21c Museum Hotel Louisville

21c Museum Hotel Louisville

700 West Main Street, Louisville, KY 40202, United States
+1 502 217 6300

rate per night


based on 217 reviews

21c Museum Hotel Louisville
Fri 8/12
Sat 8/13

About 21c Museum Hotel Louisville

  • Hotel Room
    You’ll have a private room with all the hotel’s amenities
  • Clean and Tidy
    This stay has listed several different cleanliness practices.
  • Freebies
    This stay includes Wi-Fi for free

One of the more unique hotels to be found in both downtown Louisville and across the U.S., Louisville Hotels’ 21c Museum Hotel in Louisville is the first of its kind. It’s a hybrid of a 91-room boutique hotel and multi-venue contemporary art museum.

Visitors are drawn to the collection of 19th-century art. More than 9,000 sq. ft of exhibition space feature striking artwork across multiple galleries. Pieces include a replica of David, Fallen Fruit: The Practices of Everyday Life, and Asleep in the Cyclone.

Each piece of art in the 21c Museum complements the modern aesthetics of the property’s 91 rooms. Ten different types of lodging provide guests with a choice, whether they’re looking for something spacious and cozy or need plenty of room for a group of people. All rooms come with complimentary WiFi, a 42” flat-screen TV, Nespresso coffee machine, and original artwork. The Rooftop Apartment provides panoramic views of Louisville and plenty of outdoor lounging.

21c Museum and Hotel allows guests to dine in a casual environment surrounded by 19th-century art. Proof on Main features menus for breakfast, lunch, dinner, and weekend brunch and has more than 120-plus Kentucky Bourbons.

Boisterous Louisville is right outside the 21c Museum and Hotel’s door. Guests can get lost in the many attractions of the city, including the Muhammad Ali Center, Churchill Downs, Kentucky Bourbon Trail, and Museum Row.

This unique pairing of museum and hotel is a space of luxury and contemporary offerings for travelers wanting a taste of all that Louisville has to offer.

Photos of 21c Museum Hotel Louisville

Latest deals for 21c Museum Hotel Louisville

Sat 8/13
Wed 8/17
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Deluxe Rooms($173 - $441)
Deluxe room
bed type unknown
bed type unknown


$173 totalAgoda.com
2 double beds

2 double beds



$182 totalHotels.com
bed type unknown
bed type unknown


$182 totalBooking.com
King Rooms($177)
King room
1 king bed

1 king bed



$177 totalPrestigia
Luxury Rooms($244 - $608)
Luxury room
bed type unknown
bed type unknown


$244 totalAgoda.com
2 double beds

2 double beds



$255 totalExpedia
2 double beds

2 double beds



$255 totalHotels.com
Double Rooms($178 - $269)
Double room
bed type unknown
bed type unknown


$178 totalSnaptravel
bed type unknown
bed type unknown


$210 totalFINDHOTEL
bed type unknown
bed type unknown


$227 totalPrestigia
Standard Rooms($204 - $265)
Standard room
bed type unknown
bed type unknown


$204 totalPriceline
bed type unknown
bed type unknown


$265 totalSnaptravel

Amenities at 21c Museum Hotel Louisville

  • Spa and wellness center
  • Fitness center
  • Restaurant
  • Bar/Lounge
  • Room service
  • Free Wi-Fi
  • Valet parking
  • Business center
  • Flat-screen TV
  • Meeting/Banquet facilities

Health and safety

  • Daily housekeeping
  • Contactless check-in/check-out
  • Face masks for guests available
  • Physical distancing in dining areas
  • Physical distancing rules
  • First-aid kit
  • Process in place to check health of guests
  • Enhanced cleaning
  • Hand sanitizer in guest accommodation and key areas
  • Screens or physical barriers placed between staff and guests in appropriate areas
  • Use of cleaning chemicals that are effective against coronavirus
  • Guest accommodation is disinfected between stays
  • Thermometers for guests provided by property
  • Safe
  • Delivered food is securely covered
  • Staff follow all safety protocols as directed by local authorities
  • Disinfection of high-touch surfaces

Services and conveniences

  • Conference rooms
  • ATM on-site
  • Ticket service
  • Business center
  • Concierge service
  • Safety deposit box
  • Hammam (Turkish bath)
  • Meeting/Banquet facilities
  • Room service
  • 24hr front desk


  • Free Wi-Fi
  • Internet
  • Fire extinguisher
  • Shampoo
  • Smoke alarms
  • Heating
  • Air-conditioned
  • Trash cans
  • Conditioner

Accessibility and suitability

  • Pets allowed on request. Charges may apply.
  • Increased accessibility
  • Elevator
  • Multi-lingual staff
  • Hypoallergenic
  • Allergy-free room
  • No smoking


  • Ironing service
  • Laundry facilities
  • Laundry service
  • Iron and ironing board
  • Pants press

Parking and transportation

  • EV charging station
  • Parking
  • Long-term parking (surcharge)
  • Valet parking


  • Hairdryer
  • Toilet
  • Bathrobe
  • Private bathroom


  • Spa and wellness center
  • Massage
  • Spa
  • Sauna


  • Computer use available
  • Fax/photocopying
  • Desk


  • Restaurant
  • Bar/Lounge
  • Food can be delivered to guest accommodation


  • Soundproof rooms
  • Storage available

Media and entertainment

  • Flat-screen TV

Things to do

  • Gift shop


  • Fitness center

Reviews of 21c Museum Hotel Louisville

GreatBased on 217 verified guest reviews

Pros +
Cons -

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8.0 Great
Pros:21C is an awesome bar/restaurant/gallery/hotel. We were excited to stay there on our first night of marriage since we had our first kiss there three years ago. The staff is excellent and the energy superb.
Cons:Unfortunately there was absolutely nothing distinctive about the room. For a hotel as well reviewed as this place, there needs to be a serious statement in the room with either art pieces, the design of the room, etc. This room could have easily been a new Westin or some urban Marriott concept. The rooms we stayed in had there share of use and will probably need to be renovated relatively soon. So if I were you, I'd save $100+ per night, stay at the Brown or Seelbach, and spend your savings on dinner and drinks at 21C/Proof. Or heck, get a boss Airbnb in the Highlands or Nulu.


700 West Main Street, Louisville, KY 40202

What's nearby

  • Kentucky Museum of Art and Craft73 yd
  • Kentucky Science Center122 yd
  • Muhammad Ali Center204 yd
  • Louisville Slugger Museum223 yd
  • Frazier International History Museum293 yd
  • KFC Yum Center0.4 mi
  • Louisville Palace0.7 mi
  • Louisville Slugger Field0.9 mi
  • Louisville Waterfront Park1.2 mi
  • Thomas Edison House1.2 mi
  • Conrad Caldwell House1.9 mi
  • Cave Hill Cemetery2.6 mi



Check in anytime after 4:00 PM, check out anytime before 11:00 AM


Cancellation/prepayment policies vary by room type and provider.

FAQs when booking at 21c Museum Hotel Louisville

  • 21c Museum Hotel Louisville is located at 700 West Main Street, 0.7 miles from the center of Louisville. Kentucky Museum of Art and Craft is the closest landmark to 21c Museum Hotel Louisville.

  • Check-in time is 4:00 PM and check-out time is 11:00 AM at 21c Museum Hotel Louisville.

  • Yes, 21c Museum Hotel Louisville offers free Wi-Fi.

  • 21c Museum Hotel Louisville is 5.9 miles from Louisville Standiford Field. 21c Museum Hotel Louisville is 64.6 miles from Lexington Blue Grass.

  • Yes, 21c Museum Hotel Louisville is a pet-friendly hotel.

  • KAYAK scours the web for all room deals available at 21c Museum Hotel Louisville in Louisville and lets you compare them to find the best rate for your stay. Many different travel sites will offer discounts or deals at different times for rooms at 21c Museum Hotel Louisville and KAYAK will provide you with prices from a huge range of travel sites. That means that you can always find a great deal for 21c Museum Hotel Louisville.

Nearby hotels and places to stay

Good to know

Value for money


Distance to city center

0.7 mi

Location rating


Nearest Airport

Louisville Standiford Field

Distance to airport

5.9 mi