$322 Find Cheap Flights from St. Louis to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to South America departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from St. Louis to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$609
Bogotá
Bogotá1 stop$572
Buenos Aires
Buenos Aires2 stops$1,148
Rio de Janeiro
Rio de Janeiro1 stop$949
Santiago
Santiago1 stop$947
Cartagena
Cartagena1 stop$531
Quito
Quito1 stop$687
Guayaquil
Guayaquil1 stop$739
Cali
Cali1 stop$693
Cusco
Cusco2 stops$1,090
Montevideo
Montevideo2 stops$1,273
Lima
Lima2 stops$609
Bogotá
Bogotá1 stop$572
Buenos Aires
Buenos Aires2 stops$1,148
Rio de Janeiro
Rio de Janeiro1 stop$949
Santiago
Santiago1 stop$947
Cartagena
Cartagena1 stop$531
Quito
Quito1 stop$687
Guayaquil
Guayaquil1 stop$739
Cali
Cali1 stop$693
Cusco
Cusco2 stops$1,090
Montevideo
Montevideo2 stops$1,273

Book Cheap St. Louis to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to South America

Wed, Oct 28 - Mon, Nov 9
Air Canada Logo
4:15 pm - 10:45 am
STL
-
LIM
18h 30m
2 stops
Air Canada Logo
2:55 am - 3:30 pm
LIM
-
STL
37h 35m
2 stops
$609Air Canada
Sat, Oct 31 - Wed, Nov 11
Multiple Airlines Logo
4:15 pm - 3:15 am
STL
-
LIM
35h 00m
2 stops
Multiple Airlines Logo
5:35 pm - 3:30 pm
LIM
-
STL
46h 55m
2 stops
$612Multiple Airlines
Mon, Sep 7 - Mon, Sep 14
American Airlines Logo
5:00 am - 12:48 pm
STL
-
MDE
7h 48m
1 stop
American Airlines Logo
6:00 am - 11:46 pm
MDE
-
STL
17h 46m
1 stop
$630American Airlines
Mon, Sep 7 - Mon, Sep 14
American Airlines Logo
5:00 am - 8:15 pm
STL
-
MDE
15h 15m
1 stop
American Airlines Logo
6:00 am - 9:17 pm
MDE
-
STL
15h 17m
2 stops
$635American Airlines
Wed, Sep 16 - Mon, Sep 21
United Airlines Logo
11:15 am - 9:10 pm
STL
-
MDE
9h 55m
1 stop
United Airlines Logo
9:45 am - 10:30 pm
MDE
-
STL
12h 45m
1 stop
$654United Airlines
Thu, Sep 10 - Mon, Sep 14
United Airlines Logo
11:15 am - 9:10 pm
STL
-
MDE
9h 55m
1 stop
United Airlines Logo
9:45 am - 11:57 am
MDE
-
STL
26h 12m
2 stops
$659United Airlines
Mon, Nov 9 - Sun, Nov 22
LATAM Airlines Logo
1:30 pm - 6:00 am
STL
-
LIM
15h 30m
1 stop
LATAM Airlines Logo
12:00 pm - 8:12 am
LIM
-
STL
21h 12m
1 stop
$733LATAM Airlines
Tue, Sep 8 - Thu, Sep 24
LATAM Airlines Logo
6:00 am - 9:35 pm
STL
-
LIM
15h 35m
2 stops
LATAM Airlines Logo
12:05 pm - 11:36 pm
LIM
-
STL
11h 31m
1 stop
$734LATAM Airlines
Wed, Oct 7 - Mon, Oct 19
Delta Logo
3:42 pm - 10:15 am
STL
-
GIG
16h 33m
1 stop
Delta Logo
9:00 pm - 12:56 pm
GIG
-
STL
17h 56m
1 stop
$953Delta
Tue, Jul 14 - Tue, Jul 21
Delta Logo
10:51 am - 7:15 am
STL
-
SCL
19h 24m
1 stop
Delta Logo
8:40 pm - 5:53 pm
SCL
-
STL
22h 13m
1 stop
$957Delta
Booking Insights

KAYAK's insights & trends for St. Louis to South America flights

Get data-powered insights and trends into flights from St. Louis to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from St. Louis to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to South America is July, when tickets cost $178 (return) on average. On the other hand, the most expensive months are November and August, when the average cost of round-trip tickets is $541 and $533 respectively.

How far in advance should I book a flight from St. Louis to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to South America, you should book around 3 weeks before departure, which saves you about 28% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 18 weeks before departure.

Good to know

Low seasonApril
Cheapest flight$322
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 1% increase in price.
Flight from St. Louis to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from St. Louis to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from St. Louis to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from St. Louis to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from St. Louis to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from St. Louis to South America

 
Need help choosing which airline to fly with from St. Louis to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8406 reviews
7.8Entertainment
8.1Boarding
8.5Crew
7.2Food
7.8Comfort
Airline reviews

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

2.0 MediocreAnonymous, Jun 2026
RDU - LGA
Read more Delta reviews

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Flight attendants were great. Cheerful, upbeat and friendly. Jet, in particular, was fantastic.

I have Precheck. Flew HPN to DEN and return this past weekend. Delta didn't attach my Precheck number to this trip. So it was waiting in general line especially in Denver. Unavailable.

Original flight was delayed, then cancelled and the gate staff did not expedite rebooking. Also, no instructions were given that a ticket number was needed before being called to facilitate rebooking. This could have been much more organized.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

Five hour delays every hour, I wish it were all at once

Flight delayed four separate times. I’m now one hour hours late to landing.

worst flight ever from Delta, it got delayed and kept on delaying..

Should never have had to go to Detroit from Orlando back to Tennessee!

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

It was delayed for 2 hours. Then when we arrived they took us on a very uncomfortable bus and left us there. The bus driver wouldn't let us out because no one from Latam was there. Everything was disaster.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We were not allowed to carry a bottle of water onto the 8 hour flight.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

Airline tickets are not cheap. You expect reliable competent service. Thanks to canceled flights and botched transfers we arrived at our destination two days late. This is not acceptable

Horrible! Several delays and then was cancelled! I spent over 24 hours in the airport and was unable to get a hotel or food voucher.

The entertainment they offer could use some games, and maybe they could add some cookies to the snack menu. And the automated messages are a bit repetitive. But it was comfortable temperature wise and the seats were comfortable. The crew is very polite and helpful

The entertainment is a bit limited, it would be better if they added some games to play besides the movies and tv shows. But the seats are comfortable and the crew is polite

This planes staff was top tier. Everything went great and had a great flight home.

Food was great. Staff was phenomenal. Seats were a bit hard and could use a lot more entertainment options as far as movies to choose from. WiFi was good. Overall great trip.

This was an overnight flight, and in the morning they did know coffee service. How you can throw passengers in a San Francisco airport at 5:40 a.m. in the morning and not giving them Coffee is a crime.

I was promised by United Airline (operated by ANA) that I will be seated together with my kids as I am the only adult flying with two minors. We did not get seats together in our 11 hours flight from LA to Tokyo. When asked at the gate, ANA representative said United Airline should have informed them that there is a parent flying with two minors. He said they can’t do anything in the system as the flight is full. He ask me to ask passengers next to me and the kids if they are willing to change seats. This is ridiculous! However, I went in the flight and asked other passages but no one willing to change seats. 11 hours and we were seating separately. I was very disappointed with this. It made things super inconvenient for me.

Our flight was delayed several Times due to mechanical issues. Although I understand this may happen at times, it was very inconvenient and we had to book a hotel for an overnight stay. We were traveling with my 3-yo grandson and waiting at the airport from noon until 6:30pm with no reassurance that our next rescheduled flight would depart, we had to decide what’s best for him. A day later, I found out that I may be able to demand compensation if my flight is delayed more than 4 hours. I will hav to read the fine print next time.

Flight cancelled instead of leaving Friday am now, maybe, leaving Sunday

Was given all 3 boarding passes. Was refused boarding to Brasilia in Miami even though I had up to date Brazilian Visa and US passport. Had to return to Phoenix as trip was cancelled. Waiting for refund of the fare. Missed my son's birthday and visit with him and his wife.

The pilots landing and taking off was very bad on the first flight, the second one taking off was great but landing was also rough

The check in and on the ground experience is very poor. Their online check and trip management is the worst I have ever seen and they have long lines to check in at the airport, technology is glitchy/unusable and have exorbitant baggage fees. The flight itself is fine, although the food is about what you would expect and their was no functioning entertainment for an international flight.

My experience with this flight was extremely negative and resulted in serious financial and personal consequences. The flight departed with a significant delay, which caused me to miss my international connecting flight. As a direct result of this delay — which was entirely beyond my control — I was unable to reach my final destination on time, causing me to lose a previously scheduled hair transplant surgery that had been arranged months in advance. This was not a minor inconvenience. The surgery involved: • A reserved operating room • Medical and technical staff scheduled specifically for that date • Surgical instruments prepared in advance • Strict scheduling that does not allow for easy rescheduling Due to the airline’s delay and poor handling of the situation: • I lost already paid international flight tickets • I was forced to purchase new tickets, incurring duplicate expenses • I spent over six additional hours in airports, under stressful conditions • I incurred unexpected costs for meals and transportation • I lost a medical opportunity that cannot be easily recovered, along with the emotional distress associated with it Although the airline covered one night of hotel accommodation, this did not address the real impact of the delay, nor the significant damages caused by missing a critical medical procedure. The lack of punctuality, planning, and effective solutions reflects a serious lack of responsibility toward passengers, especially when international connections and time-sensitive medical commitments are involved. I do not recommend this airline for travelers with important schedules, medical appointments, or critical connections. In my case, the delay did not merely cause inconvenience — it resulted in the loss of a surgery and substantial financial damage.

I was not able to get on the flight due to delays out of Philadelphia. I arrived in MIA at 10:30pm and there was no one at the GOL Desk. Is there any flight credit available for this flight?

I have a hand injury and the flight attendant denied to help me with luggage, she said "she couldn't help me because I should manage my own way to put the luggage on the plane" SO RUDE

I had two around 6 hours flight and they did not even offer water to us.

Overall it was good. The food was not great quality and seats were very uncomfortable. But overall the staff was very friendly and helpful.

We flew with Avianca, some how they are not n sync, making the process a bit uncomfortable.

Unfortunately it was very disappointed experience. Our first flight our was delayed 2 hours, as a consequence we missed our connecting international flight. Customer server at Miami American Airlines was very disrespectful, gave us the worst replace itenarary for the next day that we had to spend 2 hours calling Gol to get a better itinerary otherwise we wouldn't make it on time to fulfill our trip purpose. We would have missed the reason to travel all the way to Brazil if we didn't change for a better itinerary. The worst thing is that our baggage was missing for 4 days. We had no cloths for all this time, plus the aggravation to locate our baggage. Nobody knew where our baggage was. We ended up picking it up at the airport when they said that they will bring them home. Unfortunately our experience was very dissatisfied.

We sat on plane at gate delayed without communication as to why we were just sitting there

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

Trash. Sat on the runway for 40 mins…missed connecting flight because of it now I’m stuck. Thanks…a whole fkn lot.

The flight was delayed significantly and we sat on runway after landing for awhile. Best thing was the flight attendant, Jenny, in first class, who was very professional and attentive. She was excellent - the rest of the flight was not.

Crew were professional and kind. The flight was smooth. But... The internet, which we paid 35 dollars for, did not work for most of the flight. This made providing media for our child an uncomfortable hassle.

Overall fine. Seemed like one of the older model planes? Crew was mostly very kind, though some of the female attendants were a rather abrupt during the food service.

Awfully rude American worker at door when we started boarding flight. Then, walk into a blazing hot airplane with no air conditioning until twenty minutes into the flight. Free entertainment was non existent! My husband, along with the fellow passenger in our row, and I could not get entertainment to work, no WIFI! Really?? Been flying American a long time. Was very disappointed.

Flight was delayed by 6 hours... the level of incompetence was truly astounding. I won't be flying American Airlines again. I don't care if AA is direct and there is a layover with another airline, I'll take the layover.

Leave on time. We waited on the plane for hour hours and it was hot and smelly

Two hours delay, probably one hour because they didn’t bring catering and they had to bring water in board. There a change of aircraft. But delays galore at CLT so it must be a CLT and/or AA operation issue. The 1 hr additional delays because nobody could bring 2 packs of water sooner is probably the best example of this airline operates

Everything you need to know for your flight to South America

Information on your arrival and departure airports