$216 Find Cheap Flights from Mexico to Panama - Compare and Save

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Cheap Flights from Mexico to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
Panama City
2h 35mNonstop
from $347per person
David
7h 10m2 stops
from $559per person
Booking Insights

KAYAK's insights & trends for flights to Panama

Get data-powered insights and trends for flights to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest flight to Panama?

The cheapest ticket to Panama from Mexico found in the last 5 days was to Panama City, at $147 round-trip. The most popular route is Cancun (CUN) to Panama City (PTY) and the cheapest round-trip airline ticket found on this route in the last 5 days was $147.

How much is a flight to Panama?

A flight to Panama costs $430 on average. The cheapest price found on KAYAK in the last 2 weeks was $147 for the route Cancun (CUN) to Panama City (PTY). The most popular routes on KAYAK are Cancun to Panama City which costs $623 on average, and Guadalajara to Panama City, which costs $868 on average.

See prices from:

What is the cheapest month to fly from Mexico to Panama?

The cheapest month for flights from Mexico to Panama is April, when tickets cost $198 (return) on average. On the other hand, the most expensive months are March and September, when the average cost of round-trip tickets is $334 and $333 respectively.

What is the cheapest time of day to fly to Panama?

The cheapest time of day to fly to Panama is generally at night, when round-trip flights cost $509 on average. Morning departures are around 1% cheaper than evening flights, on average. The most expensive time of day to fly to Panama is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $587.

How far in advance should I book a flight from Mexico to Panama?

To get a below average price on the flight from Mexico to Panama, you should book around 2 weeks before departure, which saves you about 18% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 25 weeks before departure.

Which is the cheapest airport to fly into in Panama?

Prices will differ depending on the departure airport, but generally, the cheapest airport to fly to in Panama is Panama City Tocumen Intl Airport (PTY), with an average flight price of $338.

Good to know

Low season

June

Cheapest flight

$216
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly with an average 4% increase in price.
Flight from Mexico City to Panama City

FAQs for booking flights from Mexico to Panama

  • How does KAYAK find such low prices on flights from Mexico to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Mexico to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Mexico to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Mexico to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest day to fly to Panama?

    Based on KAYAK data, the cheapest day to fly to Panama is Friday where round-trip tickets can be as cheap as $468. On the other hand, the most expensive day to fly is Sunday, where round-trip prices are $556 on average.

Reviews of the top 3 airlines serving from Mexico to Panama

 
Need help choosing which airline to fly with from Mexico to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1542 reviews
7.4Comfort
8.1Crew
7.8Boarding
6.9Entertainment
6.9Food
Airline reviews

I always enjoy flying with Copa. Adequate legroom and comfortable seating with fantastic entertainment options.

10.0 ExcellentTisagh, Sep 2026
Read more Copa Airlines reviews

I always enjoy flying with Copa. Adequate legroom and comfortable seating with fantastic entertainment options.

It is not a good experience with Copa Airlines: flight delay, luggage delay, etc.

Problems with a missmatch between sits in checkin versus real location on the airplane

We where skipped for this flight will not head to Panama until tonight..

They didn’t have any headphones for the entertainment screen and their USB port didn’t accommodate a USB-C for more modern phones. The food was just ok. The staff was friendly but the seats were very uncomfortable for a full flight.

I had to run from the end of terminal one to the end of terminal two to make the connecting flight....probably a kilometer. No electric carts were available. I'm 76 and literally had to run to make the connection at the last minute. The connecting time was absolutely unrealistic. When Last Call was announced, I tried to get other Copa gate staff to call Gate 221 to let them know I was on my way, but they said no. I came within 1 minute of missing the flight.

I was flying business class, and the French fellow passengers were super noisy. It was not a comfortable flight. And the crew was not helpful.

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Entire experience from check in to landing was amazing the flight crew was excellent and friendly. Seats were comfortable.

No headphones given for inflight entertainment. I missed my flight from the previous day and the customer service agent tried to extort an additional $100.00 US from me for missing my flight. Really?!

At my original departure Istanbul I was told my seat and flight was cancelled from the 3rd party. I had no seat to get to my other flights .. they charged me $481 USD to board the flight that I already paid for

All went very well. We used the AIFI Airport, such a lovely facility. Definitely needs better transportation options to get there.

Both ground crew and flight crew were rude, and did not provide any level of service. They made it very difficult as we were traveling with a passenger the required assistance.

It was OK. The flight is pretty long for the airlines to only offer a simple sandwich on business class. The entertainment is similar to that on other Skyteam members. Ultimately the airline lost my bag and didn’t deliver it to me until the next day after a lengthy lost baggage report.

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

Flight was on time, good service, but there was no free WiFi, even for first class passengers

It was good in general. The Crew during the flight were very nice at all times.

The ground staff were not as friendly and nice to the passengers as the air crew. Flight attendants, cockpit crew were great and very nice to everyone on board.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

I like the crew who were very helpful in ensuring documents were in order and problems resolver in a timely manner. However I did not like the fact that I had to have my checked bag inspected.I was concerned I would have missed my flight. I was also trying to check in online only to realise that was not possible.

After boarding, there was a small issue with the aircraft which caused a delay of about 45 minutes. During boarding and while passengers were being seated, the plane was being refueled. There were also a lot of unusual noises during the flight, which was not very reassuring. In addition, there was no WiFi or entertainment available.

They should provide water to passengers who ask for it

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

Purchased a business class ticket and got a economy seat with center seat blocked they call it business. 3100usd ticket on a flight where economy costs 500usd The biggest scam insult have had on a regular airline. Avianca should be in the low cost category and kicked out of Star Alliance. I want the difference to be credited. Ets see what Avianca does. No reply so far. Avianca = low cost airline. Beware

Excellent flight and one of the smoothest landing I’ve ever experienced

Almost we lost our connection from Bogota to Aruba 🥴 Because we get out late from the plane of Medellin

This is the Spirit of Latino travel. And don’t even get me started on customer service.

My experience was amazing! They helped my elderly mother board on early through a wheelchair and were accommodating to have us sit together since our seats were in different locations. When landing at the airport in GUA they were very helpful with full of hospitality.

The flight was overbooked and the solution gave was unrespctful. I arrived 4 hour in advance in the airport and only after 2hous was possible suggest a different ticket with another company LATAM, I have accepted, but when I was checking in at LATAM the tickets was issued without luggage, what it is absurd since I have bought my tickets including it since the beginning. Due to the timing for the next flight was not possible return to Avianca to claim due to the distance between Both companies Avianca and Latam since were located in different terminals. I have insiste to the crew of Latam to call Avianca to solve it, but they could help they were alleging that only paying a thousand pesos Mexicans ($1,000 MXN) to dispatch my luggage would be accepted and I have no money at all. So I had to beg for others passagens, it was an humiliating to exchange luggage with who was platinum in order to return back the luggage in the connection airport in Brazil (GRU). I have no clue that a judicial process would be taken from my side due the lots of stress in sequence by the non professional treatment with a passenger that was just following everything said by Avianca.. Long hours of waiting until next flight and only arrive at final destine in 6hs later..

More options for your flight to Panama

Complete your trip to Panama with a hotel stay or car rental