MYR - TYS

$298 Find Cheap Flights from Myrtle Beach to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$298
Overall average: $308
Multiple Airlines
Thu 2/19Thu 2/26
MYR - TYS • 1 stop
Cheapest one-way
Multiple Airlines
Thu 1/22
MYR - TYS • multi-stop
Top airlines
American Airlines
Cheapest • from $382 (round-trip)
American Airlines
Best reviews • 7.2 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 37% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Myrtle Beach to Knoxville (MYR-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Knoxville

Thu, Feb 19 - Thu, Feb 26
Multiple Airlines Logo
10:30 am - 10:16 pm
MYR
-
TYS
11h 46m
1 stop
Multiple Airlines Logo
3:25 pm - 8:13 am
TYS
-
MYR
16h 48m
1 stop
$298Multiple Airlines
Thu, Feb 19 - Thu, Feb 26
Multiple Airlines Logo
12:39 pm - 10:16 pm
MYR
-
TYS
9h 37m
1 stop
Multiple Airlines Logo
5:53 pm - 10:59 am
TYS
-
MYR
41h 06m
2 stops
$309Multiple Airlines
Sat, Feb 28 - Sun, Mar 8
Multiple Airlines Logo
9:09 am - 8:18 pm
MYR
-
TYS
11h 09m
1 stop
Multiple Airlines Logo
9:42 pm - 8:13 am
TYS
-
MYR
10h 31m
1 stop
$326Multiple Airlines
Sat, Feb 28 - Sun, Mar 8
Multiple Airlines Logo
11:54 am - 10:07 pm
MYR
-
TYS
34h 13m
2 stops
Multiple Airlines Logo
9:42 pm - 8:13 am
TYS
-
MYR
10h 31m
1 stop
$338Multiple Airlines
Fri, Mar 13 - Sun, Mar 15
American Airlines Logo
5:10 am - 8:42 am
MYR
-
TYS
3h 32m
1 stop
American Airlines Logo
5:00 am - 8:32 am
TYS
-
MYR
3h 32m
1 stop
$382American Airlines
Fri, Feb 6 - Tue, Feb 10
Delta Logo
2:19 pm - 5:52 pm
MYR
-
TYS
3h 33m
1 stop
Delta Logo
5:40 am - 9:46 am
TYS
-
MYR
4h 06m
1 stop
$407Delta
Fri, Mar 13 - Sun, Mar 15
Multiple Airlines Logo
6:37 pm - 8:40 am
MYR
-
TYS
14h 03m
1 stop
Multiple Airlines Logo
9:43 pm - 2:32 pm
TYS
-
MYR
16h 49m
2 stops
$469Multiple Airlines
Thu, Mar 12 - Sun, Mar 15
Delta Logo
10:23 am - 4:06 pm
MYR
-
TYS
5h 43m
1 stop
Delta Logo
5:40 am - 9:33 am
TYS
-
MYR
3h 53m
1 stop
$503Delta
Fri, Feb 6 - Tue, Feb 10
United Airlines Logo
1:25 pm - 1:24 pm
MYR
-
TYS
23h 59m
2 stops
United Airlines Logo
7:20 pm - 12:41 pm
TYS
-
MYR
17h 21m
2 stops
$732United Airlines
Thu, Feb 19 - Thu, Feb 26
United Airlines Logo
1:00 pm - 10:49 am
MYR
-
TYS
21h 49m
2 stops
United Airlines Logo
7:25 pm - 4:49 pm
TYS
-
MYR
21h 24m
2 stops
$768United Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Knoxville flights

Get data-powered insights and trends into flights from Myrtle Beach to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Myrtle Beach to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Myrtle Beach to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Myrtle Beach to Knoxville is September, where tickets cost $228 (return) on average. On the other hand, the most expensive months are June and January, where the average cost of round-trip tickets is $583 and $461 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$298
Best time to beat the crowds with an average 37% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Knoxville

  • What is the cheapest flight from Myrtle Beach to Knoxville?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Knoxville was $298 for a round-trip ticket.

  • Do I need a passport to fly between Myrtle Beach and Knoxville?

    No

  • Which aircraft models fly most regularly from Myrtle Beach to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Knoxville?

    oneworld is the only airline alliance operating flights between Myrtle Beach and Knoxville.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Myrtle Beach to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11174 reviews
7.2Comfort
7.5Boarding
8.0Crew
6.9Entertainment
6.4Food
Airline reviews

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

10.0 ExcellentFatima, Jan 2026
PHL - STL
Read more American Airlines reviews

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Long delays, lack of information about the status of the flight. The flight was delayed 4 times.

Could we please end the loud announcements about credit card offers on your flights? We are trying to sleep, work, watch videos, etc. and if we need a credit card, we will ask for one. Flying is already not what it used to be.

I would like the crew to talk LESS over the PA and specifically about credit card offers. I am trying to work, sleep, watch a movie and the PA was booming about a credit card offer. Could we go back to the days when the customer was more important than selling a credit card?

No enough space plus only allowing one laggage instead of two like other airlines.

It was good. But the gate team made me check my carry on when there was plenty of space for my luggage on the plane. Otherwise our trip was fine.

The entertainment options were at best, fair. It was exactly the same as my outbound flight. It would have been more entertaining if there were some series from Apple TV, HBO, Showtime or other carriers for me to catch up with.

Concern Regarding Significant Gate Delay and Jet Bridge Issue Dear Customer Relations Team, I am writing to express my disappointment with the experience I had on my recent flight AA 2414 on Sunday January 18, 2026. What should have been a routine departure turned into a frustrating and avoidable delay due to an issue with the jet bridge at the gate. As a result, the flight was delayed by approximately 90 minutes while multiple gate changes were attempted. The lack of clear communication during this period made the situation even more challenging. Passengers were left uncertain about the cause of the delay, the expected timeline, and the next steps. This not only disrupted travel plans but also created unnecessary stress for everyone on board. I understand that operational issues can arise, but a malfunctioning jet bridge and the resulting extended delay suggest an area where procedures or equipment maintenance may need attention. I hope you will review this incident to prevent similar disruptions in the future. I would appreciate acknowledgment of this concern and consideration of appropriate compensation for the inconvenience and lost time caused by this delay. Thank you for taking the time to review my experience. I look forward to hearing from you. Sincerely, Dion Dillard

They made me pay $40 to check a bag that was listed as free when I bought my ticket. Then before boarding they offered to check any bags free.

It was a good trip. Flight Attendants were friendly and responsive.

Everything you need to know for your flight from Myrtle Beach to Knoxville

Information on your arrival and departure airports

Myrtle Beach (MYR)
Knoxville (TYS)