The Hampton Inn Muscatine is conveniently located right off of Highway 61. We are just minutes from businesses, restaurants, shops, and entertainment. Whether you are on business or pleasure the Muscatine Hampton Inn is sure to meet all your needs and more! While in town visit the Muscatine Art Center and attached Laura Musser Museum. This eloquent Historical Home built in 1908 is preserved with original woodwork, stain glass windows, mantle pieces and 1912 Estey Player Pipe Organ. For a relaxing view of the river, take a ride on the Pearl Button Paddlewheel boat across from downtown Muscatine. Our recently renovated riverfront offers a walking trail, park, and an interactive fountain for kids. Walk two blocks to 2nd street and you will find shops and restaurants, many with views overlooking the river.