$631 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 6/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to the Cayman Islands

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
-
TYS
5h 47m
1 stop
$631American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
2:42 pm - 8:34 am
GCM
-
TYS
16h 52m
2 stops
$636American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
5:03 am - 11:25 am
TYS
-
GCM
7h 22m
1 stop
American Airlines Logo
5:12 pm - 10:38 am
GCM
-
TYS
16h 26m
2 stops
$641American Airlines
Wed, Jul 15 - Sun, Jul 19
American Airlines Logo
7:01 am - 1:36 pm
TYS
-
GCM
7h 35m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
-
TYS
5h 47m
1 stop
$646American Airlines
Wed, Jul 15 - Sun, Jul 19
American Airlines Logo
5:03 am - 11:25 am
TYS
-
GCM
7h 22m
1 stop
American Airlines Logo
5:12 pm - 10:45 am
GCM
-
TYS
16h 33m
2 stops
$651American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
6:12 am - 3:07 pm
TYS
-
GCM
9h 55m
2 stops
American Airlines Logo
5:12 pm - 10:36 am
GCM
-
TYS
16h 24m
2 stops
$661American Airlines
Thu, Jul 16 - Sun, Jul 26
American Airlines Logo
6:00 am - 4:08 pm
TYS
-
GCM
11h 08m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
-
TYS
5h 47m
1 stop
$666American Airlines
Thu, Jul 16 - Sun, Jul 26
American Airlines Logo
6:00 am - 4:08 pm
TYS
-
GCM
11h 08m
2 stops
American Airlines Logo
5:12 pm - 12:34 pm
GCM
-
TYS
18h 22m
2 stops
$671American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to the Cayman Islands?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to the Cayman Islands were found on American Airlines ($631) and Delta ($636).

Find deals

Good to know

Low seasonFebruary
Cheapest flight$631
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly and prices are also 4% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11604 reviews
7.9Crew
7.2Comfort
6.4Food
7.5Boarding
6.9Entertainment
Airline reviews

The seat was comfortable, the attendants were very nice and WiFi made my life so much easier with work. Kudos!

10.0 ExcellentMadhujit, Apr 2026
DFW - CLE
Read more American Airlines reviews

The seat was comfortable, the attendants were very nice and WiFi made my life so much easier with work. Kudos!

Flight was 3 hours delayed. They gave our plan to two other routes. Need to knock that off.

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

No gate in Rome. Had stairs. Got separated from my wife in a wheel chair. Customs was a zoo. If AA doesnt have landing rights, it should be advertised.

I almost missed my flight and they helped me out enormously

Business class was very good, one of my best flights

The "on the ground" A/C was not working. It was so hot while waiting to get in the air, a passenger from the rear of the plan declared "I just can't!" and waited in the gangway until time to close the doors. It was miserable. But the crew were champs and had an amazing attitude. I know they were as miserable as we were but didn't let that affect their performance.

The captain announced to the cabin there would be a delay because they observed a "cut" on a tire during precheck that needed to be cleared by maintenance. We were delayed during this inspection and allowed to proceed after maintenance "measured the cut and decided it was acceptable". My complaint is not about the delay or due diligence. I wish the captain had been more generic when making his announcement. I was a nervous wreck all the way to Charlotte worried that we would have a blowout when landing!

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

The flight was on time and the landing was very smooth. The crew and flight attendants were all very friendly and professional.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)