$529 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
9:36 pm - 12:57 pm
TYS
-
GCM
16h 21m
1 stop
Multiple Airlines Logo
1:15 pm - 1:07 pm
GCM
-
TYS
22h 52m
2 stops
$529Multiple Airlines
Sat, Apr 18 - Sat, Apr 25
Multiple Airlines Logo
9:00 am - 12:43 pm
TYS
-
GCM
28h 43m
2 stops
Multiple Airlines Logo
1:40 pm - 2:45 pm
GCM
-
TYS
24h 05m
1 stop
$534Multiple Airlines
Sat, Apr 18 - Sat, Apr 25
Multiple Airlines Logo
12:56 pm - 12:43 pm
TYS
-
GCM
24h 47m
1 stop
Multiple Airlines Logo
1:40 pm - 2:45 pm
GCM
-
TYS
24h 05m
1 stop
$550Multiple Airlines
Sat, Mar 28 - Mon, Apr 13
Multiple Airlines Logo
9:36 pm - 12:57 pm
TYS
-
GCM
16h 21m
1 stop
Multiple Airlines Logo
1:50 pm - 10:36 am
GCM
-
TYS
43h 46m
2 stops
$557Multiple Airlines
Tue, Jun 16 - Sat, Jun 27
American Airlines Logo
5:36 am - 1:37 pm
TYS
-
GCM
9h 01m
1 stop
American Airlines Logo
4:07 pm - 10:36 am
GCM
-
TYS
17h 29m
2 stops
$561American Airlines
Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
9:36 pm - 12:57 pm
TYS
-
GCM
16h 21m
1 stop
Multiple Airlines Logo
1:15 pm - 1:05 pm
GCM
-
TYS
22h 50m
2 stops
$571Multiple Airlines
Sat, Jun 20 - Sat, Jun 27
American Airlines Logo
7:46 pm - 4:11 pm
TYS
-
GCM
21h 25m
1 stop
American Airlines Logo
4:07 pm - 10:48 am
GCM
-
TYS
17h 41m
2 stops
$574American Airlines
Tue, May 5 - Sat, May 9
American Airlines Logo
6:15 am - 11:00 am
TYS
-
GCM
5h 45m
1 stop
American Airlines Logo
4:03 pm - 11:55 pm
GCM
-
TYS
6h 52m
1 stop
$581American Airlines
Tue, May 5 - Sat, May 9
American Airlines Logo
8:48 pm - 11:00 am
TYS
-
GCM
15h 12m
2 stops
American Airlines Logo
4:03 pm - 8:32 am
GCM
-
TYS
15h 29m
1 stop
$586American Airlines
Thu, May 7 - Mon, May 11
American Airlines Logo
6:54 am - 11:33 am
TYS
-
GCM
5h 39m
1 stop
American Airlines Logo
12:35 pm - 8:01 pm
GCM
-
TYS
6h 26m
1 stop
$589American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 5h 05m.

Find deals

Good to know

Low seasonFebruary
Cheapest flight$529
Best time to beat the crowds with an average 23% drop in price.
Most popular time to fly with an average 15% increase in price.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11272 reviews
6.4Food
7.2Comfort
7.5Boarding
8.0Crew
6.9Entertainment
Airline reviews

The flight was on time/early, attentive crew, and everything overall went smoothly. Disappointed that WIFI was not working for the flight.

8.0 ExcellentGail, Feb 2026
ATL - DCA
Read more American Airlines reviews

The flight was on time/early, attentive crew, and everything overall went smoothly. Disappointed that WIFI was not working for the flight.

One day, I do so hope for a gluten free snack! Seems like with the rest of the world FINALLY figuring out what gluten free is, American Airlines would too. Fingers crossed!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

Flight was on time and the meal and service were good.

The accessible bathroom should be visible to people in Economy class.

Flight was delayed for 2 hours, then last minute the change to on time. The satélite location is far and a nightmare to get to.

This was a horrible experience. I’ve experienced several delays at this point and still not home. I was supposed to be home by 8:30 last night and here I sit at 7 am on a plane STILL unable to go home because of American Airlines.

Lexus in first class was absolutely amazing! Beat flight attendant i’ve ever seen.

Generally good. Flight left on time and the seats are comfortable. Plenty of space in front if you in you choose a comfort plus seat, completely worth spending the extra money given the amount of hours the flight lasts. The food tastes good but I would say it’s a the amount is too little. The crew was friendly and efficient. There was a some turbulence at different points into the flight. American Airlines has good deals to NZ if you book with plenty of time before you plan on going.

the plane was so hot!! the air-conditioning was barely blowing. The flight was delayed, and we had to sit on the hot plane before take off for an extended amount of time, waiting on international passengers. Would not have been so bad if it was not so hot. They said it would get better after take off, but it did not.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports

Knoxville (TYS)