$149 Find Cheap Flights from Santo Domingo to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santo Domingo to South Carolina departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to South Carolina, as well as popular online travel agencies
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Cheap Flights from Santo Domingo to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$325
Myrtle Beach
Myrtle Beach2 stops$557
Charlotte
Charlotte1 stop$298
Charleston
Charleston2 stops$325
Myrtle Beach
Myrtle Beach2 stops$557
Charlotte
Charlotte1 stop$298

Book Cheap Santo Domingo to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santo Domingo to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santo Domingo to South Carolina

Thu, Feb 5 - Wed, Feb 18
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
5:55 am - 2:20 pm
CLT
-
SDQ
7h 25m1 stop
$298Spirit Airlines
Mon, Jan 19 - Mon, Jan 26
Multiple Airlines Logo
12:15 pm - 12:40 am
SDQ
-
CLT
37h 25m2 stops
Multiple Airlines Logo
5:24 pm - 2:27 pm
CLT
-
SDQ
20h 03m1 stop
$305Multiple Airlines
Tue, Feb 10 - Tue, Feb 17
Multiple Airlines Logo
1:41 pm - 1:51 pm
SDQ
-
CLT
25h 10m1 stop
Multiple Airlines Logo
1:15 pm - 4:29 pm
CLT
-
SDQ
26h 14m2 stops
$310Multiple Airlines
Tue, Feb 10 - Tue, Feb 17
Multiple Airlines Logo
1:41 pm - 1:51 pm
SDQ
-
CLT
25h 10m1 stop
Multiple Airlines Logo
7:00 am - 9:45 pm
CLT
-
SDQ
13h 45m1 stop
$311Multiple Airlines
Tue, Feb 3 - Sat, Feb 7
Delta Logo
7:30 am - 8:55 pm
SDQ
-
CHS
14h 25m2 stops
Delta Logo
9:00 am - 12:30 am
CHS
-
SDQ
14h 30m2 stops
$325Delta
Thu, Jan 29 - Mon, Feb 2
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
JetBlue Logo
10:10 am - 8:25 pm
CHS
-
SDQ
9h 15m1 stop
$344JetBlue
Thu, Feb 12 - Thu, Feb 19
American Airlines Logo
7:00 am - 7:35 pm
SDQ
-
CHS
13h 35m2 stops
American Airlines Logo
11:58 am - 11:53 pm
CHS
-
SDQ
10h 55m2 stops
$349American Airlines
Fri, May 1 - Mon, May 4
American Airlines Logo
5:55 pm - 10:24 am
SDQ
-
CHS
16h 29m1 stop
American Airlines Logo
11:04 am - 4:55 pm
CHS
-
SDQ
5h 51m1 stop
$351American Airlines
Thu, Jan 29 - Mon, Feb 2
United Airlines Logo
2:53 pm - 11:44 pm
SDQ
-
CHS
9h 51m1 stop
United Airlines Logo
6:00 am - 3:06 pm
CHS
-
SDQ
8h 06m1 stop
$368United Airlines
Fri, May 1 - Mon, May 4
JetBlue Logo
10:35 am - 7:13 pm
SDQ
-
CHS
8h 38m1 stop
JetBlue Logo
3:30 pm - 1:19 am
CHS
-
SDQ
9h 49m1 stop
$421JetBlue
Booking Insights

KAYAK's insights & trends for Santo Domingo to South Carolina flights

Get data-powered insights and trends into flights from Santo Domingo to South Carolina to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Santo Domingo and South Carolina?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Santo Domingo to South Carolina.

There is just one airline that flies from Santo Domingo to South Carolina direct and that is Delta. The best round-trip deal found from Delta for the route is to Greenville (GSP) and costs $494.

Which airlines provide the cheapest flights from Santo Domingo to South Carolina?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Santo Domingo to South Carolina were found on Delta ($325) and JetBlue ($344).

Find deals

Good to know

Low seasonMarch
Cheapest flight$149
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly with an average 19% increase in price.
Flight from Santo Domingo to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Santo Domingo to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santo Domingo to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santo Domingo to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santo Domingo to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santo Domingo to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santo Domingo to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santo Domingo to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santo Domingo to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santo Domingo to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Santo Domingo to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santo Domingo to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8014 reviews
8.1Boarding
7.9Comfort
8.5Crew
7.9Entertainment
7.3Food
Airline reviews

Flight was delayed several times. At one point, they "pulled back" 15 minutes from the delayed boarding and sent a text saying we would board sooner than previously advised. The flight then was delayed again. And when we boarded, there was an unspecified technical issue which had us waiting in the plane for about an hour.

6.0 GoodDorothy, Dec 2025
DTW - DCA
Read more Delta reviews

Flight was delayed several times. At one point, they "pulled back" 15 minutes from the delayed boarding and sent a text saying we would board sooner than previously advised. The flight then was delayed again. And when we boarded, there was an unspecified technical issue which had us waiting in the plane for about an hour.

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The gate attendants and the crew were terrible. Because of high winds, they needed to carry more fuel, so they had to get volunteers to take the next flight at 6 am the next day. They did a terrible job of it - our flight ended up taking off just under 3 hours of the scheduled time. I hope to never fly Delta again.

Did not realize internet screen was hidden between seats and no info printed!!!!

I went to washroom twice and once there was no toilet seat cover and the other no toilet paper at all. I don't think it was ever replenished or checked before we boarded as it was very early on in the flight.

2 of the seats in row 31 the entertainment system was not working, and one seat the tray table did not go all the way down. Flight arrived early and departed on time which was great.

Very good flight crew and very nice people staff were incredible especially the gate agent

Waited at the usual crowded gate at DCA where one ends up standing up because there aren't enough seats.

The flight was delayed for about 2 hrs. Other than it, it was good.

Everything you need to know for your flight from Santo Domingo to South Carolina

Information on your arrival and departure airports

Santo Domingo (SDQ)