$361 Find Cheap Flights from South America to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Knoxville departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from South America to Knoxville

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to Knoxville

Wed, Sep 16 - Fri, Sep 25
United Airlines Logo
12:35 am - 9:57 am
UIO
-
TYS
56h 22m
2 stops
United Airlines Logo
7:15 am - 11:25 pm
TYS
-
UIO
17h 10m
1 stop
$740United Airlines
Tue, Oct 13 - Wed, Oct 21
United Airlines Logo
12:35 am - 9:45 am
UIO
-
TYS
32h 10m
2 stops
United Airlines Logo
10:42 am - 11:25 pm
TYS
-
UIO
37h 43m
2 stops
$774United Airlines
Wed, Sep 16 - Fri, Sep 25
United Airlines Logo
12:35 am - 11:59 pm
UIO
-
TYS
22h 24m
2 stops
United Airlines Logo
7:15 am - 11:25 pm
TYS
-
UIO
17h 10m
1 stop
$804United Airlines
Sun, Oct 18 - Mon, Oct 26
American Airlines Logo
6:40 am - 11:35 pm
UIO
-
TYS
15h 55m
1 stop
American Airlines Logo
7:13 am - 8:40 pm
TYS
-
UIO
14h 27m
1 stop
$827American Airlines
Sun, Oct 18 - Mon, Oct 26
American Airlines Logo
6:40 am - 8:22 am
UIO
-
TYS
24h 42m
2 stops
American Airlines Logo
7:13 am - 8:40 pm
TYS
-
UIO
14h 27m
1 stop
$831American Airlines
Wed, Sep 16 - Fri, Sep 25
Delta Logo
12:59 am - 3:25 pm
UIO
-
TYS
13h 26m
1 stop
Delta Logo
5:45 am - 6:59 pm
TYS
-
UIO
14h 14m
1 stop
$833Delta
Tue, Sep 1 - Tue, Sep 8
United Airlines Logo
12:22 pm - 9:45 pm
GYE
-
TYS
32h 23m
2 stops
United Airlines Logo
7:15 am - 8:52 pm
TYS
-
GYE
14h 37m
2 stops
$838United Airlines
Tue, Sep 1 - Tue, Sep 8
American Airlines Logo
6:00 am - 11:51 pm
GYE
-
TYS
16h 51m
1 stop
American Airlines Logo
6:00 am - 9:39 pm
TYS
-
GYE
16h 39m
1 stop
$921American Airlines
Sun, Aug 2 - Sat, Sep 26
LATAM Airlines Logo
9:00 am - 11:11 am
UIO
-
TYS
25h 11m
2 stops
LATAM Airlines Logo
5:45 pm - 7:05 pm
TYS
-
UIO
26h 20m
2 stops
$1,021LATAM Airlines
Sun, Aug 2 - Sat, Sep 26
LATAM Airlines Logo
9:00 am - 9:36 am
UIO
-
TYS
23h 36m
2 stops
LATAM Airlines Logo
5:45 pm - 6:59 pm
TYS
-
UIO
26h 14m
1 stop
$1,051LATAM Airlines
Useful Info

Good to know

Cheapest flight$361
Flight from Quito to Knoxville

FAQs for booking flights from South America to Knoxville

  • How does KAYAK find such low prices on flights from South America to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from South America to Knoxville

 
Need help choosing which airline to fly with from South America to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8406 reviews
7.2Food
8.1Boarding
7.8Comfort
7.8Entertainment
8.5Crew
Airline reviews

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

2.0 MediocreAnonymous, Jun 2026
RDU - LGA
Read more Delta reviews

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Crew helpful. Plenty of food although not great but ok. Good time.

Flight attendants were great. Cheerful, upbeat and friendly. Jet, in particular, was fantastic.

I have Precheck. Flew HPN to DEN and return this past weekend. Delta didn't attach my Precheck number to this trip. So it was waiting in general line especially in Denver. Unavailable.

Original flight was delayed, then cancelled and the gate staff did not expedite rebooking. Also, no instructions were given that a ticket number was needed before being called to facilitate rebooking. This could have been much more organized.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

Five hour delays every hour, I wish it were all at once

Flight delayed four separate times. I’m now one hour hours late to landing.

worst flight ever from Delta, it got delayed and kept on delaying..

Should never have had to go to Detroit from Orlando back to Tennessee!

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

They didn’t have any headphones for the entertainment screen and their USB port didn’t accommodate a USB-C for more modern phones. The food was just ok. The staff was friendly but the seats were very uncomfortable for a full flight.

Boarding was confusing from staff telling going to preboard and than to group 1 Airplane was not cooling at the beginning

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

The food is terrible I ask for water never got transport my mother we’re late and my sister from Lima was the worst waiting to long for wheelchair

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

A lot things happened in this trip.The fly should be less stress.

Some of the Air hostesses are not that friendly. Need improvement

Simply as follows:- First, there was no vegetarian option for the meal Second, only 2 washrooms for the entire economy class.

We sat on plane at gate delayed without communication as to why we were just sitting there

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

Trash. Sat on the runway for 40 mins…missed connecting flight because of it now I’m stuck. Thanks…a whole fkn lot.

The flight was delayed significantly and we sat on runway after landing for awhile. Best thing was the flight attendant, Jenny, in first class, who was very professional and attentive. She was excellent - the rest of the flight was not.

The plane was comfortable but the crew wasn’t friendly.

Awfully rude American worker at door when we started boarding flight. Then, walk into a blazing hot airplane with no air conditioning until twenty minutes into the flight. Free entertainment was non existent! My husband, along with the fellow passenger in our row, and I could not get entertainment to work, no WIFI! Really?? Been flying American a long time. Was very disappointed.

Flight was delayed by 6 hours... the level of incompetence was truly astounding. I won't be flying American Airlines again. I don't care if AA is direct and there is a layover with another airline, I'll take the layover.

Leave on time. We waited on the plane for hour hours and it was hot and smelly

Check in was easy. Flights were smooth. Flight attendants were courteous and friendly.

Two hours delay, probably one hour because they didn’t bring catering and they had to bring water in board. There a change of aircraft. But delays galore at CLT so it must be a CLT and/or AA operation issue. The 1 hr additional delays because nobody could bring 2 packs of water sooner is probably the best example of this airline operates

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