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MYR - TYS

$168 Find cheap flights from Myrtle Beach to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sun 6/2
Sun 6/9

Search hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
In the last 7 days travelers have searched 43,740,974 times on KAYAK, and here is why:

Save 22% or moreCompare multiple travel sites with one search.

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Filter your dealsChoose cabin class, free Wi-Fi and more.

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Cheap flight deals from Myrtle Beach to Knoxville (MYR-TYS)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
9:10 am - 12:14 pmMYR-TYS
3h 04m1 stop
6:08 pm - 10:02 pmTYS-MYR
3h 54m1 stop
$285American Airlines
Find Deal
Mon, Aug 12 - Sat, Aug 17
7:46 pm - 11:58 pmMYR-TYS
4h 12m1 stop
7:40 pm - 11:49 pmTYS-MYR
4h 09m1 stop
$410American Airlines
Find Deal
Sat, Jun 22 - Sun, Jun 23
8:09 pm - 12:02 amMYR-TYS
3h 53m1 stop
7:13 am - 10:10 amTYS-MYR
2h 57m1 stop
$420American Airlines
Find Deal
Fri, Jul 19 - Sun, Jul 21
1:20 pm - 10:14 amMYR-TYS
20h 54m1 stop
5:50 am - 2:31 pmTYS-MYR
8h 41m2 stops
$464United Airlines
Find Deal
Mon, Aug 12 - Sat, Aug 17
7:01 am - 10:37 amMYR-TYS
3h 36m1 stop
5:18 am - 10:32 amTYS-MYR
5h 14m1 stop
$507American Airlines
Find Deal
Tue, Jun 4 - Wed, Jun 5
7:43 pm - 11:51 pmMYR-TYS
4h 08m1 stop
7:53 pm - 11:55 pmTYS-MYR
4h 02m1 stop
$510American Airlines
Find Deal
Fri, May 17 - Sun, May 19
10:50 am - 2:13 pmMYR-TYS
3h 23m1 stop
7:40 pm - 12:02 amTYS-MYR
4h 22m1 stop
$517American Airlines
Find Deal
Tue, Jun 4 - Wed, Jun 5
11:30 am - 10:25 amMYR-TYS
22h 55m2 stops
5:50 am - 2:31 pmTYS-MYR
8h 41m2 stops
$642United Airlines
Find Deal
Mon, Aug 12 - Sat, Aug 17
1:07 pm - 10:11 pmMYR-TYS
9h 04m2 stops
9:00 am - 1:38 pmTYS-MYR
4h 38m1 stop
$672Delta
Find Deal
Tue, Jun 4 - Wed, Jun 5
1:07 pm - 10:11 pmMYR-TYS
9h 04m2 stops
7:46 am - 4:34 pmTYS-MYR
8h 48m2 stops
$694Delta
Find Deal
Tue, Jun 4 - Wed, Jun 5

Flights from Myrtle Beach to Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Myrtle Beach to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Knoxville?

The average price of all flights from Myrtle Beach to Knoxville clicked on KAYAK for each day over the last 12 months.
For Myrtle Beach to Knoxville, Saturday is the cheapest day to fly on average and Sunday is the most expensive. Flying from Knoxville back to Myrtle Beach, the best deals are generally found on Tuesday, with Sunday being the most expensive.

What is the cheapest month to fly from Myrtle Beach to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Myrtle Beach to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Myrtle Beach to Knoxville is January, where tickets cost $247 on average. On the other hand, the most expensive months are March and April, where the average cost of tickets is $588 and $539 respectively.

Which airlines provide the cheapest flights from Myrtle Beach to Knoxville?

The cheapest price for the route for each airline clicked by KAYAK users in the last 72 hours.
The cheapest return flight ticket from Myrtle Beach to Knoxville found by KAYAK users in the last 72 hours was for $285 on American Airlines, followed by United Airlines ($464). One-way flight deals have also been found from as low as $168 on American Airlines and from $309 on United Airlines.

Good to know

Low season

February

High season

October

Cheapest flight

$168
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Knoxville

  • What is the cheapest flight from Myrtle Beach to Knoxville?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Knoxville was $168 for a one-way ticket and $285 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Knoxville?

    No

  • Which aircraft models fly most regularly from Myrtle Beach to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Knoxville?

    oneworld, Star Alliance, and SkyTeam are the airline alliances operating flights between Myrtle Beach and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Myrtle Beach to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Myrtle Beach to Knoxville are Delta and American Airlines. With an average price for the route of $413 and an overall rating of 8.0, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $451 and an overall rating of 7.3.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top airlines flying from Myrtle Beach to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10858 reviews
7.9Comfort
8.2Boarding
8.0Entertainment
8.6Crew
7.4Food
Airline reviews

Checking in at the airport the agent only booked the first keg of my trip and had my checked luggage going to the airport with a layover! Never was issued a boarding pass for the second leg or received sticker fir my checked bag. All was well in the end! Delta agents helped to resolve the situation!!!

8.0 ExcellentAnonymous, May 2024ATL - ATW
Read more about Delta reviews

Checking in at the airport the agent only booked the first keg of my trip and had my checked luggage going to the airport with a layover! Never was issued a boarding pass for the second leg or received sticker fir my checked bag. All was well in the end! Delta agents helped to resolve the situation!!!

Delayed due to an ill passenger after loading. Not preventable on Delta's part. Was in first class. The seats are becoming worn and detaching from their velcro attachments. Only got snacks on flight. The attendant was not the friendliest.

I would fly again the whole experience was great. The only feed back I can give that they don't do that American Airlines does is the crew there is more humorous with boarding and thank their passengers. It makes it more fun to fly with them. I would however fly Delta again.

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

The pilots were good. Disappointing when planes don't have electrical ports

I liked the piloting of the aircraft. Very disappointed about lack of electrical ports. Also, although a short flight. there was enough time to hand out snacks to comfort + seats as was done for first class.

I had a wonderful experience flying with delta. The gentleman taking care of us on our flight was so nice, accommodating, and attentive. He always was smiling and giving pins to the kids which made me smile. The flight was quick too and without turbulence. Thank you for the great flying experience.

Delta is one of the best airlines I have flown

Made the Atlanta to Pittsburgh trip many times, with Delta no issues

I always fly with Delta. My friends tell me their horror stories of flying with other airlines. I just smile and say, “You should fly Delta”

They gave my seat away although it was a connecting flight with them and the flight was a bit delayed.

Flight was cancelled had to move to another gate late again no internet paid for the month and never can use it waste of money

Not being able to purchase my check in baggage online was a negative.

LATE LATE LATE!!! Plagued by late AA flights on this trip. Such a drag. This one was by far the worst.

WiFi connected but only let you go to the AA website, not even text messaging worked.

Too bad that first class seats do not recline significantly causing discomfort

Flight delayed over an over all day until it cancelled at 1:30am. Would not repeatedly delay that late. Offer hotel rooms and rebook early. Very difficult for families with small children

this is starting to seem like an american airlines standard. delayed flights and fake apologies… getting tired of it

This flight is frequently delayed. The connections seemingly are more frequently delayed. I’ve missed connections as a result twice on the same route to charlotte then Charleston. Final destination arrival has been the next day, twice in a row. No pilots, no crew. Too many excuses. Unfortunately, my days with American are over.

Entertainment was okay not because anything was wrong but it is a short flight so having no wifi is annoying but understandable. Crew was outstanding as usual

Book cheap flights from Myrtle Beach to Knoxville

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Myrtle Beach to Knoxville found on KAYAK in the last 72 hours.
5/22Wed
1 stopAmerican Airlines
6h 19mMYR-TYS
$168
5/22Wed
1 stopAmerican Airlines
4h 30mMYR-TYS
$178
6/4Tue
1 stopAmerican Airlines
7h 03mMYR-TYS
$219
6/4Tue
2 stopsAmerican Airlines
6h 40mMYR-TYS
$247
5/23Thu
1 stopAmerican Airlines
4h 31mMYR-TYS
$284
5/23Thu
2 stopsAmerican Airlines
8h 50mMYR-TYS
$289
5/22Wed
2 stopsUnited Airlines
16h 51mMYR-TYS
$309
5/23Thu
1 stopAmerican Airlines
3h 36mMYR-TYS
$313
5/23Thu
2 stopsAmerican Airlines
8h 50mMYR-TYS
$318
5/22Wed
2 stopsUnited Airlines
16h 51mMYR-TYS
$339

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Myrtle Beach - Knoxville Flights

Departure:

Myrtle Beach (MYR)United States

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - Myrtle Beach

Cabin classes: