Which airports can I use when flying from Knoxville to La Crosse?

Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).

What cabin classes can I book on flights from Knoxville to La Crosse?

Only Economy Class is available on flights from Knoxville to La Crosse.

Which airports do connecting flights from Knoxville to La Crosse pass through?

Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.

Can I save money by using flexible dates for flights from Knoxville to La Crosse?

Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Do I need a passport to fly from Knoxville to La Crosse?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Knoxville to La Crosse changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $316 to $2,040. That means the highest observed fare was about 6x higher than the lowest one.

What is the time difference between Knoxville and La Crosse?

La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What is the cheapest airline to fly from Knoxville to La Crosse?

American Airlines ($316) and Allegiant Air ($457) are the cheapest airlines to fly round-trip from Knoxville to La Crosse according to KAYAK data over the last 5 days.

What is the cheapest layover airport when flying from Knoxville to La Crosse?

Flights via Chicago O'Hare Intl (ORD) offer the most affordable fares, with an average round-trip price of $596. Based on KAYAK data over the past 3 months.

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Chicago O'Hare Intl (ORD) had the shortest average connection time for Knoxville to La Crosse layovers at 250 minutes over the past 3 months.

$316 CHEAP FLIGHTS from Knoxville to La Crosse (TYS - LSE)

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Cheapest round-trip

$316

Typical prices: $508-$836

American Airlines

Sat 9/22Sat 10/6

TYS - LSE • 1 stop

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Flight Deals

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Recent round-trip flight deals from Knoxville to La Crosse

Tue, Sep 22 - Tue, Oct 6

8:14 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 06m1 stop Chicago O'Hare Intl

6:50 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 09m1 stop Chicago O'Hare Intl

$316American Airlines

Tue, Sep 22 - Tue, Oct 6

2:00 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

11h 20m2 stops Charlotte Douglas Chicago O'Hare Intl

6:50 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 09m1 stop Chicago O'Hare Intl

$322American Airlines

Tue, Sep 22 - Tue, Oct 6

2:00 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

11h 20m2 stops Charlotte Douglas Chicago O'Hare Intl

12:23 pm - 10:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

9h 36m2 stops Chicago O'Hare Intl Miami

$359American Airlines

Fri, Oct 9 - Mon, Oct 12

6:55 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 04m1 stop Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$430American Airlines

Fri, Oct 9 - Mon, Oct 12

6:55 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 04m1 stop Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$430American Airlines

Sat, Oct 10 - Mon, Oct 12

6:55 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 04m1 stop Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$445American Airlines

Fri, Oct 9 - Sun, Oct 11

6:10 am - 7:16 pmTYS Knoxville McGhee Tyson-LSE La Crosse

14h 06m1 stop Phoenix Sky Harbor Intl

6:00 pm - 12:55 pmLSE La Crosse-TYS Knoxville McGhee Tyson

17h 55m1 stop Punta Gorda

$457Allegiant Air

Fri, Oct 9 - Mon, Oct 12

6:55 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 04m1 stop Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$481American Airlines

Sat, Oct 10 - Mon, Oct 12

11:35 am - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

13h 24m2 stops Philadelphia Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$504American Airlines

Fri, Oct 9 - Mon, Oct 12

6:05 pm - 11:59 pmTYS Knoxville McGhee Tyson-LSE La Crosse

6h 54m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$595American Airlines

Booking Insights

Price, demand and travel trends for Knoxville to La Crosse flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to La Crosse with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to La Crosse?

Round-trip flights from Knoxville to La Crosse start at $316. Prices are below average for this route right now, with typical round-trip fares ranging from $508 to $836. The lowest price found in the past 5 days was $316 on American Airlines.

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When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to La Crosse?
Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).
What cabin classes can I book on flights from Knoxville to La Crosse?
Only Economy Class is available on flights from Knoxville to La Crosse.
Which airports do connecting flights from Knoxville to La Crosse pass through?
Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.
Can I save money by using flexible dates for flights from Knoxville to La Crosse?
Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
Do I need a passport to fly from Knoxville to La Crosse?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Knoxville to La Crosse changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $316 to $2,040. That means the highest observed fare was about 6x higher than the lowest one.
What is the time difference between Knoxville and La Crosse?
La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates can be flexible, aim for a Tuesday departure instead of Monday. On this route, Tuesday flights average $345 - about $491 less than Monday (59% savings) based on the last 12 months.
If you're arriving late at night and need somewhere to stay, check out these hotels close to La Crosse Airport.
- Country Inn And Suites by Radisson La Crosse, WI
- Days Inn by Wyndham La Crosse
- Blue Way Inn La Crosse Extended Stay

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TYS - LSE

$316 Find Cheap Flights from Knoxville to La Crosse - Compare and Save

Everything you should know

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Recent round-trip flight deals from Knoxville to La Crosse

Recent one-way flight deals from Knoxville to La Crosse

Price, demand and travel trends for Knoxville to La Crosse flights

How much is a round-trip flight from Knoxville to La Crosse?

What is the cheapest airline to fly from Knoxville to La Crosse?

What is the cheapest layover airport when flying from Knoxville to La Crosse?

When flying from Knoxville to La Crosse which airport offers the shortest layover?

When to book flights from Knoxville to La Crosse

Your Knoxville to La Crosse flight questions, answered

Your guide to booking Knoxville to La Crosse flights

More options for your flight from Knoxville to La Crosse

Complete your trip to La Crosse with a hotel stay or car rental

Information on your arrival and departure airports

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Flights from domestic origins to La Crosse

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