$636 Find Cheap Flights from Knoxville to the Cayman Islands

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to the Cayman Islands Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to the Cayman Islands

Fri, Oct 23 - Fri, Oct 30
Delta Logo
5:30 am - 11:40 am
TYS
-
GCM
7h 10m
1 stop
Delta Logo
12:55 pm - 11:46 pm
GCM
-
TYS
9h 51m
1 stop
$636Delta
Sat, Aug 1 - Wed, Aug 12
Delta Logo
6:00 am - 11:31 am
TYS
-
GCM
6h 31m
1 stop
Delta Logo
1:04 pm - 11:54 pm
GCM
-
TYS
9h 50m
1 stop
$656Delta
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
6:00 am - 10:55 am
TYS
-
GCM
5h 55m
1 stop
American Airlines Logo
2:10 pm - 11:51 pm
GCM
-
TYS
8h 41m
1 stop
$661American Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
5:00 am - 1:16 pm
TYS
-
GCM
9h 16m
2 stops
American Airlines Logo
12:00 pm - 10:58 pm
GCM
-
TYS
9h 58m
2 stops
$666American Airlines
Wed, Aug 26 - Mon, Aug 31
American Airlines Logo
5:15 am - 11:27 am
TYS
-
GCM
7h 12m
1 stop
American Airlines Logo
12:00 pm - 10:58 pm
GCM
-
TYS
9h 58m
2 stops
$671American Airlines
Fri, Oct 23 - Fri, Oct 30
American Airlines Logo
6:08 am - 6:06 pm
TYS
-
GCM
12h 58m
2 stops
American Airlines Logo
9:25 am - 7:04 pm
GCM
-
TYS
8h 39m
2 stops
$676American Airlines
Tue, Jul 14 - Tue, Jul 21
Delta Logo
5:40 am - 11:31 am
TYS
-
GCM
6h 51m
1 stop
Delta Logo
12:56 pm - 11:52 pm
GCM
-
TYS
9h 56m
1 stop
$681Delta
Sat, Oct 3 - Sat, Oct 10
American Airlines Logo
6:04 pm - 11:30 am
TYS
-
GCM
18h 26m
1 stop
American Airlines Logo
3:30 pm - 8:22 am
GCM
-
TYS
15h 52m
2 stops
$683American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
8:05 pm - 11:25 am
TYS
-
GCM
16h 20m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$686American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
8:05 pm - 11:00 am
TYS
-
GCM
15h 55m
2 stops
American Airlines Logo
12:02 pm - 11:51 pm
GCM
-
TYS
10h 49m
2 stops
$691American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to the Cayman Islands flights

Get data-powered insights and trends into flights from Knoxville to the Cayman Islands to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to the Cayman Islands?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to the Cayman Islands, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to the Cayman Islands is November, when tickets cost $0 (return) on average. On the other hand, the most expensive months are May and July, when the average cost of round-trip tickets is $1,036 and $656 respectively.

Good to know

Cheapest flight$636
Most popular time to fly and prices are also 12% lower on average.
Flight from Knoxville to George Town

FAQs - booking Cayman Islands flights

  • How does KAYAK find such low prices on flights from Knoxville to the Cayman Islands?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to the Cayman Islands.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to the Cayman Islands?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to the Cayman Islands is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to the Cayman Islands?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to the Cayman Islands with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to the Cayman Islands?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to the Cayman Islands up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to the Cayman Islands

 
Need help choosing which airline to fly with from Knoxville to the Cayman Islands? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11779 reviews
7.9Crew
6.4Food
7.5Boarding
7.2Comfort
6.8Entertainment
Airline reviews

Air condition was not working for long both after boarding and also after landing ; unbearably hot and suffocating

4.0 OkayAbhisek, Apr 2026
BNA - DFW
Read more American Airlines reviews

Air condition was not working for long both after boarding and also after landing ; unbearably hot and suffocating

It was canceled at the last minute. While I was literally at the airport. Messed my entire trip up.

Flight was on-time, boarding was flawless and the crew was friendly.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to the Cayman Islands

Information on your arrival and departure airports