$591 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Mon, Jul 27 - Sat, Aug 1
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12:53 pm - 4:05 pm
TYS
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GCM
28h 12m
2 stops
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11:25 am - 10:57 pm
GCM
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TYS
10h 32m
1 stop
$561Multiple Airlines
Fri, Jul 24 - Sat, Aug 1
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8:30 am - 4:05 pm
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GCM
8h 35m
1 stop
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11:25 am - 10:57 pm
GCM
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TYS
10h 32m
1 stop
$570Multiple Airlines
Fri, Jul 24 - Thu, Jul 30
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8:30 am - 4:05 pm
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GCM
8h 35m
1 stop
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12:40 pm - 10:23 pm
GCM
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TYS
8h 43m
1 stop
$581Multiple Airlines
Mon, Jul 27 - Thu, Jul 30
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8:30 am - 5:20 pm
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GCM
9h 50m
1 stop
Multiple Airlines Logo
12:40 pm - 10:23 pm
GCM
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TYS
8h 43m
1 stop
$586Multiple Airlines
Thu, Jul 23 - Thu, Jul 30
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8:15 am - 5:20 pm
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GCM
10h 05m
1 stop
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12:40 pm - 12:45 pm
GCM
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TYS
23h 05m
1 stop
$588Multiple Airlines
Thu, Jul 23 - Sat, Aug 1
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8:15 am - 5:20 pm
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GCM
10h 05m
1 stop
Multiple Airlines Logo
11:25 am - 10:57 pm
GCM
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TYS
10h 32m
1 stop
$590Multiple Airlines
Sat, Apr 25 - Sun, May 3
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9:00 am - 4:05 pm
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GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 10:33 pm
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TYS
8h 53m
1 stop
$591Multiple Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
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GCM
16h 31m
1 stop
American Airlines Logo
5:12 pm - 10:36 am
GCM
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TYS
16h 24m
2 stops
$596American Airlines
Mon, Jul 27 - Sat, Aug 1
Multiple Airlines Logo
8:30 am - 5:20 pm
TYS
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GCM
9h 50m
1 stop
Multiple Airlines Logo
11:25 am - 10:57 pm
GCM
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TYS
10h 32m
1 stop
$597Multiple Airlines
Sat, Apr 25 - Sun, May 3
Multiple Airlines Logo
9:00 am - 4:05 pm
TYS
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GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
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TYS
8h 53m
1 stop
$604Multiple Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 6h 15m.

Good to know

Low seasonFebruary
Cheapest flight$561
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11468 reviews
7.9Crew
6.4Food
7.5Boarding
6.9Entertainment
7.2Comfort
Airline reviews

My 9:50AM flight was delayed to 3:40PM "due to incoming aircraft delay". No aircraft is "delayed" that long. Found out once we did board (after several changes in times) that the aircraft had a maintenance issue and we had to wait for another aircraft. Just tell us that. The aircraft we did get was old and the seats need to be updated. I have been traveling for several weeks with AA and you should refresh your entertainment content as frequent flyers have gone through most of your new content. I have Celiac and a shellfish allergy and continue to have struggles with meals on business and first class flights. Please keep this in mind. Sorry - was a long travel day yesterday and a bit cranky this morning with my experience comments. Still an AA fan.

4.0 OkayKathryn, Mar 2026
LAX - OMA
Read more American Airlines reviews

My 9:50AM flight was delayed to 3:40PM "due to incoming aircraft delay". No aircraft is "delayed" that long. Found out once we did board (after several changes in times) that the aircraft had a maintenance issue and we had to wait for another aircraft. Just tell us that. The aircraft we did get was old and the seats need to be updated. I have been traveling for several weeks with AA and you should refresh your entertainment content as frequent flyers have gone through most of your new content. I have Celiac and a shellfish allergy and continue to have struggles with meals on business and first class flights. Please keep this in mind. Sorry - was a long travel day yesterday and a bit cranky this morning with my experience comments. Still an AA fan.

The business steward was absolutely amazing! Smiles and kindness! Wish all AA flights are like this one!

As a first class customer, there was no power the entire flight which limited my ability to work. I find this unacceptable. The first 11 rows on the left side of the plan were out. I was only offered the option to charge my phone which was not the issue because my laptop was out of power. I asked if there was anything that can be done for me, and the answer was, "no". I was not offered any type of compensation for this AA problem which caused me unnecessary stress due to inability to address business issues on an already challenging travel day. Flight attendants tried to reset the power once but that was the extent of their support. Very disappointing for the lack of expected services on a flight. Please contact me with customer focused response to this complaint.

Not really sure I enjoyed the flight at all. The flight attendants seemed a little tired and rude at times. The snacks were lacking in taste and sustenance. The flight was incredibly turbulent for three plus hours and the pilot had to do a second pass to land at our final destination because he was coming in so fast. He must have taken a short cut and because of it we had to suffer the violent turbulence and the dropping down. It had to be one of if not the worse flights I have ever been on and have traveled vastly all over the world.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports