$74 Find Cheap Flights from Key West to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to South Carolina departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to South Carolina, as well as popular online travel agencies
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Cheap Flights from Key West to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$285
Charlotte
Charlotte1 stop$169
Charleston
Charleston1 stop$285
Charlotte
Charlotte1 stop$169

Book Cheap Key West to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to South Carolina

Fri, Jan 30 - Mon, Feb 2
Spirit Airlines Logo
2:25 pm - 6:48 pm
EYW
-
CLT
4h 23m1 stop
Spirit Airlines Logo
6:00 am - 1:30 pm
CLT
-
EYW
7h 30m1 stop
$169Spirit Airlines
Fri, Jan 30 - Mon, Feb 2
Multiple Airlines Logo
1:06 pm - 6:07 pm
EYW
-
CLT
5h 01m1 stop
Multiple Airlines Logo
7:43 pm - 10:09 am
CLT
-
EYW
38h 26m2 stops
$215Multiple Airlines
Sat, Jan 31 - Mon, Feb 2
Multiple Airlines Logo
10:49 am - 8:11 am
EYW
-
CLT
21h 22m2 stops
Multiple Airlines Logo
6:00 am - 1:30 pm
CLT
-
EYW
7h 30m1 stop
$234Multiple Airlines
Thu, Jan 1 - Thu, Jan 1
Breeze Airways Logo
10:59 am - 2:28 pm
EYW
-
CHS
3h 29m1 stop
Breeze Airways Logo
8:53 pm - 9:17 am
CHS
-
EYW
12h 24m1 stop
$285Breeze Airways
Fri, Jan 16 - Sun, Jan 18
Breeze Airways Logo
9:49 am - 1:22 pm
EYW
-
CHS
3h 33m1 stop
Breeze Airways Logo
3:01 pm - 12:26 pm
CHS
-
EYW
21h 25m1 stop
$314Breeze Airways
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
12:00 pm - 6:40 pm
EYW
-
CHS
6h 40m1 stop
American Airlines Logo
6:10 am - 1:03 pm
CHS
-
EYW
6h 53m2 stops
$358American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
1:33 pm - 9:11 pm
EYW
-
CHS
7h 38m2 stops
American Airlines Logo
6:10 am - 1:03 pm
CHS
-
EYW
6h 53m2 stops
$363American Airlines
Sat, Jan 31 - Mon, Feb 2
Delta Logo
6:06 pm - 11:54 pm
EYW
-
CLT
5h 48m1 stop
Delta Logo
2:25 pm - 7:40 pm
CLT
-
EYW
5h 15m1 stop
$407Delta
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
6:05 pm - 2:48 pm
EYW
-
CHS
20h 43m1 stop
United Airlines Logo
7:45 pm - 4:22 pm
CHS
-
EYW
20h 37m1 stop
$538United Airlines
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
2:25 pm - 7:11 pm
EYW
-
CHS
28h 46m2 stops
United Airlines Logo
7:45 pm - 4:22 pm
CHS
-
EYW
20h 37m1 stop
$543United Airlines
Booking Insights

KAYAK's insights & trends for Key West to South Carolina flights

Get data-powered insights and trends into flights from Key West to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Key West to South Carolina?

The average price of all round-trip flights from Key West to South Carolina clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to South Carolina on a Thursday and more expensive on a Friday. On your return trip to Key West, you should consider flying back on a Wednesday, and avoid Sundays for better deals.

Find deals

Good to know

Cheapest flight$74
Flight from Key West to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Key West to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Key West to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Key West to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Key West to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the evening, when round-trip flights cost $518 on average. Morning departures are around 10% more expensive than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $571.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Key West to the following destinations at these prices or less: Charlotte $253 one-way - $328 round-trip

Reviews of the top airline flying from Key West to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Key West to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11048 reviews
7.5Boarding
8.0Crew
7.2Comfort
6.9Entertainment
6.5Food
Airline reviews

I appreciated that it was on time, safe and professional. I didn’t like that I wasn’t in a place where I had a window at my window seat. It would have been nice to know that in advance. If it was mentioned in the ticketing, I didn’t notice it.

8.0 ExcellentJolene, Dec 2025
GNV - DFW
Read more American Airlines reviews

I appreciated that it was on time, safe and professional. I didn’t like that I wasn’t in a place where I had a window at my window seat. It would have been nice to know that in advance. If it was mentioned in the ticketing, I didn’t notice it.

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so didn't have any food

I enjoyed the extra leg room compared to other airlines. The first stewards made my daughter’s birthday special by giving her an extra snack. Then the last one coming home from Chicago to Appleton made our night really enjoyable Thanks for making our trip enjoyable

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

We had 3 flights. 1 & 2 were on the same plane but we had to de-board just to re-board 30 mins later. That may have been due to a crew change though. Our 3rd flight had a couple “maintenance” issues that held us up. They were quickly resolved but it took forever for someone to bring the paperwork needed so we could leave. Apparently there was a computer glitch so a driver had to bring a physical copy. It delayed us about 1 1/2 hrs. The flights themselves were smooth & no problems. For boarding, I don’t know why they don’t start with the back of the plane & move forward. It would eliminate the back up from people trying to find their seats & put their bags in the overhead bins. Unless you’re on an overseas flight, there is no food, you get a beverage & either a small bag of pretzels or a biscuit cookie. Take your own food or snacks of you want something more.

Lost bag and 2 days no word leaving for cruise no clothes or stuff

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

Internet was a bit expensive and did not work ask that week otherwise a good flight

Everything you need to know for your flight from Key West to South Carolina

Information on your arrival and departure airports

Key West (EYW)