$523 Find Cheap Flights from Panama City to Santa Cruz de la Sierra - Compare and Save

Among airlines operating Panama City to Santa Cruz de la Sierra flights:

• Copa Airlines: offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Only Copa Airlines operates flights between Panama City and Santa Cruz de la Sierra.

Flights from Panama City to Santa Cruz de la Sierra usually depart from Panama City Tocumen Intl (PTY) and arrive at Santa Cruz de la Sierra Viru Viru Intl (VVI).

Here are some options for this route, based on selected ticket types and cabin classes:

• Copa Airlines: a cabin bag and a checked bag in Economy Class

Bag allowance can vary by ticket type, cabin class, route and airline, so travelers should check the fare details before booking.

Two cabin classes are available on flights from Panama City to Santa Cruz de la Sierra:

• Economy Class
• Business Class

On this route, nonstop flights are cheaper than layover options on average. Nonstop fares average $631 round-trip, compared to $697 via a layover through Bogotá El Dorado (BOG).

The Boeing 737-800 family is used most often on this route, operated mainly by Copa Airlines. Other aircraft seen on the route include Boeing 737 MAX 8 variants.

Most connecting flights from Panama City to Santa Cruz de la Sierra pass through Bogotá El Dorado (BOG), which handles 100% of one-stop traffic on this route. Other layover airports each see under 5%.

On the Panama City to Santa Cruz de la Sierra route, being flexible with your departure day can save you up to 19%. Sunday is the cheapest day at $592 round-trip on average, while Wednesday is the most expensive at $722: a $130 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

A flight is considered delayed when it departs 15 minutes or more after its scheduled time. This is the standard used by the US Department of Transportation and most airline industry reporting. On the Panama City to Santa Cruz de la Sierra route, 9% of flights were delayed in the past 3 months, with delays averaging 2 hours 26 minutes.

Afternoon is the busiest departure period on Panama City to Santa Cruz de la Sierra flights, with 50% of flights leaving in that window. Night departures account for 50%, morning flights for 0%, and evening flights for 0%.

These are the earliest and latest flight times available from Panama City to Santa Cruz de la Sierra:

• Earliest: departs at 4:40 pm and lands at 9:40 pm
• Latest: departs at 9:45 pm and lands at 2:45 am.

The flight takes about 5h 00m.

Last-minute fares on this route - booked within 2 weeks of departure - run 21% above the route average of $642. Book 22 weeks before departure for the lowest fares.

A nonstop flight from Panama City to Santa Cruz de la Sierra takes 5h 00m, covering 2,152 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $621 to $2,441. That means the highest observed fare was about 4x higher than the lowest one.

One-way fares from Panama City to Santa Cruz de la Sierra are currently higher than usual. Average one-way flight prices are about $581, which is 45% above the typical average for this route.

Copa Airlines is the only airline operating Panama City to Santa Cruz de la Sierra flights. 91% of its flights are on time.

Afternoon flights have the fewest delays on this route. Delays tend to pile up throughout the day as one late flight pushes the next, so earlier departures are usually more reliable.

Santa Cruz de la Sierra is 1 hour ahead of Panama City (Bolivia Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Round-trip flights from Panama City to Santa Cruz de la Sierra range from $543 to $741, with an average of $642 over the past 12 months. Anything below $543 counts as a good deal.