$230 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Mon, Jul 20 - Fri, Jul 24
Multiple Airlines Logo
12:53 pm - 4:05 pm
TYS
-
GCM
28h 12m
2 stops
Multiple Airlines Logo
11:25 am - 11:19 pm
GCM
-
TYS
10h 54m
1 stop
$538Multiple Airlines
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
6:08 pm - 4:05 pm
TYS
-
GCM
22h 57m
1 stop
Multiple Airlines Logo
12:40 pm - 10:41 am
GCM
-
TYS
21h 01m
1 stop
$556Multiple Airlines
Mon, Jul 20 - Fri, Jul 24
Multiple Airlines Logo
8:30 am - 5:20 pm
TYS
-
GCM
9h 50m
1 stop
Multiple Airlines Logo
11:25 am - 11:19 pm
GCM
-
TYS
10h 54m
1 stop
$580Multiple Airlines
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
8:15 am - 5:20 pm
TYS
-
GCM
10h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 4:10 pm
GCM
-
TYS
26h 30m
2 stops
$615Multiple Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
2:42 pm - 11:56 pm
GCM
-
TYS
8h 14m
1 stop
$631American Airlines
Mon, Jul 20 - Fri, Jul 24
American Airlines Logo
6:00 am - 4:08 pm
TYS
-
GCM
11h 08m
2 stops
American Airlines Logo
5:12 pm - 10:38 am
GCM
-
TYS
16h 26m
2 stops
$634American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
12:01 pm - 8:34 am
GCM
-
TYS
19h 33m
2 stops
$636American Airlines
Thu, Jul 16 - Mon, Jul 20
Southwest Logo
4:20 pm - 11:50 am
TYS
-
GCM
20h 30m
2 stops
Southwest Logo
12:45 pm - 9:10 pm
GCM
-
TYS
7h 25m
2 stops
$645Southwest
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
7:01 am - 1:36 pm
TYS
-
GCM
7h 35m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
-
TYS
5h 47m
1 stop
$646American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
6:00 am - 4:08 pm
TYS
-
GCM
11h 08m
2 stops
American Airlines Logo
5:12 pm - 10:38 am
GCM
-
TYS
16h 26m
2 stops
$651American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from Knoxville to the Cayman Islands take?

The duration of a flight to the Cayman Islands depends on your arrival airport. The shortest route to the Cayman Islands from Knoxville is to George Town, which takes 6h 15m.

Good to know

Low seasonFebruary
Cheapest flight$230
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly and prices are also 4% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11666 reviews
7.9Crew
7.2Comfort
6.4Food
6.9Entertainment
7.5Boarding
Airline reviews

The airplane was an old model, the overhead didn’t have enough room for people’s items and made boarding and boarding disappointing and stressful. Crew allowed passengers to bring more than the permitted baggage sizes.

2.0 MediocreStella, Apr 2026
ORD - DCA
Read more American Airlines reviews

The airplane was an old model, the overhead didn’t have enough room for people’s items and made boarding and boarding disappointing and stressful. Crew allowed passengers to bring more than the permitted baggage sizes.

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

On time departure and early arrival. Flight attendant very nice.

As we approached Denver, we encountered quite a bit of turbulence. I know this can sometimes be the case as I frequently fly this route but not on American. My gripe: Usually a pilot or co-pilot alerts passengers to the possibility of turbulance ahead of time. This did not occur nor did he communiucate during what was a pretty rough ride.

The staff was nice. I appreciated that I was able to take an earlier flight, even though it was last minute. The boarding process felt rather chaotic.

Overall a good experience, however Wifi was not working on the flight.

For a 4 1/2 hour international flight all we got was 1 small pack of cookies and a drink. You had to watch movies on your own devise.

Airlines should be prohibited from using the seats they get away with.

My flight got delayed a total of five times. And the boarding gate changed four times. most of the time the platform was not up-to-date with the changes taking place. The most discouraging part of the entire trip by far.

Flight left early and arrived 30 MINUTES early at the destination. Smooth trip.

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports