$384 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to the Cayman Islands

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Wed, Feb 25 - Sun, Mar 1
Multiple Airlines Logo
3:50 pm - 1:43 pm
TYS
-
GCM
21h 53m
1 stop
Multiple Airlines Logo
2:49 pm - 6:31 pm
GCM
-
TYS
27h 42m
2 stops
$384Multiple Airlines
Thu, Feb 12 - Sun, Feb 15
Multiple Airlines Logo
7:00 am - 1:43 pm
TYS
-
GCM
6h 43m
1 stop
Multiple Airlines Logo
2:49 pm - 11:38 pm
GCM
-
TYS
32h 49m
2 stops
$464Multiple Airlines
Thu, Feb 12 - Sun, Feb 15
Multiple Airlines Logo
7:00 am - 1:43 pm
TYS
-
GCM
6h 43m
1 stop
Multiple Airlines Logo
2:49 pm - 11:38 pm
GCM
-
TYS
32h 49m
2 stops
$473Multiple Airlines
Thu, Feb 12 - Sun, Feb 15
Multiple Airlines Logo
7:00 am - 1:43 pm
TYS
-
GCM
6h 43m
1 stop
Multiple Airlines Logo
2:49 pm - 12:41 pm
GCM
-
TYS
21h 52m
1 stop
$510Multiple Airlines
Thu, Feb 12 - Sun, Feb 15
Multiple Airlines Logo
7:00 am - 1:43 pm
TYS
-
GCM
6h 43m
1 stop
Multiple Airlines Logo
2:49 pm - 8:46 pm
GCM
-
TYS
5h 57m
1 stop
$513Multiple Airlines
Sat, May 9 - Sat, May 16
American Airlines Logo
5:57 pm - 11:00 am
TYS
-
GCM
18h 03m
2 stops
American Airlines Logo
4:03 pm - 11:55 pm
GCM
-
TYS
6h 52m
1 stop
$531American Airlines
Mon, Apr 20 - Fri, Apr 24
American Airlines Logo
6:54 am - 11:32 am
TYS
-
GCM
5h 38m
1 stop
American Airlines Logo
2:10 pm - 8:32 am
GCM
-
TYS
17h 22m
2 stops
$534American Airlines
Sat, May 9 - Sat, May 16
American Airlines Logo
5:44 am - 2:13 pm
TYS
-
GCM
9h 29m
1 stop
American Airlines Logo
12:40 pm - 9:57 pm
GCM
-
TYS
8h 17m
1 stop
$551American Airlines
Mon, Apr 20 - Fri, Apr 24
United Airlines Logo
7:00 am - 12:45 pm
TYS
-
GCM
6h 45m
1 stop
United Airlines Logo
1:50 pm - 10:06 am
GCM
-
TYS
19h 16m
1 stop
$565United Airlines
Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
2:54 pm - 10:40 am
TYS
-
GCM
20h 46m
1 stop
American Airlines Logo
7:45 am - 11:59 pm
GCM
-
TYS
15h 14m
1 stop
$588American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 6h 43m.

Find deals

Good to know

Low seasonFebruary
Cheapest flight$384
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly with an average 18% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11193 reviews
6.4Food
6.9Entertainment
8.0Crew
7.5Boarding
7.2Comfort
Airline reviews

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

8.0 ExcellentMichelle, Jan 2026
DCA - SRQ
Read more American Airlines reviews

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

2 hour delay due to equipment failure. No updates via the app and airport screens (which continued to show a departure time in the past). AA eventually switched planes and the new plane was not catered or cleaned correctly.

I booked an aisle seat and was given a middle. At 6'4" 230lbs, it is not ideal to fly in the middle row for myself and passengers.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

The aircraft had several problems - from excess fuel to non operational ac. Two hours of delay in Chicago could have been avoided with proper planning and aircraft maintenance.

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Long delays, lack of information about the status of the flight. The flight was delayed 4 times.

Could we please end the loud announcements about credit card offers on your flights? We are trying to sleep, work, watch videos, etc. and if we need a credit card, we will ask for one. Flying is already not what it used to be.

I would like the crew to talk LESS over the PA and specifically about credit card offers. I am trying to work, sleep, watch a movie and the PA was booming about a credit card offer. Could we go back to the days when the customer was more important than selling a credit card?

Enough space,crew was helpful,food was good.The gates are way far especially for travelers with health issues

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)