Which airports can I use when flying from Knoxville to La Crosse?

Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).

What cabin classes can I book on flights from Knoxville to La Crosse?

Only Economy Class is available on flights from Knoxville to La Crosse.

Which airports do connecting flights from Knoxville to La Crosse pass through?

Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route.

Can I save money by using flexible dates for flights from Knoxville to La Crosse?

Yes. Flexible dates can save you up to 59% on flights from Knoxville to La Crosse. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Do I need a passport to fly from Knoxville to La Crosse?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Knoxville to La Crosse changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $543 to $888. That means the highest observed fare was about 63% higher than the lowest one.

What is the time difference between Knoxville and La Crosse?

La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

How much is a round-trip flight from Knoxville to La Crosse?

Round-trip flights from Knoxville to La Crosse typically range from $355 to $696. The lowest price found in the past 5 days was $543, on American Airlines.

Which airline is the cheapest to fly from Knoxville to La Crosse?

American Airlines ($543) offered the cheapest round-trip ticket from Knoxville to La Crosse in the last 5 days.

What is the cheapest layover airport when flying from Knoxville to La Crosse?

Flights via Chicago O'Hare Intl (ORD) offer the most affordable fares, with an average round-trip price of $524. Based on KAYAK data over the past 3 months.

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Chicago O'Hare Intl (ORD) had the shortest average connection time for Knoxville to La Crosse layovers at 3h 42m over the past 3 months.

$543 CHEAP FLIGHTS from Knoxville to La Crosse (TYS - LSE)

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$543

Typical prices: $355-$696

American Airlines

Tue 11/20Tue 12/4

TYS - LSE • 1 stop

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to La Crosse!

Flight Deals

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Recent round-trip flight deals from Knoxville to La Crosse

Fri, Nov 20 - Fri, Dec 4

8:50 pm - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

16h 06m1 stop Chicago O'Hare Intl

6:52 pm - 3:54 pmLSE La Crosse-TYS Knoxville McGhee Tyson

20h 02m1 stop Chicago O'Hare Intl

$543American Airlines

Fri, Nov 20 - Fri, Dec 4

1:51 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

11h 29m2 stops Charlotte Douglas Chicago O'Hare Intl

6:52 pm - 10:51 amLSE La Crosse-TYS Knoxville McGhee Tyson

14h 59m1 stop Chicago O'Hare Intl

$563American Airlines

Fri, Nov 20 - Fri, Dec 4

7:39 am - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 17m1 stop Chicago O'Hare Intl

12:09 pm - 7:05 pmLSE La Crosse-TYS Knoxville McGhee Tyson

5h 56m1 stop Chicago O'Hare Intl

$583American Airlines

Fri, Nov 20 - Fri, Dec 4

1:51 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

11h 29m2 stops Charlotte Douglas Chicago O'Hare Intl

12:09 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

10h 50m2 stops Chicago O'Hare Intl Charlotte Douglas

$588American Airlines

Fri, Nov 20 - Fri, Dec 4

7:39 am - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 17m1 stop Chicago O'Hare Intl

5:55 am - 5:56 pmLSE La Crosse-TYS Knoxville McGhee Tyson

11h 01m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

$589American Airlines

Fri, Nov 20 - Fri, Dec 4

8:50 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

10h 30m2 stops Charlotte Douglas Chicago O'Hare Intl

5:55 am - 3:19 pmLSE La Crosse-TYS Knoxville McGhee Tyson

8h 24m2 stops Chicago O'Hare Intl Charlotte Douglas

$594American Airlines

Wed, Nov 25 - Sun, Nov 29

8:50 pm - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

16h 06m1 stop Chicago O'Hare Intl

6:50 pm - 4:02 pmLSE La Crosse-TYS Knoxville McGhee Tyson

20h 12m1 stop Chicago O'Hare Intl

$666American Airlines

Wed, Nov 25 - Sun, Nov 29

8:50 pm - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

16h 06m1 stop Chicago O'Hare Intl

6:50 pm - 4:02 pmLSE La Crosse-TYS Knoxville McGhee Tyson

20h 12m1 stop Chicago O'Hare Intl

$683American Airlines

Wed, Nov 25 - Sun, Nov 29

8:50 pm - 11:56 amTYS Knoxville McGhee Tyson-LSE La Crosse

16h 06m1 stop Chicago O'Hare Intl

6:50 pm - 4:02 pmLSE La Crosse-TYS Knoxville McGhee Tyson

20h 12m1 stop Chicago O'Hare Intl

$732American Airlines

Wed, Nov 25 - Sun, Nov 29

8:50 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

4h 30m1 stop Chicago O'Hare Intl

12:26 pm - 12:52 amLSE La Crosse-TYS Knoxville McGhee Tyson

11h 26m2 stops Chicago O'Hare Intl Miami

$773American Airlines

Booking Insights

Price, demand and travel trends for Knoxville to La Crosse flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to La Crosse? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to La Crosse departing in november.

Find deals

Cheapest flight	$543

Round-trip flight from Knoxville to La Crosse

When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Knoxville to La Crosse?
Only Economy Class is available on flights from Knoxville to La Crosse.
Do I need a passport to fly from Knoxville to La Crosse?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
Have flight prices from Knoxville to La Crosse changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $543 to $888. That means the highest observed fare was about 63% higher than the lowest one.
Which airports can I use when flying from Knoxville to La Crosse?
Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).
Which airports do connecting flights from Knoxville to La Crosse pass through?
Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route.
Can I save money by using flexible dates for flights from Knoxville to La Crosse?
Yes. Flexible dates can save you up to 59% on flights from Knoxville to La Crosse. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
What is the time difference between Knoxville and La Crosse?
La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $345, about $491 less than Monday fares (59% savings) based on the last 12 months.
If you're arriving late at night and need somewhere to stay, check out these hotels close to La Crosse Airport.

• Country Inn And Suites by Radisson La Crosse, WI
• Days Inn by Wyndham La Crosse
• Blue Way Inn La Crosse Extended Stay

More options for your flight from Knoxville to La Crosse

Add a hotel or car rental

Airports

Cabin class

Direct Flights

Origins

Other destinations

Complete your trip to La Crosse with a hotel stay or car rental

Car rentals in La Crosse

Hotels in La Crosse

Vacations in La Crosse

TYS - LSE

$543 Find Cheap Flights from Knoxville to La Crosse - Compare and Save

Everything you should know

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Recent round-trip flight deals from Knoxville to La Crosse

Recent one-way flight deals from Knoxville to La Crosse

Price, demand and travel trends for Knoxville to La Crosse flights

How much is a round-trip flight from Knoxville to La Crosse?

Which airline is the cheapest to fly from Knoxville to La Crosse?

What is the cheapest layover airport when flying from Knoxville to La Crosse?

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Key details for Knoxville to La Crosse flights

Cheapest flight

When to book flights from Knoxville to La Crosse

Your Knoxville to La Crosse flight questions, answered

Your guide to booking Knoxville to La Crosse flights

More options for your flight from Knoxville to La Crosse

Complete your trip to La Crosse with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to La Crosse

Find direct flights to and from Knoxville and La Crosse

Flights from domestic origins to La Crosse

Flights to other popular destinations