$163 Find Cheap Flights from Santo Domingo to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santo Domingo to South Carolina departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to South Carolina, as well as popular online travel agencies
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Cheap Flights from Santo Domingo to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$325
Myrtle Beach
Myrtle Beach1 stop$467
Charlotte
Charlotte1 stop$309
Charleston
Charleston1 stop$325
Myrtle Beach
Myrtle Beach1 stop$467
Charlotte
Charlotte1 stop$309

Book Cheap Santo Domingo to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santo Domingo to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santo Domingo to South Carolina

Sat, Jan 17 - Sat, Jan 24
Multiple Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Multiple Airlines Logo
9:50 pm - 11:20 am
CLT
-
SDQ
12h 30m1 stop
$309Multiple Airlines
Wed, Jan 21 - Sun, Jan 25
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$314Spirit Airlines
Fri, Jan 23 - Sun, Feb 1
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$316Spirit Airlines
Tue, Dec 23 - Sun, Jan 4
Frontier Logo
12:35 pm - 8:29 pm
SDQ
-
CLT
8h 54m1 stop
Frontier Logo
9:33 pm - 11:20 am
CLT
-
SDQ
12h 47m1 stop
$340Frontier
Fri, May 1 - Mon, May 4
American Airlines Logo
3:25 pm - 10:42 pm
SDQ
-
CHS
7h 17m1 stop
American Airlines Logo
8:08 pm - 10:50 am
CHS
-
SDQ
14h 42m1 stop
$344American Airlines
Fri, Jan 23 - Sun, Feb 1
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$352Spirit Airlines
Tue, Dec 23 - Sun, Jan 4
Frontier Logo
12:35 pm - 8:29 pm
SDQ
-
CLT
8h 54m1 stop
Frontier Logo
10:26 am - 7:27 pm
CLT
-
SDQ
8h 01m1 stop
$354Frontier
Thu, Jan 22 - Sun, Feb 1
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$356Spirit Airlines
Thu, Jan 29 - Mon, Feb 2
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
JetBlue Logo
10:10 am - 8:21 pm
CHS
-
SDQ
9h 11m1 stop
$421JetBlue
Fri, May 1 - Mon, May 4
American Airlines Logo
1:28 pm - 10:42 pm
SDQ
-
CHS
9h 14m1 stop
American Airlines Logo
5:32 am - 12:35 pm
CHS
-
SDQ
7h 03m2 stops
$455American Airlines
Booking Insights

KAYAK's insights & trends for Santo Domingo to South Carolina flights

Get data-powered insights and trends into flights from Santo Domingo to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Santo Domingo to South Carolina?

The average price of all round-trip flights from Santo Domingo to South Carolina clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South Carolina on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Tuesday is the most expensive day to fly from Santo Domingo to South Carolina. For your return ticket, we recommend flying on a Wednesday and avoiding Mondays for the best deals.

Find deals

Good to know

Low seasonMarch
Cheapest flight$163
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly with an average 19% increase in price.
Flight from Santo Domingo to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Santo Domingo to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santo Domingo to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santo Domingo to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santo Domingo to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santo Domingo to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santo Domingo to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santo Domingo to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santo Domingo to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally at night, when round-trip flights cost $365 on average. Morning departures are around 38% more expensive than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $542.

Reviews of the top airline flying from Santo Domingo to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Santo Domingo to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santo Domingo to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8007 reviews
7.9Entertainment
7.9Comfort
7.3Food
8.1Boarding
8.5Crew
Airline reviews

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

6.0 GoodJeff, Dec 2025
JFK - MIA
Read more Delta reviews

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

For some reason, I couldn't choose my seat. The airline gave me a seat when I got there. Not happy about that. Otherwise, everything else was great!

Left on time, a bit delayed due to headwinds most of the trip.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

Everything you need to know for your flight from Santo Domingo to South Carolina

Information on your arrival and departure airports

Santo Domingo (SDQ)