PTY - VVI

$534 Find Cheap Flights from Panama City to Santa Cruz de la Sierra

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Santa Cruz de la Sierra departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

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Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$534
Overall average: $433
Copa Airlines
Fri 5/1Fri 5/22
PTY - VVI • Non-stop
Cheapest one-way
$319
Typical prices: $262-$492
Avianca
Tue 1/27
PTY - VVI • 1 stop
When to book
5 weeks
in advance
Our data shows that travelers who book at least 5 weeks in advance save around 29% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
April
Cheapest • 23% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santa Cruz de la Sierra!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to Santa Cruz de la Sierra (PTY-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Santa Cruz de la Sierra

Fri, May 1 - Fri, May 22
Copa Airlines Logo
4:40 pm - 10:38 pm
PTY
-
VVI
4h 58mnonstop
Copa Airlines Logo
1:12 am - 5:04 am
VVI
-
PTY
4h 52mnonstop
$534Copa Airlines
Sun, Jul 5 - Mon, Jul 13
Copa Airlines Logo
4:40 pm - 10:40 pm
PTY
-
VVI
5h 00mnonstop
Copa Airlines Logo
11:47 am - 3:39 pm
VVI
-
PTY
4h 52mnonstop
$552Copa Airlines
Wed, Jul 1 - Tue, Jul 7
Copa Airlines Logo
9:43 pm - 3:35 am
PTY
-
VVI
4h 52mnonstop
Copa Airlines Logo
1:12 am - 5:04 am
VVI
-
PTY
4h 52mnonstop
$570Copa Airlines
Tue, Jul 7 - Tue, Jul 14
Copa Airlines Logo
4:40 pm - 10:40 pm
PTY
-
VVI
5h 00mnonstop
Copa Airlines Logo
11:47 am - 3:39 pm
VVI
-
PTY
4h 52mnonstop
$574Copa Airlines
Tue, Apr 7 - Sun, Apr 26
Avianca Logo
5:25 pm - 1:50 am
PTY
-
VVI
7h 25m
1 stop
Avianca Logo
2:55 am - 4:30 pm
VVI
-
PTY
14h 35m
1 stop
$594Avianca
Thu, Jan 29 - Sun, Feb 15
Avianca Logo
9:45 am - 2:35 am
PTY
-
VVI
15h 50m
1 stop
Avianca Logo
3:40 am - 4:55 pm
VVI
-
PTY
14h 15m
1 stop
$696Avianca
Thu, Jan 29 - Sun, Feb 8
Avianca Logo
9:45 am - 2:35 am
PTY
-
VVI
15h 50m
1 stop
Avianca Logo
3:40 am - 4:55 pm
VVI
-
PTY
14h 15m
1 stop
$716Avianca
Tue, Apr 7 - Sun, Apr 26
Multiple Airlines Logo
10:05 pm - 8:10 am
PTY
-
VVI
33h 05m
2 stops
Multiple Airlines Logo
2:55 am - 10:10 am
VVI
-
PTY
8h 15m
1 stop
$756Multiple Airlines
Mon, Apr 6 - Sun, Apr 26
Multiple Airlines Logo
3:25 am - 5:45 pm
PTY
-
VVI
13h 20m
3 stops
Multiple Airlines Logo
2:55 am - 10:10 am
VVI
-
PTY
8h 15m
1 stop
$757Multiple Airlines
Thu, Jan 29 - Fri, Feb 6
Avianca Logo
5:50 pm - 2:35 am
PTY
-
VVI
7h 45m
1 stop
Avianca Logo
3:40 am - 4:55 pm
VVI
-
PTY
14h 15m
1 stop
$758Avianca
Booking Insights

KAYAK's insights & trends for Panama City to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from Panama City to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Panama City to Santa Cruz de la Sierra?

The average price of all round-trip flights from Panama City to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santa Cruz de la Sierra on a Sunday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Panama City to Santa Cruz de la Sierra. For your return ticket, we recommend flying on a Saturday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Panama City to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Santa Cruz de la Sierra is April, where tickets cost $433 (return) on average. On the other hand, the most expensive months are January and December, where the average cost of round-trip tickets is $719 and $667 respectively.

Can I save money by flying with a layover from Panama City to Santa Cruz de la Sierra?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $533, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Panama City to Santa Cruz de la Sierra?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Panama City to Santa Cruz de la Sierra, you should book around 5 weeks before departure, which saves you about 29% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 5 weeks before departure.

Find deals

Good to know

Low seasonJune
Cheapest flight$319
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly with an average 18% increase in price.
Flight from Panama City to Santa Cruz de la Sierra

When to book flights from Panama City to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from Panama City to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Santa Cruz de la Sierra

  • What is the cheapest flight from Panama City to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from Panama City to Santa Cruz de la Sierra was $319 for a one-way ticket and $534 for a round-trip.

  • Do I need a passport to fly between Panama City and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from Panama City.

  • Which aircraft models fly most regularly from Panama City to Santa Cruz de la Sierra?

    The Boeing 737-800 is the aircraft model that flies most regularly on the Panama City to Santa Cruz de la Sierra flight route.

  • Which airline alliances offer flights from Panama City to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between Panama City and Santa Cruz de la Sierra.

  • On which days can I fly direct from Panama City to Santa Cruz de la Sierra?

    There are nonstop flights from Panama City to Santa Cruz de la Sierra on a daily basis.

  • How does KAYAK find such low prices on flights from Panama City to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to Panama City with another airline. Booking your flights between Panama City and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Panama City to Santa Cruz de la Sierra?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl.
Find which airlines fly direct from Panama City Tocumen Intl Airport to Santa Cruz de la Sierra Viru Viru Intl Airport, which days they fly and book direct flights.

Direct departures

Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines

Copa Airlines

Wednesday

Copa Airlines

Copa Airlines

Thursday

Copa Airlines

Copa Airlines

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more direct flights

Direct returns

Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines

Copa Airlines

Wednesday

Copa Airlines

Copa Airlines

Thursday

Copa Airlines

Copa Airlines

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more direct flights

Reviews of the top airline flying from Panama City to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1559 reviews
7.8Boarding
8.1Crew
6.8Entertainment
7.4Comfort
6.8Food
Airline reviews

A lot things happened in this trip.The fly should be less stress.

6.0 GoodIrma, Jan 2026
PTY - MIA
Read more Copa Airlines reviews

A lot things happened in this trip.The fly should be less stress.

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

Some of the Air hostesses are not that friendly. Need improvement

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

Everything you need to know for your flight from Panama City to Santa Cruz de la Sierra

Information on your arrival and departure airports

Panama City (PTY)
Santa Cruz de la Sierra (VVI)