$276 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Sat, Apr 25 - Sun, May 3
Multiple Airlines Logo
12:56 pm - 5:20 pm
TYS
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GCM
29h 24m
2 stops
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
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TYS
8h 53m
1 stop
$569Multiple Airlines
Sat, Apr 25 - Mon, May 4
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12:56 pm - 5:20 pm
TYS
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GCM
29h 24m
2 stops
Multiple Airlines Logo
12:40 pm - 9:48 pm
GCM
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TYS
8h 08m
1 stop
$571Multiple Airlines
Sat, Apr 25 - Sun, May 3
Multiple Airlines Logo
9:00 am - 4:05 pm
TYS
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GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
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TYS
8h 53m
1 stop
$587Multiple Airlines
Sat, Apr 25 - Mon, May 4
Multiple Airlines Logo
9:00 am - 4:05 pm
TYS
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GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 9:48 pm
GCM
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TYS
8h 08m
1 stop
$588Multiple Airlines
Mon, Apr 27 - Mon, May 4
Multiple Airlines Logo
7:30 am - 5:20 pm
TYS
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GCM
10h 50m
2 stops
Multiple Airlines Logo
12:40 pm - 9:48 pm
GCM
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TYS
8h 08m
1 stop
$606Multiple Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
8:39 pm - 11:10 am
TYS
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GCM
15h 31m
1 stop
American Airlines Logo
12:35 pm - 7:04 pm
GCM
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TYS
5h 29m
1 stop
$616American Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
8:39 pm - 11:10 am
TYS
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GCM
15h 31m
1 stop
American Airlines Logo
1:20 pm - 8:25 am
GCM
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TYS
18h 05m
2 stops
$621American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
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GCM
16h 31m
1 stop
American Airlines Logo
12:01 pm - 11:59 pm
GCM
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TYS
10h 58m
1 stop
$626American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
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GCM
16h 31m
1 stop
American Airlines Logo
5:12 pm - 10:47 am
GCM
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TYS
16h 35m
2 stops
$631American Airlines
Thu, Jul 16 - Mon, Jul 27
American Airlines Logo
5:03 am - 11:25 am
TYS
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GCM
7h 22m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
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TYS
5h 47m
1 stop
$641American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 8h 35m.

Good to know

Low seasonFebruary
Cheapest flight$276
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11551 reviews
6.9Entertainment
7.9Crew
6.4Food
7.5Boarding
7.2Comfort
Airline reviews

Incoming flight was delayed, delaying boarding. It then took 30 mins to take off. Took 20 mins to get to a gate because they changed the gate last minute, crew weren’t ready so there was no one staffed to work the jet bridge. Boarding was so disorganized as is usual with American because everyone just stands around the gate regardless of boarding group.

2.0 MediocreSerena, Apr 2026
DCA - TPA
Read more American Airlines reviews

Incoming flight was delayed, delaying boarding. It then took 30 mins to take off. Took 20 mins to get to a gate because they changed the gate last minute, crew weren’t ready so there was no one staffed to work the jet bridge. Boarding was so disorganized as is usual with American because everyone just stands around the gate regardless of boarding group.

I cancelled my ticket less than 24 hours deadline but I didn’t get refunded.

Early morning flight and no food in First Class except a "salmon" box. No thank you. Was informed before take off by Captain that the plane was not serviced before we boarded in Phoenix. How does that happen? Need more frequent additions/turn over on the Entertainment. Thanks

Moved to earlier flight which unexpectedly had maintenance issues initially indicated as quick fix to ultimately plane changes. Moved back to original flight, also delayed. In all cases customer updates and communication very unclear, no updates on drivers for delays.

Flight was delayed. No urgency by American Airlines team to assist those with connecting flights. It was basically you are on your own to run through the terminals to try and make your connection. Thanks, Mary

I have never been assaulted they way I was today in Charlotte - shame on American

One of our group members was struggling to walk. In Charlotte we asked for a wheelchair and she was accompanied by Desmond. I was impressed by his patience and attention. In Boston she received the same service. I didn’t get the name of the helper but she went above and beyond in assisting us. A great AA service

Better snacks but flight and crew were amazing on this flight

Found that the plane used for this short flight is smaller and therefore the seats are really squeezed tight.

It was the most un-special flight experience in my life.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports