$462 Find Cheap Flights from Panama City to Italy

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Italy departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Italy

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Book Cheap Panama City to Italy Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Italy that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Italy

Tue, Feb 24 - Tue, Mar 3
Delta Logo
2:05 pm - 5:25 pm
ECP
-
FCO
20h 20m
2 stops
Delta Logo
12:40 pm - 10:39 pm
FCO
-
ECP
16h 59m
1 stop
$477Delta
Wed, Feb 25 - Wed, Mar 4
KLM Logo
12:10 pm - 11:30 am
ECP
-
VCE
16h 20m
2 stops
KLM Logo
1:20 pm - 10:39 pm
VCE
-
ECP
16h 19m
2 stops
$479KLM
Tue, Feb 24 - Tue, Mar 3
Delta Logo
2:05 pm - 5:25 pm
ECP
-
FCO
20h 20m
2 stops
Delta Logo
12:00 pm - 10:39 pm
FCO
-
ECP
17h 39m
2 stops
$481Delta
Wed, Feb 25 - Wed, Mar 4
KLM Logo
9:26 am - 9:10 am
ECP
-
FCO
16h 44m
2 stops
KLM Logo
12:40 pm - 10:39 pm
FCO
-
ECP
16h 59m
1 stop
$489KLM
Wed, Feb 25 - Wed, Mar 4
KLM Logo
9:26 am - 9:10 am
ECP
-
FCO
16h 44m
2 stops
KLM Logo
12:00 pm - 10:39 pm
FCO
-
ECP
17h 39m
2 stops
$494KLM
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
6:30 am - 7:45 am
ECP
-
FCO
18h 15m
2 stops
United Airlines Logo
7:05 am - 7:51 pm
FCO
-
ECP
19h 46m
3 stops
$511United Airlines
Wed, Feb 18 - Wed, Feb 25
United Airlines Logo
5:00 pm - 7:45 am
ECP
-
FCO
31h 45m
2 stops
United Airlines Logo
11:00 am - 12:04 pm
FCO
-
ECP
56h 04m
2 stops
$517United Airlines
Wed, Feb 18 - Wed, Feb 25
United Airlines Logo
5:00 pm - 7:45 am
ECP
-
FCO
31h 45m
2 stops
United Airlines Logo
11:00 am - 4:11 pm
FCO
-
ECP
36h 11m
2 stops
$523United Airlines
Wed, Feb 18 - Wed, Feb 25
United Airlines Logo
6:30 am - 11:00 am
ECP
-
FCO
21h 30m
3 stops
United Airlines Logo
11:00 am - 12:04 pm
FCO
-
ECP
32h 04m
2 stops
$530United Airlines
Wed, Feb 18 - Wed, Feb 25
Delta Logo
8:03 am - 10:30 am
ECP
-
FCO
19h 27m
1 stop
Delta Logo
12:40 pm - 10:39 pm
FCO
-
ECP
16h 59m
1 stop
$558Delta
Booking Insights

KAYAK's insights & trends for Panama City to Italy flights

Get data-powered insights and trends into flights from Panama City to Italy to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Panama City and Italy?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Panama City to Italy.

There are 2 airlines that fly nonstop from Panama City to Italy. They are KLM and Delta. The cheapest airline for this route is Delta, with the best round-trip deal found costing $729 and arriving in Rome Fiumicino Airport (FCO). On average, KLM offers the best prices for nonstop flights between Panama City and Italy.

Which airlines provide the cheapest flights from Panama City to Italy?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to Italy were found on Delta ($477) and KLM ($479).

Good to know

Cheapest flight$379
Most popular time to fly with an average 5% increase in price.
Flight from Panama City to Rome

FAQs - booking Italy flights

  • How does KAYAK find such low prices on flights from Panama City to Italy?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Italy.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Italy?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Italy is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Italy?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Italy with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Italy?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Italy up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to Italy

 
Need help choosing which airline to fly with from Panama City to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8039 reviews
8.1Boarding
8.5Crew
7.2Food
7.9Comfort
7.8Entertainment
Airline reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

8.0 ExcellentG, Jan 2026
FLL - ATL
Read more Delta reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

I’m grateful for the KLM Air France shuttle bus service to Ottawa. However due to construction and other issues related to the chaotic Uber pickup system at YUL, it’s a challenge to find the Kelios bus service to Ottawa. The signs are not clear or even available. No staff to guide passengers. It’s a stressful experience.

At the airport, terrible, I do not want to even remember it. It was too humiliating for a business class passenger.

Flight was ok but lack of communication cost me to literally beg to be put on another flight as connecting flight had departed

They forgot to serve food and the crew was very unfriendly. Never experienced such a bad KLM flight. Usually fly from Toronto. New York was different.

Couldn’t get boarding pass in SLC even with help from a redcoat, so had to find a desk in AMS to get boarding pass. Technical problems so not sure why. Very inconvenient. The KLM app is not as user friendly as most apps. Also had to wait almost an hour on the tarmac for a fuel truck, which caused us to miss a connecting bus in LUX.

The immigration hall in Amsterdam was understaffed, so passport checking was slower than it should be for a major airport. They need to get the automatic readers up and running for non EU passport holders. Waiting in line after a long flight feels a bit abusive.

Over 1 Hr delay. No APU so no AC on ground. Plane was hot during boarding and then they closed the doors over 20 minutes before engine start so interior of plane was steamy hot and stuffy. Could have been helped by opening doors until ready to depart.

First of all we couldn’t check in online, then we learn at the airport we were on stand by for KLM’s mistake of overbooking. The seats were not comfy at all. Our luggage got lost.

KLM remains a quality flag carrier airline which maintains its standards whilst all their competitors are lowering theirs.

The baggage drop-off in Stuttgart is bad: after online check-in you cannot use the automated baggage drop off as indicated on the website. You can use the terminals but have to cue to 1 of three open and slowly working counters to drop the bags. took about 45 minutes wait time.

UGH I HAD TO MISS MY FIRST FLIGHT TO TAMPA CAUSE OF THE 10 MINUTE DELAY OF THE ORLANDO TO MIAMI ONE SO THEY HAD ME GET ANOTHER TICKET. I AM NOT HAPPY AT ALL BECAUSE IT MADE ME MISS MY CONNECTING FLIGHT FROM TAMPA TO LONDON AND FORCED ME TO MISS A DAY AT MY ROOM IN THE UK.

Wish they didnt delay off-boarding for 10 minutes so i could connect to my flight from miami to tampa

It was fine. My connection in Charlotte to go to WPB was too late and I had to spend the night in the Charlotte Airport in the mini suites.

Boarding was organized and timely. Food was mediocre, especially for first class travel.

We were 4+ hours delayed. AA is absolutely obnoxious. They just kept pushing back the time to the point where we did not get into Vegas until after midnight when we were supposed to arrive like 845pm.

My last flight on 25 Dec, it’s Christmas Day, everyone happy and very good mood. I really enjoy traveling with Americans Airlines from Miami to Minneapolis my home town after long flight from lhe to Doha then Miami. Thank you again to make my travels comfortable and relaxed. Best regards

I don’t know who decides what food to serve on these flights but I would be so embarrassed if I served this to anyone and call it food…

For whatever reason, the flight was not catered -we were told it would be a 45 minute delay waiting for catering - so no food. There were opened candy and peanuts in the seatback pocket. Flight landed early in DFW but due to the assigned gate not being available, we sat on the ground for 30 minutes waiting for the gate to open - making the flight actually arrive at the gate late.

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

Flight was delayed 17 hours due to aircraft issues. American did provide hotel, transportation and meals, 3 hours past boarding time, but it took us another hour to get the vouchers.

Everything you need to know for your flight from Panama City to Italy

Information on your arrival and departure airports