fri, Nov 14
American Airlines Logo
7:20 pm - 11:15 pmTYS-ECP
4h 55m1 stop
American Airlines Logo
5:55 pm - 10:51 pmECP-TYS
3h 56m1 stop
$337American Airlines
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Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
9:08 am - 1:47 pmTYS-ECP
5h 39m1 stop
American Airlines Logo
11:18 am - 11:20 pmECP-TYS
11h 02m2 stops
$364American Airlines
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Sun, Aug 31 - Sun, Sep 7
American Airlines Logo
11:15 am - 2:03 pmTYS-ECP
3h 48m1 stop
American Airlines Logo
6:59 pm - 12:07 amECP-TYS
4h 08m1 stop
$367American Airlines
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Fri, Sep 12 - Fri, Sep 19
United Airlines Logo
7:25 pm - 2:36 pmTYS-ECP
20h 11m2 stops
United Airlines Logo
3:03 pm - 7:53 pmECP-TYS
27h 50m1 stop
$586United Airlines
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Fri, Nov 7 - Fri, Nov 14
United Airlines Logo
4:55 pm - 1:47 pmTYS-ECP
21h 52m2 stops
United Airlines Logo
3:00 pm - 8:09 pmECP-TYS
28h 09m1 stop
$591United Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
United Airlines Logo
6:45 am - 1:47 pmTYS-ECP
32h 02m3 stops
United Airlines Logo
6:30 am - 11:44 pmECP-TYS
16h 14m1 stop
$592United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Knoxville to Panama City flights

Get data-powered insights and trends into flights from Knoxville to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama City is August, where tickets cost $366 (return) on average. On the other hand, the most expensive months are November and February, where the average cost of round-trip tickets is $670 and $628 respectively.

Good to know

Low seasonFebruary
Cheapest flight$130
Best time to beat the crowds but there is an average 31% increase in price.
Most popular time to fly with an average 1% increase in price.
Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Panama City

  • What is the cheapest flight from Knoxville to Panama City?

    In the last 3 days, the lowest price for a flight from Knoxville to Panama City was $130 for a one-way ticket and $259 for a round-trip.

  • Do I need a passport to fly between Knoxville and Panama City?

    No, a passport isn't needed to fly from Knoxville to Panama City. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from Knoxville to Panama City?

    On your way to Panama City, you’ll fly out from Knoxville McGhee Tyson. You’ll be landing at Panama City NW Florida Beaches.

  • Which aircraft models fly most regularly from Knoxville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Panama City?

    oneworld, SkyTeam, and Star Alliance are the airline alliances operating flights between Knoxville and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Panama City, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Panama City are Delta and American Airlines. With an average price for the route of $424 and an overall rating of 8.0, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $515 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7982 reviews
7.9Entertainment
8.5Crew
7.9Comfort
8.2Boarding
7.3Food
Airline reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

8.0 ExcellentJeanne, Aug 2025MSY - JFK
Read more Delta reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

The seats got pretty uncomfortable pretty fast. The armrests are bigger than on other planes, so I had less room in the actual seat. My butt hurt by the end of the flight. :/ comfort was the primary issue. The crew were fantastic!

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

this crew didn't care much. bumping carts into seats more times than i care to remember

Everything was fine except the entertainment was not working for half of the flight.

Easy boarding with an extremely kind attendant. Seats were spacious and we had 3 seats for 2 people so we could stretch out. Comfortable air flow and very attentive and hospital attendants. Bathrooms and food were the only negative. Bathrooms were so small you could hardly get in and close the door. I don’t think an obese person would fit or a person with a movement disability. Food was the trending food for flights, nonexistent. We spent $40 getting sandwich and snack at airport for our 6 hour flught.

I am very bothered by the events today. I can't believe the flight attendants allowed someone to take my seat and made me move. It was embarrassing. I was in the right. The lady just didn't want move. I can't believe delta would allow this to stand and disrespect my rights as a passenger. The lady complained about her leg and that she couldn't move. Firstly somehow she was able to make it to row 24. Not sure how much her leg could have hurt. Secondly, I'm in plenty of pain myself. I just finished chemotherapy a several weeks ago. My body is constantly sore. Yet deltas flight attendants didn't appropriately protect my rights. In the end they found me a seat on the plane but I want to understand how delta can operate this way. They in essence allowed a bully to get their way.

Good flights. On time. They had a gluten free snack option which was nice

Crew was friendly Love the entertainment in the seat head rest.

Lower number on this flight so spaced out passengers. Able to enjoy more room to relax during flight. It was lovely.

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

This flight never occurred because AA couldn’t get their act together.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

Waited on the runway for takeoff for 2.5 hours. Air traffic rerouted us. The plane didn't have enough fuel, so had to go back to the gate. Had to wait for a new pilot. Should have landed at 5:22. Didn't land until 9:10. Trash flight.

The boarding was pretty easy. However, the first class seats are not lay flat as other airlines (like JetBlue) has and therefore sleeping was a challenge.

Everything about the flight was lovely…We left early, arrived early, cabin crew were efficient and helpful. Flight was easy and most pleasant.

Would have thought that they would gas up plane before everyone got on board

Fine. On time, cabin service was fine, bag arrived. All good. Flying into DCA so did not collide with any helicopters, which is also good. Horrid incident that could have and should have been prevented.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

Everything you need to know for your flight from Knoxville to Panama City

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