TYS - LSE

$764 Find Cheap Flights from Knoxville to La Crosse - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$951
Typical prices: $355-$551
American Airlines
Fri 4/6Sun 4/8
TYS - LSE • 1 stop
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Flight Deals

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to La Crosse

Tue, Apr 6 - Thu, Apr 8
American Airlines Logo
8:48 pm - 11:54 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
4h 06m1 stop Chicago O'Hare Intl
American Airlines Logo
5:40 am - 11:18 amLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 38m1 stop Chicago O'Hare Intl
$951American Airlines
Tue, Apr 6 - Thu, Apr 8
American Airlines Logo
5:08 pm - 11:54 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
7h 46m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
American Airlines Logo
5:40 am - 11:18 amLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 38m1 stop Chicago O'Hare Intl
$957American Airlines
Tue, Apr 6 - Thu, Apr 8
American Airlines Logo
2:06 pm - 11:54 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
10h 48m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
5:40 am - 5:07 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
10h 27m2 stops Chicago O'Hare Intl Charlotte Douglas
$962American Airlines
Mon, Mar 29 - Mon, Mar 29
American Airlines Logo
7:55 am - 11:34 amTYS  Knoxville McGhee Tyson-LSE La Crosse
4h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
7:30 pm - 10:55 amLSE  La Crosse-TYS Knoxville McGhee Tyson
14h 25m1 stop Chicago O'Hare Intl
$1,385American Airlines
Booking Insights

Price, demand and travel trends for Knoxville to La Crosse flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Knoxville to La Crosse?

Round-trip flights from Knoxville to La Crosse typically range from $355 to $551. The lowest price found in the past 5 days was $951, on American Airlines.

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Key details for Knoxville to La Crosse flights

Cheapest flight

$951
Round-trip flight from Knoxville to La Crosse

When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to La Crosse flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Knoxville to La Crosse?

    Only Economy Class is available on flights from Knoxville to La Crosse.

  • Do I need a passport to fly from Knoxville to La Crosse?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • Have flight prices from Knoxville to La Crosse changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $764 to $1,385. That means the highest observed fare was about 81% higher than the lowest one.

  • Which airports can I use when flying from Knoxville to La Crosse?

    Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).

  • Which airports do connecting flights from Knoxville to La Crosse pass through?

    Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route.

  • Can I save money by using flexible dates for flights from Knoxville to La Crosse?

    Yes. Flexible dates can save you up to 59% on flights from Knoxville to La Crosse. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What is the time difference between Knoxville and La Crosse?

    La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Knoxville to La Crosse flights

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