Which airports can I use when flying from Myrtle Beach to Knoxville?

Flights from Myrtle Beach to Knoxville usually depart from Myrtle Beach Intl (MYR) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from Myrtle Beach to Knoxville?

Only Economy Class is available on flights from Myrtle Beach to Knoxville.

Which airports do connecting flights from Myrtle Beach to Knoxville pass through?

One-stop flights from Myrtle Beach to Knoxville most commonly connect through: • Charlotte Douglas (CLT) - 88% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 8% of one-stop connections • Baltimore/Washington (BWI) - 4% of one-stop connections

Can I save money by using flexible dates for flights from Myrtle Beach to Knoxville?

Yes. Flexible dates can save you up to 73% on flights from Myrtle Beach to Knoxville. Saturday is the cheapest departure day at $316 round-trip on average, while Thursday is the most expensive at $1,152, a difference of $836. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

How long is a flight from Myrtle Beach to Knoxville?

A nonstop flight from Myrtle Beach to Knoxville takes 00m, covering 323 miles.

Do I need a passport to fly from Myrtle Beach to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Myrtle Beach to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $239 to $1,183. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from Myrtle Beach to Knoxville looking right now?

One-way fares from Myrtle Beach to Knoxville are currently lower than usual. Average one-way flight prices are about $151, which is 45% below the typical average for this route.

How much time can I save by choosing a different layover airport from Myrtle Beach to Knoxville?

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 3h 46m, compared with 3h 48m via Charlotte Douglas (CLT) and 7h 24m via Baltimore/Washington (BWI).

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include: • Budget • Alamo • Enterprise Rent-A-Car • Thrifty • Avis

How much should I expect to pay for a Myrtle Beach to Knoxville flight?

Round-trip flights from Myrtle Beach to Knoxville range from $316 to $544, with an average of $359 over the past 12 months. Anything below $316 counts as a good deal.

How much is a round-trip flight from Myrtle Beach to Knoxville?

Round-trip flights from Myrtle Beach to Knoxville typically range from $316 to $544. The lowest price found in the past 5 days was $239, on Delta.

What's the cheapest day of the week to fly from Myrtle Beach to Knoxville?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Myrtle Beach to Knoxville. It’s 12% cheaper than the average day, while Thursday is the most expensive, with prices 220% higher.

Which airline is the cheapest to fly from Myrtle Beach to Knoxville?

Delta ($239) and American Airlines ($259) are the cheapest airlines to fly round-trip from Myrtle Beach to Knoxville according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Myrtle Beach to Knoxville?

Charlotte Douglas (CLT) is the most popular layover for the Myrtle Beach to Knoxville route. 88% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via CLT.

What is the cheapest layover airport when flying from Myrtle Beach to Knoxville?

Flights via Charlotte Douglas (CLT) offer the most affordable fares, with an average round-trip price of $459. Based on KAYAK data over the past 3 months.

When flying from Myrtle Beach to Knoxville which airport offers the shortest layover?

Charlotte Douglas (CLT) had the shortest average connection time for Myrtle Beach to Knoxville layovers at 2h 29m over the past 3 months.

$133 CHEAP FLIGHTS from Myrtle Beach to Knoxville (MYR - TYS)

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$239

Typical prices: $316-$544

Delta

Mon 11/26Mon 12/3

MYR - TYS • 1 stop

Cheapest one-way

$133

Typical prices: $182-$328

Multiple Airlines

Fri 11/16

MYR - TYS • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Myrtle Beach and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

December

Cheapest • 12% price drop

January

Most popular

Good to know

Top layover airports

Charlotte Douglas (CLT)

Cheapest • Avg $459 (round-trip)

Atlanta Hartsfield-Jackson (ATL)

Shortest trip • 3h 46m (one-way)

Insights

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We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from Myrtle Beach to Knoxville (MYR-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Myrtle Beach to Knoxville

Thu, Nov 26 - Thu, Dec 3

4:00 pm - 10:12 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

6h 12m1 stop Atlanta Hartsfield-Jackson

5:40 am - 10:07 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 27m1 stop Atlanta Hartsfield-Jackson

$239Delta

Fri, Dec 11 - Mon, Dec 14

8:34 pm - 11:59 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 25m1 stop Charlotte Douglas

6:00 am - 10:11 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 11m1 stop Charlotte Douglas

$259American Airlines

Mon, Nov 23 - Fri, Nov 27

6:51 pm - 10:22 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 31m1 stop Atlanta Hartsfield-Jackson

5:40 am - 10:07 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 27m1 stop Atlanta Hartsfield-Jackson

$279Delta

Wed, Dec 9 - Tue, Dec 15

8:07 am - 11:51 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 44m1 stop Charlotte Douglas

8:09 am - 1:24 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

5h 15m1 stop Charlotte Douglas

$287American Airlines

Wed, Dec 16 - Sun, Dec 20

3:25 pm - 8:50 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

5h 25m1 stop Baltimore/Washington

7:15 pm - 10:00 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

14h 45m2 stops Nashville Intl Baltimore/Washington

$314Southwest

Wed, Dec 16 - Sun, Dec 20

3:25 pm - 8:50 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

5h 25m1 stop Baltimore/Washington

8:00 am - 6:40 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

10h 40m1 stop Baltimore/Washington

$318Southwest

Wed, Dec 9 - Tue, Dec 15

8:10 am - 7:50 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

11h 40m2 stops Baltimore/Washington Nashville Intl

7:05 am - 1:15 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

6h 10m1 stop Nashville Intl

$323Southwest

Mon, Dec 14 - Sat, Dec 19

2:18 pm - 6:30 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

4h 12m1 stop Atlanta Hartsfield-Jackson

9:00 am - 2:54 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

5h 54m1 stop Atlanta Hartsfield-Jackson

$337Delta

Thu, Nov 26 - Thu, Dec 3

12:00 pm - 8:49 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

20h 49m2 stops Washington, D.C. Reagan-National Charlotte Douglas

8:00 pm - 11:58 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

3h 58m1 stop Charlotte Douglas

$340American Airlines

Mon, Dec 14 - Sat, Dec 19

10:45 am - 7:50 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

9h 05m1 stop Nashville Intl

7:45 pm - 10:00 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

14h 15m2 stops Nashville Intl Baltimore/Washington

$343Southwest

Recent last minute flight deals from Myrtle Beach to Knoxville

Wed, Nov 4 - Fri, Nov 6

2:42 pm - 8:05 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

17h 23m1 stop Fort Lauderdale

7:20 am - 11:44 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

28h 24m2 stops Key West Tampa

$446Multiple Airlines

Mon, Nov 2 - Mon, Nov 23

1:53 pm - 5:14 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

27h 21m1 stop Fort Lauderdale

7:11 pm - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

13h 39m1 stop Orlando

$449Multiple Airlines

Sat, Oct 31 - Mon, Nov 23

2:42 pm - 9:25 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

18h 43m1 stop Fort Lauderdale

7:11 pm - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

13h 39m1 stop Orlando

$457Multiple Airlines

Mon, Nov 2 - Mon, Nov 23

6:12 pm - 5:14 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

23h 02m2 stops Tampa Fort Lauderdale

7:11 pm - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

13h 39m1 stop Orlando

$478Multiple Airlines

Mon, Nov 2 - Sun, Nov 22

1:53 pm - 5:14 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

27h 21m1 stop Fort Lauderdale

9:16 am - 8:03 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

22h 47m1 stop Fort Lauderdale

$493Multiple Airlines

Sat, Oct 31 - Sun, Nov 22

2:42 pm - 9:25 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

18h 43m1 stop Fort Lauderdale

9:16 am - 8:03 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

22h 47m1 stop Fort Lauderdale

$501Multiple Airlines

Mon, Nov 2 - Sun, Nov 22

1:53 pm - 5:14 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

27h 21m1 stop Fort Lauderdale

11:04 am - 8:03 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

20h 59m2 stops Jacksonville Fort Lauderdale

$503Multiple Airlines

Sat, Oct 31 - Mon, Nov 23

5:58 pm - 9:25 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

15h 27m2 stops Tampa Fort Lauderdale

7:11 pm - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

13h 39m1 stop Orlando

$504Multiple Airlines

Sat, Oct 31 - Sun, Nov 22

2:42 pm - 9:25 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

18h 43m1 stop Fort Lauderdale

11:04 am - 8:03 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

20h 59m2 stops Jacksonville Fort Lauderdale

$511Multiple Airlines

Thu, Nov 5 - Sun, Nov 8

5:10 am - 8:48 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 38m1 stop Charlotte Douglas

8:04 pm - 11:55 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

3h 51m1 stop Charlotte Douglas

$741American Airlines

Booking Insights

Price, demand and travel trends for Myrtle Beach to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Myrtle Beach to Knoxville? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Myrtle Beach to Knoxville departing in november.
What's the cheapest day of the week to fly from Myrtle Beach to Knoxville?: Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Myrtle Beach to Knoxville. It’s 12% cheaper than the average day, while Thursday is the most expensive, with prices 220% higher.

Find deals

Low season	April
High season	January
Cheapest flight	$133

Beat the crowds with an average 78% drop in travelers.

The most popular month to fly with an average 22% increase in travelers.

One-way flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Myrtle Beach to Knoxville?
Only Economy Class is available on flights from Myrtle Beach to Knoxville.
How long is a flight from Myrtle Beach to Knoxville?
A nonstop flight from Myrtle Beach to Knoxville takes 00m, covering 323 miles.
Do I need a passport to fly from Myrtle Beach to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Myrtle Beach to Knoxville flight?
Round-trip flights from Myrtle Beach to Knoxville range from $316 to $544, with an average of $359 over the past 12 months. Anything below $316 counts as a good deal.
Have flight prices from Myrtle Beach to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $239 to $1,183. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from Myrtle Beach to Knoxville looking right now?
One-way fares from Myrtle Beach to Knoxville are currently lower than usual. Average one-way flight prices are about $151, which is 45% below the typical average for this route.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

• Budget
• Alamo
• Enterprise Rent-A-Car
• Thrifty
• Avis
Which airports can I use when flying from Myrtle Beach to Knoxville?
Flights from Myrtle Beach to Knoxville usually depart from Myrtle Beach Intl (MYR) and arrive at Knoxville McGhee Tyson (TYS).
Which airports do connecting flights from Myrtle Beach to Knoxville pass through?
One-stop flights from Myrtle Beach to Knoxville most commonly connect through:

• Charlotte Douglas (CLT) - 88% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 8% of one-stop connections
• Baltimore/Washington (BWI) - 4% of one-stop connections
Can I save money by using flexible dates for flights from Myrtle Beach to Knoxville?
Yes. Flexible dates can save you up to 73% on flights from Myrtle Beach to Knoxville. Saturday is the cheapest departure day at $316 round-trip on average, while Thursday is the most expensive at $1,152, a difference of $836.

Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
How much time can I save by choosing a different layover airport from Myrtle Beach to Knoxville?
Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 3h 46m, compared with 3h 48m via Charlotte Douglas (CLT) and 7h 24m via Baltimore/Washington (BWI).

If your dates are flexible, aim for a Saturday departure and avoid flying on Thursday. On this route, Saturday flights average $316, about $836 less than Thursday fares (73% savings) based on the last 12 months.
If you can choose when to travel, plan your Myrtle Beach to Knoxville trip for December. Fares historically average $316 round-trip in that month - typically $836 less than the most expensive month, which is May (based on the last 12 months).

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MYR - TYS

$133 Find Cheap Flights from Myrtle Beach to Knoxville - Compare and Save

Everything you should know

Cheap Flights from Myrtle Beach to Knoxville (MYR-TYS)

Recent round-trip flight deals from Myrtle Beach to Knoxville

Recent one-way flight deals from Myrtle Beach to Knoxville

Recent last minute flight deals from Myrtle Beach to Knoxville

Price, demand and travel trends for Myrtle Beach to Knoxville flights

How much is a round-trip flight from Myrtle Beach to Knoxville?

What's the cheapest day of the week to fly from Myrtle Beach to Knoxville?

Which airline is the cheapest to fly from Myrtle Beach to Knoxville?

What’s the most popular layover airport when flying from Myrtle Beach to Knoxville?

What is the cheapest layover airport when flying from Myrtle Beach to Knoxville?

When flying from Myrtle Beach to Knoxville which airport offers the shortest layover?

Key details for Myrtle Beach to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from Myrtle Beach to Knoxville

Your Myrtle Beach to Knoxville flight questions, answered

Your guide to booking Myrtle Beach to Knoxville flights

More options for your flight from Myrtle Beach to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Myrtle Beach to Knoxville

Find direct flights to and from Myrtle Beach and Knoxville

Flights from domestic origins to Knoxville

Flights to other popular destinations

Find deals for your return flight