$611 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Tue, Sep 1 - Thu, Sep 10
Delta Logo
7:07 am - 11:41 am
TYS
-
GCM
5h 34m
1 stop
Delta Logo
12:55 pm - 11:47 pm
GCM
-
TYS
9h 52m
1 stop
$611Delta
Tue, Sep 1 - Tue, Sep 8
American Airlines Logo
7:16 pm - 11:00 am
TYS
-
GCM
16h 44m
2 stops
American Airlines Logo
2:10 pm - 10:25 am
GCM
-
TYS
19h 15m
2 stops
$616American Airlines
Wed, Sep 2 - Thu, Sep 10
Multiple Airlines Logo
3:46 pm - 5:20 pm
TYS
-
GCM
26h 34m
2 stops
Multiple Airlines Logo
12:40 pm - 8:14 am
GCM
-
TYS
18h 34m
1 stop
$625Multiple Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
5:12 pm - 10:48 am
GCM
-
TYS
16h 36m
2 stops
$636American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
12:33 pm - 8:34 am
GCM
-
TYS
19h 01m
1 stop
$639American Airlines
Mon, Jul 27 - Fri, Jul 31
American Airlines Logo
8:05 pm - 11:25 am
TYS
-
GCM
16h 20m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$646American Airlines
Mon, Jul 27 - Fri, Jul 31
American Airlines Logo
6:00 am - 4:10 pm
TYS
-
GCM
11h 10m
2 stops
American Airlines Logo
12:02 pm - 8:31 am
GCM
-
TYS
19h 29m
2 stops
$651American Airlines
Thu, Jul 16 - Tue, Jul 21
Delta Logo
5:40 am - 11:31 am
TYS
-
GCM
6h 51m
1 stop
Delta Logo
12:56 pm - 11:52 pm
GCM
-
TYS
9h 56m
1 stop
$656Delta
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
7:17 pm - 11:00 am
TYS
-
GCM
16h 43m
2 stops
American Airlines Logo
5:10 pm - 11:05 am
GCM
-
TYS
16h 55m
2 stops
$661American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
6:00 am - 11:00 am
TYS
-
GCM
6h 00m
1 stop
American Airlines Logo
4:07 pm - 11:59 pm
GCM
-
TYS
6h 52m
1 stop
$671American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to the Cayman Islands?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to the Cayman Islands, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to the Cayman Islands is November, when tickets cost $0 (return) on average. On the other hand, the most expensive months are May and July, when the average cost of round-trip tickets is $1,036 and $656 respectively.

Good to know

Low seasonFebruary
Cheapest flight$611
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 10% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11631 reviews
6.9Entertainment
7.9Crew
7.5Boarding
6.4Food
7.2Comfort
Airline reviews

We got delayed getting out of DFW for broken overhead bins. Once the flight got underway the captain kept the seatbelt sign lit the entire flight despite little perceptible turbulence, preventing use of the rest rooms and any sort of refreshment service in the main cabin.

6.0 GoodMark, May 2026
LAS - DFW
Read more American Airlines reviews

We got delayed getting out of DFW for broken overhead bins. Once the flight got underway the captain kept the seatbelt sign lit the entire flight despite little perceptible turbulence, preventing use of the rest rooms and any sort of refreshment service in the main cabin.

Flight delays for communication overall not a good experience uncomfortable on the plane. Person in front of me reclined his seat, putting them inches from my lap.

There were flight delays making our flight arrive at our destination after midnight didn’t seem to have enough crew or airplanes for the flights laid over in Dallas should’ve had plenty of time to make it to our next flight only made it because that flight was also delayed because our plane wasn’t even at the airport yet overall have not had a good experience on American

Flight left on time. Captain provided relevant announcements. We had to wait 45 minutes to desembark due to the ramp closed because of lightening.

It's a long flight and that is always difficult. I was comfortable and well. The movies available were great and the crew was good.

Cancelled flight. Still waiting to get home for grand daughter’s graduation .

So overall the flight was just average and nothing special. They overbooked some of the flights and they ended up running out of overhead storage space so we had to check our carry-ons which wasn't terrible but we were inconvenienced because of the second connecting flight with a long layover we couldn't get our bags until the final destination. Most of the flight attendants were pretty good and overall the meals were not that great because the chicken was dry and overcooked. They also didn't provide butter or any kind of spread with the bread which is cheap and concerning. The American airlines staff at the check-in counter was kind of unprofessional because this lady just started singing in the middle of checking us in and that's weird. The worst part of the flights was the terrible conditions of the bathrooms which were unclean and did not have toilet paper or toilet tissue available which is kind of insane for a 14-hour and 8 and 1/2 hour flight.

Requested early boarding to disinfect seat, tray table, etc. before general boarding. Instructed to board after wheelchair passengers. Waited on jet bridge behind 12 wheelchair passengers. Stopped immediately after entering plane to wait for gate agent in rear of plane cleaning a seat that was wet, got to my row and found both seats adjacent to mine already occupied, with the lack of room making it impossible for me to clean my own space and defeating the purpose of my boarding early. Cleaned the armrests and tray table as best I could.

Seat bottom cushions are not good. I’m 165# & they hurt my butt. Plenty of legroom.

The wifi experience is awful. I had to try again and again, taking over 30 minutes, to connect to the wifi. I had to watch the same two ads over and over until I was finally successful. Once connected, it was anything but "high speed" and disconnected at least three times during the flight.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports