$531 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Sat, May 9 - Sat, May 16
American Airlines Logo
5:57 pm - 11:00 am
TYS
-
GCM
18h 03m
2 stops
American Airlines Logo
11:55 am - 9:40 pm
GCM
-
TYS
8h 45m
2 stops
$531American Airlines
Sat, May 9 - Sat, May 16
American Airlines Logo
5:00 am - 3:03 pm
TYS
-
GCM
11h 03m
1 stop
American Airlines Logo
11:55 am - 11:59 pm
GCM
-
TYS
11h 04m
1 stop
$551American Airlines
Fri, Jul 17 - Sat, Jul 25
American Airlines Logo
6:00 am - 1:10 pm
TYS
-
GCM
8h 10m
1 stop
American Airlines Logo
2:10 pm - 8:35 am
GCM
-
TYS
17h 25m
2 stops
$566American Airlines
Wed, Feb 11 - Wed, Feb 18
American Airlines Logo
6:05 am - 11:26 am
TYS
-
GCM
5h 21m
1 stop
American Airlines Logo
1:05 pm - 11:59 pm
GCM
-
TYS
10h 54m
1 stop
$571American Airlines
Tue, Feb 17 - Tue, Feb 24
American Airlines Logo
6:10 am - 8:15 pm
TYS
-
GCM
14h 05m
2 stops
American Airlines Logo
1:05 pm - 11:59 pm
GCM
-
TYS
10h 54m
1 stop
$576American Airlines
Thu, Mar 5 - Thu, Mar 12
United Airlines Logo
7:00 am - 1:45 pm
TYS
-
GCM
6h 45m
1 stop
United Airlines Logo
1:50 pm - 4:45 pm
GCM
-
TYS
25h 55m
1 stop
$585United Airlines
Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
5:00 pm - 10:40 am
TYS
-
GCM
18h 40m
1 stop
American Airlines Logo
7:45 am - 11:59 pm
GCM
-
TYS
15h 14m
1 stop
$588American Airlines
Thu, Mar 5 - Thu, Mar 12
American Airlines Logo
6:05 am - 8:15 pm
TYS
-
GCM
14h 10m
2 stops
American Airlines Logo
12:00 pm - 9:54 pm
GCM
-
TYS
8h 54m
1 stop
$594American Airlines
Sun, Mar 1 - Sat, Mar 7
United Airlines Logo
6:45 am - 1:45 pm
TYS
-
GCM
7h 00m
1 stop
United Airlines Logo
5:15 pm - 9:49 am
GCM
-
TYS
16h 34m
1 stop
$596United Airlines
Sun, Mar 1 - Sat, Mar 7
American Airlines Logo
6:05 am - 8:15 pm
TYS
-
GCM
14h 10m
2 stops
American Airlines Logo
3:45 pm - 7:42 am
GCM
-
TYS
15h 57m
2 stops
$601American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 5h 21m.

Find deals

Good to know

Low seasonFebruary
Cheapest flight$531
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly with an average 18% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11160 reviews
7.5Boarding
6.4Food
7.2Comfort
8.0Crew
6.9Entertainment
Airline reviews

It was a good trip. Flight Attendants were friendly and responsive.

10.0 ExcellentR, Jan 2026
DTW - CLT
Read more American Airlines reviews

It was a good trip. Flight Attendants were friendly and responsive.

Qatar airways ,boarding arrangements at Hamid international airport could been better

Crew in Columbia was not prepared for landing. It was a bit of a disaster and getting bags took forever.

My seat tv didn’t work the whole trip. And the seat space is too small despite being seated at the front.

The seat cushions were very worn so they were extremely uncomfortable.

Delayed, no updates, had a rewards number but was not working

The seats from lax to DFW was so tight that I could not move my legs . No WiFi and had to pay . Not a good selection of entertainment

AA should improve their in air internet & entertainment options. Seems unreasonable to charge $20/hr and should have some form of free connections. The entertainment options are also pretty limited, movies are outdated and the series only show 3-5 episodes.

The professionals have excellent customer service, the seats don´t have enough space.

We were upgraded to First Class and it was a great flight

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)