MYR - TYS

$180 Find Cheap Flights from Myrtle Beach to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$279
Overall average: $316
Multiple Airlines
Wed 12/17Sun 12/21
MYR - TYS • 1 stop
Cheapest one-way
$180
Multiple Airlines
Tue 12/16
MYR - TYS • 2 stops
When to travel
September
Cheapest • 37% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Myrtle Beach to Knoxville (MYR-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Knoxville

Wed, Dec 17 - Sun, Dec 21
Multiple Airlines Logo
9:54 am - 8:18 am
MYR
-
TYS
22h 24m1 stop
Multiple Airlines Logo
2:56 pm - 6:08 pm
TYS
-
MYR
27h 12m1 stop
$279Multiple Airlines
Wed, Dec 17 - Sun, Dec 21
Multiple Airlines Logo
9:54 am - 8:18 am
MYR
-
TYS
22h 24m1 stop
Multiple Airlines Logo
9:56 pm - 6:11 pm
TYS
-
MYR
20h 15m2 stops
$313Multiple Airlines
Fri, Dec 19 - Tue, Dec 23
Multiple Airlines Logo
10:40 am - 9:34 pm
MYR
-
TYS
34h 54m2 stops
Multiple Airlines Logo
9:27 pm - 6:08 pm
TYS
-
MYR
20h 41m1 stop
$357Multiple Airlines
Fri, Apr 3 - Sun, Apr 5
Southwest Logo
10:35 am - 9:15 pm
MYR
-
TYS
10h 40m1 stop
Southwest Logo
6:35 am - 1:30 pm
TYS
-
MYR
6h 55m1 stop
$358Southwest
Fri, Dec 19 - Tue, Dec 23
Multiple Airlines Logo
6:00 am - 12:00 pm
MYR
-
TYS
6h 00m1 stop
Multiple Airlines Logo
9:08 am - 6:08 pm
TYS
-
MYR
9h 00m1 stop
$423Multiple Airlines
Fri, Dec 19 - Tue, Dec 23
Multiple Airlines Logo
6:00 am - 8:03 am
MYR
-
TYS
26h 03m3 stops
Multiple Airlines Logo
9:08 am - 6:08 pm
TYS
-
MYR
9h 00m1 stop
$424Multiple Airlines
Wed, Dec 17 - Sun, Dec 21
Multiple Airlines Logo
9:54 am - 11:31 am
MYR
-
TYS
25h 37m2 stops
Multiple Airlines Logo
5:52 pm - 6:08 pm
TYS
-
MYR
24h 16m3 stops
$472Multiple Airlines
Fri, Apr 3 - Sun, Apr 5
Southwest Logo
10:35 am - 9:15 pm
MYR
-
TYS
10h 40m1 stop
Southwest Logo
7:25 pm - 10:00 am
TYS
-
MYR
14h 35m2 stops
$483Southwest
Fri, Dec 19 - Tue, Dec 23
Multiple Airlines Logo
6:00 am - 8:03 am
MYR
-
TYS
26h 03m3 stops
Multiple Airlines Logo
9:27 pm - 11:59 pm
TYS
-
MYR
26h 32m2 stops
$497Multiple Airlines
Wed, Dec 17 - Sun, Dec 21
Multiple Airlines Logo
9:54 am - 11:31 am
MYR
-
TYS
25h 37m2 stops
Multiple Airlines Logo
6:00 am - 6:37 pm
TYS
-
MYR
12h 37m2 stops
$500Multiple Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Knoxville flights

Get data-powered insights and trends into flights from Myrtle Beach to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Knoxville?

The average price of all round-trip flights from Myrtle Beach to Knoxville clicked on KAYAK for each day over the last 12 months.

For Myrtle Beach to Knoxville, Tuesday is the cheapest day to fly on average and Sunday is the most expensive. Flying from Knoxville back to Myrtle Beach, the best deals are generally found on Tuesday, with Thursday being the most expensive.

What is the cheapest month to fly from Myrtle Beach to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Myrtle Beach to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Myrtle Beach to Knoxville is September, where tickets cost $228 (return) on average. On the other hand, the most expensive months are June and January, where the average cost of round-trip tickets is $583 and $497 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$180
Best time to beat the crowds with an average 38% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Myrtle Beach to Knoxville

When to book flights from Myrtle Beach to Knoxville

Are your dates flexible? Find out the best times to travel from Myrtle Beach to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to Knoxville

  • What is the cheapest flight from Myrtle Beach to Knoxville?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to Knoxville was $180 for a one-way ticket and $279 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and Knoxville?

    No

  • Which aircraft models fly most regularly from Myrtle Beach to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Myrtle Beach to Knoxville?

    oneworld is the only airline alliance operating flights between Myrtle Beach and Knoxville.

  • How does KAYAK find such low prices on flights from Myrtle Beach to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Myrtle Beach to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11047 reviews
7.2Comfort
6.9Entertainment
6.5Food
7.5Boarding
8.0Crew
Airline reviews

Attendants were pleasant and the flight was smooth and relaxed.

10.0 ExcellentDawn C, Dec 2025
DFW - MIA
Read more American Airlines reviews

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

I liked the humor of the captain and crew on the flight from Flagstaff to Dallas. They were humorous.

AA delayed the flight for 3 hours and 50 minutes, but delayed the last 2 hours, 30 minutes at a time, so if we knew before, could have stayed at home and worked instead of being at the airport wasting time... The plane's crew was excellent, not their fault.

After arriving in Dallas, the aircraft taxied for an unusually long time and was unable to park at the gate, which caused a significant delay and made me miss my connecting flight. I then had to wait in a very long line to be rebooked, and I was told that no hotel or meal accommodations would be provided. What is even more unacceptable is that my luggage was mishandled and has still not been located. My suitcase contains important medications that I urgently need, and I have been unable to access them due to the airline’s mishandling. This situation has caused me considerable stress and inconvenience, and I need this issue to be resolved immediately.

RIC Staff was not enough. Elderly passengers had to wait 30 minutes to deplane, so we could board and still had to walk as no chairs were provided. And, passenger in front of my seat assignment rammed seat against my legs entire flight time. Was mildly bruised and left thigh still sore.

Liked that it was on time. Staff professional and friendly.

Things were delayed a little. But that didn’t affect my plans. It was fine. I was surprised it was so full thanksgiving day. The crew were friendly and professional.

I appreciated that it was on time, safe and professional. I didn’t like that I wasn’t in a place where I had a window at my window seat. It would have been nice to know that in advance. If it was mentioned in the ticketing, I didn’t notice it.

Everything you need to know for your flight from Myrtle Beach to Knoxville

Information on your arrival and departure airports

Myrtle Beach (MYR)
Knoxville (TYS)