$229 Find Cheap Flights from Santa Fe to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Fe to South Carolina departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Santa Fe to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$264
Greenville
Greenville1 stop$424
Charlotte
Charlotte1 stop$731
Charleston
Charleston1 stop$264
Greenville
Greenville1 stop$424
Charlotte
Charlotte1 stop$731

Book Cheap Santa Fe to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Fe to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to South Carolina

Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
6:15 am - 1:36 pmSAF-CHS
5h 21m1 stop
American Airlines Logo
2:26 pm - 9:01 pmCHS-SAF
8h 35m1 stop
$264American Airlines
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Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
6:15 am - 1:33 pmSAF-CHS
5h 18m1 stop
American Airlines Logo
9:42 am - 4:29 pmCHS-SAF
8h 47m2 stops
$274American Airlines
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Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
6:15 am - 7:04 pmSAF-CHS
10h 49m2 stops
American Airlines Logo
9:42 am - 4:29 pmCHS-SAF
8h 47m2 stops
$279American Airlines
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Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
6:15 am - 1:33 pmSAF-CHS
5h 18m1 stop
American Airlines Logo
7:02 am - 1:35 pmCHS-SAF
8h 33m1 stop
$314American Airlines
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Tue, Aug 26 - Sat, Aug 30
American Airlines Logo
7:15 am - 4:49 pmSAF-GSP
7h 34m1 stop
American Airlines Logo
5:39 pm - 9:59 pmGSP-SAF
6h 20m1 stop
$424American Airlines
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Tue, Aug 26 - Sat, Aug 30
American Airlines Logo
6:15 am - 5:32 pmSAF-GSP
9h 17m2 stops
American Airlines Logo
5:39 pm - 9:59 pmGSP-SAF
6h 20m1 stop
$434American Airlines
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Tue, Aug 26 - Sat, Aug 30
American Airlines Logo
9:51 am - 11:35 pmSAF-GSP
11h 44m2 stops
American Airlines Logo
6:00 am - 3:02 pmGSP-SAF
11h 02m2 stops
$439American Airlines
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Tue, Aug 26 - Sat, Aug 30
American Airlines Logo
9:51 am - 11:01 pmSAF-GSP
11h 10m2 stops
American Airlines Logo
8:49 am - 4:21 pmGSP-SAF
9h 32m2 stops
$469American Airlines
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Sat, Sep 13 - Sat, Sep 20
United Airlines Logo
7:00 am - 3:24 pmSAF-SAV
6h 24m1 stop
United Airlines Logo
4:45 pm - 9:23 amSAV-SAF
18h 38m2 stops
$523United Airlines
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Sun, Aug 31 - Thu, Sep 4
United Airlines Logo
7:00 am - 3:10 pmSAF-CHS
6h 10m1 stop
United Airlines Logo
4:12 pm - 10:00 pmCHS-SAF
7h 48m1 stop
$731United Airlines
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Booking Insights

KAYAK's insights & trends for Santa Fe to South Carolina flights

Get data-powered insights and trends into flights from Santa Fe to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Santa Fe to South Carolina?

The average price of all round-trip flights from Santa Fe to South Carolina clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South Carolina on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Santa Fe to South Carolina. For your return ticket, we recommend flying on a Tuesday and avoiding Mondays for the best deals.

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Good to know

Cheapest flight$229
Flight from Santa Fe to Greenville

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Santa Fe to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Fe to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Fe to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santa Fe to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Fe to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santa Fe to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Fe to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santa Fe to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $480 on average. Morning departures are around 21% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $606.

Reviews of the top airline flying from Santa Fe to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Santa Fe to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Fe to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 10000 reviews
7.5Boarding
6.9Entertainment
6.5Food
8.0Crew
7.2Comfort
Airline reviews

Food was ok, but not as good as I have had before on AA.

10.0 ExcellentAnonymous, Aug 2025MIA - ORD
Read more American Airlines reviews

Food was ok, but not as good as I have had before on AA.

No issues. They did change our gate FOUR times in about 30 minutes which was mildly annoying but the flight was fine.

Great flight. No issues at all. I still think boarding could be more efficient but otherwise, a good experience.

Pretty good. The food was just mediocre, the boarding and crew were good.

The comfort of the seats was great, the crew eased my child’s anxieties and the fact that I had full cans of my beverage choice was great.

My flight got switched and my prepaid bag didnt transfer over properly so I paid to check ANOTHER BAG. I was placed in a middle seat and it was just miserable. At least it was a bulkhead row so I had legroom. The flight just never seem3d to end

4 hours late, including over +1 hour waiting in plane to take off. Baggage left behind too.

Sat on the ground in Cincinnati for 50 minutes before deplaning

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Crew should be nicer and emphatic with customers. Same cookies as the past 20 years. Seat are ok and the plane was clean though it was delayed.

Everything you need to know for your flight from Santa Fe to South Carolina

Information on your arrival and departure airports

Santa Fe (SAF)

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