SAN

$116 Find Cheap Flights from Florida Keys to San Diego

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from Florida Keys to San Diego

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to San Diego that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to San Diego

Thu, Aug 6 - Sun, Aug 9
Delta Logo
6:18 pm - 10:57 pm
EYW
-
SAN
7h 39m
1 stop
Delta Logo
8:00 am - 7:51 pm
SAN
-
EYW
8h 51m
1 stop
$369Delta
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
8:35 am - 10:57 am
MIA
-
SAN
5h 22mnonstop
American Airlines Logo
7:10 am - 7:56 pm
SAN
-
MIA
9h 46m
1 stop
$389American Airlines
Sun, May 24 - Sat, May 30
American Airlines Logo
8:55 am - 11:18 am
MIA
-
SAN
5h 23mnonstop
American Airlines Logo
1:55 pm - 11:59 pm
SAN
-
MIA
7h 04m
1 stop
$390American Airlines
Thu, May 14 - Thu, May 21
Frontier Logo
6:30 am - 8:42 am
MIA
-
SAN
29h 12m
1 stop
Frontier Logo
10:07 pm - 7:00 am
SAN
-
MIA
29h 53m
1 stop
$391Frontier
Fri, May 22 - Wed, May 27
Frontier Logo
6:00 am - 6:30 pm
MIA
-
SAN
15h 30m
1 stop
Frontier Logo
4:17 pm - 5:33 am
SAN
-
MIA
10h 16m
2 stops
$392Frontier
Tue, May 12 - Wed, May 13
Frontier Logo
8:10 am - 11:50 pm
MIA
-
SAN
18h 40m
2 stops
Frontier Logo
6:25 am - 5:38 am
SAN
-
MIA
20h 13m
1 stop
$393Frontier
Tue, Jun 2 - Thu, Jun 18
Multiple Airlines Logo
6:00 am - 6:30 pm
MIA
-
SAN
15h 30m
1 stop
Multiple Airlines Logo
6:25 am - 8:10 pm
SAN
-
MIA
10h 45m
1 stop
$395Multiple Airlines
Fri, Jun 5 - Tue, Jun 16
Frontier Logo
6:00 am - 6:30 pm
MIA
-
SAN
15h 30m
1 stop
Frontier Logo
4:17 pm - 5:54 am
SAN
-
MIA
10h 37m
2 stops
$396Frontier
Tue, Jul 28 - Thu, Jul 30
Frontier Logo
6:50 am - 6:58 pm
MIA
-
SAN
15h 08m
1 stop
Frontier Logo
10:04 am - 5:51 am
SAN
-
MIA
16h 47m
1 stop
$397Frontier
Tue, Jul 14 - Wed, Jul 22
Delta Logo
7:00 am - 12:08 pm
MIA
-
SAN
8h 08m
1 stop
Delta Logo
5:01 pm - 5:45 am
SAN
-
MIA
9h 44m
1 stop
$399Delta
Useful Info

Good to know

Low seasonJanuary
Cheapest flight$116
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Miami to San Diego

FAQs for booking flights from Florida Keys to San Diego

  • How does KAYAK find such low prices on flights from Florida Keys to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Florida Keys to San Diego

 
Need help choosing which airline to fly with from Florida Keys to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
Alaska AirlinesOverall score based on 12319 reviews
7.1Food
8.5Crew
8.1Boarding
7.8Comfort
7.0Entertainment
Airline reviews

The seat on the plane out was broken and would not lean back. I have back problems and sitting up straight was hard on my lower back and caused pain for over half the flight. Since I paid extra for First Class so I would not have these issues. This needs to be addressed.

6.0 GoodTerence, Apr 2026
TPA - SAN
Read more Alaska Airlines reviews

The seat on the plane out was broken and would not lean back. I have back problems and sitting up straight was hard on my lower back and caused pain for over half the flight. Since I paid extra for First Class so I would not have these issues. This needs to be addressed.

No headphones provided. No gf food. Only 1 beverage cart run sAN to HNL. Rarely saw crew members

A solidly good experience, but would’ve appreciated more communication with regards to travel delays.

No issues and clear sailing. What a preferred to have sat in one of empty seats other than my assigned seat that would be my only complaint if it was to complain.

Perpetually delayed, flight out was delayed almost 2 hours, flight home was delayed an hour and a half. On the way back no refreshments as an option, yet they gave it out to 1st class. No apology or notice of the delay going out both ways. Seats are nice feature wise, but the adjustable headrests don't stay up anymore. Feels more like a budget airline

Four hour delay. Missed our event. And they offered me $75. Absolutely shameful.

I have been flying commercial for decades. I was in one of the ladder boarding groups, had my bag tagged because they thought there was not going to be enough space for it in the overhead bins. I politely asked one of the attendance if I could try to find a space- she said I could and I did. I then took the bag tag off and gave it to one of the other attendants as I was told to do by the first one. He, in a curt, anal, and disrespectful manner, told me that I needed to take my bag down from the overhead bin and check it. This was a situation I’ve never encountered before. The attendant’s attitude was confrontational and belittling in front of other onlooking passengers as if daring me to challenge him. I am a physician who takes care of patients day in and day out. Not wanting to make a scene, I calmly told him, “do what you need to do.” he took my bag down from the overhead bin, put the back tag back on it, and checked it only to make room for another bag that was also supposed to be technically checked by a following passenger. The same male attendant later came up to me and said “you shouldn’t have showed me the bag tag,” as if conveying that he was just following protocol was a justification for treating me like a kid out of line. I cared about this because it took 15 minutes from my life to then retrieve the bag at baggage claim and it also felt like really poor customer service. I understand the need for protocols. This is also a service industry, and we the passengers are the clients. We should be made to feel welcome and respected and our life in transit made as easy as it can be within reason. This attendant clearly needs to be reminded of that. Of note, an older female fellow passenger sitting next to me agreed with this assessment.

The boarding process could be clearer, there's never a call for group f

good, no complaints but nothing to rave about. It was fine

I love Alaska! We arrived on the later side without seat assignments only to find the had oversold the flight by 1. The attendants worked extra hard to find a way for our party of 7 to stay together and we made it on the flight! Loved the free WiFi also!

Everything went smoothly, although the usual gripes about airline travel were still present: the boarding process is inefficient, the snack selection is limited, and so on. Since there was extra space on the flight, the gate agent rearranged many people's seats to put people on the aisles and windows, leaving the middle seats empty, as much as possible, which was pretty great.

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

One of the flight attendants was a little cranky. I appreciated the free wifi and plug to charge my laptop

WiFi didn’t work most of the time. The usb chargers would work only occasionally for 5 mins and wouldn’t charge after that. Had to keep trying repeatedly at each of the seats in the row.

The crew bent over backwards to thank us for flying and make us comfortable. The food service was quick and efficient. The Captain communicated and said goodbye and thank you as we departed. They really stood out!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

my mom urmila patel needed a wheelchair which was not available on the curbside. she needed to walk almost 50 meters inside (at the risk of falling) and then had to wait in line to get a wheelchair (this is not ok). Once obtained she had to seat in it for 30-45 minutes for someone to take her in thru the checkin process (which was fairly smooth and easy). the lady who helped her with her checkin process was very courteous and helpful

Staff at the check-in counter were friendly, happy and helpful. They tagged our bags and sent us to “bag drop off” but were not very clear about where that was. The airport was busy we headed off in what we thought was the right direction until a gentleman waved us down and actually came after us. He was the baggage handler for Delta and recognized our “deer in the headlights “ look-he brought us to the right area (which was marked as the Southwest Airlines Drop Off) and sent us on our way. Wonderful guy, low key and working with a big smile on his face. Loved it. Loved him.

Arlene was a great flight attendant. I also liked how one of the other flight attendants gave us a heads up about snacks and asked everyone to remove their headphones when it was their turn to order. Good idea.

I haven’t flown economy in over 20 years but it was not bad. Room by my feet for my bag and seat was roomy enough. Surprised in a good way.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

The crew was great. Very friendly and responsive. The plane was old, small and tight. We ran out of overhead space and I had to check. Middle seat was particularly tight.

The flight was delayed from take off because only one runway was operational in San Francisco.

Several missed and almost missed connections. It felt like everything was being patched together last minute without enough resources and it ended up being an extremely stressful experience that basically ruined our weekend on the west coast. What a waste.

Packed in plane small uncomfortable seats elbow to elbow nobody wants to be in that situation for the money they paid

Checking in united could not figure out my star alliance gold. Baggage did not get marked priority and didn't receive boarding passes. When got to SFO lounge personal fixed everything Immediately

Flight left on time, arrived early, pleasant staff provided water, coffee, etc. access to bathrooms was reasonable and were well maintained. blankets were available, lots of entertainment options. LUGGAGE SERVICE WAS GREAT. I got my one checked bag quickly and was able to make a bus connection for a 2 hour bus ride saving me from waiting another 1.5 hours.

Terrible, if possible won't be flying again anytime soon!

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

Horrible service no Wi-Fi connection on both leg of the flight and they are refusing to fix bad service

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Going non stop to lax like I paid for. Not stopping in MCI for gas. Too long of delays

Delayed for mechanical and no updates on what was happening and how long the delay might be.

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

The experience at checkin for my American Airlines flight from Sacramento to LAX was very good including the assistance I received in getting my bags checked in and boarding passes printed. Was pleasantly surprised the my bags were checked through all the way to my destination at Clark International Airport in Angeles, Philippines.

It was an early flight and most people napped/slept and the crew let us which was nice.

Our flight was canceled. I will never use Kayak nor Frontier for travel again. The entire experience was a headache.

It didn’t happen. I booked it and then was told it wasn’t available and then forced to pay far higher prices for a worse option

This company socks. It's fraud. They canceled our flight yesterday, and today we were late because of a really long line at the check in bag. At the rebook station, there was ton of people. The workers were all rude. I am gonna make a report to FTC.

Flight got delayed for 5 hours no good explanation was offered ;(

There was no one at the counter to assist with our check in. The app didn’t work, so I arrived at the airport with time to check in and I couldn’t because no employees were there. When I finally got someone on the phone, it was inside the 60min rule and they said I could no longer check in and they could sell me another ticket. We had to scramble and pay an additional $800 for tickets and THEN AFTER (about 60 min from my original convo with customer service and 10min after original departure time) I had boarded my new flight, there was email saying my original flight from Frontier was delayed and leaving 2hr 50min later, but I STILL wouldn’t have been able to check in. Which means customer service should have been able to see it and let me check in because I was well within my check in time. When I call Frontier, they hang up on me. So their app didn’t work and they employees left and they take zero responsibility or assistance with their “customer service”

Terrible. The canceled my entire flight when I requested a refund for a trip frontier canceled trip one way.

i was unable to check in the flight. refund requested

Everyone seemed to be in zone 1 for boarding. Maybe break it up a little. Otherwise, smooth flight.

I think Frontier was very good at communication. Their app worked very well. Loading was great and the flight was nice and easy.

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