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Find cheap flights from Florida Keys to San Diego from $56

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sat 6/8
Sat 6/15

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Good to know

Low season

January

High season

July

Cheapest flight

$56
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from Miami to San Diego

FAQs for booking flights from Florida Keys to San Diego

  • How does KAYAK find such low prices on flights from Florida Keys to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Prefer to fly non-stop from Florida Keys to San Diego?

Find which airlines fly direct from Florida Keys to San Diego, which days they fly and book direct flights.

Nonstop departures

Florida Keys to San Diego

Monday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Tuesday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Wednesday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Thursday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Friday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Saturday

ANA, Aer Lingus, Aeromexico, +56 more

ANA, Aer Lingus, +57 more

Sunday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

See more direct flights

Nonstop returns

San Diego to Florida Keys

Monday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Tuesday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Wednesday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Thursday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Friday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

Saturday

ANA, Aer Lingus, Aeromexico, +56 more

ANA, Aer Lingus, +57 more

Sunday

ANA, Aer Lingus, Aeromexico, +57 more

ANA, Aer Lingus, +58 more

See more direct flights
See more direct flights

Top 5 airlines serving from Florida Keys to San Diego

 
Need help choosing which airline to fly with from Florida Keys to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10789 reviews
8.6Crew
8.2Boarding
7.4Food
8.0Entertainment
7.9Comfort
Airline reviews

There was a loud squeaky sound the whole time we were flying.

6.0 GoodEliza, Apr 2024SAN - LAX
Read more about Delta reviews

There was a loud squeaky sound the whole time we were flying.

Had a broken tray in business class. Crew just shrugged it off.

I didn’t like that I could not select my seat and was assigned a seat when I checked in at LAX

Great experience overall. Check in at Austin was congested as they only have about 6 check in kiosks, one was broken, and there was a lot of Spring Break travelers.

Bag drop off was slow and annoying. Only 2 agents at the entire delta desk, and no one directing traffic for what line to be in, many confused people slowed down the process. Boarding was fine. Seats in Delta comfort plus were fine. Snacks were great! Definitely a bonus. The entertainment system was awful — old, slow, not responsive, and completely unable to play games due to some kind of error. But on the other hand, thank you to Delta for the free WiFi. That made it better.

Everything was very good other than I had selected a specific seat when I booked the flight and they changed it once I checked-in the day before my flight. I was still in first class but lost my aisle seat for a window seat. Being tall, the aisle offers more comfort so I always select an aisle seat.

Flight diverted in SD. Later take off in Seattle by 1.3hrs

Crew was not friendly when I went to request a seat change.

Really impressive staff at airport and on plane, especially given how busy it was

Was a great smooth flight from Detroit to San Diego.

I’ve had a couple flights this week on United that were delayed by an hour or more

Should have video screens Plane audio was poor and without wired connection hard to understand crew. Should serve more than just cups of water and pretzels on six hour flight. Did not see crew rest of flight. Fix charging sockets to retain charging blocks.

Generally good but there wasn’t any staff available when my luggage didn’t appear at baggage claim in Fresno. It took about half an hour to locate a staff member to open up the locked room where it was being kept.

Do not like the feeling of being in the basic economy. Everyone should feel good no matter what.

Our original business class flight was cancelled so we not only downgraded but we were also spread out across the plane not sitting together in separate middle seats. My poor kids were scared and couldn’t see me on the flight and the crew wasn’t sensitive to the situation and what the airlines did to us. Very dissatisfied with United airlines.

The WiFi didn’t work and the seats are too close together. Very uncomfortable.

So so. Terrible aircraft choice for that leg of the flight.

delay several times and wait extra long to board. no entertainment service because there are problem for some rows. always encounter some delays for the last flight of the day.

On time every leg of the journey and exceptional staff at counter, gate, and on board. I haven’t travelled in US for a long time and was genuinely surprised how pleasant this was.

This was a Lufthansa flight. Disappointing main meal. Very rough over Canada and arrival at FRA. IFE was almost unusable.

Fight crew was not very attentive and the bastions were gross!

Our flight was great we left Kona earlier and got into LAX almost an 1hour earlier as well. LAX AA is in repair so to get out and found our bus to get pick up was a bit confusing.

Plane was good but was delayed. probably not AA fault but caused a 1 hour delay. Seating was cramped.

5 hour flight - full flight - not enough room to use my computer - slightly delayed - Admirals club was excellent quality food, drink made up for flight seating. No food offerred on flight, you ahd to prebook.

We experience delays on departure and connecting flights resulting in 14 hour to our next departure. We were accommodated with a night's stay but was only provided a 12 dollar meals accommodation. The airlines rules state.at least 50 dollars. In any case, it can not make up for the whole day missed on our vacation in Sydney Australia.

I can say I will not be taking this airline again any time soon. Seat were uncomfortable and too tight. Lack of chair screen and little overhead space.

Plane felt so crowded and tightly packed. The chair itself was not comfortable.

They attended to my needs as I couldn't walk and they provided a wheelchair for me.q

Poor availability of food. Cold cabin temperature. Extremely long waiting time for a flight attendant to respond to a call button signal.

2.5h delay due to unruly passenger in first class. Had to be removed from the flight. No food unless pre ordered. Didn't know we would need it because of delay.

The guy with severe body odor sat next to me. For the whole duration of the flight it was a torture. The airline should have better policy on limiting people with bad body odor to board the flight. Passengers should not be the ones to endure bad odor for the whole duration of the flight. The airline should be e the one to ensure decent air quality for ever passenger.

They charged me 212.00 for a heavy check in bag at the gate. The pricing and process was so confusing - as if it was designed to purposefully gouge customers who need to board plane. That experience combined with the outrageous price charged will prevent me from ever flying Spirit again. And I’ll be sure to tell the story to anyone who cares to hear.

The text told me it was changed to Terminal E and Gate D5. But with no one on site to ask questions there was confusion on where to go as all the gates were E's. Then we took the skyline to the D area. We left to get something to eat. No announcement was made but my daughter happened to asked and they told her our gate was moved to D12. I will not fly Spirit again.

The agent at the check in desk was absolutely rude. The rest of the team after that was good, but the check in process at LAS was miserable. The woman at the desk spoke like we were stupid and was rude throughout the process.

Its so random that they only allow 40 pounds on checked bags when all airlines take 55. They then charge you for each 10 extra pounds, so my checked suitcase was $130 and the flight $30 ... its like whattt, im for sure not traveling with Spirit again

So bad. The check in process was laborious and the check in agent didn't seem to know how to manage the process efficiently and was confused about how to check in my son's sports equipment. The baggage fees were outrageous and so expensive. $90 for a carry on bag? And $200 additional for 2 check ins. The security lines were insanely long and the terminal was not very nice in the Spirit area. $5 for a water on board. It was my first and last time flying Spirit - I tried to save $ by flying them due to the accommodating schedule but I should have paid for Southwest, because it would've actually ended up less expensive due to the free bags with Southwest. There were no charging ports on the airplane, no wifi and really uncomfortable seating. The flight crew were great though, courteous and efficient in their boarding. Flight was delayed 1 hour, but we made up 15 minutes in flight.

My experience was better than expected. What I did find not so great was the seats. Very little room, they did not recline and the tray table was the size of a post card. There was no food to try, just standard snacks that you had to pay for and I don’t know of any entertainment. I would fly again even though everything was an upcharge. Flight was on time with little disturbance

thy don't even ofer water we have to buy it for $4.49 and paid for our cary on bags $100 each we never will fly in this company again.

Super cool and laid back, three lovely ladies. Couldn’t ask for better service.

It was fine. Boarding was a little rude. On flight staff was great. The cost to purchase everything was a bit annoying but I get that's the business model.

Frontier is a crappy airline nothing about it is honest

They cancelled the flight then did nothing to help us rebook. It was awful - I won’t fly with them again

The truck that was refueling the plane drove away with the hose still connected to the plane and ripped part of the plane off with it

Crew members are very rude and not cooperate with passengers.

30 minute delay due to boarding and settling of a family.

The boarding time. I was in Section 1 the lady in charge just let people in section 3 without see us. Make a line , I have to step out and ask her. We were in the line and she just take my ticket and that’s it, so if I don’t ask her she could leave us at the end! We paid more for that privilege and. She doesn’t care….

See my previous comment which is mostly about our flight from Phoenix to SFO

I am HIGHLY unhappy with the amount of money I spent on the flight. Paid in advance only to find the flight at a discount price a week or so before the flight. I will not fly frontier again and have bad mouthed your business since to anyone I have spoken with about flying (which has been many a people). Crew was mediocre and instead of moving me to a spot where I could gain some leg room they sat their flight attendant there. Won’t be flying frontier in the future.

Well, I didn’t have food! So NA wasn’t an option. I’ll be back!

First time flying with Frontier . From buying tickets ,getting boarding pass and boarding plane was super easy. Definitely would fly again with Frontier .

Book cheap flights from Florida Keys to San Diego

Recent round-trip flight deals

5/25Sat
1 stop
12h 54mMIA-SAN
5/29Wed
1 stop
8h 44mSAN-MIA
$154
6/11Tue
1 stopSpirit Airlines
8h 55mMIA-SAN
6/12Wed
2 stopsSpirit Airlines
11h 32mSAN-MIA
$162
5/18Sat
1 stopFrontier
13h 14mMIA-SAN
5/21Tue
1 stopFrontier
12h 21mSAN-MIA
$174
5/30Thu
1 stopFrontier
16h 55mMIA-SAN
6/3Mon
1 stopFrontier
12h 52mSAN-MIA
$176
10/15Tue
nonstopAmerican Airlines
5h 23mMIA-SAN
10/21Mon
nonstopAmerican Airlines
5h 07mSAN-MIA
$236
8/29Thu
nonstopAmerican Airlines
5h 06mMIA-SAN
9/2Mon
nonstopAmerican Airlines
5h 07mSAN-MIA
$237
8/6Tue
1 stopDelta
10h 27mMIA-SAN
8/9Fri
1 stopDelta
8h 11mSAN-MIA
$256
9/4Wed
1 stopDelta
7h 39mEYW-SAN
9/7Sat
1 stopDelta
10h 21mSAN-EYW
$256
9/4Wed
2 stopsUnited Airlines
12h 45mEYW-SAN
9/7Sat
2 stopsUnited Airlines
24h 58mSAN-EYW
$506
6/3Mon
2 stopsUnited Airlines
26h 03mEYW-SAN
6/5Wed
3 stopsUnited Airlines
18h 06mSAN-EYW
$670

Search by stops

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Recent one-way flight deals

5/18Sat
1 stopFrontier
13h 14mMIA-SAN
$56
6/18Tue
2 stopsSpirit Airlines
17h 44mMIA-SAN
$82
5/25Sat
nonstopAmerican Airlines
5h 22mMIA-SAN
$93
5/25Sat
nonstopAmerican Airlines
5h 22mMIA-SAN
$94
5/15Wed
1 stopDelta
8h 25mMIA-SAN
$128
6/25Tue
1 stopDelta
8h 30mMIA-SAN
$158
5/13Mon
1 stopUnited Airlines
9h 25mMIA-SAN
$179
9/24Tue
2 stopsUnited Airlines
17h 59mMIA-SAN
$249
6/6Thu
nonstopAlaska Airlines
5h 20mMIA-SAN
$419
5/20Mon
nonstopAlaska Airlines
5h 24mMIA-SAN
$1,344

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Last minute flights from Florida Keys to San Diego

Last minute flight, train and bus deals

5/10Fri
multi-stop
9h 11mMIA-SAN
5/15Wed
multi-stop
8h 25mSAN-MIA
$288
5/11Sat
multi-stopFrontier
26h 01mMIA-SAN
5/17Fri
multi-stopFrontier
18h 50mSAN-MIA
$309
5/11Sat
multi-stopSpirit Airlines
9h 43mMIA-SAN
5/17Fri
multi-stopSpirit Airlines
21h 18mSAN-MIA
$339
5/11Sat
multi-stopSpirit Airlines
9h 43mMIA-SAN
5/14Tue
multi-stopSpirit Airlines
8h 18mSAN-MIA
$343
5/12Sun
multi-stopUnited Airlines
7h 29mMIA-SAN
5/14Tue
multi-stopUnited Airlines
13h 37mSAN-MIA
$432
5/10Fri
nonstopAmerican Airlines
5h 24mMIA-SAN
5/15Wed
multi-stopAmerican Airlines
7h 08mSAN-MIA
$446
5/10Fri
nonstopAmerican Airlines
5h 24mMIA-SAN
5/13Mon
nonstopAmerican Airlines
4h 58mSAN-MIA
$457
5/10Fri
multi-stopUnited Airlines
12h 37mMIA-SAN
5/13Mon
multi-stopUnited Airlines
13h 37mSAN-MIA
$463
5/10Fri
multi-stopDelta
7h 25mMIA-SAN
5/13Mon
multi-stopDelta
8h 04mSAN-MIA
$486
5/11Sat
multi-stopDelta
8h 25mMIA-SAN
5/14Tue
multi-stopDelta
10h 09mSAN-MIA
$1,346

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Flights to San Diego

Destination:

San Diego (SAN)United States

Return flight deals:

San Diego - Florida Keys

Cabin classes:

$164
$193
$202
$36