Introduction
How to get there
Where to stay
Renting a car

Defiance travel guide

Defiance Tourism | Defiance Guide

You're Going to Love Defiance

With a population of 155, Defiance is a must-see destination in Missouri, United States. Consider staying at least one whole day in Defiance to see all of its attractions.

How to Get to Defiance

Plane

Although Defiance doesn’t have its own airport, you can fly to St. Louis Lambert Airport (STL), which is located 23 miles from Defiance. Columbia Regional is the most popular, with regular flights from American Airlines, Air Canada, Alaska Airlines and other airlines departing from the United States. The shortest domestic flight to Defiance departs from Detroit and takes around 1h 31m.

Train

Amtrak is the only carrier operating train routes to Defiance. The train journey from Defiance to Chicago takes 4h 46m and costs around $27 for a one-way ticket. When coming by train from Kansas City, expect to pay about $35 for a 5h 40m trip.

Car

Another option to get to Defiance is to pick up a car rental from St. Louis, which is about 31 miles from Defiance. You’ll find branches of Turo and Dollar, among others, in St. Louis.

Bus

Several bus lines operate bus routes to Defiance, including Greyhound, FlixBus and Bus. From Nashville, the bus ride to Defiance takes 345 miles and will cost you around $100. From Chicago, the ticket costs about $44 for a journey of 365 miles.

Plane

Although Defiance doesn’t have its own airport, you can fly to St. Louis Lambert Airport (STL), which is located 23 miles from Defiance. Columbia Regional is the most popular, with regular flights from American Airlines, Air Canada, Alaska Airlines and other airlines departing from the United States. The shortest domestic flight to Defiance departs from Detroit and takes around 1h 31m.

Train

Amtrak is the only carrier operating train routes to Defiance. The train journey from Defiance to Chicago takes 4h 46m and costs around $27 for a one-way ticket. When coming by train from Kansas City, expect to pay about $35 for a 5h 40m trip.

Car

Another option to get to Defiance is to pick up a car rental from St. Louis, which is about 31 miles from Defiance. You’ll find branches of Turo and Dollar, among others, in St. Louis.

Bus

Several bus lines operate bus routes to Defiance, including Greyhound, FlixBus and Bus. From Nashville, the bus ride to Defiance takes 345 miles and will cost you around $100. From Chicago, the ticket costs about $44 for a journey of 365 miles.

Airports near Defiance

COUColumbia Regional
STLLambert-St Louis
BLVBelleville

Airlines serving Defiance

Lufthansa
Good (7,046 reviews)
KLM
Good (1,334 reviews)
British Airways
Good (6,844 reviews)
Delta
Excellent (7,934 reviews)
Turkish Airlines
Good (3,791 reviews)
Iberia
Good (2,701 reviews)
Air France
Good (1,446 reviews)
Austrian Airlines
Good (780 reviews)
United Airlines
Good (8,697 reviews)
Emirates
Excellent (3,215 reviews)
Qatar Airways
Good (3,563 reviews)
Air Canada
Good (9,250 reviews)
Scandinavian Airlines
Good (1,349 reviews)
Brussels Airlines
Good (346 reviews)
Finnair
Good (1,275 reviews)
Alaska Airlines
Excellent (9,971 reviews)
Singapore Airlines
Excellent (1,292 reviews)
Cathay Pacific
Good (855 reviews)
Aer Lingus
Good (1,076 reviews)
Malaysia Airlines
Good (254 reviews)
Show more

Where to stay in popular areas of Defiance

Most booked hotels in Defiance

See all
Drury Plaza Hotel St. Louis Chesterfield
3 stars
Excellent (9.3, 888 reviews)
$151+
View
DoubleTree by Hilton Hotel St. Louis - Chesterfield
4 stars
Excellent (8.6, 920 reviews)
$183+
View
The Wildwood Hotel
3 stars
Excellent (8.6, 727 reviews)
$111+
View
Hilton Garden Inn St. Louis/Chesterfield
3 stars
Excellent (8, 598 reviews)
$145+
View
Super 8 by Wyndham Eureka/Six Flags Nearby
2 stars
Good (6.9, 583 reviews)
$71+
View
Super 8 by Wyndham O'Fallon MO/St. Louis Area
2 stars
Good (6.7, 310 reviews)
$73+
View

Renting a car in Defiance

Expect to pay $3.41 per gallon in Defiance (average price from the past 30 days). Depending on the size of your rental car, filling up the tank will cost between $40.88 and $54.51.

Expect to pay $3.41 per gallon in Defiance (average price from the past 30 days). Depending on the size of your rental car, filling up the tank will cost between $40.88 and $54.51.

Defiance Travel Guide - View the KAYAK Defiance city guide for the best Defiance travel tips. To help you organize your Defiance trip ideas, this Defiance visitors guide provides travel information and trip tips about how to get there, where to stay, what to do, where to eat and more.