TYS - LSE

$467 Find Cheap Flights from Knoxville to La Crosse

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to La Crosse

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to La Crosse, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to La Crosse, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$467
American Airlines
Wed 1/21Sun 1/25
TYS - LSE • 1 stop
Cheapest one-way
Multiple Airlines
Sun 12/28
TYS - LSE • multi-stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to La Crosse!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to La Crosse (TYS-LSE)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to La Crosse that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to La Crosse

Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
5:15 pm - 10:16 pm
TYS
-
LSE
6h 01m1 stop
American Airlines Logo
6:00 am - 12:46 pm
LSE
-
TYS
5h 46m1 stop
$467American Airlines
Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
3:00 pm - 10:16 pm
TYS
-
LSE
8h 16m2 stops
American Airlines Logo
6:00 am - 12:46 pm
LSE
-
TYS
5h 46m1 stop
$473American Airlines
Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
7:41 am - 4:16 pm
TYS
-
LSE
9h 35m2 stops
American Airlines Logo
6:00 am - 1:54 pm
LSE
-
TYS
6h 54m2 stops
$478American Airlines
Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
7:54 am - 11:07 am
TYS
-
LSE
4h 13m1 stop
American Airlines Logo
5:08 pm - 10:09 pm
LSE
-
TYS
4h 01m1 stop
$544American Airlines
Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
7:54 am - 11:07 am
TYS
-
LSE
4h 13m1 stop
American Airlines Logo
6:00 am - 3:46 pm
LSE
-
TYS
8h 46m2 stops
$550American Airlines
Wed, Jan 21 - Sun, Jan 25
American Airlines Logo
10:11 am - 4:16 pm
TYS
-
LSE
7h 05m2 stops
American Airlines Logo
11:37 am - 8:56 pm
LSE
-
TYS
8h 19m2 stops
$555American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to La Crosse flights

Get data-powered insights and trends into flights from Knoxville to La Crosse to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Knoxville and La Crosse?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Knoxville to La Crosse.

There is just one airline that flies from Knoxville to La Crosse direct and that is American Airlines. The best round-trip deal found from American Airlines for the route is $420.

Find deals

Good to know

Cheapest flight$467
Flight from Knoxville to La Crosse

When to book flights from Knoxville to La Crosse

Are your dates flexible? Find out the best times to travel from Knoxville to La Crosse based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to La Crosse

  • What is the cheapest flight from Knoxville to La Crosse?

    In the last 3 days, the lowest price for a flight from Knoxville to La Crosse was $467 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and La Crosse?

    No

  • Which aircraft models fly most regularly from Knoxville to La Crosse?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to La Crosse?

    oneworld is the only airline alliance operating flights between Knoxville and La Crosse.

  • How does KAYAK find such low prices on flights from Knoxville to La Crosse?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to La Crosse.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to La Crosse?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to La Crosse from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to La Crosse?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to La Crosse with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and LSE can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to La Crosse?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to La Crosse from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to La Crosse

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to La Crosse. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to La Crosse? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11072 reviews
8.0Crew
7.2Comfort
7.5Boarding
6.5Food
6.9Entertainment
Airline reviews

My last flight on 25 Dec, it’s Christmas Day, everyone happy and very good mood. I really enjoy traveling with Americans Airlines from Miami to Minneapolis my home town after long flight from lhe to Doha then Miami. Thank you again to make my travels comfortable and relaxed. Best regards

10.0 ExcellentAnonymous, Dec 2025
MIA - MSP
Read more American Airlines reviews

My last flight on 25 Dec, it’s Christmas Day, everyone happy and very good mood. I really enjoy traveling with Americans Airlines from Miami to Minneapolis my home town after long flight from lhe to Doha then Miami. Thank you again to make my travels comfortable and relaxed. Best regards

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

WiFi didn’t work the entire flight. Very disappointing. Minimal food and options - sadly the state of current affairs. All other aspects of the flight were fine.

Great flight - friendly and attentive team! Seats in coach were comfy, but a little cramped - but that is the case with all airlines ;)

The boarding by groups is pointless. The first two groups worked fine, but almost Noone boarded in goups three thru five leaving the vast majority boarding when group six was called. It defeated the purpose of spreading out the crowd.

For whatever reason, the flight was not catered -we were told it would be a 45 minute delay waiting for catering - so no food. There were opened candy and peanuts in the seatback pocket. Flight landed early in DFW but due to the assigned gate not being available, we sat on the ground for 30 minutes waiting for the gate to open - making the flight actually arrive at the gate late.

The pilot greased the landing and the crew was fantastic.

I bought wifi and most of the flight could not even use it my apps would just spin. I couldn't even listen to music. super frustrating.

delayed due to weather. Could not communicate with family since the wifi was broken

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

Everything you need to know for your flight from Knoxville to La Crosse

Information on your arrival and departure airports

Knoxville (TYS)
La Crosse (LSE)