SDQ - TYS

$349 Find Cheap Flights from Santo Domingo to Knoxville - Compare and Save

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Everything you should know

Cheapest round-trip
$499
Typical prices: $540-$708
Multiple Airlines
Mon 1/22Thu 1/25
SDQ - TYS • 1 stop
Cheapest one-way
$349
Typical prices: $377-$467
Multiple Airlines
Fri 11/16
SDQ - TYS • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Santo Domingo and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
April
Cheapest • 10% price drop
April
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Fort Lauderdale (FLL)
Cheapest • Avg $421 (round-trip)
Miami (MIA)
Shortest trip • 6h 57m (one-way)
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Insights
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Flight Deals

Cheap Flights from Santo Domingo to Knoxville (SDQ-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santo Domingo to Knoxville

Fri, Jan 22 - Mon, Jan 25
Multiple Airlines Logo
6:10 am - 1:07 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
7h 57m1 stop Newark
Multiple Airlines Logo
8:10 am - 5:25 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 15m1 stop Newark
$499Multiple Airlines
Thu, Jan 21 - Mon, Jan 25
Multiple Airlines Logo
5:02 pm - 1:44 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
21h 42m2 stops Miami Philadelphia
Multiple Airlines Logo
8:10 am - 5:25 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 15m1 stop Newark
$514Multiple Airlines
Fri, Jan 22 - Fri, Jan 29
Multiple Airlines Logo
6:10 am - 1:07 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
7h 57m1 stop Newark
Multiple Airlines Logo
8:10 am - 5:25 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 15m1 stop Newark
$519Multiple Airlines
Thu, Jan 21 - Fri, Jan 29
Multiple Airlines Logo
5:02 pm - 1:44 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
21h 42m2 stops Miami Philadelphia
Multiple Airlines Logo
8:10 am - 5:25 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 15m1 stop Newark
$534Multiple Airlines
Wed, Jan 13 - Mon, Jan 18
American Airlines Logo
6:00 am - 6:18 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
13h 18m2 stops Miami Washington, D.C. Reagan-National
American Airlines Logo
5:15 pm - 9:56 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
15h 41m2 stops Charlotte Douglas Miami
$711American Airlines
Wed, Jan 13 - Mon, Jan 18
American Airlines Logo
6:00 am - 6:18 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
13h 18m2 stops Miami Washington, D.C. Reagan-National
American Airlines Logo
7:37 pm - 9:56 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
13h 19m1 stop Miami
$711American Airlines
Wed, Jan 13 - Mon, Jan 18
American Airlines Logo
6:00 am - 11:59 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
18h 59m1 stop Miami
American Airlines Logo
7:37 pm - 9:56 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
13h 19m1 stop Miami
$719American Airlines
Thu, Jan 21 - Wed, Jan 27
Delta Logo
3:49 pm - 11:58 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 am - 2:24 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
8h 09m1 stop Atlanta Hartsfield-Jackson
$785Delta
Thu, Jan 21 - Mon, Jan 25
Delta Logo
3:49 pm - 11:58 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 am - 2:24 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
8h 09m1 stop Atlanta Hartsfield-Jackson
$785Delta
Thu, Jan 21 - Sun, Jan 31
Delta Logo
3:49 pm - 11:58 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 am - 2:24 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
8h 09m1 stop Atlanta Hartsfield-Jackson
$785Delta
Booking Insights

Price, demand and travel trends for Santo Domingo to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What's the cheapest day of the week to fly from Santo Domingo to Knoxville?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Santo Domingo to Knoxville. It’s 11% cheaper than the average day, while Tuesday is the most expensive, with prices 425% higher.

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Key details for Santo Domingo to Knoxville flights

Low season

July

Cheapest flight

$349
Beat the crowds with an average 88% drop in travelers.
The most popular month to fly with an average 113% increase in travelers.
One-way flight from Santo Domingo to Knoxville

When to book flights from Santo Domingo to Knoxville

Are your dates flexible? Find out the best times to travel from Santo Domingo to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santo Domingo to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Santo Domingo to Knoxville?

    Only Economy Class is available on flights from Santo Domingo to Knoxville.

  • How long is a flight from Santo Domingo to Knoxville?

    A nonstop flight from Santo Domingo to Knoxville takes 00m, covering 1,484 miles.

  • Do I need a passport to fly from Santo Domingo to Knoxville?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Santo Domingo to Knoxville flight?

    Round-trip flights from Santo Domingo to Knoxville range from $540 to $708, with an average of $603 over the past 12 months. Anything below $540 counts as a good deal.

  • Have flight prices from Santo Domingo to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $499 to $2,405. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Santo Domingo to Knoxville looking right now?

    One-way fares from Santo Domingo to Knoxville are currently higher than usual. Average one-way flight prices are about $618, which is 52% above the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $82 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Santo Domingo to Knoxville?

    Flights from Santo Domingo to Knoxville usually depart from Santo Domingo Las Americas (SDQ) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Santo Domingo to Knoxville pass through?

    One-stop flights from Santo Domingo to Knoxville most commonly connect through:

    • Miami (MIA) - 78% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 14% of one-stop connections
    • Fort Lauderdale (FLL) - 4% of one-stop connections
    • Philadelphia (PHL) - 3% of one-stop connections

  • Can I save money by using flexible dates for flights from Santo Domingo to Knoxville?

    Yes. Flexible dates can save you up to 83% on flights from Santo Domingo to Knoxville. Saturday is the cheapest departure day at $540 round-trip on average, while Tuesday is the most expensive at $3,170, a difference of $2,630.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Santo Domingo to Knoxville?

    Flying via Miami (MIA) gives the shortest average 1-stop total travel time at 6h 57m, compared with 7h 39m via Atlanta Hartsfield-Jackson (ATL) and 8h 50m via Philadelphia (PHL).

  • What is the time difference between Santo Domingo and Knoxville?

    Knoxville is 1 hour behind Santo Domingo (Eastern Time vs Atlantic Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Santo Domingo to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Tuesday. On this route, Saturday flights average $540, about $2,630 less than Tuesday fares (83% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Santo Domingo to Knoxville trip for April. Fares historically average $540 round-trip in that month - typically $483 less than the most expensive month, which is February (based on the last 12 months).

More options for your flight from Santo Domingo to Knoxville

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