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MYR - TYS

$158 Find cheap flights from Myrtle Beach to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sun 5/26
Sun 6/2

Search hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
In the last 7 days travelers have searched 44,335,567 times on KAYAK, and here is why:

Save 22% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Bundle and saveSave money when you bundle your flight + hotel.

Cheap flight deals from Myrtle Beach to Knoxville (MYR-TYS)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
6:12 pm - 9:48 pmMYR-TYS
3h 36m1 stop
5:58 pm - 11:55 pmTYS-MYR
5h 57m1 stop
$225American Airlines
Find Deal
Wed, May 22 - Wed, May 29
7:01 am - 12:08 pmMYR-TYS
5h 07m1 stop
5:19 am - 9:59 amTYS-MYR
4h 40m1 stop
$250American Airlines
Find Deal
Sat, May 25 - Tue, Jun 4
5:01 am - 10:32 amMYR-TYS
5h 31m1 stop
6:45 am - 10:32 amTYS-MYR
3h 47m1 stop
$255American Airlines
Find Deal
Fri, Jun 7 - Tue, Jun 11
7:43 pm - 1:03 amMYR-TYS
5h 20m1 stop
5:19 am - 8:16 amTYS-MYR
2h 57m1 stop
$259American Airlines
Find Deal
Thu, May 23 - Thu, May 30
5:07 am - 8:41 amMYR-TYS
3h 34m1 stop
7:53 pm - 11:55 pmTYS-MYR
4h 02m1 stop
$280American Airlines
Find Deal
Fri, May 24 - Mon, May 27
1:00 pm - 9:08 pmMYR-TYS
8h 08m1 stop
7:00 am - 12:14 pmTYS-MYR
5h 14m1 stop
$290United Airlines
Find Deal
Sat, May 11 - Tue, May 14
1:00 pm - 9:08 pmMYR-TYS
8h 08m1 stop
7:00 am - 12:14 pmTYS-MYR
5h 14m1 stop
$311United Airlines
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Sat, May 11 - Tue, May 14
1:30 pm - 11:44 pmMYR-TYS
10h 14m2 stops
5:50 am - 2:07 pmTYS-MYR
8h 17m1 stop
$462United Airlines
Find Deal
Sat, May 25 - Sat, Jun 1
6:00 am - 9:31 amMYR-TYS
3h 31m1 stop
6:50 pm - 8:52 amTYS-MYR
14h 02m2 stops
$472Delta
Find Deal
Sat, May 11 - Tue, May 14
6:00 am - 9:31 amMYR-TYS
3h 31m1 stop
6:50 pm - 8:52 amTYS-MYR
14h 02m2 stops
$536Delta
Find Deal
Sat, May 11 - Tue, May 14

Flights from Myrtle Beach to Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Myrtle Beach to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Knoxville?

The average price of all flights from Myrtle Beach to Knoxville clicked on KAYAK for each day over the last 12 months.
For Myrtle Beach to Knoxville, Saturday is the cheapest day to fly on average and Sunday is the most expensive. Flying from Knoxville back to Myrtle Beach, the best deals are generally found on Tuesday, with Sunday being the most expensive.

What is the cheapest month to fly from Myrtle Beach to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Myrtle Beach to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Myrtle Beach to Knoxville is January, where tickets cost $247 on average. On the other hand, the most expensive months are March and April, where the average cost of tickets is $588 and $539 respectively.

Which airlines provide the cheapest flights from Myrtle Beach to Knoxville?

The cheapest price for the route for each airline clicked by KAYAK users in the last 72 hours.
The cheapest return flight ticket from Myrtle Beach to Knoxville found by KAYAK users in the last 72 hours was for $225 on American Airlines, followed by United Airlines ($290). One-way flight deals have also been found from as low as $158 on American Airlines and from $179 on United Airlines.

Good to know

Low season

February

High season

October

Cheapest flight

$158
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Knoxville

  • What is the cheapest flight from Myrtle Beach to Knoxville?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Knoxville was $158 for a one-way ticket and $225 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Knoxville?

    No

  • Which aircraft models fly most regularly from Myrtle Beach to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Knoxville?

    oneworld, Star Alliance, and SkyTeam are the airline alliances operating flights between Myrtle Beach and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Myrtle Beach to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Myrtle Beach to Knoxville are Delta and American Airlines. With an average price for the route of $413 and an overall rating of 8.0, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $453 and an overall rating of 7.3.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top airlines flying from Myrtle Beach to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10966 reviews
7.4food
7.9comfort
8.6crew
8.0entertainment
8.2boarding
Airline reviews

Delta is one of the best airlines I have flown

10.0 ExcellentKellie, Apr 2024ANC - SEA
Read more about Delta reviews

Delta is one of the best airlines I have flown

Made the Atlanta to Pittsburgh trip many times, with Delta no issues

I always fly with Delta. My friends tell me their horror stories of flying with other airlines. I just smile and say, “You should fly Delta”

I'm a larger, athletic guy (6'2", 260lbs powerlifter) and I found the seats incredibly uncomfortable with minimal leg room, especially in a window seat. Now, I full understand that being smaller may change my view but even if I was 80lbs less, my legs would be the same size and I was sandwiched between my seat and the seat in front of me.

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

This flight was ridiculous. I had to have a connecting flight from New York to orlando Florida??? The flight left late and because it was a short flight there was no first class amenities. I had one alcohol drink. The flight crew was fine, but it sure did not feel like first class. Delta to me dropped the ball by giving me a connecting flight. By the time we got to Raleigh we would have missed the next flight. Lucky for me the flight never came so now I was stuck waiting for a later flight that came in late also.

Our flight was delayed in Atlanta. The staff could have gave us an explanation for the delay and how long it would be.

I liked the ease of checking in, luggage check in, wheel chair assistance, boarding and flight.

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive.

this is starting to seem like an american airlines standard. delayed flights and fake apologies… getting tired of it

This flight is frequently delayed. The connections seemingly are more frequently delayed. I’ve missed connections as a result twice on the same route to charlotte then Charleston. Final destination arrival has been the next day, twice in a row. No pilots, no crew. Too many excuses. Unfortunately, my days with American are over.

Entertainment was okay not because anything was wrong but it is a short flight so having no wifi is annoying but understandable. Crew was outstanding as usual

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

The Flight attendant had an attitude and didn't allow anyone any time to prepare for landing despite being absent throughout the entire trip

Flight boarded without pilots. Sat on plane for 3 hrs. after over an hour late boarding. Plane never took off. Had to deplane near midnight. Line for rebooking was 3 hours + long. I had to leave.

The flight was great but board was a nightmare. The gate was changed 4 times during the layover period

The experience was great and much better than the flight going out. of course I was in first class but the service was excellent

Cold air blew constantly on my legs almost making me numb.

Missed the flight because of them and up geting a rental car

Book cheap flights from Myrtle Beach to Knoxville

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Myrtle Beach to Knoxville found on KAYAK in the last 72 hours.
5/22Wed
1 stopAmerican Airlines
4h 30mMYR-TYS
$158
5/11Sat
1 stopUnited Airlines
8h 08mMYR-TYS
$179
5/23Thu
1 stopAmerican Airlines
4h 31mMYR-TYS
$279
5/11Sat
2 stopsUnited Airlines
10h 05mMYR-TYS
$284
5/11Sat
1 stopUnited Airlines
21h 16mMYR-TYS
$299
5/22Wed
2 stopsAmerican Airlines
8h 50mMYR-TYS
$313
5/11Sat
2 stopsAmerican Airlines
8h 50mMYR-TYS
$343

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Last minute flights from Myrtle Beach to Knoxville

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Myrtle Beach to Knoxville that are departing in the next 10 days.
5/1Wed
multi-stopAmerican Airlines
3h 15mMYR-TYS
5/8Wed
multi-stopAmerican Airlines
5h 57mTYS-MYR
$252
5/1Wed
multi-stopUnited Airlines
11h 20mMYR-TYS
5/8Wed
multi-stopUnited Airlines
5h 14mTYS-MYR
$497
5/1Wed
multi-stopUnited Airlines
11h 20mMYR-TYS
5/8Wed
multi-stopUnited Airlines
9h 52mTYS-MYR
$502

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Myrtle Beach - Knoxville Flights

Departure:

Myrtle Beach (MYR)United States

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - Myrtle Beach

Cabin classes: