Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (63% of total searches to Lesbos). The next most popular destinations are Míthymna (23%) and Skala Eresou (9%). Searches for hotels in Petra (5%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as $57 (Míthymna) in the last 3 days. The average price is $95.