The Comfort Inn hotel in Perryville, MO, minutes from Lake Perry, will get you refreshed and ready to take on the day for business or leisure. We are near Southeast Missouri State University, Mayfest and St. Joseph of Apple Creek. We offer amenities that include free hot breakfast, free WiFi, free weekday newspaper, an outdoor pool, guest laundry facilities, a meeting room plus copy and fax. Each comfortable room features a TV, refrigerator, coffee maker and hair dryer. Select rooms include a hot tub and desk. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.