$174 Find Cheap Flights from St. Louis to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to South America departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from St. Louis to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$570
Bogotá
Bogotá1 stop$267
Buenos Aires
Buenos Aires2 stops$1,048
Rio de Janeiro
Rio de Janeiro1 stop$769
Santiago
Santiago2 stops$755
Cartagena
Cartagena2 stops$580
Quito
Quito1 stop$625
Guayaquil
Guayaquil1 stop$720
Cali
Cali2 stops$563
Cusco
Cusco2 stops$935
Montevideo
Montevideo2 stops$954
Lima
Lima2 stops$570
Bogotá
Bogotá1 stop$267
Buenos Aires
Buenos Aires2 stops$1,048
Rio de Janeiro
Rio de Janeiro1 stop$769
Santiago
Santiago2 stops$755
Cartagena
Cartagena2 stops$580
Quito
Quito1 stop$625
Guayaquil
Guayaquil1 stop$720
Cali
Cali2 stops$563
Cusco
Cusco2 stops$935
Montevideo
Montevideo2 stops$954

Book Cheap St. Louis to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to South America

Mon, Jan 26 - Sat, Jan 31
Multiple Airlines Logo
5:42 pm - 1:55 pm
STL
-
MDE
19h 13m1 stop
Multiple Airlines Logo
2:50 pm - 11:33 pm
MDE
-
STL
9h 43m1 stop
$331Multiple Airlines
Mon, Jan 26 - Sat, Jan 31
Multiple Airlines Logo
8:22 pm - 2:15 pm
STL
-
MDE
16h 53m2 stops
Multiple Airlines Logo
2:50 pm - 11:33 pm
MDE
-
STL
9h 43m1 stop
$375Multiple Airlines
Mon, Feb 9 - Thu, Feb 19
Delta Logo
9:59 am - 9:20 pm
STL
-
LIM
10h 21m1 stop
Delta Logo
11:40 pm - 2:47 pm
LIM
-
STL
16h 07m1 stop
$644Delta
Mon, Feb 9 - Tue, Feb 17
American Airlines Logo
6:00 am - 9:30 pm
STL
-
LIM
14h 30m2 stops
American Airlines Logo
12:45 am - 3:01 pm
LIM
-
STL
15h 16m2 stops
$649American Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
7:40 am - 7:50 am
STL
-
SCL
46h 10m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$755United Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
7:40 am - 7:50 am
STL
-
SCL
22h 10m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$756United Airlines
Tue, Jan 13 - Mon, Jan 26
LATAM Airlines Logo
5:00 pm - 2:05 pm
STL
-
SCL
18h 05m2 stops
LATAM Airlines Logo
9:30 pm - 11:54 am
SCL
-
STL
17h 24m1 stop
$764LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
5:00 pm - 2:05 pm
STL
-
SCL
19h 05m2 stops
LATAM Airlines Logo
5:15 am - 11:42 pm
SCL
-
STL
20h 27m2 stops
$765LATAM Airlines
Mon, Feb 2 - Mon, Feb 16
American Airlines Logo
11:55 am - 9:00 am
STL
-
SCL
18h 05m2 stops
American Airlines Logo
11:55 pm - 1:16 pm
SCL
-
STL
16h 21m2 stops
$769American Airlines
Fri, Mar 20 - Mon, Mar 30
Delta Logo
7:10 am - 7:40 am
STL
-
SCL
22h 30m1 stop
Delta Logo
7:45 pm - 3:53 pm
SCL
-
STL
22h 08m2 stops
$804Delta
Booking Insights

KAYAK's insights & trends for St. Louis to South America flights

Get data-powered insights and trends into flights from St. Louis to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from St. Louis to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to South America is February, when tickets cost $601 (return) on average. On the other hand, the most expensive months are June and January, when the average cost of round-trip tickets is $868 and $864 respectively.

What’s the cheapest day of the week to fly from St. Louis to South America?

The average price of all round-trip flights from St. Louis to South America clicked on KAYAK for each day over the last 12 months.

For St. Louis to South America, Wednesday is the cheapest day to fly on average and Friday is the most expensive. Flying from South America back to St. Louis, the best deals are generally found on Tuesday, with Sunday being the most expensive.

How far in advance should I book a flight from St. Louis to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to South America, you should book around 10 weeks before departure, which saves you about 30% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$174
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly with an average 14% increase in price.
Flight from St. Louis to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from St. Louis to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from St. Louis to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from St. Louis to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from St. Louis to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the morning, when round-trip flights cost $785 on average. Morning departures are around 2% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $831.

Reviews of the top 5 airlines serving from St. Louis to South America

 
Need help choosing which airline to fly with from St. Louis to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8005 reviews
8.1Boarding
7.3Food
8.5Crew
7.9Comfort
7.9Entertainment
Airline reviews

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

10.0 ExcellentVenkata Krishna, Dec 2025
ATL - SDF
Read more Delta reviews

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

Left on time, a bit delayed due to headwinds most of the trip.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Horrible the worst airlines I have ever flown. Cancelled flight with no choices and when contacted them they were not helpful

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

Not great experience - we were super late boarding due to issues with aircraft. Then when we finally all got onboard and seated and they started taxiing out to the runway they just stopped then turned around and went back to the airport. Apparently the crew “ran out of time” to legally fly us. They mentioned that they were about 2 minutes away from taking off. I understand the rules and safety but kinda wonder why they would have bothered boarding us in the first place? Had to go all the way back and de plane and then wait in a HUGE line to get a hotel (this is somewhere around 2:30am) finally got to hotel by Uber (no shuttle after 20min so gave up) and they ended up putting us all back on the same aircraft at 10am next morning so got about 2.5 hours sleep. They did give us. $250 credit, but it was a São Paulo Brazil flight out of Dulles. The flight and everything was fine.

United overall experience is great these days. Airport experience was very organized. Staff on flight were great. App and information as good as it gets.

United have really come back. Airport and boarding process is clear and good, app and information also very good

They charged a fee for 1st bag checked. Others in same party were free.

Flight was delayed 8 times. We were sitting at the airport for 14 hours. We got 2 hours of sleep (if that) on what was not meant to be a red-eye.

The movies offered were great. Staff were very pleasant and very efficient.

After a delay at the gate, C3, at Ohare on Sunday, I left my Blk ski coat on the bench at the gate, lost! Please review my lob claim, thx.

Very bad! They kept delaying my flight and wouldn’t do anything about it

They brought an empty plane to the gate. Then a flight delay was announced for maintenance and waiting on a part. I was then put on a flight to San Francisco instead with a connecting flight to my final destination. Arrived at my final destination 2 hours late.

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

I liked the humor of the captain and crew on the flight from Flagstaff to Dallas. They were humorous.

AA delayed the flight for 3 hours and 50 minutes, but delayed the last 2 hours, 30 minutes at a time, so if we knew before, could have stayed at home and worked instead of being at the airport wasting time... The plane's crew was excellent, not their fault.

After arriving in Dallas, the aircraft taxied for an unusually long time and was unable to park at the gate, which caused a significant delay and made me miss my connecting flight. I then had to wait in a very long line to be rebooked, and I was told that no hotel or meal accommodations would be provided. What is even more unacceptable is that my luggage was mishandled and has still not been located. My suitcase contains important medications that I urgently need, and I have been unable to access them due to the airline’s mishandling. This situation has caused me considerable stress and inconvenience, and I need this issue to be resolved immediately.

It was just fine. I managed to make all my connection too sbut had trouble in Munich with no wheel chair and trouble trying to get help from the airport people to get to the other terminal for my flight. Finally a wonderful lady Amelia, helped me to make my flight connection Timon with zero time to spare.

Over 40 years ago my AC return flight was canceled, during this last summer the same thing happened. AC denied everything Canadian like paying for accommodations and basic necessities. So why would I ever want to fly AC again? This last flight my wife took the return flight had problems and left late, so I guess they are getting better. However I have no faith in this airline so I drove to this last destination! I'll never fly AC again!!!

Great check in process in LA and good service The check in process as well as at the gate is way better in the US versus canada 🇨🇦

Super experience. Earlier than schedule departure and arrival. Baggage handling was very good

Allow me to book extra bag check in as free though I packed in 1 luggage but that was 7 LBS overweight so make another bag to free check in.

I would like to get my money back. I flight was 4 hours late on the way to detroit, And same on my way back to Brussels they cancelled my flight and give me an other ticket and i had to wait 5 hours.

All attendents were very efficient, pleasant and happy. Everything went smoothly. The seats could have been wider. There could have been more free food instead of just one small bar.

My seat was one of those that couldn't recline, but the problem was that it was abnormally upright, so the headrest actually made the seat concave, which was uncomfortable and hard on my lower back. I had to ball my jacket up and use it as lumbar support. goodness I had it with me.

Boarding was so so after zone 3 was called all other zones went in

I liked a lot , the flight attendant so nice ,the seat very comfortable I enjoyed the flight , I will do it again with Air Canada,

Everything you need to know for your flight to South America

Information on your arrival and departure airports