$280 Find Cheap Flights from Santa Fe to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Fe to South Carolina departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to South Carolina, as well as popular online travel agencies
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Cheap Flights from Santa Fe to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$319
Greenville
Greenville2 stops$379
Charlotte
Charlotte1 stop$309
Charleston
Charleston2 stops$319
Greenville
Greenville2 stops$379
Charlotte
Charlotte1 stop$309

Book Cheap Santa Fe to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Fe to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to South Carolina

Fri, Jan 16 - Mon, Jan 19
American Airlines Logo
5:05 pm - 12:40 am
SAF
-
CLT
5h 35m1 stop
American Airlines Logo
5:23 am - 9:57 am
CLT
-
SAF
6h 34m1 stop
$309American Airlines
Fri, Feb 13 - Fri, Feb 20
American Airlines Logo
6:33 pm - 8:33 am
SAF
-
CHS
12h 00m2 stops
American Airlines Logo
3:45 pm - 8:49 pm
CHS
-
SAF
7h 04m1 stop
$319American Airlines
Fri, Feb 13 - Fri, Feb 20
American Airlines Logo
6:33 pm - 8:33 am
SAF
-
CHS
12h 00m2 stops
American Airlines Logo
6:33 am - 3:02 pm
CHS
-
SAF
10h 29m2 stops
$324American Airlines
Fri, Feb 13 - Fri, Feb 20
American Airlines Logo
6:15 am - 2:52 pm
SAF
-
CHS
6h 37m1 stop
American Airlines Logo
3:45 pm - 8:49 pm
CHS
-
SAF
7h 04m1 stop
$334American Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
10:45 am - 11:44 pm
SAF
-
CHS
10h 59m2 stops
United Airlines Logo
4:01 pm - 8:47 pm
CHS
-
SAF
6h 46m1 stop
$374United Airlines
Sat, Jan 24 - Tue, Jan 27
United Airlines Logo
7:00 am - 9:36 pm
SAF
-
SAV
12h 36m2 stops
United Airlines Logo
3:54 pm - 8:47 pm
SAV
-
SAF
6h 53m1 stop
$374United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
10:45 am - 11:44 pm
SAF
-
CHS
10h 59m2 stops
United Airlines Logo
11:00 am - 8:47 pm
CHS
-
SAF
11h 47m2 stops
$379United Airlines
Sat, Jan 24 - Tue, Jan 27
United Airlines Logo
7:00 am - 10:46 pm
SAF
-
SAV
13h 46m2 stops
United Airlines Logo
10:10 am - 8:47 pm
SAV
-
SAF
12h 37m2 stops
$379United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
10:45 am - 11:48 pm
SAF
-
GSP
11h 03m2 stops
United Airlines Logo
10:00 am - 8:47 pm
GSP
-
SAF
12h 47m2 stops
$379United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
7:00 am - 3:05 pm
SAF
-
CHS
6h 05m1 stop
United Airlines Logo
4:01 pm - 8:47 pm
CHS
-
SAF
6h 46m1 stop
$389United Airlines
Booking Insights

KAYAK's insights & trends for Santa Fe to South Carolina flights

Get data-powered insights and trends into flights from Santa Fe to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Santa Fe to South Carolina?

The average price of all round-trip flights from Santa Fe to South Carolina clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South Carolina on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Santa Fe to South Carolina. For your return ticket, we recommend flying on a Tuesday and avoiding Mondays for the best deals.

Find deals

Good to know

Cheapest flight$280
Flight from Santa Fe to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Santa Fe to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Fe to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Fe to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santa Fe to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Fe to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santa Fe to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Fe to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santa Fe to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $480 on average. Morning departures are around 21% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $606.

Reviews of the top airline flying from Santa Fe to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Santa Fe to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Fe to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11055 reviews
7.5Boarding
6.9Entertainment
8.0Crew
7.2Comfort
6.5Food
Airline reviews

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

8.0 ExcellentAustin, Dec 2025
ECP - CLT
Read more American Airlines reviews

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

Flight was on time is the only good thing. Person loading the plane called 1-6 to board at the same time, made it chaotic. Plane was too small for even putting backpacks in overhead. Seat for normal sized people were too small. The WIFI didn't work. When we landed had to wait because not enough ground crew.

Did not understand a single word the attendant said on the pa system. I was glad it was not an emergency.

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Everything you need to know for your flight from Santa Fe to South Carolina

Information on your arrival and departure airports

Santa Fe (SAF)