Which airports can I use when flying from Knoxville to La Crosse?

Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).

What cabin classes can I book on flights from Knoxville to La Crosse?

Only Economy Class is available on flights from Knoxville to La Crosse.

Which airports do connecting flights from Knoxville to La Crosse pass through?

Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.

Can I save money by using flexible dates for flights from Knoxville to La Crosse?

Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Do I need a passport to fly from Knoxville to La Crosse?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Knoxville to La Crosse changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $430 to $1,345. That means the highest observed fare was about 3x higher than the lowest one.

What is the time difference between Knoxville and La Crosse?

La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What is the cheapest airline to fly from Knoxville to La Crosse?

American Airlines ($430) offered the cheapest round-trip ticket from Knoxville to La Crosse in the last 5 days.

What is the cheapest layover airport when flying from Knoxville to La Crosse?

Flights via Chicago O'Hare Intl (ORD) offer the most affordable fares, with an average round-trip price of $596. Based on KAYAK data over the past 3 months.

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Chicago O'Hare Intl (ORD) had the shortest average connection time for Knoxville to La Crosse layovers at 250 minutes over the past 3 months.

$430 CHEAP FLIGHTS from Knoxville to La Crosse (TYS - LSE)

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Cheapest round-trip

$430

Typical prices: $508-$836

American Airlines

Mon 10/8Mon 10/22

TYS - LSE • 1 stop

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Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Discover the best prices for you by selecting your travel dates on KAYAK.

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Recent round-trip flight deals from Knoxville to La Crosse

Thu, Oct 8 - Thu, Oct 22

7:30 am - 11:53 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 23m1 stop Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$430American Airlines

Thu, Oct 8 - Thu, Oct 22

7:17 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

12h 03m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

6:55 pm - 11:59 pmLSE La Crosse-TYS Knoxville McGhee Tyson

4h 04m1 stop Chicago O'Hare Intl

$436American Airlines

Thu, Oct 8 - Thu, Oct 22

7:17 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

12h 03m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

12:23 pm - 9:33 pmLSE La Crosse-TYS Knoxville McGhee Tyson

8h 10m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

$496American Airlines

Thu, Oct 29 - Sun, Nov 1

10:00 am - 6:20 pmTYS Knoxville McGhee Tyson-LSE La Crosse

9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl

12:24 pm - 11:32 pmLSE La Crosse-TYS Knoxville McGhee Tyson

10h 08m2 stops Chicago O'Hare Intl Dallas/Fort Worth

$573American Airlines

Mon, Sep 14 - Fri, Sep 18

8:15 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

5h 05m1 stop Chicago O'Hare Intl

5:22 pm - 10:50 amLSE La Crosse-TYS Knoxville McGhee Tyson

16h 28m1 stop Chicago O'Hare Intl

$804American Airlines

Mon, Sep 14 - Fri, Sep 18

4:46 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

8h 34m2 stops Philadelphia Chicago O'Hare Intl

5:22 pm - 10:50 amLSE La Crosse-TYS Knoxville McGhee Tyson

16h 28m1 stop Chicago O'Hare Intl

$810American Airlines

Mon, Sep 14 - Fri, Sep 18

4:46 pm - 12:20 amTYS Knoxville McGhee Tyson-LSE La Crosse

8h 34m2 stops Philadelphia Chicago O'Hare Intl

12:02 pm - 11:22 pmLSE La Crosse-TYS Knoxville McGhee Tyson

10h 20m2 stops Chicago O'Hare Intl Dallas/Fort Worth

$1,345American Airlines

Booking Insights

Price, demand and travel trends for Knoxville to La Crosse flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to La Crosse with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to La Crosse?

Round-trip flights from Knoxville to La Crosse start at $430. Prices are below average for this route right now, with typical round-trip fares ranging from $508 to $836. The lowest price found in the past 5 days was $430 on American Airlines.

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Cheapest flight	$430

Flight from Knoxville to La Crosse

When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to La Crosse?
Flights from Knoxville to La Crosse usually depart from Knoxville McGhee Tyson (TYS) and arrive at La Crosse (LSE).
What cabin classes can I book on flights from Knoxville to La Crosse?
Only Economy Class is available on flights from Knoxville to La Crosse.
Which airports do connecting flights from Knoxville to La Crosse pass through?
Most connecting flights from Knoxville to La Crosse pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.
Can I save money by using flexible dates for flights from Knoxville to La Crosse?
Yes. Being flexible with your travel dates can save you up to 59% on the Knoxville to La Crosse route. Tuesday is the cheapest departure day at $345 round-trip on average, while Monday is the most expensive at $836, a difference of $491. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
Do I need a passport to fly from Knoxville to La Crosse?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Knoxville to La Crosse changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $430 to $1,345. That means the highest observed fare was about 3x higher than the lowest one.
What is the time difference between Knoxville and La Crosse?
La Crosse is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates can be flexible, aim for a Tuesday departure instead of Monday. On this route, Tuesday flights average $345 - about $491 less than Monday (59% savings) based on the last 12 months.
If you're arriving late at night and need somewhere to stay, check out these hotels close to La Crosse Airport.
- Country Inn And Suites by Radisson La Crosse, WI
- Days Inn by Wyndham La Crosse
- Blue Way Inn La Crosse Extended Stay

Everything you need to know for your flight from Knoxville to La Crosse

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Knoxville (TYS)

La Crosse (LSE)

TYS - LSE

$430 Find Cheap Flights from Knoxville to La Crosse - Compare and Save

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Cheap Flights from Knoxville to La Crosse (TYS-LSE)

Recent round-trip flight deals from Knoxville to La Crosse

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Price, demand and travel trends for Knoxville to La Crosse flights

How much is a round-trip flight from Knoxville to La Crosse?

What is the cheapest airline to fly from Knoxville to La Crosse?

What is the cheapest layover airport when flying from Knoxville to La Crosse?

When flying from Knoxville to La Crosse which airport offers the shortest layover?

Key details for Knoxville to La Crosse flights

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Everything you need to know for your flight from Knoxville to La Crosse

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