TYS - ECP

$105 Find Cheap Flights from Knoxville to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$209
Overall average: $568
Delta
Wed 2/4Wed 2/11
TYS - ECP • 1 stop
Cheapest one-way
$105
Delta
Wed 2/4
TYS - ECP • 1 stop
Top airlines
American Airlines
Cheapest • from $209 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
August
Cheapest • 17% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama City

Wed, Feb 4 - Wed, Feb 11
Delta Logo
5:40 am - 8:39 am
TYS
-
ECP
3h 59m1 stop
Delta Logo
7:20 am - 1:50 pm
ECP
-
TYS
5h 30m1 stop
$209Delta
Thu, Apr 30 - Tue, May 5
Delta Logo
5:40 pm - 7:38 pm
TYS
-
ECP
2h 58m1 stop
Delta Logo
5:20 pm - 11:54 pm
ECP
-
TYS
5h 34m1 stop
$232Delta
Mon, Mar 9 - Wed, Mar 11
Southwest Logo
6:30 am - 9:15 am
TYS
-
ECP
3h 45m1 stop
Southwest Logo
1:20 pm - 8:05 pm
ECP
-
TYS
5h 45m1 stop
$242Southwest
Mon, Mar 9 - Wed, Mar 11
Southwest Logo
6:30 am - 9:15 am
TYS
-
ECP
3h 45m1 stop
Southwest Logo
7:30 am - 8:05 pm
ECP
-
TYS
11h 35m2 stops
$247Southwest
Mon, Mar 9 - Wed, Mar 11
Southwest Logo
6:30 am - 5:25 pm
TYS
-
ECP
11h 55m2 stops
Southwest Logo
10:10 am - 8:05 pm
ECP
-
TYS
8h 55m2 stops
$258Southwest
Tue, Mar 10 - Sat, Mar 14
Southwest Logo
6:35 am - 9:35 am
TYS
-
ECP
4h 00m1 stop
Southwest Logo
2:50 pm - 9:05 pm
ECP
-
TYS
5h 15m1 stop
$264Southwest
Fri, Mar 27 - Tue, Mar 31
Delta Logo
5:30 am - 8:39 am
TYS
-
ECP
4h 09m1 stop
Delta Logo
7:05 am - 11:15 am
ECP
-
TYS
3h 10m1 stop
$268Delta
Tue, Mar 10 - Sat, Mar 14
Southwest Logo
6:35 am - 1:10 pm
TYS
-
ECP
7h 35m2 stops
Southwest Logo
2:50 pm - 9:05 pm
ECP
-
TYS
5h 15m1 stop
$269Southwest
Tue, Apr 28 - Sat, May 2
American Airlines Logo
5:00 am - 10:58 am
TYS
-
ECP
6h 58m1 stop
American Airlines Logo
4:40 pm - 10:25 pm
ECP
-
TYS
4h 45m1 stop
$274American Airlines
Fri, Mar 27 - Tue, Mar 31
Southwest Logo
6:30 am - 12:50 pm
TYS
-
ECP
7h 20m2 stops
Southwest Logo
7:00 am - 5:40 pm
ECP
-
TYS
9h 40m2 stops
$275Southwest
Booking Insights

KAYAK's insights & trends for Knoxville to Panama City flights

Get data-powered insights and trends into flights from Knoxville to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama City is August, where tickets cost $356 (return) on average. On the other hand, the most expensive months are February and April, where the average cost of round-trip tickets is $568 and $482 respectively.

Good to know

Low seasonDecember
Cheapest flight$105
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Panama City

  • What is the cheapest flight from Knoxville to Panama City?

    In the last 3 days, the lowest price for a flight from Knoxville to Panama City was $105 for a one-way ticket and $209 for a round-trip.

  • Do I need a passport to fly between Knoxville and Panama City?

    No, a passport isn't needed to fly from Knoxville to Panama City. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from Knoxville to Panama City?

    On your way to Panama City, you’ll fly out from Knoxville McGhee Tyson. You’ll be landing at Panama City NW Florida Beaches.

  • Which aircraft models fly most regularly from Knoxville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Panama City?

    oneworld, and SkyTeam are the airline alliances operating flights between Knoxville and Panama City, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Panama City, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Panama City are Delta and American Airlines. With an average price for the route of $407 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $510 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8025 reviews
7.2Food
7.9Comfort
8.1Boarding
8.5Crew
7.8Entertainment
Airline reviews

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

8.0 ExcellentBrian, Dec 2025
DTW - TPA
Read more Delta reviews

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

The flight was an hour and a half late departing which was inconvenient

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports