Which airports can I use when flying from Knoxville to La Crosse?

Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).

What cabin classes can I book on flights from Knoxville to La Crosse?

Only Economy Class is available on flights from Knoxville to La Crosse.

Which airports do connecting flights from Knoxville to La Crosse pass through?

Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.

Can I save money by using flexible dates for flights from Knoxville to La Crosse?

Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Do I need a passport to fly from Knoxville to La Crosse?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Knoxville to La Crosse changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $355 to $496. That means the highest observed fare was about 39% higher than the lowest one.

What is the time difference between Knoxville and La Crosse?

La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

How much should I expect to pay for a Knoxville to La Crosse flight?

Round-trip flights from Knoxville to La Crosse range from $508 to $836, with an average of $696 over the past 12 months. Anything below $508 counts as a good deal.

What is the cheapest layover airport when flying from Knoxville to La Crosse?

Flights via Chicago O'Hare Intl (ORD) offer the most affordable fares, with an average round-trip price of $596. Based on KAYAK data over the past 3 months.

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Chicago O'Hare Intl (ORD) had the shortest average connection time for Knoxville to La Crosse layovers at 250 minutes over the past 3 months.

$355 CHEAP FLIGHTS from Knoxville to La Crosse (TYS - LSE)

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Cheapest round-trip

$355

Typical prices: $508-$836

American Airlines

Sun 10/21Fri 10/26

TYS - LSE • 1 stop

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Flight Deals

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Recent round-trip flight deals from Knoxville to La Crosse

Wed, Oct 21 - Mon, Oct 26

6:55 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 04m1 stop Chicago O'Hare Intl

12:23 pm - 6:20 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 57m1 stop Chicago O'Hare Intl

$355American Airlines

Wed, Oct 21 - Mon, Oct 26

6:05 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 54m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

12:23 pm - 6:20 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 57m1 stop Chicago O'Hare Intl

$414American Airlines

Fri, Oct 30 - Sun, Nov 1

7:30 am - 11:53 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 23m1 stop Chicago O'Hare Intl

12:22 pm - 6:46 pmLSE La Crosse-TYS Knoxville McGhee Tyson

5h 24m1 stop Chicago O'Hare Intl

$430American Airlines

Thu, Oct 29 - Sun, Nov 1

7:30 am - 11:53 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 23m1 stop Chicago O'Hare Intl

6:01 am - 11:01 amLSE La Crosse-TYS Knoxville McGhee Tyson

4h 00m1 stop Chicago O'Hare Intl

$430American Airlines

Fri, Oct 30 - Mon, Nov 2

7:30 am - 11:53 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 23m1 stop Chicago O'Hare Intl

6:01 am - 11:06 amLSE La Crosse-TYS Knoxville McGhee Tyson

4h 05m1 stop Chicago O'Hare Intl

$430American Airlines

Fri, Oct 30 - Sun, Nov 1

10:48 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

8h 32m2 stops Charlotte Douglas Chicago O'Hare Intl

6:01 am - 11:01 amLSE La Crosse-TYS Knoxville McGhee Tyson

4h 00m1 stop Chicago O'Hare Intl

$436American Airlines

Fri, Oct 30 - Mon, Nov 2

10:00 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl

6:01 am - 11:06 amLSE La Crosse-TYS Knoxville McGhee Tyson

4h 05m1 stop Chicago O'Hare Intl

$436American Airlines

Thu, Oct 29 - Sun, Nov 1

10:00 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl

6:01 am - 11:01 amLSE La Crosse-TYS Knoxville McGhee Tyson

4h 00m1 stop Chicago O'Hare Intl

$436American Airlines

Booking Insights

Price, demand and travel trends for Knoxville to La Crosse flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to La Crosse with more confidence.

Airlines

Layovers

What is the cheapest airline to fly from Knoxville to La Crosse?

American Airlines ($355) offered the cheapest round-trip ticket from Knoxville to La Crosse in the last 5 days.

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Cheapest flight	$355

Flight from Knoxville to La Crosse

When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to La Crosse?
Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).
What cabin classes can I book on flights from Knoxville to La Crosse?
Only Economy Class is available on flights from Knoxville to La Crosse.
Which airports do connecting flights from Knoxville to La Crosse pass through?
Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.
Can I save money by using flexible dates for flights from Knoxville to La Crosse?
Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
Do I need a passport to fly from Knoxville to La Crosse?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Knoxville to La Crosse changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $355 to $496. That means the highest observed fare was about 39% higher than the lowest one.
What is the time difference between Knoxville and La Crosse?
La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
How much should I expect to pay for a Knoxville to La Crosse flight?
Round-trip flights from Knoxville to La Crosse range from $508 to $836, with an average of $696 over the past 12 months. Anything below $508 counts as a good deal.

If your dates can be flexible, aim for a Tuesday departure instead of Monday. On this route, Tuesday flights average $345 - about $491 less than Monday (59% savings) based on the last 12 months.
If you're arriving late at night and need somewhere to stay, check out these hotels close to La Crosse Airport.
- Country Inn And Suites by Radisson La Crosse, WI
- Days Inn by Wyndham La Crosse
- Blue Way Inn La Crosse Extended Stay

Everything you need to know for your flight from Knoxville to La Crosse

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Knoxville (TYS)

La Crosse (LSE)

TYS - LSE

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Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Recent round-trip flight deals from Knoxville to La Crosse

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Price, demand and travel trends for Knoxville to La Crosse flights

What is the cheapest airline to fly from Knoxville to La Crosse?

What is the cheapest layover airport when flying from Knoxville to La Crosse?

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Key details for Knoxville to La Crosse flights

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Your guide to booking Knoxville to La Crosse flights

Everything you need to know for your flight from Knoxville to La Crosse

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