STL - STI

$543 Find Cheap Flights from St. Louis to Santiago de los Caballeros

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Santiago de los Caballeros departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago de los Caballeros

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Santiago de los Caballeros, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Santiago de los Caballeros, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$543
Delta
Tue 3/17Wed 3/25
STL - STI • 2 stops
Cheapest one-way
Multiple Airlines
Sat 1/31
STL - STI • multi-stop
Top airlines
Delta
Cheapest • from $543 (round-trip)
American Airlines
Best reviews • 7.2 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago de los Caballeros!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Santiago de los Caballeros (STL-STI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Santiago de los Caballeros that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Santiago de los Caballeros

Tue, Mar 17 - Wed, Mar 25
Delta Logo
6:32 am - 7:15 pm
STL
-
STI
11h 43m
2 stops
Delta Logo
6:33 am - 4:32 pm
STI
-
STL
10h 59m
2 stops
$543Delta
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
5:15 am - 8:29 pm
STL
-
STI
14h 14m
1 stop
American Airlines Logo
1:30 pm - 10:32 am
STI
-
STL
22h 02m
1 stop
$545American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
10:20 am - 8:29 pm
STL
-
STI
9h 09m
2 stops
American Airlines Logo
7:00 am - 11:58 pm
STI
-
STL
17h 58m
1 stop
$549American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
11:22 am - 8:29 pm
STL
-
STI
8h 07m
1 stop
American Airlines Logo
1:30 pm - 11:58 pm
STI
-
STL
11h 28m
1 stop
$553American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
8:00 am - 8:29 pm
STL
-
STI
11h 29m
2 stops
American Airlines Logo
1:30 pm - 11:58 pm
STI
-
STL
11h 28m
1 stop
$558American Airlines
Thu, May 28 - Tue, Jun 2
American Airlines Logo
6:20 am - 9:01 pm
STL
-
STI
13h 41m
2 stops
American Airlines Logo
7:00 am - 9:01 pm
STI
-
STL
15h 01m
2 stops
$569American Airlines
Thu, May 28 - Tue, Jun 2
Delta Logo
5:00 pm - 12:05 pm
STL
-
STI
18h 05m
1 stop
Delta Logo
8:59 pm - 1:17 pm
STI
-
STL
17h 18m
2 stops
$583Delta
Sat, Feb 21 - Sat, Feb 28
American Airlines Logo
6:36 pm - 1:31 pm
STL
-
STI
16h 55m
2 stops
American Airlines Logo
2:31 pm - 8:35 am
STI
-
STL
20h 04m
2 stops
$598American Airlines
Sat, Feb 21 - Sat, Feb 28
American Airlines Logo
11:06 am - 9:30 pm
STL
-
STI
8h 24m
1 stop
American Airlines Logo
2:31 pm - 8:35 am
STI
-
STL
20h 04m
2 stops
$608American Airlines
Sat, May 23 - Thu, May 28
Delta Logo
5:30 pm - 12:05 pm
STL
-
STI
17h 35m
2 stops
Delta Logo
6:10 am - 4:40 pm
STI
-
STL
11h 30m
1 stop
$613Delta
Booking Insights

KAYAK's insights & trends for St. Louis to Santiago de los Caballeros flights

Get data-powered insights and trends into flights from St. Louis to Santiago de los Caballeros to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from St. Louis to Santiago de los Caballeros?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from St. Louis to Santiago de los Caballeros were found on Delta ($543) and American Airlines ($545).

Good to know

Low seasonOctober
Cheapest flight$543
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from St. Louis to Santiago de los Caballeros

When to book flights from St. Louis to Santiago de los Caballeros

Are your dates flexible? Find out the best times to travel from St. Louis to Santiago de los Caballeros based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Santiago de los Caballeros

  • What is the cheapest flight from St. Louis to Santiago de los Caballeros?

    In the last 3 days, the lowest price for a flight from St. Louis to Santiago de los Caballeros was $543 for a round-trip ticket.

  • Do I need a passport to fly between St. Louis and Santiago de los Caballeros?

    Yes, you'll most likely have to show a valid passport before boarding the plane in St. Louis and on arrival in Santiago de los Caballeros.

  • Which aircraft models fly most regularly from St. Louis to Santiago de los Caballeros?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Santiago de los Caballeros?

    Star Alliance, and oneworld are the airline alliances operating flights between St. Louis and Santiago de los Caballeros, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Santiago de los Caballeros, United Airlines or American Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Santiago de los Caballeros are United Airlines and American Airlines. With an average price for the route of $609 and an overall rating of 7.4, United Airlines is the most popular choice. American Airlines is also a great choice for the route, with an average price of $699 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from St. Louis to Santiago de los Caballeros?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Santiago de los Caballeros.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Santiago de los Caballeros?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago de los Caballeros from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Santiago de los Caballeros?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago de los Caballeros with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and STI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Santiago de los Caballeros?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago de los Caballeros from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from St. Louis to Santiago de los Caballeros

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Santiago de los Caballeros. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Santiago de los Caballeros? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11213 reviews
7.5Boarding
6.9Entertainment
8.0Crew
6.4Food
7.2Comfort
Airline reviews

Update to handle the delay was very bad, crews no smiles or welcome or thanks. Don’t care attitude

2.0 MediocreManikandan, Jan 2026
DFW - ORD
Read more American Airlines reviews

Update to handle the delay was very bad, crews no smiles or welcome or thanks. Don’t care attitude

It would be nice to have some low carb options in the snacks.

I was trying to take 2 one and a half hour one way trips and I experienced almost 20 delays over the course of those two trips. Only a few of them were due to weather the rest was disorganization

No gates avail at DFW so our incoming had to wait 30 mins for a plane to push back because they Had mechanical. We boarded 90 mins delayed and then we had a mechanical. Come on American…do better. Also at my seat the tray table had not been cleaned. Floor had not been cleaned. But captain and flight Att were very picture and apologetic.

Crew was helpful and cheerful especially when they had no refreshments to work with. The plane was never serviced and had nothing but limited water and coffee onboard. For the price point, a concern of services.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

Flight was canceled. I asked to be rerouted to OKC and then took an Uber.

AA did not allow to board a flight because my connecting flight from DFW had been canceled. I got on another flight to another city. No service on the plane and I did not use their entertainment system.

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

Everything you need to know for your flight from St. Louis to Santiago de los Caballeros

Information on your arrival and departure airports