$128 Find Cheap Flights from Charleston to Florida Keys

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to Florida Keys departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Florida Keys

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Florida Keys, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Florida Keys, as well as popular online travel agencies
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Cheap Flights from Charleston to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$278
Key West
Key West1 stop$265
Miami
Miami1 stop$278
Key West
Key West1 stop$265

Book Cheap Charleston to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to Florida Keys

Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:11 pm - 10:36 pm
CRW
-
EYW
4h 25m
1 stop
American Airlines Logo
5:03 pm - 10:00 pm
EYW
-
CRW
4h 57m
1 stop
$265American Airlines
Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:00 am - 11:24 am
CRW
-
EYW
5h 24m
1 stop
American Airlines Logo
2:01 pm - 10:00 pm
EYW
-
CRW
7h 59m
2 stops
$271American Airlines
Sat, May 2 - Wed, Jun 10
Delta Logo
4:10 pm - 8:48 pm
CRW
-
MIA
4h 38m
1 stop
Delta Logo
12:01 pm - 6:15 pm
MIA
-
CRW
6h 14m
1 stop
$278Delta
Tue, May 12 - Tue, May 19
American Airlines Logo
6:00 am - 1:12 pm
CRW
-
MIA
7h 12m
2 stops
American Airlines Logo
4:31 pm - 9:30 pm
MIA
-
CRW
4h 59m
1 stop
$284American Airlines
Sun, Sep 27 - Sat, Oct 3
Delta Logo
6:40 pm - 12:54 am
CRW
-
MIA
6h 14m
1 stop
Delta Logo
6:00 am - 10:26 am
MIA
-
CRW
4h 26m
1 stop
$288Delta
Sun, Apr 19 - Sat, Apr 25
Multiple Airlines Logo
8:52 pm - 12:03 pm
CRW
-
MIA
39h 11m
2 stops
Multiple Airlines Logo
5:30 pm - 2:03 pm
MIA
-
CRW
20h 33m
1 stop
$293Multiple Airlines
Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:11 pm - 10:36 pm
CRW
-
EYW
4h 25m
1 stop
American Airlines Logo
5:03 pm - 10:00 pm
EYW
-
CRW
4h 57m
1 stop
$294American Airlines
Fri, Apr 24 - Sat, May 2
Delta Logo
7:10 pm - 12:54 am
CRW
-
MIA
5h 44m
1 stop
Delta Logo
6:00 am - 10:20 am
MIA
-
CRW
4h 20m
1 stop
$298Delta
Wed, Jul 1 - Wed, Jul 8
Delta Logo
2:42 pm - 7:53 pm
CRW
-
EYW
5h 11m
1 stop
Delta Logo
7:45 am - 2:02 pm
EYW
-
CRW
6h 17m
1 stop
$308Delta
Sat, Apr 18 - Sat, Apr 25
Delta Logo
4:10 pm - 8:48 pm
CRW
-
MIA
4h 38m
1 stop
Delta Logo
6:00 am - 10:20 am
MIA
-
CRW
4h 20m
1 stop
$313Delta
Booking Insights

KAYAK's insights & trends for Charleston to Florida Keys flights

Get data-powered insights and trends into flights from Charleston to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Charleston to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $368, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Charleston to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to Florida Keys is December, when tickets cost $253 (return) on average. On the other hand, the most expensive months are April and March, when the average cost of round-trip tickets is $575 and $480 respectively.

Good to know

Low seasonFebruary
Cheapest flight$128
Best time to beat the crowds but there is an average 4% increase in price.
Most popular time to fly with an average 34% increase in price.
Flight from Charleston to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Charleston to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Charleston to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from Charleston to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Charleston to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8387 reviews
7.8Entertainment
7.2Food
8.5Crew
7.9Comfort
8.1Boarding
Airline reviews

N Everything was perfect from boarding to assistance to baggage in Tampa

10.0 ExcellentDeborah, Apr 2026
LAX - TPA
Read more Delta reviews

N Everything was perfect from boarding to assistance to baggage in Tampa

Snacks and included beverages were appreciated. Boarding went smoothly. Plenty of overhead bin space. Seats get very uncomfortable after a couple of hours. After waiting 10 painful minutes for my walker, a very nice Delta guest agent pushed me in a wheelchair to the gate. It was finally delivered to me after another 15 minutes . Our checked bag was on the carousel long b4 I was able to retrieve it. Fortunately it was still there but somewhere along the way the straps we used to secure it were removed and and were not reattached. Wish I had made note of the agents name.

The whole experience was excellent. As it most often is with Delta

We waited an hour on the runway to get a gate in Orlando

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The staff on board and gate was nice - a welcome change from the usual. We also arrived early, which was a great benefit, given that it takes 30 minutes plus to get bags at SRQ.

They took all carry-on luggage from Groups 6 -9 - I was group 5 and waiting in line to board - they made me check my luggage too. That then went to baggage claim and delayed departure from the airport. There was overhead room in my seating area - Delta over reacted. Also, had a gentleman next to me that took up 1/2 my seat.

Sorry I didn't realize I was writing a review for each leg. Please see my previous review - it applies to the entire flight, not just a single leg.

boarded at 5:30 pm, pushed away from gate at 6pm ... takeoff was not until ~6:45pm; disappointing

Paid for wifi that didn't work. No plug in seat to work. No entertainment.

Incoming flight was delayed, delaying boarding. It then took 30 mins to take off. Took 20 mins to get to a gate because they changed the gate last minute, crew weren’t ready so there was no one staffed to work the jet bridge. Boarding was so disorganized as is usual with American because everyone just stands around the gate regardless of boarding group.

I would have liked vegetarian and gluten free options for evening dinner time flight. I would have like a pillow on the international overnight flight . The veg wrap and oaten desert on the international flight was good

We hoarded. Then we deplaned. Then we waited for 10 hours in the MSP airport due to a wheel misfunction. We understand safety but communication between crew and airport staff was horrible. When we did finally board, we were rushed on and because we were waiting for a “fresh” pilot and crew, we sat in a roasting plane with no A/C for an hour. My question is why was this flight not cancelled right away when they knew this would be a huge issue OR, why did AA not get a substitute plane, considering this was already a full flight? To me, this appears to be a complete breakdown in leadership and utter systems failure. The compensation for completely disrupting travel plans for hundreds, which we paid dearly for, was measly. While we appreciated the lodging for the night, $12 in meal vouchers isn’t going to sustain anyone for over 12 hours. “We apologize; our hands are tied” is no longer an acceptable explanation. We are so completely turned off by this experience and will definitely seek alternative avenues when we need to fly.

Check in was rough because the check in crew did not know how to manage my international visa documents. Required a long process and 4 people to finally be able to proceed to security. They told us incorrect information several times before acknowledging we did indeed have everything we needed from the start.

Mechanical issue delayed us 2hrs and then once we landed sat on tarmac for 30mins because someone left a vehicle in front of the gaye

Plane from partner PSA was filthy. Plastic needs to be thoroughly cleaned. Really disgusting to look at and wonder about cleanliness of parts less visible.

Flight delay for mechanical. Inbound arrived on time. No one said why mechanical delay.

It was a train wreck but on an airplane. First off, flight was delayed then we board only to hear two announcements, First weather delays in Orlando and second backup battery warning on emergency lights. After sitting on the plane for almost 2 hours they have us deplane due to the maintenance issue. We were told they were getting another plane. In the mean time, I notice another American- Orlando flight and ask the gate agent if I can switch. He says he cant help me and I'd have to walk to A13 from A37. Really!? I get down there and get a seat only to get an announcement my original flight was RE-boarding. The Then inflight there's no communication and I notice on flightaware were circling over the Gulf of America. I call the flight attendant and of course she has no clue and apparently 5m later the pilot finally tells us about another delay. Why does American always have these service and delay issues? They are my LAST choice in flights now!

Flight boarded, departed and landed on time. Excellent service from flight attendant in FIRST

Flight to Tampa was delayed taking off due to plane arriving late but no other issues

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports