$335 Find Cheap Flights from Sioux Falls to South America - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Sioux Falls to South America departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Sioux Falls to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Sioux Falls to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Sioux Falls to South America

Mon, Jan 11 - Mon, Jan 18
Delta Logo
5:25 am - 4:20 am
FSD
-
SCL
19h 55m
2 stops
Delta Logo
11:48 pm - 10:12 pm
SCL
-
FSD
25h 24m
2 stops
$947Delta
Thu, Aug 27 - Thu, Sep 3
Multiple Airlines Logo
5:30 am - 1:25 pm
FSD
-
SCL
30h 55m
3 stops
Multiple Airlines Logo
11:00 pm - 11:22 pm
SCL
-
FSD
25h 22m
2 stops
$952Multiple Airlines
Thu, Aug 27 - Wed, Sep 2
LATAM Airlines Logo
5:30 am - 7:15 am
FSD
-
SCL
24h 45m
1 stop
LATAM Airlines Logo
12:40 am - 7:59 pm
SCL
-
FSD
20h 19m
2 stops
$962LATAM Airlines
Sun, Sep 6 - Tue, Sep 22
American Airlines Logo
6:06 pm - 9:00 am
FSD
-
GRU
12h 54m
1 stop
American Airlines Logo
11:15 pm - 6:11 pm
GRU
-
FSD
20h 56m
2 stops
$971American Airlines
Thu, Aug 27 - Thu, Sep 3
LATAM Airlines Logo
5:30 am - 1:25 pm
FSD
-
SCL
30h 55m
3 stops
LATAM Airlines Logo
8:30 am - 7:59 pm
SCL
-
FSD
36h 29m
3 stops
$983LATAM Airlines
Sun, Sep 6 - Tue, Sep 22
LATAM Airlines Logo
5:30 am - 5:40 am
FSD
-
GRU
22h 10m
1 stop
LATAM Airlines Logo
10:50 pm - 7:49 pm
GRU
-
FSD
22h 59m
1 stop
$996LATAM Airlines
Mon, Jan 11 - Mon, Jan 18
LATAM Airlines Logo
5:25 am - 10:41 am
FSD
-
SCL
50h 16m
3 stops
LATAM Airlines Logo
10:20 am - 10:12 pm
SCL
-
FSD
38h 52m
2 stops
$1,012LATAM Airlines
Sat, Nov 14 - Fri, Nov 27
United Airlines Logo
3:03 pm - 7:15 am
FSD
-
GRU
13h 12m
1 stop
United Airlines Logo
9:30 pm - 9:45 pm
GRU
-
FSD
27h 15m
1 stop
$1,036United Airlines
Sat, Nov 14 - Fri, Nov 27
United Airlines Logo
11:10 am - 10:20 am
FSD
-
GRU
20h 10m
2 stops
United Airlines Logo
9:30 pm - 9:45 pm
GRU
-
FSD
27h 15m
1 stop
$1,040United Airlines
Mon, Jan 11 - Mon, Jan 18
American Airlines Logo
7:00 am - 7:45 am
FSD
-
SCL
21h 45m
1 stop
American Airlines Logo
11:45 pm - 4:59 pm
SCL
-
FSD
20h 14m
1 stop
$1,047American Airlines
Booking Insights

KAYAK's insights & trends for Sioux Falls to South America flights

Get data-powered insights and trends into flights from Sioux Falls to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Sioux Falls to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Sioux Falls to South America were found on Delta ($947) and American Airlines ($971).

Good to know

Cheapest flight

$335
Flight from Sioux Falls to Sao Paulo

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Sioux Falls to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Sioux Falls to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Sioux Falls to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Sioux Falls to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Sioux Falls to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Sioux Falls to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Sioux Falls to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Sioux Falls to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Sioux Falls to South America

 
Need help choosing which airline to fly with from Sioux Falls to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11827 reviews
7.9Crew
6.4Food
7.2Comfort
7.5Boarding
6.8Entertainment
Airline reviews

This flight was of course delayed because American cannot have flights that are not delayed.

4.0 OkayStephen, Jul 2026
DFW - BHM
Read more American Airlines reviews

This flight was of course delayed because American cannot have flights that are not delayed.

Well, true to American Airlines, both of my flights were delayed. But it’s a good thing that American is so consistently incompetent because if the first flight was delayed in the second flight was on time then I might’ve had a problem..

I sat at the airport all night from 8 pm until midnight. The airline kept delaying the flight. They also kept moving us to different gates - 4 times. Then they told us we didn’t have a pilot so we had to wait. Then they cancelled the flight at midnight! I ended up having to rent a car to drive home. So i ended up not even being able to fly on the flight i paid for. Ridiculous, and no agents could help at all. I will not ever book this flight.

Not great. I understand delays happen due to weather and crew issues, but it was unacceptable that no agents were available at the counters inside the airport for customer service or help getting on a standby list. The app was not helpful either. I stood in line for an hour waiting for someone to show up at the gate to help me get on a standby flight. Customer care does not seem to be a priority.

Mechanical delay > Crew Time out. No communication to passengers. Crew time out was positioned as a surprise (even though it must have been know at the time of boarding that the crew would time out.

Not much space for someone 6 feet high in normal economy seat. My knee hurt

Long delays to board due to mechanical issues with plane.

Aside from the little delay, overall was flight good. Made it safely. Thanks!

I had a carry on and a personal bag. I put my personal item under my seat and on way to the seat I put my bag up. I usually close my eyes and rest as I was on call for last 36 hours. I heard very loud announcements that someone needs to identify their bag. Pretty sure it was not mine until the hostess pointed out my jacket details attached to the bag. I asked why she got my bag out. I got berated and did not want to create a scene. But this person needs to be talked to.

Other than being delayed 5.5 hours and having to get a hotel because I missed my connecting flight, it was an okay flight. No in-flight Wi-Fi or entertainment.

Everything you need to know for your flight to South America

Information on your arrival and departure airports