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$536 Find cheap flights from South America to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight to Knoxville departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Mon 6/17
Mon 6/24

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Good to know

Low season

August

High season

December

Cheapest flight

$536
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Quito to Knoxville

FAQs for booking flights from South America to Knoxville

  • How does KAYAK find such low prices on flights from South America to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Prefer to fly non-stop from South America to Knoxville?

Find which airlines fly direct from South America to McGhee Tyson, which days they fly and book direct flights.

Nonstop departures

South America to Knoxville McGhee Tyson

Monday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Tuesday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Wednesday

ANA, Aer Lingus, Aeromexico, +24 more

ANA, Aer Lingus, +25 more

Thursday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

Friday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Saturday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Sunday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

See more direct flights

Nonstop returns

Knoxville McGhee Tyson to South America

Monday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Tuesday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Wednesday

ANA, Aer Lingus, Aeromexico, +24 more

ANA, Aer Lingus, +25 more

Thursday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

Friday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Saturday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Sunday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

See more direct flights
See more direct flights

Top airlines flying from South America to Knoxville

 
Need help choosing which airline to fly with from South America to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10647 reviews
7.9Comfort
8.2Boarding
8.6Crew
8.0Entertainment
7.4Food
Airline reviews

They were an hour late and they didn’t have my wheelchair for me

2.0 Mediocresal, May 2024ATL - AUS
Read more about Delta reviews

They were an hour late and they didn’t have my wheelchair for me

The Flight crew didn’t serve us until about 1.5 hours into the flight because of turbulence but after it ended it was fine to move around. They served us water only and snacks and then NEVER, NOT ONE TIME came through to collect trash until right before landing about 1.5 hours later. There was absolutely no need for that. They crew was just standing around talking and visiting with each other and really never tried to see if we might want something besides water or even try to come pick up trash. This is VERY unusual for a Delta flight but it was not what I would have expected for a 4 hour flight.

The 1st class male crew member was very pleasant - the short female with round glasses , maybe in 50’s had no personality- never spoke when delivering my food, drink, & never smiled the whole trip! In fact looked annoyed when the boarding proses was happening- I would never hire this woman - unfriendly . Have never dealt with a crew member like her-

5-hour delay due to storms in Tanoa and airspace restricted by Miami traffic controllers.

A regional sized plane was used for a cross country flight with no overhead bin space. I had to "pink check" my laptop and my medications. I was NOT pleased!!!!

Absolutely nothing flight was cancelled and delayed for 2 days. Barely a heads up I want a full refund

The plane from SNA wouldn’t start after 5 tries. The team gave me an option of flying direct from LAX and giving me a Lyft ride there! Perfect!

Best airline! Always friendly and welcoming. Skyclub was great and loved the fast free wifi on board. I also love that you can pre-order your meal on the app!

Atlanta boarding crew at gate were filled with arrogance and were disrespectful. In flight crew showed indifference to the needs of passengers. This is about the flight from ATL to BDL.

The boarding was horrible. You couldn’t hear the announcements at all. Probably because there is so much in the area for businesses. They need a louder PA system. Other than that it was a good Delta experience.

As no headphones/ ear pieces in back of seat for entertainment system, would have been to been offered rather than asking & waiting a long time. I know we are in economy but cost of ticket was high.

The flight was short. However, my bag was delayed and was put on another flight.

Flight attendant was incredible. Very efficient, friendly and pleasant. Patricia was one of the best I have ever seen. Please give her a big raise!

LIT to DFW - 3 hours late; the entire plane had been boarded before they told us there was a delay due to a weather-related ground stop in Dallas. DFW to MAY - 2+ hours late due to A/C needing to be repaired after everyone had boarded, then when we finally reach the runway, the First Officer timed out and we had to taxi all the way back to the gate and wait for a new one. I arrived in New Orleans 5+ hours later than I should have. Return flights were completely cancelled; rebooked through the app to fly through CLT instead of DFW. MSY to CLT had no issues, but CLT to LIT was delayed 1.25 hrs because flight attendants had not arrived to the airport yet. At least they didn’t make us all sit on the plane to wait for them. I should have driven.

Tray table was filthy when I sat down. I needed to have someone come clean it because there was food and stains on it WiFi didn’t work after paying for in-flight WiFi. Food was terrible and was not filling at all Chicken was rubbery Flight attendant had an attitude, interrupted me and wasn’t able to answer basic questions about the food selection such as “does the chicken have red sauce in it”. If your flight attendants are not going to know what is in the meals so we can make an educated decision based on dietary restrictions, they shouldn’t be on the plane. My 1.5 year old niece was sleeping and dropped her binkie. I went on the ground under the chairs looking for it. It was at that time that she came up to me as I’m CLEARLY on all 4s with a flashlight and said “I need to get by”. I said one moment please I’m getting something from under the seat (while my head was literally under the seat). Her reply was “no you need to move now” and proceeded to almost push me out of the way. I looked up and all I saw was her toes under my eyes. When I looked in front of me, her private parts were inches away from my face. I then made a comment “you couldn’t waited 2 seconds?” and her response was, “no I need to use the bathroom”. I understand that and would never want to be the reason someone couldn’t get to the bathroom but I was under the seat. She could’ve gone around the other way instead of harassing me, basically placing her private parts on my head and borderline pushing me out of the way. You don’t pay that much for this deplorable experience. This was by far the worst experience I have ever had on American. I will be absolutely thinking twice and thrice about flying American Airlines again. I would rather pay more to fly delta because at least I know their WiFi will work and their flight attendants won’t have a shitty attitude for no reason, nor will they act the way this woman did. Unacceptable.

Liked - nothing. Disliked - delayed 35+ min sitting on the plane. Caused me to miss my connection in Charlotte. American Airlines is the worst US Air Carrier company with atrocious customer service.

Worst situation ever! I booked my tickets for this trip on Alaska Airlines. I guess AA is a partner and we flew nonstop from Eugene to PHX on an AA jet. I had to pay for luggage from PHX to EUG. And this was an Alaska Airlines reservation paid for with Alaska airlines credit card! Got to the PHX airport and was not able to check bags because of some weird issue with the AA software. My reservation had to be the-entered by the agent. I will never pick another American Airlines flight on the Alaska Airlines website. While on vacation, I tried to upgrade our seats for the trip home. The request just buffered and never went through. I tried four times and was charged four times on my credit card. The card was charged but the seats were never changed. What a wreck!

Left from gate 30 minutes before flight. Never been late to a flight ever. It says 15 minutes before explicitly on the ticket.

I like the boarding process, it was fast. The seat doesn’t have a TV for a long flight and food wasn’t served, just snacks.

Left on time. Arrived early. Turbulence coming in and gate not open due to early arrival but expected.

Book cheap flights from South America to Knoxville

Recent round-trip flight deals

6/24Mon
2 stopsUnited Airlines
36h 17mUIO-TYS
10/1Tue
2 stopsUnited Airlines
41h 30mTYS-UIO
$536
7/14Sun
1 stopDelta
23h 31mUIO-TYS
10/2Wed
2 stopsDelta
14h 05mTYS-UIO
$548
6/24Mon
2 stopsUnited Airlines
36h 17mUIO-TYS
10/1Tue
1 stopUnited Airlines
17h 30mTYS-UIO
$554
6/13Thu
2 stopsAmerican Airlines
22h 47mUIO-TYS
9/18Wed
2 stopsAmerican Airlines
19h 53mTYS-UIO
$630
9/20Fri
2 stopsAmerican Airlines
21h 55mUIO-TYS
9/24Tue
2 stopsAmerican Airlines
19h 58mTYS-UIO
$694
6/16Sun
3 stops
30h 44mSCL-TYS
6/23Sun
3 stops
27h 16mTYS-SCL
$807
6/16Sun
3 stops
30h 44mSCL-TYS
6/23Sun
2 stops
23h 19mTYS-SCL
$851
10/27Sun
2 stopsAvianca
29h 15mGYE-TYS
10/31Thu
2 stopsAvianca
14h 13mTYS-GYE
$907
7/21Sun
2 stopsCopa Airlines
32h 06mSCL-TYS
8/9Fri
2 stopsCopa Airlines
23h 19mTYS-SCL
$1,120
7/22Mon
2 stopsAvianca
19h 55mSCL-TYS
8/8Thu
2 stopsAvianca
18h 20mTYS-SCL
$1,269

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Last minute flights from South America to Knoxville

Last minute flight, train and bus deals

5/22Wed
multi-stopAmerican Airlines
21h 33mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
17h 56mTYS-GYE
$892
5/22Wed
multi-stopAmerican Airlines
16h 42mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
17h 41mTYS-GYE
$894
5/22Wed
multi-stopAmerican Airlines
23h 38mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
22h 53mTYS-GYE
$900
5/22Wed
multi-stopAmerican Airlines
16h 42mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
19h 25mTYS-GYE
$902
5/22Wed
multi-stopAmerican Airlines
9h 07mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
16h 19mTYS-GYE
$956
5/22Wed
multi-stopAmerican Airlines
9h 07mGYE-TYS
6/5Wed
multi-stopAmerican Airlines
16h 19mTYS-GYE
$1,031
5/21Tue
multi-stopAvianca
29h 36mGYE-TYS
6/5Wed
multi-stopAvianca
18h 35mTYS-GYE
$3,992

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Flights to Knoxville

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - South America

Cabin classes: