SAN

$122 Find Cheap Flights from Florida Keys to San Diego

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$224
Overall average: $434
Frontier
Sat 12/13Mon 12/15
MIA - SAN • 1 stop
Cheapest non-stop
$237
Typical prices: $333-$553
American Airlines
Sat 1/24Sat 1/31
MIA - SAN • Non-stop
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Flight Deals
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Flight Deals

Cheap Flights from Florida Keys to San Diego

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to San Diego that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to San Diego

Sat, Dec 13 - Mon, Dec 15
Frontier Logo
6:00 am - 3:52 pmMIA-SAN
12h 52m1 stop
Frontier Logo
6:25 am - 11:18 pmSAN-MIA
13h 53m1 stop
$224Frontier
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Sat, Feb 21 - Tue, Feb 24
Southwest Logo
6:50 pm - 11:10 pmMIA-SAN
7h 20m1 stop
Southwest Logo
7:25 am - 8:05 pmSAN-MIA
9h 40m1 stop
$225Southwest
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Sat, Feb 14 - Tue, Feb 17
American Airlines Logo
9:17 am - 12:16 pmMIA-SAN
5h 59mnonstop
American Airlines Logo
4:58 pm - 6:01 amSAN-MIA
10h 03m1 stop
$228American Airlines
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Sun, Dec 21 - Wed, Dec 31
Frontier Logo
7:05 am - 12:11 pmMIA-SAN
8h 06m1 stop
Frontier Logo
1:06 pm - 5:35 amSAN-MIA
13h 29m1 stop
$229Frontier
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Fri, Jan 23 - Wed, Mar 4
Multiple Airlines Logo
5:14 pm - 8:23 pmMIA-SAN
30h 09m1 stop
Multiple Airlines Logo
6:25 am - 5:19 amSAN-MIA
19h 54m1 stop
$230Multiple Airlines
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Thu, Jan 8 - Sun, Jan 11
Southwest Logo
6:55 am - 1:20 pmMIA-SAN
9h 25m2 stops
Southwest Logo
9:45 pm - 11:20 amSAN-MIA
10h 35m1 stop
$231Southwest
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Tue, Feb 10 - Sat, Feb 14
Multiple Airlines Logo
8:10 am - 10:46 pmMIA-SAN
17h 36m2 stops
Multiple Airlines Logo
11:20 am - 2:56 pmSAN-MIA
24h 36m1 stop
$233Multiple Airlines
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Sat, Jan 24 - Sat, Jan 31
American Airlines Logo
7:00 am - 3:03 pmMIA-SAN
11h 03m1 stop
American Airlines Logo
1:27 pm - 9:26 pmSAN-MIA
4h 59mnonstop
$236American Airlines
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Fri, Jan 9 - Sun, Jan 11
United Airlines Logo
6:05 pm - 5:28 pmEYW-SAN
26h 23m2 stops
United Airlines Logo
10:40 pm - 1:03 pmSAN-EYW
11h 23m1 stop
$410United Airlines
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Fri, Jan 9 - Sun, Jan 11
United Airlines Logo
4:15 pm - 10:33 pmEYW-SAN
9h 18m1 stop
United Airlines Logo
10:40 pm - 1:03 pmSAN-EYW
11h 23m1 stop
$418United Airlines
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Good to know

Low seasonSeptember
Cheapest flight$124
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 15% increase in price.
Flight from Key West to San Diego

FAQs for booking flights from Florida Keys to San Diego

  • How does KAYAK find such low prices on flights from Florida Keys to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Florida Keys to San Diego

 
Need help choosing which airline to fly with from Florida Keys to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
Alaska AirlinesOverall score based on 11396 reviews
8.1Boarding
8.5Crew
7.0Entertainment
7.8Comfort
7.1Food
Airline reviews

I always like flying with Alaska, great service and leg room

10.0 ExcellentAnonymous, Dec 2025MCO - SAN
Read more Alaska Airlines reviews

I always like flying with Alaska, great service and leg room

They changed our flight from a one stop 3 hour layover to a non-stop. Saved us hours and got us there sooner.

A very good experience - all staff was friendly and helpful.

My mother suffers from Lupus and has challenges walking. I specifically called Alaska airlines, stated her condition and made sure my mother’s had wheel char assistance towards gate and into the gate hall so she just had to get into the plane and walk a couple of steps. It was assured by Alaska team that the service was granted in both airports , DEN and SAN . In Denver , the wheelchair assistance never arrived. I had to personally grab another airline wheelchair sit my mom.Then I had to go to Alaska Airlines front desk twice to let them know my mother was waiting at the wheelchair service station. Upon arrival to SD Airport , there was no wheelchair service waiting for her in the hall before deplaning. She had to walk her way out in pain. Absolutely inconsiderate and unacceptable by the airline! Never again flying with Alaska Airlines.

Waiting 2 hours after landing to arrive at a gate was ridiculous.

I was a pilot with EAL so my input maters more than the average traveler. The crew at the ticket counter were amazing. I was traveling with a frozen 20 pound turkey from our farm in Oxford Florida and they were over the top in helping me get through TSA. The gate personnel were likewise accommodating. You and Jet Blue are my favorite airlines . Would love to do an add for Alaska Airlines. Nels Siverson

My flight got canceled never left san diego and miss out my fam event

Excellent service from staff at the gate as well as flight attendants on board. Seats had more room than many other airlines and if they were just a little better cushioned they would have been perfect.

Everything was great, your crew is always very pleasant. Your airplanes are always so cold though.

They cancelled like the flight at midnight, seven hours before the departure. Terrible.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They changed planes and the new plane couldn’t carry enough fuel to fly across the country so we had to stop in Kansas City to refuel. Flight was delayed .

Flight was too crowded and seats are too small, especially since passengrs are getting larger. Having a middle seat is ALWAYS tough! Woman on my left was large & kept creeping in to my space. Flight personnel were great! Have more savory rather than sweet snacks please.

The crew took good care of us. The flight from ATL to SFO is a longer one, and there were multiple beverage offerings. I like the 757's that Delta uses. Good airplane that is comfortable. I do wish Delta would separate Priority boarding from the better seats. I would gladly take a smaller seat in an open row than be jammed into Comfort just to get priority boarding, just to make sure I don't have to check a bag.

Gate agent rushed to fill hot jetway with crowd so it took over 12 minutes to go from gate to plane. Just like a discount airline Pooly prepared cabin and third time that claim of rough air prevented any cabin service. Friends on a Southwest flight at similar time had service.

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

Food was surprisingly good but the WiFi was not great

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

Plane boarded early a quickly, was mostly full. We left close to on time. And landed early.

7 hours delayed due to operational issues on United’s end. Basically laziness.

Flight was timely, relatively comfortable, with decent entertainment and food served. Only problem encountered was with the free messaging which I highly appreciate, but it did not work from iphone to non-iphones.

The internet service I paid for didn’t work at all and the flight crew was not very friendly.

Subject: Formal Complaint: Discriminatory and Unprofessional Conduct – Request for Immediate Action & Compensation Dear [Airline Customer Relations Team], I am writing to file a formal complaint regarding my recent travel experience with [Airline], which was by far the worst I have ever encountered. What occurred was not only unprofessional, but in several instances discriminatory, unsafe, and unacceptable. On the first leg of my trip, I arrived only four minutes past check-in. Instead of making any attempt to resolve the matter, your representative flatly denied me boarding and made me wait while she attended to passengers who arrived after me. By the time a manager intervened, it was too late to board, costing me time, money, and unnecessary frustration. The second leg of my trip (Chicago–San Francisco) raised even more serious concerns. From the outset, it was apparent that the staff—particularly two attendants—prioritized Caucasian passengers while dismissing African American and minority passengers. • When a Caucasian passenger in the exit row refused to comply with federal safety requirements, I, as a first responder, immediately offered to switch seats and assume the responsibility. My offer was blatantly ignored, and instead, a Caucasian passenger seated further up was chosen. This was discriminatory and deeply insulting, especially as I was actively de-escalating the situation that could have delayed the flight further. • During a lengthy tarmac delay of over 90 minutes, passengers were given conflicting and unreasonable instructions that created unnecessary distress and tension. • Throughout the flight, a visibly intoxicated passenger directly in front of me was disruptive, rude to others, failed to comply with seatbelt and electronic device rules, and yet faced no enforcement from the crew. In stark contrast, I was singled out for repeated compliance checks even though I was following every rule. This unequal treatment was so obvious that multiple passengers around me spoke up in my defense. This pattern of behavior demonstrated a clear lack of professionalism, disregard for passenger safety, and discriminatory treatment. I expect far better from an airline of your stature. As a paying customer subjected to this unacceptable treatment, I am formally requesting: 1. A full investigation into the conduct of the staff on both flights. 2. A written apology acknowledging the discriminatory and unprofessional behavior I endured. 3. Appropriate compensation for the distress, inconvenience, and mishandling of my travel. If this matter is not addressed promptly and thoroughly, I will have no choice but to escalate my complaint further, including filing with the U.S. Department of Transportation and sharing my experience through other channels. I trust [Airline] will take this complaint seriously and provide a timely resolution.

Check in was quick and easy during early hours. Flight was on time, and customer services was a plus.

The flight was comfortable with the exit row and great service

Plane was crowded and even when we hit altitude, the plane was hot, not enough air flow.

1. when we went to check in, our 2 first class seats had been CANCELED and the flight was sold out. This was done without our prior knowledge. It was all we could do to restore one first class seat for my wife and I flew economy. 2, Our flight home was scheduled to leave at 10:30 pm. Due to tsunami warnings, the roads were closed and our flight status was uncertain as to whether it would leave as scheduled. It was announced that it would now leave at 11:20 pm and the roads were now open since the tsunami had come and gone. We made a mad dash to the airport and checked in. Delays were announced at 12:30 pm, 1:30 am, 2:30 am and at 3:30 am it was canceled. Since this was a flight due to natural (tsunami) causes, there was no compensation. We were told to return at 1:00 pm the next day and our baggage would be kept on the plane since the same plane was going to leave at 1:00 pm. We had to return to our hotel for the rest of the night. The same plane did not leave at 1:00 pm and our baggage was gone! All in all, it was a miserable performance by UA. Information was hard to obtain and no one knew what was going on and what was going to happen. Hundreds of passengers slept on the floor, chairs, etc. No food and no water was made available to the passengers. It was a situation where UA could care less what was going on. As a one million mile flyer, I had not experienced anything like this before and it was hugely disappointing!

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

We are too tired and frustrated to comment politely at this point

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

The stewardess hit me with the food kart twice on the head and didn't say I'm sorry once. The same stewardess gave me a warm Apple Juice with No ice. The Flight was delayed for Departure 6 times, starting from 2:36pm, finally taking off 7:50pm. I was late picking up my child from the sitter by 3 hours.

Did not get the seat I selected and paid for.

My flight was delayed for several hours. Sitting at gate 16 for several hours, I got a text from Kayak the gate changed to 9 before it was announced. Very bad communication at each gate from American Airlines employees. I received 10 notifications of delay from Kayak. My vacation started off horrible! I will write to American Airlines corporate office also.

There was no one at the counter to assist with our check in. The app didn’t work, so I arrived at the airport with time to check in and I couldn’t because no employees were there. When I finally got someone on the phone, it was inside the 60min rule and they said I could no longer check in and they could sell me another ticket. We had to scramble and pay an additional $800 for tickets and THEN AFTER (about 60 min from my original convo with customer service and 10min after original departure time) I had boarded my new flight, there was email saying my original flight from Frontier was delayed and leaving 2hr 50min later, but I STILL wouldn’t have been able to check in. Which means customer service should have been able to see it and let me check in because I was well within my check in time. When I call Frontier, they hang up on me. So their app didn’t work and they employees left and they take zero responsibility or assistance with their “customer service”

Terrible. The canceled my entire flight when I requested a refund for a trip frontier canceled trip one way.

i was unable to check in the flight. refund requested

Everyone seemed to be in zone 1 for boarding. Maybe break it up a little. Otherwise, smooth flight.

I think Frontier was very good at communication. Their app worked very well. Loading was great and the flight was nice and easy.

The experience was good. No frills but I got there safe and sound and on time.

Great for the price. No wifi or entertainment, but gate agents and crew were fantastic and we boarded quickly and left on time.

After boarding and un-boarding twice over 6+hours, the flight was canceled.

Severe turbulence. Captain never came on to reassure passengers after things settled down.

Boarding in Orlando was not good. Giant mob at the gate, should have been lines.

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