$172 Find Cheap Flights from Mexico to Panama

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1 adult, Economy, 0 bags

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Booking Insights

KAYAK's insights & trends for flights to Panama

Get data-powered insights and trends for flights to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest flight to Panama?

These are the best round-trip prices found by users searching on KAYAK in the last 72 hours.

The cheapest ticket to Panama from Mexico found in the last 72 hours was to Panama City, at $144 round-trip. The most popular route is Cancun (CUN) to Panama City (PTY) and the cheapest round-trip airline ticket found on this route in the last 72 hours was $144.

How much is a flight to Panama?

The average and cheapest price for all round-trip flights to Panama from each origin found by users searching on KAYAK in the last month.

A flight to Panama costs $400 on average. The cheapest price found on KAYAK in the last 2 weeks was $144 for the route Cancun (CUN) to Panama City (PTY). The most popular routes on KAYAK are Cancun to Panama City which costs $391 on average, and Guadalajara to Panama City, which costs $464 on average.

See prices from:

What is the cheapest month to fly from Mexico to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Mexico to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico to Panama is July, when tickets cost $316 (return) on average. On the other hand, the most expensive months are April and December, when the average cost of round-trip tickets is $348 and $347 respectively.

What is the cheapest time of day to fly to Panama?

The average price for all round-trip flights from Mexico to Panama depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Panama is generally at night, when round-trip flights cost $473 on average. Morning departures are around 5% cheaper than evening flights, on average. The most expensive time of day to fly to Panama is generally in the evening, which is peak travel time and where the average cost of a ticket is $554.

How far in advance should I book a flight from Mexico to Panama?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights to Panama, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico to Panama, you should book around 3 weeks before departure, which saves you about 17% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Which is the cheapest airport to fly into in Panama?

Prices will differ depending on the departure airport, but generally, the cheapest airport to fly to in Panama is Panama City Tocumen Intl Airport (PTY), with an average flight price of $321.

Good to know

Low seasonJune
Cheapest flight$172
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly and prices are also 6% lower on average.
Flight from Cancun to Panama City

FAQs for booking flights from Mexico to Panama

  • How does KAYAK find such low prices on flights from Mexico to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Mexico to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Mexico to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Mexico to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest day to fly to Panama?

    Based on KAYAK data, the cheapest day to fly to Panama is Tuesday where round-trip tickets can be as cheap as $426. On the other hand, the most expensive day to fly is Sunday, where round-trip prices are $534 on average.

Reviews of the top 3 airlines serving from Mexico to Panama

 
Need help choosing which airline to fly with from Mexico to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1584 reviews
8.1Crew
7.4Comfort
7.8Boarding
6.8Entertainment
6.8Food
Airline reviews

I had to run from the end of terminal one to the end of terminal two to make the connecting flight....probably a kilometer. No electric carts were available. I'm 76 and literally had to run to make the connection at the last minute. The connecting time was absolutely unrealistic. When Last Call was announced, I tried to get other Copa gate staff to call Gate 221 to let them know I was on my way, but they said no. I came within 1 minute of missing the flight.

2.0 MediocreFred, May 2026
UIO - PTY
Read more Copa Airlines reviews

I had to run from the end of terminal one to the end of terminal two to make the connecting flight....probably a kilometer. No electric carts were available. I'm 76 and literally had to run to make the connection at the last minute. The connecting time was absolutely unrealistic. When Last Call was announced, I tried to get other Copa gate staff to call Gate 221 to let them know I was on my way, but they said no. I came within 1 minute of missing the flight.

I was flying business class, and the French fellow passengers were super noisy. It was not a comfortable flight. And the crew was not helpful.

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Entire experience from check in to landing was amazing the flight crew was excellent and friendly. Seats were comfortable.

Boarding was confusing from staff telling going to preboard and than to group 1 Airplane was not cooling at the beginning

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

Friendly crew, good food options, food not the best and seats not as comfy but that’s typical.

The food is terrible I ask for water never got transport my mother we’re late and my sister from Lima was the worst waiting to long for wheelchair

Seats were awful. Media should have been included for such a long flight.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

All went very well. We used the AIFI Airport, such a lovely facility. Definitely needs better transportation options to get there.

Both ground crew and flight crew were rude, and did not provide any level of service. They made it very difficult as we were traveling with a passenger the required assistance.

From the check-in, to the flight, and arriving, everything went very smoothly. Unfortunately, when I received my baggage it was severely damaged. I have a hard shelled suitcase and it was completely smashed it. I’m not sure how this could happened but I am extremely disappointed that my belongings were damaged beyond repair and continued use.

Really nice, all good, nice crew and all on time

Unfortunately I had an awful boarding experience. Our first flight with Aeromexico was fine and landed on time however it couldn’t find a gate and we were late which made us lose our connecting flight with Aeromexico. The staff handled it horribly when we explained our situation and would not led us board when we missed the boarding time by a couple minutes. The staff were extremely rude and did not attempt to even help us. Because of this incident, my husband and I missed a full day of work which negatively impacted our salary which we need. Please compensate us for the work that we missed.

It was OK. The flight is pretty long for the airlines to only offer a simple sandwich on business class. The entertainment is similar to that on other Skyteam members. Ultimately the airline lost my bag and didn’t deliver it to me until the next day after a lengthy lost baggage report.

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

Aeroméxico cancelled my ticket without advice AND It make a last minute mess in my intinerary, no solving my situation, bad advice and bad customer service

Flight was on time, good service, but there was no free WiFi, even for first class passengers

It was good in general. The Crew during the flight were very nice at all times.

After boarding, there was a small issue with the aircraft which caused a delay of about 45 minutes. During boarding and while passengers were being seated, the plane was being refueled. There were also a lot of unusual noises during the flight, which was not very reassuring. In addition, there was no WiFi or entertainment available.

Seating was tight. Seats don't recline. Initial flight was cancelled. Lost two days of vacation.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

I actually upgraded to the medium level of seats from basic and even doing that it may have been physically the most uncomfortable flight I have ever had. They packed everyone like is a train to death camp. It was a red eye so I hoped to get some sleep but it was physically impossible to find a comfortable way to rest. I met other folks on the same flight and they said the same thing. It was an utterly miserable flight and if I have any other options I will never fly with them again

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

The flight attendant smashed her beverage cart into my knee, causing significant amount of pain. The seats were extremely uncomfortable. No food or drink is offered unless you want to pay the ridiculous prices for it. The schedule of flying in the overnight hours is also very uncomfortable.

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

Last seat of Bussines Class it does recline but passenger seating behind kept pushing since they did not have space once my seat was reclined

We waited for one hour to deboard the plane after landing. That could be better

Everything you need to know for your flight to Panama

Cabin class types available on flights to Panama

Cabin classes available on flights to Panama. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.