$537 Find Cheap Flights from Panama City to Italy - Compare and Save

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1 adult, Economy, 0 bags

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Price, demand and travel trends for Panama City to Italy flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Panama City to Italy right now?

Here are the cheapest round-trip fares from Panama City to Italy on KAYAK in the last week:

• Rome Fiumicino (FCO) from $734
• Milan Malpensa (MXP) from $736
• Venice Marco Polo (VCE) from $762
• Palermo Punta Raisi (PMO) from $1,439

What’s the cheapest month to fly from Panama City to Italy?

January is the cheapest time of year to fly, with average fares of $447. Prices are highest in June, when average flight costs increase to around $1,539.

Which airport in Italy is the cheapest to fly to from Panama City?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Italy are:

• Milan Linate (LIN) from $884
• Palermo Punta Raisi (PMO) from $928
• Milan Malpensa (MXP) from $1,008

What’s the cheapest day to fly from Panama City to Italy?

Thursday tends to be the cheapest day to fly from Panama City to Italy, while Monday is the most expensive. Fares run about 47% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Panama City to Italy?

Data from the past 12 months shows it's cheapest to fly to Italy during the evening with average prices of $884. The morning is the most expensive time to fly, with average prices of $1,394.

Key details for Panama City to Italy flights

Low season

January

Cheapest flight

$537
Beat the crowds with an average 50% drop in travelers.
The most popular month to fly with an average 39% increase in travelers.
One-way flight from Panama City to Milan Linate Airport

Your Panama City to Italy flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Panama City to Italy?

    Yes. Fares from Panama City to Italy are low right now. As a rule of thumb, a round-trip under $783 (cheaper than most fares this year) is a good deal, so if you spot one at or below that, it's a good time to book.

  • How much should I budget for a flight from Panama City to Italy?

    Over the past 12 months, round-trip fares from Panama City to Italy have ranged from $783 to $1,417.

  • What are the main airports serving Italy?

    Italy has 43 airports. The three busiest are Rome Fiumicino (FCO) (38% of arrivals), Milan Malpensa (MXP) (28%) and Milan Linate (LIN) (14%).

  • What airlines fly nonstop from Panama City to Italy?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Panama City to Italy. However, Delta offers a one-stop option.

  • Which cabin classes are available on flights from Panama City to Italy?

    On flights from Panama City to Italy you can book Economy Class, Business Class or First Class.

  • What are some popular landmarks in Italy?

    KAYAK travelers' favorite landmarks in Italy include:

    • Piazza Navona
    • Colosseum
    • Fontana di Trevi
    • Pantheon

Your guide to booking Panama City to Italy flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for January when flights are typically cheapest and avoid June when prices are at their highest.
  • Flying on Thursday is usually the cheapest. Flights on Monday cost about 47% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, Milan Linate (LIN) is the cheapest airport to fly into from Panama City. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Rome, which is the most popular destination in Italy. From there, it's easy to continue on to other popular destinations such as Milan, Venice and Florence.

Reviews of the top airlines flying from Panama City to Italy

 
Need help choosing which airline to fly with from Panama City to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
KLMOverall score based on 1591 reviews
7.8Boarding
7.7Comfort
8.4Crew
7.2Entertainment
7.4Food
Airline reviews

The flight itself was fine, food was expired and gross, staff were mostly amazing! KLM messed up rebooking for our first two flights that got cancelled and we almost didn’t make it to Amsterdam for an additional two days

4.0 OkayJessica, Sep 2026
Read more KLM reviews

The flight itself was fine, food was expired and gross, staff were mostly amazing! KLM messed up rebooking for our first two flights that got cancelled and we almost didn’t make it to Amsterdam for an additional two days

I think I previously submitted my feedback about flight lead Katherine in a different field by mistake. Please see those comments. Comments for Hyd to AMS are it was good. The flight lead and service met expectations for satisfactory high quality service but the flight lead did not stand out as exceptional as did the leads on the other two flights so I don’t remember anything specific one way or the other besides the fact I was satisfied.

Had to cancel and rebook, KLM connection was cancelled prior to departure, ended up flying to Munich on non-Delta carrier.

The crew were unprofessional with a racist element. I was physically abused as well from one of the crew members

They forgot to serve food and the crew was very unfriendly. Never experienced such a bad KLM flight. Usually fly from Toronto. New York was different.

Over 1 Hr delay. No APU so no AC on ground. Plane was hot during boarding and then they closed the doors over 20 minutes before engine start so interior of plane was steamy hot and stuffy. Could have been helped by opening doors until ready to depart.

My flight was delayed by 6 hours then I missed BOTH of my connecting flights, I then had to stay in the AIRPORT at JFK because soooooo many people also suffered from missing flights and there was no hotels available. I would like to be compensated for this experience! I had to stay in the airport for over 16 hours!

Cabin crew were excellent, very proffesional, polite and friendly, in flight snack was underwhelming, a packet of cheese biscuits, im sure KLM could run to a sandwich!

The baggage service at Malpensa was the worst ever. We wanted for over an hour without any information, they broke my suitcase, and the services of the local luggage services company was below any usual services level of a KLM partner.

All and all pretty good. It’s crowded but that is what flying is all about. But no complaints otherwise.

Great flight. Thank you for the upgrade to first class.

Everything was great. The only thing that wasn’t was the breakfast calzone which was basically warm bread. It was very tasteless and wasn’t good at all

I usually like delta. However this is my second flight that the wifi does not work

Both legs on the way were smaller planes, each had a mechanical issue causing a delay

Delayed flight. Dirty seats, dirty seat belts with food stuck on it from previous passengers maybe. No one cleaned the seats or flight.

No headphones, forced to sit in another seat that I did not book, had to check my carry on when I boarded the plane I saw backpacks and other non carry on items stuffed in the carry on holder! Horrible experience Wi-Fi did not work either

There was no food, so :( to that one. The flight was delayed by 3 hours. Not Delta's fault. Not the crew's fault. Considering how tired all us passengers were, everything went surprisingly well. The flight crew were very helpful, friendly, and professional. I always fly Delta.

Terrible. Waited on runway for 1+ hour after landing and then was brought to wrong terminal

Pushing back flight and ultimately cancelling it after multiple changes and hours of delays. Comm were terrible as to what was going on and what options were available.

Planes were clean, no water or snacks on either flight.

More options for your flight from Panama City to Italy

Complete your trip to Italy with a hotel stay or car rental