$356 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to the Cayman Islands

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Wed, Feb 25 - Thu, Mar 5
Multiple Airlines Logo
3:50 pm - 1:43 pm
TYS
-
GCM
21h 53m1 stop
Multiple Airlines Logo
2:49 pm - 11:27 pm
GCM
-
TYS
8h 38m1 stop
$356Multiple Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
3:52 pm - 1:43 pm
TYS
-
GCM
21h 51m1 stop
Multiple Airlines Logo
2:49 pm - 12:41 pm
GCM
-
TYS
21h 52m1 stop
$363Multiple Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
3:52 pm - 1:43 pm
TYS
-
GCM
21h 51m1 stop
Multiple Airlines Logo
2:49 pm - 10:34 am
GCM
-
TYS
19h 45m2 stops
$377Multiple Airlines
Sat, Feb 28 - Thu, Mar 5
Multiple Airlines Logo
9:08 pm - 1:43 pm
TYS
-
GCM
16h 35m1 stop
Multiple Airlines Logo
2:49 pm - 11:27 pm
GCM
-
TYS
8h 38m1 stop
$383Multiple Airlines
Sat, Feb 28 - Thu, Mar 5
Multiple Airlines Logo
1:52 pm - 1:43 pm
TYS
-
GCM
23h 51m2 stops
Multiple Airlines Logo
2:49 pm - 11:27 pm
GCM
-
TYS
8h 38m1 stop
$393Multiple Airlines
Sat, Jan 17 - Sat, Jan 24
Multiple Airlines Logo
5:30 pm - 1:53 pm
TYS
-
GCM
20h 23m2 stops
Multiple Airlines Logo
2:34 pm - 8:39 am
GCM
-
TYS
18h 05m1 stop
$397Multiple Airlines
Wed, Feb 25 - Wed, Mar 4
Multiple Airlines Logo
3:50 pm - 1:43 pm
TYS
-
GCM
21h 53m1 stop
Multiple Airlines Logo
11:30 am - 12:02 pm
GCM
-
TYS
24h 32m2 stops
$401Multiple Airlines
Sun, Feb 22 - Thu, Mar 5
Multiple Airlines Logo
5:56 pm - 4:05 pm
TYS
-
GCM
46h 09m2 stops
Multiple Airlines Logo
2:49 pm - 11:27 pm
GCM
-
TYS
8h 38m1 stop
$402Multiple Airlines
Sat, Feb 28 - Wed, Mar 4
Multiple Airlines Logo
9:08 pm - 1:43 pm
TYS
-
GCM
16h 35m1 stop
Multiple Airlines Logo
11:30 am - 12:02 pm
GCM
-
TYS
24h 32m2 stops
$428Multiple Airlines
Thu, Feb 26 - Thu, Mar 5
Multiple Airlines Logo
6:30 am - 11:35 am
TYS
-
GCM
29h 05m2 stops
Multiple Airlines Logo
2:49 pm - 11:27 pm
GCM
-
TYS
8h 38m1 stop
$439Multiple Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Knoxville and Cayman Islands?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Knoxville to the Cayman Islands.

There is just one airline that flies from Knoxville to the Cayman Islands direct and that is American Airlines. The best round-trip deal found from American Airlines for the route is to George Town (GCM) and costs $503.

Find deals

Good to know

Low seasonFebruary
Cheapest flight$356
Best time to beat the crowds with an average 18% drop in price.
Most popular time to fly with an average 20% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11088 reviews
6.9Entertainment
7.5Boarding
7.2Comfort
6.4Food
8.0Crew
Airline reviews

The economy seats are very cramped and the food was bizarre. However, I did like the greek yogurt option for breakfast.

2.0 MediocreGabrielle, Jan 2026
DFW - DUB
Read more American Airlines reviews

The economy seats are very cramped and the food was bizarre. However, I did like the greek yogurt option for breakfast.

While I didn’t watch much tv I would have liked a few more options of TV series from Apple TV or hbo max ..

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

Nothing to write home about, average flight experience. Seats were spacious enough, crew friendly enough. Loved the AA entertainment/wifi service.

Kayak was among the missing. There was not the usual advice regarding next gate after arriving in Dallas. No communication after the reminder to check in before the Moline flight. What happened?

They should have allowed for extra time to de-ice the plane before boarding passengers. This delayed us about 10-15 mins after we boarded. Overall experience was fine. Crew was friendly and on top of everything. We didn’t have any issues during the flight.

Experience was good. We were delayed in leaving by 15 mins because the flight was waiting on a family that was late in getting to the gate. Food and drink options were as expected. I highly recommend checking in ahead of time using the airline’s app so that it’s quicker to get your luggage tags as soon as you arrive at the terminal. No more waiting in long lines!

Overall experience was great. Flights were almost on time in departing and we arrived at our destination as scheduled. No issues with amenities or flight crew. Everything went well as as expected. Will fly again with American Airlines in the future!

We never made it due to delays on both ends. Gate attendant said it was mechanical but the system said otherwise, so no compensation. That’s not right.

Our flight from Eagle to Vail was delayed to the point we missed our connection to Savannah. Now we’re a family of 4 in a hotel room with luggage, no toiletries, no clean clothes. Gate attendant said the delay was mechanical but it was put in the system as something else so no compensation. That’s just wrong.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)