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$265 Find cheap flights from South America to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Knoxville departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sun 5/26
Sun 6/2

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Good to know

Low season

October

High season

December

Cheapest flight

$265
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly with an average 8% increase in price.
Flight from Quito to Knoxville

FAQs for booking flights from South America to Knoxville

  • How does KAYAK find such low prices on flights from South America to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Prefer to fly non-stop from South America to Knoxville?

Find which airlines fly direct from South America to McGhee Tyson, which days they fly and book direct flights.

Nonstop departures

South America to Knoxville McGhee Tyson

Monday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Tuesday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Wednesday

ANA, Aer Lingus, Aeromexico, +24 more

ANA, Aer Lingus, +25 more

Thursday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

Friday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Saturday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Sunday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

See more direct flights

Nonstop returns

Knoxville McGhee Tyson to South America

Monday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Tuesday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Wednesday

ANA, Aer Lingus, Aeromexico, +24 more

ANA, Aer Lingus, +25 more

Thursday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

Friday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Saturday

ANA, Aer Lingus, Aeromexico, +25 more

ANA, Aer Lingus, +26 more

Sunday

ANA, Aer Lingus, Aeromexico, +26 more

ANA, Aer Lingus, +27 more

See more direct flights
See more direct flights

Top airlines flying from South America to Knoxville

 
Need help choosing which airline to fly with from South America to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10966 reviews
8.6crew
7.9comfort
8.2boarding
7.4food
8.0entertainment
Airline reviews

Delta is one of the best airlines I have flown

10.0 ExcellentKellie, Apr 2024ANC - SEA
Read more about Delta reviews

Delta is one of the best airlines I have flown

Made the Atlanta to Pittsburgh trip many times, with Delta no issues

I always fly with Delta. My friends tell me their horror stories of flying with other airlines. I just smile and say, “You should fly Delta”

I'm a larger, athletic guy (6'2", 260lbs powerlifter) and I found the seats incredibly uncomfortable with minimal leg room, especially in a window seat. Now, I full understand that being smaller may change my view but even if I was 80lbs less, my legs would be the same size and I was sandwiched between my seat and the seat in front of me.

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

This flight was ridiculous. I had to have a connecting flight from New York to orlando Florida??? The flight left late and because it was a short flight there was no first class amenities. I had one alcohol drink. The flight crew was fine, but it sure did not feel like first class. Delta to me dropped the ball by giving me a connecting flight. By the time we got to Raleigh we would have missed the next flight. Lucky for me the flight never came so now I was stuck waiting for a later flight that came in late also.

Our flight was delayed in Atlanta. The staff could have gave us an explanation for the delay and how long it would be.

I liked the ease of checking in, luggage check in, wheel chair assistance, boarding and flight.

Flight was delayed an no one make an announcement about it., they only have Coca Cola and nothing else., the food that was served was cold… very bad experience and service

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

Flight delayed over an over all day until it cancelled at 1:30am. Would not repeatedly delay that late. Offer hotel rooms and rebook early. Very difficult for families with small children

this is starting to seem like an american airlines standard. delayed flights and fake apologies… getting tired of it

Both flights yesterday, experienced hard landings. Harder than I’ve ever felt before. Im hopeful there was weather involved and not pilot error. Other than the landing, the flight was quite good~

The plane was old and in new of a cleaning up and renovating on the interior. Seats and carpets were very worn and dirty looking. Cushioning on the seats was broken down and not as comfortable as newer jet seats. Food was a little below average but okay. Staff were friendly and hard working but did not pick up debris or food they spilled when collecting from the customers. But they were very helpful and professional.

A disaster, I lost my connection due to overcrowding at the Miami airport, having a 3-hour layover and the airline did nothing to reboard me on time and I had to sleep on the floor for 18 hours.

The food has never improved. It will never improve. But when I'm boarding a flight in priority boarding and I've spent 10 hours inside the security area of the airport and I get "randomly" selected for additional screening as I board the plane when the flight has already been delayed, and I work as a military contractor that has been issued visas direct from JMOD, I find it ridiculous. I would never recommend anyone to use AA on international flights. JAL is a better airline with older planes. The flight attendants on international hauls on American also have a chip on their shoulder and really dont deliver the same level of service code share partners do.

The flight was 90 minutes long and the stewardesses were extremely slow. I was in row 16 and they did not serve us drinks until we were descending for landing in a 90 minute flight. Unacceptably slow and at least 10 rows (20 to 31) did not receive any drinks or snacks for the entire duration of the flight because of the slowness of the stewardesses. There is no rationale to delay beverage service to brew coffee for a flight at six p m.

This flight is frequently delayed. The connections seemingly are more frequently delayed. I’ve missed connections as a result twice on the same route to charlotte then Charleston. Final destination arrival has been the next day, twice in a row. No pilots, no crew. Too many excuses. Unfortunately, my days with American are over.

Entertainment was okay not because anything was wrong but it is a short flight so having no wifi is annoying but understandable. Crew was outstanding as usual

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

Book cheap flights from South America to Knoxville

Recent round-trip flight deals

7/15Mon
2 stopsAmerican Airlines
19h 32mUIO-TYS
8/31Sat
2 stopsAmerican Airlines
17h 39mTYS-UIO
$506
6/13Thu
2 stopsAmerican Airlines
23h 18mUIO-TYS
9/18Wed
2 stopsAmerican Airlines
17h 39mTYS-UIO
$517
5/29Wed
2 stopsAmerican Airlines
21h 09mUIO-TYS
10/5Sat
2 stopsAmerican Airlines
17h 39mTYS-UIO
$569
6/13Thu
2 stopsDelta
11h 38mUIO-TYS
9/18Wed
1 stopDelta
7h 50mTYS-UIO
$572
9/20Fri
2 stopsDelta
24h 52mUIO-TYS
9/24Tue
1 stopDelta
7h 50mTYS-UIO
$588
5/28Tue
2 stopsUnited Airlines
20h 56mUIO-TYS
10/5Sat
2 stopsUnited Airlines
17h 30mTYS-UIO
$648
9/19Thu
2 stopsUnited Airlines
40h 43mUIO-TYS
9/24Tue
1 stopUnited Airlines
31h 10mTYS-UIO
$650
7/14Sun
1 stop
14h 45mUIO-TYS
10/2Wed
2 stops
13h 39mTYS-UIO
$657
8/22Thu
2 stopsCopa Airlines
32h 07mSCL-TYS
8/27Tue
2 stopsCopa Airlines
27h 51mTYS-SCL
$1,013
8/22Thu
2 stopsCopa Airlines
18h 48mSCL-TYS
8/27Tue
2 stopsCopa Airlines
31h 00mTYS-SCL
$1,067

Search by stops

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Recent one-way flight deals

5/29Wed
1 stop
23h 42mUIO-TYS
$265
5/8Wed
1 stop
22h 48mUIO-TYS
$294
5/8Wed
1 stop
22h 48mUIO-TYS
$295
5/28Tue
2 stopsUnited Airlines
20h 56mUIO-TYS
$305
5/7Tue
2 stops
27h 03mUIO-TYS
$367
5/7Tue
2 stops
27h 03mUIO-TYS
$368
5/8Wed
2 stopsUnited Airlines
32h 46mUIO-TYS
$380
5/9Thu
2 stopsAmerican Airlines
19h 38mUIO-TYS
$383
5/7Tue
1 stopAmerican Airlines
8h 43mUIO-TYS
$455
5/12Sun
2 stopsAvianca
15h 31mUIO-TYS
$1,880

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Last minute flights from South America to Knoxville

Last minute flight, train and bus deals

4/28Sun
multi-stopUnited Airlines
32h 39mUIO-TYS
8/29Thu
multi-stopUnited Airlines
18h 40mTYS-UIO
$756
4/28Sun
multi-stopUnited Airlines
21h 25mUIO-TYS
8/29Thu
multi-stopUnited Airlines
18h 40mTYS-UIO
$782
4/29Mon
multi-stopAmerican Airlines
12h 40mUIO-TYS
8/29Thu
multi-stopAmerican Airlines
19h 53mTYS-UIO
$788
4/29Mon
multi-stopAmerican Airlines
8h 17mUIO-TYS
8/29Thu
multi-stopAmerican Airlines
19h 53mTYS-UIO
$789
4/29Mon
multi-stopAmerican Airlines
16h 22mUIO-TYS
8/29Thu
multi-stopAmerican Airlines
19h 53mTYS-UIO
$791
4/28Sun
multi-stopUnited Airlines
21h 25mUIO-TYS
8/29Thu
multi-stopUnited Airlines
12h 30mTYS-UIO
$820
4/29Mon
multi-stop
15h 31mUIO-TYS
8/29Thu
multi-stop
23h 56mTYS-UIO
$1,487
4/29Mon
multi-stop
23h 36mUIO-TYS
8/29Thu
multi-stop
23h 56mTYS-UIO
$1,496
4/29Mon
multi-stopAvianca
28h 51mUIO-TYS
8/29Thu
multi-stopAvianca
38h 40mTYS-UIO
$1,627
4/29Mon
multi-stopAvianca
22h 01mUIO-TYS
8/29Thu
multi-stopAvianca
38h 40mTYS-UIO
$2,123

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Flights to Knoxville

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - South America

Cabin classes: