$247 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

lø., mar. 28 - lø., apr. 4
Multiple Airlines Logo
9:36 pm - 12:57 pm
TYS
-
GCM
16h 21m
1 stop
Multiple Airlines Logo
1:15 pm - 1:16 pm
GCM
-
TYS
47h 01m
2 stops
$521Multiple Airlines
on., jun. 17 - on., jun. 24
American Airlines Logo
6:00 am - 4:11 pm
TYS
-
GCM
11h 11m
1 stop
American Airlines Logo
12:01 pm - 11:59 pm
GCM
-
TYS
10h 58m
1 stop
$576American Airlines
on., jun. 17 - on., jun. 24
American Airlines Logo
6:00 am - 11:01 am
TYS
-
GCM
6h 01m
1 stop
American Airlines Logo
5:12 pm - 10:36 am
GCM
-
TYS
16h 24m
2 stops
$581American Airlines
fr., aug. 7 - fr., aug. 14
American Airlines Logo
7:00 am - 1:10 pm
TYS
-
GCM
7h 10m
1 stop
American Airlines Logo
12:10 pm - 9:10 am
GCM
-
TYS
20h 00m
2 stops
$601American Airlines
ti., apr. 21 - ti., apr. 28
United Airlines Logo
7:05 am - 12:30 pm
TYS
-
GCM
6h 25m
1 stop
United Airlines Logo
1:35 pm - 11:41 pm
GCM
-
TYS
9h 06m
1 stop
$609United Airlines
on., jun. 17 - on., jun. 24
American Airlines Logo
5:00 am - 11:01 am
TYS
-
GCM
7h 01m
2 stops
American Airlines Logo
12:01 pm - 8:34 am
GCM
-
TYS
19h 33m
2 stops
$616American Airlines
ti., apr. 21 - ti., apr. 28
American Airlines Logo
5:00 am - 11:31 am
TYS
-
GCM
7h 31m
1 stop
American Airlines Logo
12:00 pm - 9:40 pm
GCM
-
TYS
8h 40m
2 stops
$629American Airlines
fr., aug. 7 - fr., aug. 14
American Airlines Logo
5:13 am - 11:25 am
TYS
-
GCM
7h 12m
1 stop
American Airlines Logo
12:10 pm - 11:41 pm
GCM
-
TYS
10h 31m
1 stop
$631American Airlines
ma., apr. 13 - on., apr. 22
American Airlines Logo
6:30 am - 11:00 am
TYS
-
GCM
5h 30m
1 stop
American Airlines Logo
12:35 pm - 8:00 pm
GCM
-
TYS
6h 25m
1 stop
$641American Airlines
ma., apr. 13 - on., apr. 22
American Airlines Logo
5:57 pm - 11:00 am
TYS
-
GCM
18h 03m
2 stops
American Airlines Logo
12:35 pm - 8:00 pm
GCM
-
TYS
6h 25m
1 stop
$646American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to the Cayman Islands?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to the Cayman Islands were found on United Airlines ($609) and American Airlines ($629).

Find deals

Good to know

Low seasonFebruary
Cheapest flight$247
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly with an average 8% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11403 reviews
7.5Boarding
8.0Crew
7.2Comfort
6.4Food
6.9Entertainment
Airline reviews

The crew was excellent and overall the flight was good. No complaints.

10.0 ExcellentMichelle, Mar 2026
DFW - LGA
Read more American Airlines reviews

The crew was excellent and overall the flight was good. No complaints.

I didn't end up taking this flight. I got up at 4am for a flight that was supposed to board at 6am - at 5:55am you delayed the flight to 10am. The airport is under construction so I switched to a later flight as I wasn't going to sit in the airport for 4 hours. They said the delay was due to the crew needing rest from a flight coming in late the night before - if that was the case then I think you should have delayed the flight much sooner so that passengers wouldn't get up so early and get to the airport to sit and wait.

Never had such a lazy first class attendant. Literally spent 60%+ of the flight playing games on her personal phone making up excuses of why she was unavailable.

The flight attendants and the service is getting worse by the day.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Like all of the flights I took to get down to Dallas. They were delayed

Other than nearly three hour delay for maintenance issues, everything went smooth

Plane from partner PSA was filthy. Plastic needs to be thoroughly cleaned. Really disgusting to look at and wonder about cleanliness of parts less visible.

The baggage claim experience was poor. The plane crew and the AA app said that checked baggage in CLT would be at carousel 7 but the sign at Baggage Claim said carousel 1. The carousel 1 sign had the correct flight # listed above the belt. But the luggage never came. I went to an AA baggage claim office after about 1 hour and the clerk directed me to another AA room that was poorly marked, with a closed door and no obvious way to know what to do. Finally someone opened the door and my bag was inside. The clerk was totally unable to explain why.

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)