Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Havana (65% of total searches to Cuba). The next most popular destinations are Varadero (31%) and Cayo Coco (3%). Searches for hotels in Cayo Santa Maria (2%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Cuba is Ciudad de La Habana. Matanzas and Ciego de Avila are also very popular.