Which airports can I use when flying from Knoxville to Panama City?

Flights from Knoxville to Panama City usually depart from Knoxville McGhee Tyson (TYS) and arrive at Panama City NW Florida Beaches (ECP).

What cabin classes can I book on flights from Knoxville to Panama City?

Only Economy Class is available on flights from Knoxville to Panama City.

Which airports do connecting flights from Knoxville to Panama City pass through?

One-stop flights from Knoxville to Panama City most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 52% of one-stop connections • Nashville Intl (BNA) - 30% of one-stop connections • Charlotte Douglas (CLT) - 18% of one-stop connections Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Knoxville to Panama City?

Yes. Being flexible with your travel dates can save you up to 43% on the Knoxville to Panama City route. Wednesday is the cheapest departure day at $278 round-trip on average, while Thursday is the most expensive at $486, a difference of $208. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

How long is a flight from Knoxville to Panama City?

A nonstop flight from Knoxville to Panama City takes 0h 00m, covering 390 miles.

What are the earliest and latest flights from Knoxville to Panama City?

These are the earliest and latest flight times available from Knoxville to Panama City: • Earliest: departs at 12:00 am and lands at 12:00 am • Latest: departs at 12:00 am and lands at 12:00 am. The flight takes about 0h 00m.

Do I need a passport to fly from Knoxville to Panama City?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Knoxville to Panama City changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,524. That means the highest observed fare was about 6x higher than the lowest one.

How are flight prices from Knoxville to Panama City looking right now?

One-way fares from Knoxville to Panama City are currently lower than usual. Average one-way flight prices are about $171, which is 34% below the typical average for this route.

How much time can I save by choosing a different layover airport from Knoxville to Panama City?

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 3h 59m, compared with 4h 01m via Nashville Intl (BNA) and 4h 21m via Charlotte Douglas (CLT).

What is the time difference between Knoxville and Panama City?

Panama City is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Panama City NW Florida Beaches Airport (ECP)?

Panama City NW Florida Beaches Airport (ECP) hosts 5 major car rental companies, with daily rates starting from around $29 for economy cars. Top options include: · Dollar · Budget · Hertz · Alamo · Avis

How much should I expect to pay for a Knoxville to Panama City flight?

Round-trip flights from Knoxville to Panama City range from $313 to $485, with an average of $378 over the past 12 months. Anything below $313 counts as a good deal.

What is the cheapest airline to fly from Knoxville to Panama City?

Delta ($243) and Southwest ($248) are the cheapest airlines to fly round-trip from Knoxville to Panama City according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Knoxville to Panama City?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the Knoxville to Panama City route. 52% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from Knoxville to Panama City?

Flights via Nashville Intl (BNA) offer the most affordable fares, with an average round-trip price of $374. Based on KAYAK data over the past 3 months.

When flying from Knoxville to Panama City which airport offers the shortest layover?

Nashville Intl (BNA) had the shortest average connection time for Knoxville to Panama City layovers at 167 minutes over the past 3 months.

$122 CHEAP FLIGHTS from Knoxville to Panama City (TYS - ECP)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$243

Typical prices: $313-$485

Delta

Tue 9/11Fri 9/14

TYS - ECP • 1 stop

Cheapest one-way

$122

Typical prices: $184-$333

American Airlines

Sat 10/6

TYS - ECP • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Knoxville and Panama City. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

May

Cheapest • 18% price drop

August

Most popular

Good to know

Top layover airports

Nashville Intl (BNA)

Cheapest • Avg $374 (round-trip)

Atlanta Hartsfield-Jackson (ATL)

Shortest trip • 3h 59m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Panama City!

Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-ECP)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Knoxville to Panama City

Fri, Sep 11 - Mon, Sep 14

4:00 pm - 7:08 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 08m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:18 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 18m1 stop Atlanta Hartsfield-Jackson

$243Delta

Fri, Sep 11 - Mon, Sep 14

5:40 am - 8:16 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 36m1 stop Atlanta Hartsfield-Jackson

7:35 am - 1:21 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 46m1 stop Atlanta Hartsfield-Jackson

$243Delta

Sat, Sep 26 - Thu, Oct 1

5:40 am - 8:18 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 38m1 stop Atlanta Hartsfield-Jackson

1:46 pm - 8:15 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

5h 29m1 stop Atlanta Hartsfield-Jackson

$243Delta

Tue, Oct 27 - Sat, Oct 31

8:20 am - 3:30 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

8h 10m2 stops Baltimore/Washington Nashville Intl

6:10 am - 11:50 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 40m1 stop Dallas Love Field

$248Southwest

Tue, Oct 27 - Sat, Oct 31

7:15 am - 9:40 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 25m1 stop Nashville Intl

6:10 am - 11:50 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 40m1 stop Dallas Love Field

$286Southwest

Sat, Sep 19 - Sat, Sep 26

6:50 am - 11:05 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

5h 15m1 stop Nashville Intl

7:45 am - 11:55 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 10m1 stop Nashville Intl

$299Southwest

Sat, Oct 17 - Wed, Oct 21

7:58 pm - 11:53 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 55m1 stop Charlotte Douglas

11:04 am - 4:18 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 14m1 stop Charlotte Douglas

$385American Airlines

Mon, Nov 9 - Wed, Nov 11

7:14 pm - 10:52 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 38m1 stop Charlotte Douglas

5:41 pm - 10:48 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 07m1 stop Charlotte Douglas

$440American Airlines

Fri, Feb 5 - Tue, Feb 9

5:20 pm - 8:06 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

27h 46m1 stop Houston George Bush Intcntl

6:30 am - 5:37 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

10h 07m1 stop Houston George Bush Intcntl

$676United Airlines

Tue, Oct 27 - Sat, Oct 31

5:40 pm - 4:18 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

23h 38m3 stops Chicago O'Hare Intl Detroit Metropolitan Wayne County Houston George Bush Intcntl

9:06 am - 9:57 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

11h 51m1 stop Houston George Bush Intcntl

$715United Airlines

Recent last minute flight deals from Knoxville to Panama City

Wed, Aug 26 - Mon, Aug 31

4:38 pm - 6:35 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

2h 57m1 stop Atlanta Hartsfield-Jackson

7:35 am - 1:34 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 59m1 stop Atlanta Hartsfield-Jackson

$542Delta

Wed, Aug 26 - Mon, Aug 31

1:55 pm - 6:45 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

5h 50m1 stop Dallas Love Field

5:10 am - 1:25 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

7h 15m2 stops Houston Hobby Dallas Love Field

$582Southwest

Wed, Aug 26 - Mon, Aug 31

7:00 am - 5:00 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

11h 00m2 stops Nashville Intl Austin Bergstrom

5:10 am - 12:20 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

6h 10m2 stops Houston Hobby Nashville Intl

$587Southwest

Mon, Aug 24 - Fri, Aug 28

4:38 pm - 8:08 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 30m1 stop Atlanta Hartsfield-Jackson

11:31 am - 5:19 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 48m1 stop Atlanta Hartsfield-Jackson

$637Delta

Sun, Aug 23 - Tue, Aug 25

3:41 pm - 6:27 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 46m1 stop Charlotte Douglas

11:42 am - 5:34 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 52m1 stop Charlotte Douglas

$662American Airlines

Mon, Aug 24 - Fri, Aug 28

7:41 pm - 11:30 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 49m1 stop Atlanta Hartsfield-Jackson

9:27 am - 1:34 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 07m1 stop Atlanta Hartsfield-Jackson

$662Delta

Sun, Aug 23 - Tue, Aug 25

5:55 pm - 8:10 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 15m1 stop Nashville Intl

10:30 am - 6:55 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

7h 25m2 stops Austin Bergstrom Nashville Intl

$667Southwest

Mon, Aug 24 - Fri, Aug 28

6:02 pm - 1:06 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

20h 04m1 stop Chicago O'Hare Intl

2:27 pm - 2:37 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

23h 10m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$938United Airlines

Mon, Aug 24 - Fri, Aug 28

7:20 pm - 1:06 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

18h 46m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

1:47 pm - 10:37 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

19h 50m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$969United Airlines

Mon, Aug 24 - Fri, Aug 28

6:02 pm - 1:06 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

20h 04m1 stop Chicago O'Hare Intl

2:27 pm - 2:37 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

23h 10m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$993United Airlines

Booking Insights

Price, demand and travel trends for Knoxville to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to Panama City with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to Panama City?

Round-trip flights from Knoxville to Panama City start at $243. Prices are below average for this route right now, with typical round-trip fares ranging from $313 to $485. The lowest price found in the past 5 days was $243 on Delta.

What's the cheapest day of the week to fly from Knoxville to Panama City?

Wednesday is the cheapest day of the week to fly from Knoxville to Panama City, it is 27% cheaper than the average day. Thursday is the most expensive day with flight prices 28% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Knoxville to Panama City?

May is the cheapest month to fly from Knoxville to Panama City at $312 round-trip.
December ($720) and February ($497) are the most expensive months.
The price difference between flying in the cheapest and most expensive months is 130% on average.

This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	January
High season	August
Cheapest flight	$122

Best time to beat the crowds with an average 14% drop in price.

Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to Panama City?
Flights from Knoxville to Panama City usually depart from Knoxville McGhee Tyson (TYS) and arrive at Panama City NW Florida Beaches (ECP).
What cabin classes can I book on flights from Knoxville to Panama City?
Only Economy Class is available on flights from Knoxville to Panama City.
Which airports do connecting flights from Knoxville to Panama City pass through?
One-stop flights from Knoxville to Panama City most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 52% of one-stop connections
• Nashville Intl (BNA) - 30% of one-stop connections
• Charlotte Douglas (CLT) - 18% of one-stop connections

Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Knoxville to Panama City?
Yes. Being flexible with your travel dates can save you up to 43% on the Knoxville to Panama City route. Wednesday is the cheapest departure day at $278 round-trip on average, while Thursday is the most expensive at $486, a difference of $208. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How long is a flight from Knoxville to Panama City?
A nonstop flight from Knoxville to Panama City takes 0h 00m, covering 390 miles.
What are the earliest and latest flights from Knoxville to Panama City?
These are the earliest and latest flight times available from Knoxville to Panama City:

• Earliest: departs at 12:00 am and lands at 12:00 am
• Latest: departs at 12:00 am and lands at 12:00 am.

The flight takes about 0h 00m.
Do I need a passport to fly from Knoxville to Panama City?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Knoxville to Panama City changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,524. That means the highest observed fare was about 6x higher than the lowest one.
How are flight prices from Knoxville to Panama City looking right now?
One-way fares from Knoxville to Panama City are currently lower than usual. Average one-way flight prices are about $171, which is 34% below the typical average for this route.
How much time can I save by choosing a different layover airport from Knoxville to Panama City?
Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 3h 59m, compared with 4h 01m via Nashville Intl (BNA) and 4h 21m via Charlotte Douglas (CLT).
What is the time difference between Knoxville and Panama City?
Panama City is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
What car rental options are available at Panama City NW Florida Beaches Airport (ECP)?
Panama City NW Florida Beaches Airport (ECP) hosts 5 major car rental companies, with daily rates starting from around $29 for economy cars. Top options include:
· Dollar
· Budget
· Hertz
· Alamo
· Avis
How much should I expect to pay for a Knoxville to Panama City flight?
Round-trip flights from Knoxville to Panama City range from $313 to $485, with an average of $378 over the past 12 months. Anything below $313 counts as a good deal.

If your dates can be flexible, aim for a Wednesday departure instead of Thursday. On this route, Wednesday flights average $278 - about $208 less than Thursday (43% savings) based on the last 12 months.
If you can choose when to travel, plan your Knoxville to Panama City trip for May. Fares historically average $312 round-trip in that month - typically $408 less than the most expensive month, which is December (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City NW Florida Beaches Airport.
- Hilton Garden Inn Panama City Airport

Everything you need to know for your flight from Knoxville to Panama City

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Knoxville (TYS)

Panama City (ECP)

TYS - ECP

$122 Find Cheap Flights from Knoxville to Panama City - Compare and Save

Everything you should know

Cheap Flights from Knoxville to Panama City (TYS-ECP)

Recent round-trip flight deals from Knoxville to Panama City

Recent one-way flight deals from Knoxville to Panama City

Recent last minute flight deals from Knoxville to Panama City

Price, demand and travel trends for Knoxville to Panama City flights

How much is a round-trip flight from Knoxville to Panama City?

What's the cheapest day of the week to fly from Knoxville to Panama City?

What is the cheapest month to fly from Knoxville to Panama City?

What is the cheapest airline to fly from Knoxville to Panama City?

What is the most popular layover airport when flying from Knoxville to Panama City?

What is the cheapest layover airport when flying from Knoxville to Panama City?

When flying from Knoxville to Panama City which airport offers the shortest layover?

Key details for Knoxville to Panama City flights

Low season

High season

Cheapest flight

When to book flights from Knoxville to Panama City

Your Knoxville to Panama City flight questions, answered

Your guide to booking Knoxville to Panama City flights

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to Panama City

Complete your trip to Panama City with a hotel stay or car rental

Find direct flights to and from Knoxville and Panama City

Flights to other popular destinations

Flights from domestic origins to Panama City

Choose which airport to fly into in Panama City

Find deals for your return flight