SAN

$147 Find Cheap Flights from Florida Keys to San Diego - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

Save 20% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Flight Deals
Useful Info
Flight Deals

Cheap Flights from Florida Keys to San Diego

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to San Diego that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to San Diego

Thu, Aug 20 - Mon, Aug 24
Frontier Logo
6:50 am - 3:41 pm
MIA
-
SAN
11h 51m
1 stop
Frontier Logo
8:59 pm - 2:33 pm
SAN
-
MIA
38h 34m
2 stops
$267Frontier
Tue, Sep 15 - Sat, Sep 26
Frontier Logo
5:50 am - 11:51 pm
MIA
-
SAN
21h 01m
1 stop
Frontier Logo
6:25 am - 12:46 am
SAN
-
MIA
15h 21m
1 stop
$270Frontier
Mon, Aug 24 - Mon, Aug 31
Multiple Airlines Logo
3:30 pm - 12:09 pm
MIA
-
SAN
23h 39m
1 stop
Multiple Airlines Logo
6:25 am - 11:55 pm
SAN
-
MIA
14h 30m
2 stops
$308Multiple Airlines
Wed, Aug 19 - Wed, Aug 26
Southwest Logo
2:25 pm - 9:05 pm
MIA
-
SAN
9h 40m
2 stops
Southwest Logo
8:35 am - 9:50 pm
SAN
-
MIA
10h 15m
2 stops
$319Southwest
Mon, Aug 17 - Thu, Aug 27
Multiple Airlines Logo
6:00 am - 11:51 pm
MIA
-
SAN
20h 51m
1 stop
Multiple Airlines Logo
12:09 pm - 8:53 pm
SAN
-
MIA
29h 44m
1 stop
$332Multiple Airlines
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
8:30 pm - 10:49 pm
MIA
-
SAN
5h 19mnonstop
American Airlines Logo
10:45 pm - 6:53 am
SAN
-
MIA
5h 08mnonstop
$379American Airlines
Tue, Sep 8 - Sat, Sep 12
American Airlines Logo
7:40 pm - 10:00 pm
MIA
-
SAN
5h 20mnonstop
American Airlines Logo
10:30 pm - 6:33 am
SAN
-
MIA
5h 03mnonstop
$379American Airlines
Mon, Nov 23 - Thu, Nov 26
Delta Logo
3:35 pm - 9:41 pm
MIA
-
SAN
9h 06m
1 stop
Delta Logo
12:50 pm - 12:52 am
SAN
-
MIA
9h 02m
1 stop
$399Delta
Wed, Dec 30 - Sat, Jan 9
Delta Logo
8:00 am - 3:20 pm
MIA
-
SAN
10h 20m
1 stop
Delta Logo
10:30 pm - 11:36 am
SAN
-
MIA
10h 06m
1 stop
$404Delta
Tue, Sep 8 - Thu, Sep 10
Southwest Logo
11:50 am - 7:35 pm
MIA
-
SAN
10h 45m
1 stop
Southwest Logo
12:35 pm - 10:00 pm
SAN
-
MIA
6h 25m
1 stop
$409Southwest
Useful Info

Good to know

Low season

January

Cheapest flight

$147
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 8% increase in price.
Flight from Miami to San Diego

FAQs for booking flights from Florida Keys to San Diego

  • How does KAYAK find such low prices on flights from Florida Keys to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Florida Keys to San Diego

 
Need help choosing which airline to fly with from Florida Keys to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4228 reviews
7.0Food
8.0Comfort
8.6Crew
7.5Entertainment
8.1Boarding
Airline reviews

3 hour delay. Had to change plans and was still delayed.

2.0 MediocreAnonymous, Jan 2026
SFO - SAN
Read more Southwest reviews

3 hour delay. Had to change plans and was still delayed.

The flight crew was extremely rude and especially not helpful when our flight was delayed.

Delays delays delays. Late taking off, late landing, wait for a gate, etc.

First time traveling on Southwest since bag fees were implemented. Usual good service. Just more expensive now.

Plane late from DC to Austin 30 minutes. Crew made up much of the time enroute to San Diego.

Our first flight was so delayed that we had 10 mins to board the next one. We requested if the flight attendant could allow us off there plane first and they denied our request even though I have seen this done before. Luck was on our side that we didn’t miss our next flight.

Everything was great except for the in-flight wifi that wasn't working.

It was great! The new boeing has much more space and charging ports!

Took a little longer than normal, but the process is clear and easy to understand.

Baggage check in would have been better if the service clerk told the other clerk that she was merging her two long lines of customers with her line so she could move luggage. Instead she only told the customers. When I told the agent and ask if she could direct who is next in line so we weren’t trying to cut in front of each other she said it’s not her problem and she can’t work three lines. I was shocked. Understood that they were working more than their share but some organization so the customers aren’t getting upset at each other would have gone a long way

Everything went smoothly from the transfer from Orlando to a quick board. Flight was not full and we were able to get underway a little early. My only critique is that in Orlando, they offered active duty service members and veterans to board ahead of their zones in the initial boarding process. They did not offer to veterans in San Diego. Both flights were comfortable

The seat on the plane out was broken and would not lean back. I have back problems and sitting up straight was hard on my lower back and caused pain for over half the flight. Since I paid extra for First Class so I would not have these issues. This needs to be addressed.

We left about 30 minutes late due to ramp issues. It did not impact me, but I know others on the flight had very tight connections to Maui.

Alaska Airlines have beautiful new airplanes that have comfortable seats but tight for a tall person like myself. They do provide upgrades to flyers but at a $140 cost. My flight went smooth and prompt as well as without a hitch. The flight crew were warm and friendly as well as very attentive. I'd recommend this airline over Frontier airlines any day.

Did not like that every price option offered, even the more expensive one, required I pay for my seat. My seat was changed without my consent My TSA did not show in Boarding Pass

I always like flying with Alaska, great service and leg room

I was a pilot with EAL so my input maters more than the average traveler. The crew at the ticket counter were amazing. I was traveling with a frozen 20 pound turkey from our farm in Oxford Florida and they were over the top in helping me get through TSA. The gate personnel were likewise accommodating. You and Jet Blue are my favorite airlines . Would love to do an add for Alaska Airlines. Nels Siverson

Spent 30 minutes in tarmac bcoz arrived earlier and crew nit ready for us. Told that the airport is being renovated so limited arrival space. 6 hours flight should have not two snacks but one major meal.

The staff and crew were excellent. The entire flight process was so friendly and smooth.

The flight was excellent with the exception of being sent from Florida to Seattle before finally being sent from Seattle to Hawaii.

Crew was real good, flight was smooth and came in early.

Gate agent rushed to fill hot jetway with crowd so it took over 12 minutes to go from gate to plane. Just like a discount airline Pooly prepared cabin and third time that claim of rough air prevented any cabin service. Friends on a Southwest flight at similar time had service.

Not a "Delta" issue, but a JFK issue: We booked a connecting flight with 3 1/2 hours between to clearn immigration and customs. Our inbound flight (BCN to JFK) was on the taxiway 45 minutes which ate into our layover time. Immigtration was insanely quick with the CBP MPC app; however, clearing TSA (again, after we were ALREADY cleared in Spain on the inbound international flight) took over 95 minutes. This left us with 10 minutes before boarding the connecting flight (JFK to SAN) to walk to the far end of Terminal 4 and try to find food. We didn't find any food that could promise to serve us in under 10 minutes so we boarded the Delta flight after coming off a plance and an 8-hour flight knowing that we wouldn't be served any food on the next 5 1/2 hour flight. I feel like Delta needs to put pressure on the JFK TSA to open more screening stations (by our count, we saw only 5 scanners open and a line of - as we said - over 90 minutes. The insult is that we WERE ALREADY SCREENED through TSA, but as you come off one flight into the USA, you have to go through the whole process again. It seems like if you have a connecting flight, there should be a way to pass through immigration and customs without needing to return through TSA.

Rough day of travel all the way around. Wrong info given to us multiple times and mistakes in their booking making our trip 10 hours longer than planned. I’m bummed because I fly Delta all the time and love them. Mistakes happen. Just bummed that this was a rare trip our whole family was traveling together.

It was good until there was a 3 hour delay because there was not any pilots to fly the plane.

Everything was very good other than I had selected a specific seat when I booked the flight and they changed it once I checked-in the day before my flight. I was still in first class but lost my aisle seat for a window seat. Being tall, the aisle offers more comfort so I always select an aisle seat.

Flight diverted in SD. Later take off in Seattle by 1.3hrs

Was a great smooth flight from Detroit to San Diego.

The boarding process was terrible especially with an indirect flight Chicago to Seattle to San Diego was terrible talking about we overbooked a flight idk if I’d take this airline ever again we got off our flight from Chicago to Seattle and we traveled for business and they told us our connecting flight was over booked and their was no seats asking people to take a delayed next flight and they don’t tell anyone coughing to wear masks seats 30A-B were terrible during the flight no one wants to sit next to people coughing all around I don’t want to be sick traveling for work or get sick anytime it’s very upsetting the staff doesn’t take this stuff serious to tell them to wear masks when they see people coughing and sneezing

They made us check our bag…. Even though there was plenty of space up top… and then proceeded to shatter by brand new luggage 😞

The seat when "flat" was not flat and pad was too thin to cover it.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

We are too tired and frustrated to comment politely at this point

My flight was delayed for several hours. Sitting at gate 16 for several hours, I got a text from Kayak the gate changed to 9 before it was announced. Very bad communication at each gate from American Airlines employees. I received 10 notifications of delay from Kayak. My vacation started off horrible! I will write to American Airlines corporate office also.

The service and food needs to improve to catch up with other international flights

The flight crew was fantastic! Which the seats had a small TV.

also wi-fi never worked attendant said satellite coverage is spotty over water ..... but we were over land!

They attended to my needs as I couldn't walk and they provided a wheelchair for me.q

This time my flight was smooth and uneventful. They started boarding even earlier than it was scheduled. I was pleasantly surprised. Thank you!

Boarding was a mess - the agent basically called every group in rapid succession, so there was no organization at all. The economy seats are a joke, and main cabin extra seats were sold out when I purchased my flight. As such, I was locked in the same position for four hours. Being 6’6”, it was impossible to get my bag out from under the seat in front of me, and I couldn’t have used my laptop even if my bag were accessible due to the minuscule seat pitch. Also the wifi was broken. American is a joke - can’t wait until they merge with Spirit.

Terrible. The canceled my entire flight when I requested a refund for a trip frontier canceled trip one way.

i was unable to check in the flight. refund requested

Great for the price. No wifi or entertainment, but gate agents and crew were fantastic and we boarded quickly and left on time.

Decent clean onboard experience. Okay discount airline experience. Unfortunately, any customer service interactions are difficult and unhelpful. There is no service. Also, a premium seat only gets you premium boarding if you line up first. Once they start general boarding you must go to the back of the line. Not very premium

I went to the Frontier counter in San Jose at 1030am or so on Sunday 10/13/24 to see if I could get an earlier flight to San Diego in lieu of my reserved 630pm flight. One thing led to another, and I was able to obtain an open seat for about $ 56. on the earlier flight. Fine. Then the agent asked if I "was checking a bag". Not knowing that carry-ons cost extra per Frontier policy, I thought that she meant a regular checked bag. Therefore, I said no. Once I got to the gate, the same gate agent who sold me a ticket told me that I had to pay $99 for a carry-on, and that all bags were extra on Frontier. Having never flown on Frontier, I was not aware of this. Part of the issue was that she was not a native English speaker, so there was a miscommunication as to what "bag" meant. I would have preferred for her to have clearly let me know at the front counter that any bag including a carry-on cost $99. It would have had the same outcome, as I had to take my carry-on. But it got hectic at the last minute at the gate itself. The baggage policy should have mentioned "including carry-ons" when we first spoke.

Literally everything could have been better. Why are the planes always late?

9hrs delay and didn’t provided anything until after flight landed $75 voucher for fiuture travel no meals or anything.

They cancelled the flight then did nothing to help us rebook. It was awful - I won’t fly with them again

The truck that was refueling the plane drove away with the hose still connected to the plane and ripped part of the plane off with it

The boarding time. I was in Section 1 the lady in charge just let people in section 3 without see us. Make a line , I have to step out and ask her. We were in the line and she just take my ticket and that’s it, so if I don’t ask her she could leave us at the end! We paid more for that privilege and. She doesn’t care….

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
National City
Julian
Borrego Springs
Poway
Alpine
Santee
Lemon Grove

Everything you need to know for your flight to San Diego

Information on the airport you'll fly into in San Diego