SDQ - TYS

$242 Find Cheap Flights from Santo Domingo to Knoxville - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$499
Typical prices: $550-$592
Multiple Airlines
Wed 10/7Wed 10/14
SDQ - TYS • 2 stops
Cheapest one-way
$242
Multiple Airlines
Sat 10/3
SDQ - TYS • 2 stops
Top airlines
Cheapest • from $628 (round-trip)
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santo Domingo and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $573 (round-trip)
Shortest trip • 7h 34m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santo Domingo to Knoxville (SDQ-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santo Domingo to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santo Domingo to Knoxville

Wed, Oct 7 - Wed, Oct 14
Multiple Airlines Logo
12:41 pm - 11:11 am
SDQ
-
TYS
22h 30m
2 stops
Multiple Airlines Logo
8:10 am - 4:30 pm
TYS
-
SDQ
8h 20m
1 stop
$499Multiple Airlines
Sat, Aug 15 - Sun, Aug 23
Multiple Airlines Logo
2:55 pm - 8:36 am
SDQ
-
TYS
41h 41m
2 stops
Multiple Airlines Logo
9:30 am - 2:35 am
TYS
-
SDQ
17h 05m
1 stop
$503Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
Multiple Airlines Logo
3:35 pm - 6:04 pm
SDQ
-
TYS
26h 29m
1 stop
Multiple Airlines Logo
6:54 pm - 9:45 pm
TYS
-
SDQ
26h 51m
1 stop
$511Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
Multiple Airlines Logo
3:30 pm - 7:05 pm
SDQ
-
TYS
27h 35m
2 stops
Multiple Airlines Logo
9:10 am - 5:29 am
TYS
-
SDQ
20h 19m
1 stop
$609Multiple Airlines
Wed, Oct 7 - Wed, Oct 14
American Airlines Logo
2:00 pm - 9:54 pm
SDQ
-
TYS
7h 54m
1 stop
American Airlines Logo
7:13 am - 7:55 pm
TYS
-
SDQ
12h 42m
1 stop
$628American Airlines
Wed, Oct 7 - Wed, Oct 14
American Airlines Logo
11:30 am - 11:30 pm
SDQ
-
TYS
12h 00m
2 stops
American Airlines Logo
8:37 pm - 10:50 am
TYS
-
SDQ
14h 13m
2 stops
$632American Airlines
Sun, Nov 8 - Thu, Nov 19
Multiple Airlines Logo
3:30 pm - 1:31 pm
SDQ
-
TYS
23h 01m
2 stops
Multiple Airlines Logo
6:30 am - 2:35 am
TYS
-
SDQ
19h 05m
1 stop
$646Multiple Airlines
Wed, Oct 14 - Sat, Oct 31
American Airlines Logo
2:00 pm - 9:54 pm
SDQ
-
TYS
7h 54m
1 stop
American Airlines Logo
6:30 pm - 2:00 pm
TYS
-
SDQ
19h 30m
1 stop
$648American Airlines
Tue, Aug 4 - Sun, Aug 16
American Airlines Logo
7:00 am - 11:59 pm
SDQ
-
TYS
16h 59m
1 stop
American Airlines Logo
6:00 am - 3:24 pm
TYS
-
SDQ
9h 24m
1 stop
$650American Airlines
Wed, Oct 14 - Sat, Oct 31
American Airlines Logo
11:30 am - 9:56 pm
SDQ
-
TYS
10h 26m
2 stops
American Airlines Logo
6:30 pm - 2:00 pm
TYS
-
SDQ
19h 30m
1 stop
$653American Airlines
Booking Insights

KAYAK's insights & trends for Santo Domingo to Knoxville flights

Get data-powered insights and trends into flights from Santo Domingo to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santo Domingo to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santo Domingo to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santo Domingo to Knoxville is June, where tickets cost $0 (return) on average. On the other hand, the most expensive months are February and January, where the average cost of round-trip tickets is $1,023 and $780 respectively.

Good to know

Low seasonSeptember
Cheapest flight$242
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from Santo Domingo to Knoxville

When to book flights from Santo Domingo to Knoxville

Are your dates flexible? Find out the best times to travel from Santo Domingo to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Santo Domingo to Knoxville

  • What is the cheapest flight from Santo Domingo to Knoxville?

    In the last 5 days, the lowest price for a flight from Santo Domingo to Knoxville was $242 for a one-way ticket and $499 for a round-trip.

  • Do I need a passport to fly between Santo Domingo and Knoxville?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Santo Domingo and on arrival in Knoxville.

  • Which aircraft models fly most regularly from Santo Domingo to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santo Domingo to Knoxville?

    oneworld is the only airline alliance operating flights between Santo Domingo and Knoxville.

  • How does KAYAK find such low prices on flights from Santo Domingo to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santo Domingo to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santo Domingo to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Santo Domingo is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santo Domingo to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Santo Domingo with another airline. Booking your flights between Santo Domingo and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santo Domingo to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Santo Domingo up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santo Domingo to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Santo Domingo to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santo Domingo to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11723 reviews
7.2Comfort
6.4Food
7.5Boarding
7.9Crew
6.8Entertainment
Airline reviews

Rudest flight attendants ever, waited over 20 for light to be answered and it never was then tried to flag down an attendant who said someone else would come, just needed water to take some medicine Food bad

4.0 OkayLisa, Jun 2026
LHR - PHL
Read more American Airlines reviews

Rudest flight attendants ever, waited over 20 for light to be answered and it never was then tried to flag down an attendant who said someone else would come, just needed water to take some medicine Food bad

I had the best flight crew I have ever experienced in all my years flying with AA. I would specially like to thank Till Tatum/96038 for her kindness professionalism and outstanding service! My son turned 8 years old one day before our flight and she went out of her way to make him feel so special. We will never forget this flight! The whole crew made a special card for Frankie’s bday and it really touched our hearts. He will never forget it and neither will we! Thank you with all our hearts! We hope to be on more flights with Till Tatum and this amazing crew.

Hydraulic leak caused the flight to be cancelled. Auto system scheduled us on a 3 am flight. Wevhsedvrebook on the app and hit schedules later in the afternoon. Our luggage per gate and ticket agent would be rescanned and put in our new flight. Did not happen. Our luggage stayed in hsv. Baggage claim in wash dc unable to help. We filed a claim. Several emails about our luggage were in conflict with one another. Called as baggage and was on hold 30 minutes. Oscar said one of 2 was out fir delivery then cancelled. About 45 minutes later both pieces were delivered. Their system is suspect

My entertainment unit kept locking up and had to be restarted multiple times. Also those commercials for Budapest and Ralph Laureen. Come on those were stuff only those who can afford the outrageous fees of first and business class would be interested in.. And the fact you have no military discount is not good either,

I was not clear if food was offered or not.

Flight cancelled. Twice. And no communication. No gate agent. Went past boarding time and had to go and see email from AA. Airport communication was bad

I love the e fact that the staff communicated swiftly when my flight was delayed and gate number changed

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

Delayed and horrible communication and sat on flight for an hour before taking off

I was a Wheelchair Assist’ passenger on a London Heathrow to PHL flight yesterday. The process of getting me and my carry-on bag from the ticket counter to the gate was not good at all. It was the worst in my 5 years of experience using this service offered by American. The Philadelphia ‘Wheelchair Assist’ service was, and always has been Excellent! Not so at Heathrow. I was handed off to three different wheelchair drivers; had to sit in a very dingy holding area for 30 minutes while waiting for our gate change announcement; got crammed into a overloaded service vehicle to take me from the holding area to the gate ; was dumped at the end of the line of already-boarding passengers with my heavy carryon and no one helped me up the ramp way at the gate to board the plane. Overall it was a miserable experience!

Everything you need to know for your flight from Santo Domingo to Knoxville

Information on your arrival and departure airports