Find flights
Deals
When to book
FAQs & Tips
Airlines

Find cheap flights from St. Louis to South America from $101

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to South America departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Mon 5/27
Mon 6/3

Search hundreds of travel sites at once for deals on flights to South America

In the last 7 days travelers have searched 44,335,567 times on KAYAK, and here is why:

Save 22% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima1 stop$633
Bogotá
Bogotá1 stop$469
Buenos Aires
Buenos Aires3 stops$891
Cartagena
Cartagena1 stop$370
Santiago
Santiago3 stops$720
Rio de Janeiro
Rio de Janeiro1 stop$1,088
Quito
Quito2 stops$423
Guayaquil
Guayaquil2 stops$563
Cali
Cali1 stop$409
Montevideo
Montevideo2 stops$943
Caracas
Caracas2 stops$5,949

Good to know

Low season

September

High season

December

Cheapest flight

$101
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 25% increase in price.
Flight from St. Louis to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from St. Louis to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to St. Louis with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South America

  • Morning departure is around 12% cheaper than an evening flight, on average*.
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 5 airlines serving from St. Louis to South America

 
Need help choosing which airline to fly with from St. Louis to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10966 reviews
8.6crew
7.4food
8.0entertainment
8.2boarding
7.9comfort
Airline reviews

Delta is one of the best airlines I have flown

10.0 ExcellentKellie, Apr 2024ANC - SEA
Read more about Delta reviews

Delta is one of the best airlines I have flown

Made the Atlanta to Pittsburgh trip many times, with Delta no issues

I always fly with Delta. My friends tell me their horror stories of flying with other airlines. I just smile and say, “You should fly Delta”

I'm a larger, athletic guy (6'2", 260lbs powerlifter) and I found the seats incredibly uncomfortable with minimal leg room, especially in a window seat. Now, I full understand that being smaller may change my view but even if I was 80lbs less, my legs would be the same size and I was sandwiched between my seat and the seat in front of me.

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

This flight was ridiculous. I had to have a connecting flight from New York to orlando Florida??? The flight left late and because it was a short flight there was no first class amenities. I had one alcohol drink. The flight crew was fine, but it sure did not feel like first class. Delta to me dropped the ball by giving me a connecting flight. By the time we got to Raleigh we would have missed the next flight. Lucky for me the flight never came so now I was stuck waiting for a later flight that came in late also.

Our flight was delayed in Atlanta. The staff could have gave us an explanation for the delay and how long it would be.

I liked the ease of checking in, luggage check in, wheel chair assistance, boarding and flight.

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive.

Everything was as you would expect in coach - fine. Flight was close to on time.

Everthing ok , crew very nice but but we had a bad experience with the wheel chair we had to wait too much for the chair, my husband couldn’t walk and he was in lot of pain , LATAM has to take care of that

No air in the middle rows. Had a hard time breathing. Was dying of heat.

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

Terrible They charged me 157$ for excess baggage even though my bags were within the normally accepted limits Flight was late. Service was poor. The snacks were really bad

Horrific checkin procedure with neither Delta nor Latam figuring out how to check me in. 4 hrs on customer support with both and both airlines pointing to each other who should do checking. I was not checked in until morning of flight, which for international flight is concerning.

It was ok for the most part, it is missing something

It was a good experience, the flight was a little too long & the food was ok

the flight from Boston to Curitiba was on time actually 30 minutes earlier. latam was not able to unload the luggage for custom checkup in Sao Paulo ii took two and half hours . i missed the flight to Curitiba spend the night in hotel and then flying in the morning to Curitiba

Tough flight with turbulence… I was told by a fellow passenger that it is common. Nonetheless, very stressful. Cordial staff.

I was told we'd have a hot breakfast option in first class, so I chose not get a hot breakfast. It was a very strange meal, but the fresh fruit was very good quality. Service was excellent from ORD to ELP. No service from MBS to ORD, not even water. However, when flying American from FNT to ORD, which is a shorter flight, they at least pass out snacks and offer water.

Last minute gate change nearly caused us to miss our flight. Change was not announced or displayed in the main board at the old gate. Terrible communication. When we landed we had to wait 20 minutes because there was another plane at the assigned gate. Not the crew’s fault, but adding 20 minutes to a 45 minute flight sucked.

Nothing beats ANA customer service on my opinion. Maybe because of their Japanese culture (and food). Arigatō

So so. Terrible aircraft choice for that leg of the flight.

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

Flight delayed from Cape Town to Washington then got diverted to miami and in miami we had to fend for ourselves , im still trying to get to Shreveport now

delay several times and wait extra long to board. no entertainment service because there are problem for some rows. always encounter some delays for the last flight of the day.

I just wrote a text which was supposed to be for the flight from Denver to spokane not Frankfurt to Denver.

On time every leg of the journey and exceptional staff at counter, gate, and on board. I haven’t travelled in US for a long time and was genuinely surprised how pleasant this was.

Hated every minute of it. This flight should have only taken 1.5hrs but was delayed over 10hours. Now I am being told I cannot be compensated or refunded my ticket price or extra leg room, which I purchased but did not receive, because the airline is throwing the blame on the 3rd party I purchased tickets through and 3rd party putting the blame on airline. No one wants to help. They received their money and that's all they care about. Im going on 3 days of still trying to get to my final destination, had to cancel car rental, car insurance and hotel. Currently staying in airport until hotels open up. Thank you Lufthansa, Kayak, Underpricer and United for making this trip the worst ever.

I think the seats on some of their planes are uncomfortable. You can be ok on a short flight of two hours but no more than that. The delays, and also the refreshments on the plane were not enough.

Flight delayed over an over all day until it cancelled at 1:30am. Would not repeatedly delay that late. Offer hotel rooms and rebook early. Very difficult for families with small children

Not sure why JAL partnered with American Airlines because their service is no where near similar. Flight attendants were not friendly and didn’t smile. Food was horrible…

this is starting to seem like an american airlines standard. delayed flights and fake apologies… getting tired of it

Terrible boarding , Business class seats are sub standard. As usual crew will miss your food too

Just get Economy Plus for international flights, so worth it the extra room, bigger seats…

This flight is frequently delayed. The connections seemingly are more frequently delayed. I’ve missed connections as a result twice on the same route to charlotte then Charleston. Final destination arrival has been the next day, twice in a row. No pilots, no crew. Too many excuses. Unfortunately, my days with American are over.

Entertainment was okay not because anything was wrong but it is a short flight so having no wifi is annoying but understandable. Crew was outstanding as usual

It was spectacular. I had basic Economy and was given so much space and their seats lean back so far. Staff was superb, food was superb, everything was superb, Finnair is Fantastic.

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

Food was icecold or frozen including breakfast. Hopeless service. Rude crew.

The flight was very uncomfortable and there was no snacks served for the 13 hours international flight. In addition, the flight was delayed 3 hours

Due to a strike taking place with the airline, it negatively impacted my flight in multiple ways. My flight was delayed over 2 hours and the food served was mediocre at best.

Cabin crew were great. Seats are criminal for tall people

Flight was delayed 1.5 hrs due to problem with a previous flight to mine; I was informed appropriately via Text & Email, however, website did not keep up with messages sent by nearly an hour. When checking-in warm & friendly reception at check-in desk until female Air Canada Rep noticed my flight number and instantly pivoted to a condescending & sarcastic comments about getting my bag checked in since I’m running so late; then tone instantly changed again few minutes later when she muttered, “Oh, they’ve delayed it” another sign systems & worse front line staff, not fully informed or simply not reading their flight status updates. Flight crew were very friendly & did a great job trying to make up lost time due to the delay.

It was great, love the experience and will definitely recommend 👌. Communication was great

My flight was great! Gate attendants and crew were great… pleasant and in good spirits. Flight delayed several hours and we were well informed of the status while on plane. Thank you!

The fact that I got to Toronto alive and well and safe is a huge plus. I thank the captain and crew for a safe flight The comfort of the aircraft leaves much to be desired. Human beings should not have to be that cramped and squashed on a flight that we pay a lot for and even have to pay for lousy food choices The cabin crew were pleasant and helpful Kudos to them as the flight was packed to capacity and there was a lot of work for them in a short space of time All in all a good experience, but too cramped

It was great to check carryon luggage at no charge when there was no room for ours. A hidden benefit of having low-tier tickets. Also great to stay off plane as long as possible. Airline gave us seats we wanted on this last leg, again at no charge.

Fresh fuit or veg snacks would be so great, but there are two good restaurants in Denver airport. Try Etais UDIS or Freshens DIA for nutritious delicious pita sandwiches/ donairs and crepes in Freshens.

Book cheap flights from St. Louis to South America

Recent round-trip flight deals

5/21Tue
1 stopSpirit Airlines
14h 03mSTL-MDE
6/3Mon
1 stopSpirit Airlines
8h 13mMDE-STL
$347
5/25Sat
1 stopSpirit Airlines
7h 22mSTL-MDE
6/8Sat
1 stopSpirit Airlines
15h 06mMDE-STL
$351
9/10Tue
2 stopsAmerican Airlines
8h 26mSTL-CTG
9/17Tue
2 stopsAmerican Airlines
20h 11mCTG-STL
$385
9/10Tue
1 stopDelta
6h 50mSTL-CTG
9/17Tue
1 stopDelta
9h 25mCTG-STL
$418
7/30Tue
1 stopAmerican Airlines
17h 06mSTL-BOG
8/30Fri
1 stopAmerican Airlines
8h 32mBOG-STL
$481
7/16Tue
1 stopDelta
13h 24mSTL-BOG
8/27Tue
2 stopsDelta
16h 39mBOG-STL
$494
5/21Tue
2 stopsLATAM Airlines
30h 24mSTL-MDE
6/4Tue
2 stopsLATAM Airlines
25h 35mMDE-STL
$500
7/30Tue
1 stopLATAM Airlines
21h 47mSTL-BOG
8/30Fri
2 stopsLATAM Airlines
27h 47mBOG-STL
$536
5/28Tue
1 stopUnited Airlines
14h 35mSTL-UIO
6/3Mon
1 stopUnited Airlines
15h 45mUIO-STL
$571
5/28Tue
1 stopUnited Airlines
14h 35mSTL-UIO
6/3Mon
2 stopsUnited Airlines
39h 01mUIO-STL
$591

Search by stops

Search by airline

Search by price

Recent one-way flight deals

5/25Sat
1 stopSpirit Airlines
7h 22mSTL-MDE
$101
5/7Tue
1 stop
16h 44mSTL-BOG
$108
5/7Tue
2 stopsSpirit Airlines
25h 26mSTL-BOG
$124
5/7Tue
3 stopsSpirit Airlines
25h 26mSTL-BOG
$138
5/1Wed
2 stopsCopa Airlines
15h 38mSTL-BOG
$283
5/8Wed
2 stopsCopa Airlines
18h 30mSTL-EZE
$514
5/7Tue
1 stopLATAM Airlines
9h 35mSTL-BOG
$580
5/8Wed
2 stopsUnited Airlines
16h 00mSTL-BOG
$641
5/7Tue
2 stopsLATAM Airlines
26h 44mSTL-BOG
$664
5/9Thu
1 stopAmerican Airlines
24h 31mSTL-SCL
$865

Search by stops

Search by airline

Search by price

Last minute flights from St. Louis to South America

Last minute flight, train and bus deals

4/30Tue
multi-stopSpirit Airlines
21h 48mSTL-CTG
5/7Tue
multi-stopSpirit Airlines
21h 24mCTG-STL
$448
4/30Tue
multi-stopSpirit Airlines
21h 48mSTL-CTG
5/7Tue
multi-stopSpirit Airlines
21h 24mCTG-STL
$468
5/1Wed
multi-stopLATAM Airlines
12h 40mSTL-LIM
5/8Wed
multi-stopLATAM Airlines
12h 28mLIM-STL
$663
5/1Wed
multi-stopAmerican Airlines
11h 18mSTL-LIM
5/8Wed
multi-stopAmerican Airlines
16h 52mLIM-STL
$665
5/1Wed
multi-stopDelta
19h 39mSTL-LIM
5/7Tue
multi-stopDelta
15h 52mLIM-STL
$668
5/1Wed
multi-stopUnited Airlines
14h 21mSTL-LIM
5/7Tue
multi-stopUnited Airlines
15h 28mLIM-STL
$730
5/1Wed
multi-stopAmerican Airlines
8h 37mSTL-CTG
5/6Mon
multi-stopAmerican Airlines
9h 54mCTG-STL
$879
4/30Tue
multi-stopDelta
6h 51mSTL-CTG
5/3Fri
multi-stopDelta
15h 02mCTG-STL
$881
5/1Wed
multi-stopLATAM Airlines
22h 32mSTL-CTG
5/5Sun
multi-stopLATAM Airlines
32h 16mCTG-STL
$1,017
4/30Tue
multi-stopUnited Airlines
11h 50mSTL-LIM
5/3Fri
multi-stopUnited Airlines
11h 23mLIM-STL
$1,033

Search by stops

Search by airline

Search by price

St. Louis - South America Flights

Departure:

St. Louis (STL)United States

Return flight deals:

South America - St. Louis

Cabin classes: