MYR - TYS

$137 Find Cheap Flights from Myrtle Beach to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$312
Typical prices: $316-$515
Multiple Airlines
Sat 10/13Tue 10/16
MYR - TYS • 1 stop
Cheapest one-way
$137
Typical prices: $182-$303
Southwest
Sat 10/27
MYR - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Myrtle Beach and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
October
Cheapest • 1% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Charlotte Douglas (CLT)
Cheapest • Avg $404 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 3h 46m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Myrtle Beach to Knoxville (MYR-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Knoxville

Tue, Oct 13 - Fri, Oct 16
Multiple Airlines Logo
4:03 pm - 10:05 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
18h 02m1 stop Fort Lauderdale
Multiple Airlines Logo
9:24 pm - 9:13 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
11h 49m1 stop Fort Lauderdale
$312Multiple Airlines
Mon, Oct 5 - Thu, Oct 29
American Airlines Logo
8:12 pm - 11:55 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 43m1 stop Charlotte Douglas
American Airlines Logo
10:00 am - 1:31 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 31m1 stop Charlotte Douglas
$319American Airlines
Tue, Sep 22 - Wed, Sep 23
Multiple Airlines Logo
10:50 am - 10:04 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
23h 14m1 stop Fort Lauderdale
Multiple Airlines Logo
5:18 pm - 12:14 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
18h 56m1 stop Tampa St. Petersburg
$323Multiple Airlines
Mon, Nov 9 - Fri, Nov 13
Southwest Logo
1:40 pm - 9:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
8h 00m1 stop Baltimore/Washington
Southwest Logo
8:10 am - 6:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
10h 45m1 stop Baltimore/Washington
$330Southwest
Mon, Nov 9 - Sun, Nov 15
American Airlines Logo
6:12 am - 9:45 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 33m1 stop Charlotte Douglas
American Airlines Logo
6:07 pm - 10:04 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 57m1 stop Charlotte Douglas
$333American Airlines
Fri, Nov 27 - Sun, Dec 6
American Airlines Logo
5:10 am - 8:49 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 39m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 51m1 stop Charlotte Douglas
$333American Airlines
Mon, Nov 9 - Fri, Nov 13
Southwest Logo
1:40 pm - 9:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
8h 00m1 stop Baltimore/Washington
Southwest Logo
7:25 pm - 9:55 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 30m2 stops Nashville Intl Baltimore/Washington
$335Southwest
Mon, Oct 5 - Thu, Oct 29
Multiple Airlines Logo
1:53 pm - 5:14 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
27h 21m1 stop Fort Lauderdale
Multiple Airlines Logo
6:24 pm - 2:02 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
43h 38m2 stops Jacksonville Akron/Canton
$339Multiple Airlines
Fri, Nov 13 - Fri, Nov 13
American Airlines Logo
5:10 am - 8:48 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 38m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 51m1 stop Charlotte Douglas
$347American Airlines
Mon, Nov 23 - Mon, Nov 30
American Airlines Logo
8:44 pm - 11:59 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 15m1 stop Charlotte Douglas
American Airlines Logo
3:47 pm - 10:03 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
6h 16m1 stop Charlotte Douglas
$347American Airlines
Booking Insights

Price, demand and travel trends for Myrtle Beach to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Myrtle Beach to Knoxville with more confidence.

What's the cheapest day of the week to fly from Myrtle Beach to Knoxville?

Monday is the cheapest day of the week to fly from Myrtle Beach to Knoxville, it is 2% cheaper than the average day. Wednesday is the most expensive day with flight prices 102% higher than average. Based on deals found by KAYAK users in the last 12 months.

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Key details for Myrtle Beach to Knoxville flights

Low season

August

Cheapest flight

$137
Most popular time to fly with an average 63% increase in price.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Myrtle Beach to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Myrtle Beach to Knoxville?

    Flights from Myrtle Beach to Knoxville usually depart from Myrtle Beach Intl (MYR) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from Myrtle Beach to Knoxville?

    Only Economy Class is available on flights from Myrtle Beach to Knoxville.

  • Which airports do connecting flights from Myrtle Beach to Knoxville pass through?

    One-stop flights from Myrtle Beach to Knoxville most commonly connect through:

    • Charlotte Douglas (CLT) - 90% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 7% of one-stop connections
    • Baltimore/Washington (BWI) - 3% of one-stop connections

    Charlotte Douglas (CLT) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Myrtle Beach to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 52% on the Myrtle Beach to Knoxville route. Monday is the cheapest departure day at $311 round-trip on average, while Wednesday is the most expensive at $641, a difference of $330. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How long is a flight from Myrtle Beach to Knoxville?

    A nonstop flight from Myrtle Beach to Knoxville takes 0h 00m, covering 323 miles.

  • Do I need a passport to fly from Myrtle Beach to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Myrtle Beach to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $312 to $1,047. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Myrtle Beach to Knoxville looking right now?

    One-way fares from Myrtle Beach to Knoxville are currently lower than usual. Average one-way flight prices are about $223, which is 12% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Myrtle Beach to Knoxville?

    Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 3h 44m, compared with 3h 46m via Atlanta Hartsfield-Jackson (ATL) and 7h 24m via Baltimore/Washington (BWI).

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    · Budget
    · Alamo
    · Thrifty
    · Enterprise Rent-A-Car
    · Payless

  • How much should I expect to pay for a Myrtle Beach to Knoxville flight?

    Round-trip flights from Myrtle Beach to Knoxville range from $316 to $515, with an average of $316 over the past 12 months. Anything below $316 counts as a good deal.

Your guide to booking Myrtle Beach to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Monday departure instead of Wednesday. On this route, Monday flights average $311 - about $330 less than Wednesday (51% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Myrtle Beach to Knoxville trip for October. Fares historically average $313 round-trip in that month - typically $839 less than the most expensive month, which is May (based on the last 12 months).

More options for your flight from Myrtle Beach to Knoxville

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