$363 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Best Cayman Islands Flight Deals from Knoxville

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
George Town
George Town1 stop$540
George Town
George Town1 stop$540

Cheap Flights from Knoxville to the Cayman Islands

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Wed, Dec 24 - Sun, Dec 28
Delta Logo
6:15 am - 2:20 pmTYS-GCM
8h 05m1 stop
Delta Logo
1:55 pm - 7:29 pmGCM-TYS
5h 34m1 stop
$540Delta
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Sun, Jan 4 - Fri, Jan 9
Delta Logo
5:30 am - 12:30 pmTYS-GCM
7h 00m1 stop
Delta Logo
2:00 pm - 11:44 pmGCM-TYS
9h 44m1 stop
$550Delta
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Sun, Jan 4 - Fri, Jan 9
American Airlines Logo
5:59 am - 4:00 pmTYS-GCM
10h 01m2 stops
American Airlines Logo
2:15 pm - 11:45 pmGCM-TYS
9h 30m2 stops
$644American Airlines
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Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
7:00 am - 1:12 pmTYS-GCM
7h 12m1 stop
American Airlines Logo
12:25 pm - 11:03 pmGCM-TYS
9h 38m1 stop
$665American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
6:05 am - 1:12 pmTYS-GCM
8h 07m2 stops
American Airlines Logo
12:10 pm - 9:56 amGCM-TYS
20h 46m2 stops
$669American Airlines
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Wed, Dec 24 - Sun, Dec 28
American Airlines Logo
6:52 am - 7:51 pmTYS-GCM
12h 59m1 stop
American Airlines Logo
8:30 am - 9:33 pmGCM-TYS
13h 03m2 stops
$699American Airlines
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Sat, Dec 27 - Sat, Jan 3
American Airlines Logo
6:18 pm - 12:05 pmTYS-GCM
17h 47m1 stop
American Airlines Logo
8:30 am - 6:03 pmGCM-TYS
9h 33m1 stop
$1,386American Airlines
Find Deal
Sat, Dec 27 - Sat, Jan 3
American Airlines Logo
4:05 pm - 12:05 pmTYS-GCM
20h 00m1 stop
American Airlines Logo
8:30 am - 11:49 pmGCM-TYS
15h 19m1 stop
$1,508American Airlines
Find Deal
Sat, Dec 27 - Sat, Jan 3
American Airlines Logo
4:05 pm - 12:05 pmTYS-GCM
20h 00m1 stop
American Airlines Logo
8:30 am - 9:30 pmGCM-TYS
13h 00m2 stops
$1,512American Airlines
Find Deal
Sat, Dec 27 - Sat, Jan 3
American Airlines Logo
6:18 pm - 12:05 pmTYS-GCM
17h 47m1 stop
American Airlines Logo
6:10 pm - 8:32 amGCM-TYS
14h 22m1 stop
$1,584American Airlines
Find Deal
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KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to the Cayman Islands?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to the Cayman Islands were found on Delta ($540) and American Airlines ($644).


Good to know

Low seasonMarch
High seasonJune
Cheapest flight$363
Best time to beat the crowds with an average 23% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to the Cayman Islands?

    The cheapest time of day to fly to the Cayman Islands is generally in the morning, when round-trip flights cost $611 on average. The most expensive time of day to fly to the Cayman Islands is generally in the morning, which is peak travel time and where the average cost of a ticket is $611.

Reviews of the top airlines flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7956 reviews
8.5Crew
8.2Boarding
7.9Entertainment
7.9Comfort
7.3Food
Airline reviews

Did not know my son and I had different seating arrangements. He was fine, but it was disappointing.

4.0 OkayAnonymous, Jul 2025ATL - ROC
Read more Delta reviews

Did not know my son and I had different seating arrangements. He was fine, but it was disappointing.

Flight was canceled, and no effort was made to help with rebooking, no hotel vouchers, no car transportation and minimal food voucher and most places for food were closed by the time the voucher was given. Waited for 3 hours for bags. Simply the worst travel experience I have ever had

Food was surprisingly good but the WiFi was not great

this crew didn't care much. bumping carts into seats more times than i care to remember

Very late arrival at PWM. Late jet getting to ATL. Equipment problem with aircraft - could not get enough water onto plane., Another delay getting FAA approval for flight with bottled H2O. Not the crew’s problem.

Everything was fine except the entertainment was not working for half of the flight.

Easy boarding with an extremely kind attendant. Seats were spacious and we had 3 seats for 2 people so we could stretch out. Comfortable air flow and very attentive and hospital attendants. Bathrooms and food were the only negative. Bathrooms were so small you could hardly get in and close the door. I don’t think an obese person would fit or a person with a movement disability. Food was the trending food for flights, nonexistent. We spent $40 getting sandwich and snack at airport for our 6 hour flught.

At first, we were on the runway for about an hour, literally. The Captain did explain that the Control Tower just had a change shift (sounds like an unrealistic excuse) and then that we had to change a runway. A regular economy seat is made for 12 yo twiggy. I understand Delta wants to push for an upgrade, but after sitting in a Comfort seat and in First class. I would say First class is not worthy of my money. The landing was delayed because of the weather in NYC, I don't hold that against Delta, of course. The Captain did alert us to that upon takeoff in Vegas and again as we reached NY.

No one fussed at me about my pap machine as a 3rd pice on the plane. Boarding was pleasant and smooth. The boarding agent in Anchorage was a fun character- he could be in a movie. :~) The on-board crew were downright pleasant. No militant attitudes on Delta. Like all planes these days the seats are too narrow for standard Americans and at 5’2” there is barely enough leg room. I don’t know how tall people fold themselves into the seats. But that’s nothing specific to Delta

Great. Very smooth. Plenty of information. However, wish they would give out a menu in advance of making a dinner choice like other international airlines. The flight attendant says chicken or pasta and there are details about ingredients or spices requiring the passenger to ask which requires the flight attendant to answer many times. So easy to solve this problem. P

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

After a two hour delay, my flight was CANCELLED! No pilot available. Such BS.

Overall very good, only complaint I have is the crew from CLT to SAT could have collected trash sooner.

The AA app really sucks ... Every flight & connecting flights were delayed over 30 mins. One connecting flight on American Eagle said it was delayed in its arrival ... when it was actually parked across from the gate for over 1 hr before they pulled it to the gate. Seats in the economy/ main cabin are packed together like sardines ... no leg room.

Initial flight was cancelled at the time of arrival to the airport, flight alternative requires switching from direct to flight with a layover, and the plane felt like it would split apart, it was so rattle-y.

Amazing food, great staff, with one noticable detail missing ...but no seat entertainment in any of aircraft ...I am not a fan

Flight was delayed again and again ultimately almost three hours getting us to our location at close to midnight by the time we got in and out of airport to destination. I had taken time off work to enjoy an evening at destination and that was now wasted

AA re-routed flight from HNL to LAX due to delay. My group of 3 with reserved seats in row 9 was broken up, with one assigned to a middle seat, another in the last row of the plane. Not happy. No explanation to the delay. No apologies. No compensation. Would have been nice to be offered an Admiral Club admission or a voucher for the extra 3 hours of layover in LAX. Could not hear the boarding gate announcements in LAX. Adjacent gate was boarding at the same time. Loud speakers were competing against each other. Barely made my boarding group.

Boarding gate in Honolulu was staffed with a great clerk with a soothing voice despite the flight delay of over an hour. Flight attendants in the plane were all grumpy, not pleasant looking bunch. Their sour attitude showed throughout the flight. Inly able to get a select few movies started. Most of the movie links in the “free entertainment” did not work.

Above and beyond effort from this crew in a tough situation. So helpful and understanding. Thank you!

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