PTY - VVI

$544 Find Cheap Flights from Panama City to Santa Cruz de la Sierra

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Santa Cruz de la Sierra departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Cruz de la Sierra

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Santa Cruz de la Sierra, as well as popular online travel agencies
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Flights Deals

Cheap Flights from Panama City to Santa Cruz de la Sierra (PTY-VVI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Santa Cruz de la Sierra that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Santa Cruz de la Sierra

Wed, Aug 13 - Tue, Aug 26
Avianca Logo
5:25 pm - 1:50 amPTY-VVI
7h 25m1 stop
Avianca Logo
2:55 am - 4:30 pmVVI-PTY
14h 35m1 stop
$544Avianca
Find Deal
Mon, Dec 1 - Sun, Dec 14
Avianca Logo
11:25 am - 2:00 amPTY-VVI
13h 35m1 stop
Avianca Logo
3:05 am - 4:30 pmVVI-PTY
14h 25m1 stop
$545Avianca
Find Deal
Fri, Oct 3 - Sat, Oct 4
Avianca Logo
5:25 pm - 1:50 amPTY-VVI
7h 25m1 stop
Avianca Logo
2:55 am - 10:10 amVVI-PTY
8h 15m1 stop
$566Avianca
Find Deal
Wed, Aug 13 - Tue, Aug 26
Copa Airlines Logo
9:43 pm - 3:37 amPTY-VVI
4h 54mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$571Copa Airlines
Find Deal
Wed, Dec 10 - Tue, Dec 23
Copa Airlines Logo
3:38 pm - 9:44 pmPTY-VVI
5h 06mnonstop
Copa Airlines Logo
12:55 am - 4:50 amVVI-PTY
4h 55mnonstop
$587Copa Airlines
Find Deal
Sat, Aug 9 - Sat, Aug 16
Copa Airlines Logo
4:17 pm - 10:19 pmPTY-VVI
5h 02mnonstop
Copa Airlines Logo
1:09 am - 5:04 amVVI-PTY
4h 55mnonstop
$593Copa Airlines
Find Deal
Thu, Dec 11 - Sat, Jan 3
Copa Airlines Logo
3:38 pm - 9:44 pmPTY-VVI
5h 06mnonstop
Copa Airlines Logo
12:55 am - 4:50 amVVI-PTY
4h 55mnonstop
$603Copa Airlines
Find Deal
Fri, Aug 22 - Thu, Aug 28
Copa Airlines Logo
9:43 pm - 3:37 amPTY-VVI
4h 54mnonstop
Copa Airlines Logo
12:15 pm - 4:10 pmVVI-PTY
4h 55mnonstop
$614Copa Airlines
Find Deal
Fri, Aug 15 - Sat, Aug 30
Copa Airlines Logo
9:43 pm - 3:39 amPTY-VVI
4h 56mnonstop
Copa Airlines Logo
12:15 pm - 4:10 pmVVI-PTY
4h 55mnonstop
$616Copa Airlines
Find Deal
Fri, Aug 15 - Sat, Aug 30
 Logo
11:05 am - 1:50 amPTY-VVI
13h 45m1 stop
 Logo
7:00 pm - 10:10 amVVI-PTY
16h 10m2 stops
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KAYAK's insights & trends for Panama City to Santa Cruz de la Sierra flights

Get data-powered insights and trends into flights from Panama City to Santa Cruz de la Sierra to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Panama City to Santa Cruz de la Sierra?

The average price of all round-trip flights from Panama City to Santa Cruz de la Sierra clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santa Cruz de la Sierra on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Panama City to Santa Cruz de la Sierra. For your return ticket, we recommend flying on a Monday and avoiding Fridays for the best deals.

What is the cheapest month to fly from Panama City to Santa Cruz de la Sierra?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Santa Cruz de la Sierra is April, where tickets cost $354 (return) on average. On the other hand, the most expensive months are June and January, where the average cost of round-trip tickets is $908 and $630 respectively.

Can I save money by flying with a layover from Panama City to Santa Cruz de la Sierra?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $646, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Panama City to Santa Cruz de la Sierra?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Panama City to Santa Cruz de la Sierra, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Panama City to Santa Cruz de la Sierra, you should book around 5 weeks before departure. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJanuary
High seasonMay
Cheapest flight$544
Best time to beat the crowds but there is an average 23% increase in price.
Most popular time to fly and prices are also 18% lower on average.
Flight from Panama City to Santa Cruz de la Sierra

When to book flights from Panama City to Santa Cruz de la Sierra

Are your dates flexible? Find out the best times to travel from Panama City to Santa Cruz de la Sierra based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Santa Cruz de la Sierra

  • What is the cheapest flight from Panama City to Santa Cruz de la Sierra?

    In the last 3 days, the lowest price for a flight from Panama City to Santa Cruz de la Sierra was $660 for a one-way ticket and $544 for a round-trip.

  • Do I need a passport to fly between Panama City and Santa Cruz de la Sierra?

    Yes, you’ll need a passport to travel to Santa Cruz de la Sierra from Panama City.

  • Which aircraft models fly most regularly from Panama City to Santa Cruz de la Sierra?

    The Boeing 737-800 is the aircraft model that flies most regularly on the Panama City to Santa Cruz de la Sierra flight route.

  • Which airline alliances offer flights from Panama City to Santa Cruz de la Sierra?

    Star Alliance is the only airline alliance operating flights between Panama City and Santa Cruz de la Sierra.

  • On which days can I fly direct from Panama City to Santa Cruz de la Sierra?

    There are nonstop flights from Panama City to Santa Cruz de la Sierra on a daily basis.

  • Which is the best airline for flights from Panama City to Santa Cruz de la Sierra, Copa Airlines or Avianca?

    The two airlines most popular with KAYAK users for flights from Panama City to Santa Cruz de la Sierra are Copa Airlines and Avianca. With an average price for the route of $544 and an overall rating of 7.5, Copa Airlines is the most popular choice. Avianca is also a great choice for the route, with an average price of $358 and an overall rating of 6.7.

  • How does KAYAK find such low prices on flights from Panama City to Santa Cruz de la Sierra?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Santa Cruz de la Sierra.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Santa Cruz de la Sierra?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Cruz de la Sierra from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Santa Cruz de la Sierra?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Cruz de la Sierra with an airline and back to Panama City with another airline. Booking your flights between Panama City and VVI can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Santa Cruz de la Sierra?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Cruz de la Sierra from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Panama City to Santa Cruz de la Sierra

  • Looking for a cheap flight? 25% of our users found flights on this route for $645 or less round-trip.

Prefer to fly direct from Panama City to Santa Cruz de la Sierra?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl.
Find which airlines fly direct from Panama City Tocumen Intl Airport to Santa Cruz de la Sierra Viru Viru Intl Airport, which days they fly and book direct flights.

Direct departures

Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl

Monday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Tuesday

BoA, Copa Airlines, United Airlines

BoA, Copa Airlines, +1 more

Wednesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Thursday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Sunday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

See more direct flights

Direct returns

Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl

Monday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Tuesday

BoA, Copa Airlines, United Airlines

BoA, Copa Airlines, +1 more

Wednesday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Thursday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Friday

Copa Airlines, United Airlines

Copa Airlines, United Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

BoA, Copa Airlines, United Airlines

BoA, Copa Airlines, +1 more

See more direct flights

Reviews of the top airlines flying from Panama City to Santa Cruz de la Sierra

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Santa Cruz de la Sierra. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Santa Cruz de la Sierra? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1455 reviews
6.8Entertainment
7.8Boarding
6.8Food
7.4Comfort
8.1Crew
Airline reviews

It was ok. However, the food was quite poor since I don't eat pasta.

6.0 GoodFernando, Jun 2025PTY - MVD
Read more Copa Airlines reviews

It was ok. However, the food was quite poor since I don't eat pasta.

Tell people to remain in their seats during the meal/beverage distribution. Enforce boarding by group numbers. No one was checking. Tell people to turn their electronics speakers off. Bigger cups for drinks.

There was no individual at the front check in when I arrived. I waited for at least 15 minutes and walked around asking security/janitors if they could help and they did not have a solution. So I had to take my checked bag through security and they threw away some of my items. I ended up making it to the gate only a few minutes before it closed due to my waiting for an agent at check in.

The flight was delayed twice and I could not speak with anyone at the airport about checking in. The phone number to Copa - the customer service agents were polite. They are just limited at helping because they are not at the airport

We were in transit from Lima (flight at 1.10am) and we were in stand by in our flight from Panama to Washington. We wait from 4.30 am to 18.30pm in the Airport. The company give us 2 x 15 dollars for eat during the day and a personnal travel voucher of 400 dollars each. Do they buy food one time something in the Airport ??? And one of us live in France so the voucher is not usable. More than 24 hours travel !! And our place were near the toilets, with 8 children around us. The boy behind my seat stamped his feet on my back all the flight. Really Wonder full ! So we are totally unhappy with our travel. Thanks Copa Airlines....

My flight delayed and i misss the connection they send me to orlando no to tampa i have to pay a uber to my house

I upgraded myself to Business Class at the last minute so I had a DREAMS window seat. Seeing as I've never flown Business before everything was novel and fun for me and it made the 7 hour flight much more enjoyable for sure.

The flight was delayed about 4 hours without any explanation. No wifi or entertainment at all on planes. Had to pay for checked bags I was allowed according to reservations.

It was good, plane is a bit older so seats are somewhat flat

Great from check in all the way to the end. Very happy with Copa

Seats are very tight even in Plus, no complimentary snacks or beverage

Late departure. When the flight arrived in Medellin the plane sat at the gate for 20 minutes waiting for a bus for us to get off the plane.

I receive a service for what I pay, so it is fair.

A few years ago long flights 6 hours or so used to have video screens and they offered ear phones. The food cart used to come and drinks. Now absolutely nothing. Avianca is as bad as Spirit Airlines. Avianca will now be my last choice when booking my next flight.

Terrible, We had to stay in Bogota for two days due to weather but the airline did not provide for the same day flight. Only two days later

Business class seats did not lie flat. There was only powdered milk for your coffee....in Business Class!! Food was good.

The seats were very uncomfortable. I would have upgrade or got different flight if I knew. I usually sleep in the plane but I couldn’t sleep at all. Very uncomfortable. Also no food or drink everything was to purchase, and that’s u usual for international flight.

COP 7,000 for a cup of mediocre coffee. I thought I was on Spirit Airlines for a minute. Otherwise the flight was fine. Nothing exceptional to report.

I paid over $200 for seat selection for these flights and I was still stuck on long international flights in seats that do not recline and do not have the head support cushion. At this point basically all airlines have those for all seats, and this really took me by surprise and made me not ever want to travel on Avianca. The Kayak agent who called me for the seat selection (Donovan) was courteous, but it seems the system for this doesn't work. I was offered seat selection, for the $200+, but without being able to see what I was selecting, with no guarantee where I'd be...and then I still ended up in terrible seats. On my way to, and especially after, a very intense business trip, the seat situation really soured my experience.

I enjoyed it! In that case, I should have been offered this choice. On my first trip to Miami, I was asked to pay $320 for my luggage just for getting it totally broken. I cannot accept this situation at all!!!!

Everything you need to know for your flight from Panama City to Santa Cruz de la Sierra

Information on your arrival and departure airports

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