$561 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Sun, Jan 25 - Thu, Jan 29
Delta Logo
5:40 am - 12:40 pmTYS-GCM
7h 00m1 stop
Delta Logo
2:05 pm - 11:45 pmGCM-TYS
9h 40m1 stop
$561Delta
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Fri, Jan 23 - Mon, Jan 26
Delta Logo
6:30 am - 2:40 pmTYS-GCM
8h 10m1 stop
Delta Logo
2:05 pm - 9:24 pmGCM-TYS
7h 19m1 stop
$565Delta
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Fri, Jan 23 - Mon, Jan 26
American Airlines Logo
7:54 am - 8:20 pmTYS-GCM
12h 26m2 stops
American Airlines Logo
12:50 pm - 11:59 pmGCM-TYS
11h 09m1 stop
$570American Airlines
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Sun, Jan 25 - Thu, Jan 29
American Airlines Logo
6:20 am - 11:50 amTYS-GCM
5h 30m1 stop
American Airlines Logo
12:50 pm - 11:59 pmGCM-TYS
11h 09m1 stop
$625American Airlines
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Sun, Jan 25 - Thu, Jan 29
American Airlines Logo
6:00 am - 8:20 pmTYS-GCM
14h 20m2 stops
American Airlines Logo
12:50 pm - 9:21 pmGCM-TYS
8h 31m2 stops
$630American Airlines
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Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
9:36 pm - 12:43 pmTYS-GCM
16h 07m1 stop
Multiple Airlines Logo
1:15 pm - 3:11 pmGCM-TYS
24h 56m2 stops
$633Multiple Airlines
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Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
5:00 pm - 11:08 amTYS-GCM
19h 08m1 stop
American Airlines Logo
7:45 am - 11:59 pmGCM-TYS
15h 14m1 stop
$653American Airlines
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Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
5:00 am - 2:25 pmTYS-GCM
10h 25m2 stops
American Airlines Logo
7:45 am - 11:59 pmGCM-TYS
15h 14m1 stop
$720American Airlines
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Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
5:00 am - 2:25 pmTYS-GCM
10h 25m2 stops
American Airlines Logo
11:30 am - 11:40 pmGCM-TYS
11h 10m2 stops
$850American Airlines
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Sat, Dec 27 - Sat, Jan 3
American Airlines Logo
6:53 pm - 11:50 amTYS-GCM
16h 57m1 stop
American Airlines Logo
7:30 am - 12:38 amGCM-TYS
17h 08m1 stop
$1,085American Airlines
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Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Knoxville and Cayman Islands?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Knoxville to the Cayman Islands.

There is just one airline that flies from Knoxville to the Cayman Islands direct and that is American Airlines. The best round-trip deal found from American Airlines for the route is to George Town (GCM) and costs $503.

Which airlines provide the cheapest flights from Knoxville to the Cayman Islands?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to the Cayman Islands were found on Delta ($561) and American Airlines ($570).

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Good to know

Low seasonFebruary
Cheapest flight$561
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly with an average 16% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to the Cayman Islands?

    The cheapest time of day to fly to the Cayman Islands is generally in the morning, when round-trip flights cost $611 on average. The most expensive time of day to fly to the Cayman Islands is generally in the morning, which is peak travel time and where the average cost of a ticket is $611.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11043 reviews
6.9Entertainment
8.0Crew
6.4Food
7.5Boarding
7.2Comfort
Airline reviews

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

8.0 ExcellentWayne, Nov 2025MIA - BWI
Read more American Airlines reviews

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

The flight was delayed multiple times, again no fault of American but again the extra cost, for everything makes it feel like a cheap airline! Especially when flights are outrageously expensive already

Horrible. Both legs of my flight were delayed more than 6 hours. No compensation, no screens on the plane, and the plane was not clean.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)