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Find cheap flights from Houston to South America from $127

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Houston to South America departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sat 6/8
Sat 6/15

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Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima1 stop$500
Bogotá
Bogotá1 stop$265
Buenos Aires
Buenos Aires3 stops$739
Medellín
Medellín1 stop$245
Cartagena
Cartagena1 stop$269
Santiago
Santiago3 stops$508
Quito
Quito3 stops$389
Guayaquil
Guayaquil1 stop$287
Cali
Cali2 stops$318
Cusco
Cusco3 stops$705
Pereira
Pereira3 stops$374
Barranquilla
Barranquilla2 stops$279
Montevideo
Montevideo2 stops$1,064
Santa Marta
Santa Marta3 stops$457

Good to know

Cheapest flight

$127
Flight from Houston George Bush Airport to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Houston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Houston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Houston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from Houston is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Houston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to Houston with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Houston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from Houston up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Book cheap flights from Houston to South America

Recent round-trip flight deals

6/8Sat
1 stopSpirit Airlines
20h 02mIAH-MDE
6/15Sat
1 stopSpirit Airlines
7h 41mMDE-IAH
$245
5/31Fri
2 stopsSpirit Airlines
30h 35mIAH-MDE
6/3Mon
1 stopSpirit Airlines
9h 06mMDE-IAH
$247
5/26Sun
3 stops
26h 20mIAH-MDE
5/31Fri
1 stop
7h 51mMDE-IAH
$315
6/6Thu
3 stops
28h 08mIAH-MDE
6/12Wed
1 stop
8h 38mMDE-IAH
$319
9/10Tue
1 stopDelta
6h 50mHOU-CTG
9/17Tue
1 stopDelta
8h 05mCTG-HOU
$482
9/10Tue
2 stopsAmerican Airlines
17h 41mHOU-CTG
9/17Tue
2 stopsAmerican Airlines
19h 42mCTG-HOU
$487
9/16Mon
1 stopAvianca
13h 15mIAH-LIM
10/1Tue
2 stopsAvianca
17h 15mLIM-IAH
$500
8/24Sat
2 stopsAvianca
27h 25mIAH-LIM
9/6Fri
1 stopAvianca
10h 20mLIM-IAH
$512
9/12Thu
2 stopsAmerican Airlines
17h 41mHOU-CTG
9/19Thu
2 stopsAmerican Airlines
9h 45mCTG-HOU
$518
6/5Wed
1 stopDelta
17h 38mHOU-CTG
6/11Tue
2 stopsDelta
14h 52mCTG-HOU
$525

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Recent one-way flight deals

6/18Tue
1 stopSpirit Airlines
9h 35mIAH-MDE
$127
5/29Wed
3 stops
35h 37mIAH-MDE
$129
5/29Wed
2 stops
36h 38mIAH-MDE
$134
9/20Fri
1 stopAvianca
13h 15mIAH-LIM
$238
11/1Fri
2 stopsAvianca
23h 55mIAH-LIM
$243
6/19Wed
1 stopVolaris
32h 47mIAH-LIM
$323
6/23Sun
1 stopVolaris
32h 47mIAH-LIM
$334
7/15Mon
2 stopsAmerican Airlines
19h 36mHOU-CTG
$387
7/12Fri
2 stopsAmerican Airlines
17h 44mHOU-CTG
$397
6/4Tue
1 stopAeromexico
27h 37mIAH-LIM
$592

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Last minute flights from Houston to South America

Last minute flight, train and bus deals

5/12Sun
multi-stop
8h 38mIAH-MDE
5/18Sat
multi-stop
10h 11mMDE-IAH
$388
5/12Sun
multi-stop
25h 04mIAH-MDE
5/18Sat
multi-stop
10h 11mMDE-IAH
$390
5/11Sat
multi-stopSpirit Airlines
26h 41mIAH-MDE
5/17Fri
multi-stopSpirit Airlines
29h 59mMDE-IAH
$602
5/11Sat
multi-stopSpirit Airlines
26h 41mIAH-MDE
5/17Fri
multi-stopSpirit Airlines
29h 59mMDE-IAH
$632
5/13Mon
multi-stopDelta
17h 38mHOU-CTG
5/16Thu
multi-stopDelta
8h 08mCTG-HOU
$852
5/13Mon
multi-stopDelta
17h 38mHOU-CTG
5/16Thu
multi-stopDelta
13h 32mCTG-HOU
$854
5/10Fri
multi-stopAmerican Airlines
15h 58mHOU-CTG
5/13Mon
multi-stopAmerican Airlines
18h 35mCTG-HOU
$908
5/11Sat
multi-stopLATAM Airlines
6h 52mHOU-CTG
5/16Thu
multi-stopLATAM Airlines
8h 08mCTG-HOU
$937
5/14Tue
multi-stopLATAM Airlines
36h 21mHOU-EZE
5/21Tue
multi-stopLATAM Airlines
27h 59mEZE-HOU
$1,058
5/12Sun
multi-stopAmerican Airlines
10h 10mIAH-LIM
5/26Sun
multi-stopAmerican Airlines
12h 07mLIM-IAH
$1,603

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