PTY - VVI

$467 Find Cheap Flights from Panama City to Santa Cruz de la Sierra

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Santa Cruz de la Sierra departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to Santa Cruz de la Sierra (PTY-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Santa Cruz de la Sierra

Fri, Nov 21 - Fri, Nov 28
Copa Airlines Logo
9:43 pm - 3:36 amPTY-VVI
4h 53mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$467Copa Airlines
Find Deal
Wed, Dec 10 - Tue, Dec 23
Avianca Logo
5:55 pm - 2:35 amPTY-VVI
7h 40m1 stop
Avianca Logo
3:40 am - 2:00 pmVVI-PTY
11h 20m1 stop
$529Avianca
Find Deal
Fri, Nov 21 - Sat, Nov 29
Copa Airlines Logo
9:43 pm - 3:36 amPTY-VVI
4h 53mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$530Copa Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 27
Copa Airlines Logo
4:40 pm - 10:46 pmPTY-VVI
5h 06mnonstop
Copa Airlines Logo
11:40 am - 3:35 pmVVI-PTY
4h 55mnonstop
$546Copa Airlines
Find Deal
Mon, Nov 3 - Wed, Nov 5
Copa Airlines Logo
4:40 pm - 10:46 pmPTY-VVI
5h 06mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$551Copa Airlines
Find Deal
Tue, Dec 9 - Fri, Dec 26
Copa Airlines Logo
4:40 pm - 10:46 pmPTY-VVI
5h 06mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$567Copa Airlines
Find Deal
Mon, Oct 13 - Tue, Oct 21
Copa Airlines Logo
9:43 pm - 3:36 amPTY-VVI
4h 53mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$594Copa Airlines
Find Deal
Wed, Dec 10 - Tue, Dec 23
Copa Airlines Logo
9:43 pm - 3:36 amPTY-VVI
4h 53mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$614Copa Airlines
Find Deal
Thu, Nov 20 - Sat, Nov 29
Avianca Logo
2:55 am - 2:35 amPTY-VVI
22h 40m1 stop
Avianca Logo
3:40 am - 1:00 amVVI-PTY
22h 20m1 stop
$647Avianca
Find Deal
Tue, Dec 9 - Wed, Dec 24
Multiple Airlines Logo
2:55 am - 2:35 amPTY-VVI
22h 40m1 stop
Multiple Airlines Logo
6:25 pm - 8:50 amVVI-PTY
15h 25m2 stops
$717Multiple Airlines
Find Deal

Everything you should know

Top airlines
Copa Airlines
Cheapest • from $467 (round-trip)
Copa Airlines
Best reviews • 7.6 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
5 weeks
in advance
Our data shows that travelers who book at least 5 weeks in advance save around 31% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
April
Cheapest • 32% price drop
May
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$467
Typical prices: $367-543
Copa Airlines
Fri 11/21Fri 11/28
PTY - VVI • Non-stop
Cheapest non-stop
$467
Typical prices: $410-570
Copa Airlines
Mon 11/3Thu 11/6
PTY - VVI • Non-stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santa Cruz de la Sierra!
Booking Insights

KAYAK's insights & trends for Panama City to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from Panama City to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to Santa Cruz de la Sierra?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to Santa Cruz de la Sierra departing in November.

What’s the cheapest day of the week to fly from Panama City to Santa Cruz de la Sierra?

The average price of all round-trip flights from Panama City to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santa Cruz de la Sierra on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Panama City to Santa Cruz de la Sierra. For your return ticket, we recommend flying on a Monday and avoiding Fridays for the best deals.

What is the cheapest month to fly from Panama City to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Santa Cruz de la Sierra is April, where tickets cost $360 (return) on average. On the other hand, the most expensive months are January and July, where the average cost of round-trip tickets is $672 and $635 respectively.

Can I save money by flying with a layover from Panama City to Santa Cruz de la Sierra?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $678, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Panama City to Santa Cruz de la Sierra?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Panama City to Santa Cruz de la Sierra, you should book around 5 weeks before departure, which saves you about 31% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJune
Cheapest flight$467
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 20% lower on average.
Flight from Panama City to Santa Cruz de la Sierra

When to book flights from Panama City to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from Panama City to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Santa Cruz de la Sierra

  • What is the cheapest flight from Panama City to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from Panama City to Santa Cruz de la Sierra was $671 for a one-way ticket and $467 for a round-trip.

  • Do I need a passport to fly between Panama City and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from Panama City.

  • Which aircraft models fly most regularly from Panama City to Santa Cruz de la Sierra?

    The Boeing 737-800 is the aircraft model that flies most regularly on the Panama City to Santa Cruz de la Sierra flight route.

  • Which airline alliances offer flights from Panama City to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between Panama City and Santa Cruz de la Sierra.

  • On which days can I fly direct from Panama City to Santa Cruz de la Sierra?

    There are nonstop flights from Panama City to Santa Cruz de la Sierra on a daily basis.

  • Which is the best airline for flights from Panama City to Santa Cruz de la Sierra, Copa Airlines or Avianca?

    The two airlines most popular with KAYAK users for flights from Panama City to Santa Cruz de la Sierra are Copa Airlines and Avianca. With an average price for the route of $600 and an overall rating of 7.6, Copa Airlines is the most popular choice. Avianca is also a great choice for the route, with an average price of $363 and an overall rating of 6.7.

  • How does KAYAK find such low prices on flights from Panama City to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to Panama City with another airline. Booking your flights between Panama City and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Panama City to Santa Cruz de la Sierra?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl.
Find which airlines fly direct from Panama City Tocumen Intl Airport to Santa Cruz de la Sierra Viru Viru Intl Airport, which days they fly and book direct flights.

Direct departures

Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines

Copa Airlines

Wednesday

Copa Airlines, BoA

Copa Airlines, BoA

Thursday

Copa Airlines

Copa Airlines

Friday

Copa Airlines, BoA

Copa Airlines, BoA

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more direct flights

Direct returns

Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines, BoA

Copa Airlines, BoA

Wednesday

Copa Airlines

Copa Airlines

Thursday

Copa Airlines, BoA

Copa Airlines, BoA

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more direct flights

Reviews of the top airlines flying from Panama City to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1542 reviews
7.4Comfort
6.8Food
8.1Crew
6.8Entertainment
7.8Boarding
Airline reviews

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

10.0 ExcellentMichael, Sep 2025PBM - PTY
Read more Copa Airlines reviews

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

I selected first class expecting excetional service. It was mediocre at best. The food service was cold, meal choices was poor and on one leg they did provide dessert. I did enjoy the lay day seat but the movies were old and nothing current. Boarding the plane is always hot. So boarding is quite warm until your in the air. I took a small personal air fan. Update the meals and movies.

Did upgrade, travel in business it was great (more room I could sleep)

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

Boarding, crew were excellent, food was ok and entertainment need to improve

Usb plugs for charging your phone does not work in every flight. uncomfortable chairs even in higher categories.

The check in is the only positive thing in Avianca. The seat is the most uncomfortable I have traveled, the distance is minimal.

No food, terms when selling are not clear. To pricy for the service in general

It was horrible. My experience with Avianca. I didn’t know it was Pakistan international Airlines but anyway, whatever it is it is bad horrible you guys need to upgrade everything in those planes. And you guys charge $130 for a carry-on did they wanna let me in with my carry-on that I travel everywhere with the luggage you guys are such a dog thank you

Seats are very tight even in Plus, no complimentary snacks or beverage

Late departure. When the flight arrived in Medellin the plane sat at the gate for 20 minutes waiting for a bus for us to get off the plane.

I receive a service for what I pay, so it is fair.

A few years ago long flights 6 hours or so used to have video screens and they offered ear phones. The food cart used to come and drinks. Now absolutely nothing. Avianca is as bad as Spirit Airlines. Avianca will now be my last choice when booking my next flight.

Business class seats did not lie flat. There was only powdered milk for your coffee....in Business Class!! Food was good.

Everything you need to know for your flight from Panama City to Santa Cruz de la Sierra

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