$475 Find Cheap Flights from Sioux Falls to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Sioux Falls to South America departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Sioux Falls to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Sioux Falls to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Sioux Falls to South America

Fri, Oct 2 - Sat, Oct 24
Multiple Airlines Logo
1:20 pm - 8:00 pm
FSD
-
GRU
28h 40m
2 stops
Multiple Airlines Logo
8:30 pm - 10:12 pm
GRU
-
FSD
27h 42m
2 stops
$981Multiple Airlines
Tue, Jul 7 - Tue, Aug 4
LATAM Airlines Logo
5:20 am - 5:05 am
FSD
-
GRU
45h 45m
2 stops
LATAM Airlines Logo
12:55 pm - 7:59 pm
GRU
-
FSD
33h 04m
2 stops
$1,040LATAM Airlines
Fri, Oct 2 - Sat, Oct 24
United Airlines Logo
7:40 am - 9:30 am
FSD
-
GRU
23h 50m
2 stops
United Airlines Logo
9:00 pm - 9:43 pm
GRU
-
FSD
50h 43m
2 stops
$1,049United Airlines
Fri, Oct 2 - Sat, Oct 24
United Airlines Logo
6:20 pm - 9:35 am
FSD
-
GRU
13h 15m
1 stop
United Airlines Logo
9:30 pm - 2:35 pm
GRU
-
FSD
19h 05m
2 stops
$1,077United Airlines
Fri, Oct 2 - Sat, Oct 24
American Airlines Logo
12:25 pm - 9:00 am
FSD
-
GRU
18h 35m
1 stop
American Airlines Logo
10:30 pm - 4:40 pm
GRU
-
FSD
20h 10m
2 stops
$1,101American Airlines
Tue, Jul 7 - Tue, Aug 4
United Airlines Logo
7:35 am - 9:40 am
FSD
-
GRU
24h 05m
1 stop
United Airlines Logo
9:50 pm - 4:23 pm
GRU
-
FSD
20h 33m
2 stops
$1,158United Airlines
Tue, Jul 7 - Tue, Aug 4
United Airlines Logo
7:35 am - 9:40 am
FSD
-
GRU
24h 05m
1 stop
United Airlines Logo
10:20 pm - 11:31 pm
GRU
-
FSD
27h 11m
1 stop
$1,162United Airlines
Mon, Jun 15 - Mon, Jun 22
LATAM Airlines Logo
5:24 am - 6:55 am
FSD
-
SCL
24h 31m
2 stops
LATAM Airlines Logo
11:00 pm - 7:59 pm
SCL
-
FSD
21h 59m
2 stops
$1,180LATAM Airlines
Mon, Jun 15 - Mon, Jun 22
Delta Logo
5:24 am - 7:15 am
FSD
-
SCL
24h 51m
1 stop
Delta Logo
11:00 pm - 7:59 pm
SCL
-
FSD
21h 59m
2 stops
$1,185Delta
Fri, Oct 2 - Sat, Oct 24
American Airlines Logo
12:25 pm - 9:00 am
FSD
-
GRU
18h 35m
1 stop
American Airlines Logo
10:00 pm - 11:46 am
GRU
-
FSD
15h 46m
1 stop
$1,256American Airlines
Booking Insights

KAYAK's insights & trends for Sioux Falls to South America flights

Get data-powered insights and trends into flights from Sioux Falls to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Sioux Falls to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 7 days.

In the past 7 days, the cheapest round-trip tickets from Sioux Falls to South America were found on LATAM Airlines ($1,040) and United Airlines ($1,049).

Good to know

Cheapest flight$475
Flight from Sioux Falls to Santiago

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Sioux Falls to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Sioux Falls to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Sioux Falls to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Sioux Falls to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Sioux Falls to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Sioux Falls to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Sioux Falls to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Sioux Falls to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Sioux Falls to South America

 
Need help choosing which airline to fly with from Sioux Falls to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11644 reviews
6.4Food
7.5Boarding
6.9Entertainment
7.9Crew
7.2Comfort
Airline reviews

Cancelled flight. Still waiting to get home for grand daughter’s graduation .

2.0 MediocreDebbie A, May 2026
BTV - PHL
Read more American Airlines reviews

Cancelled flight. Still waiting to get home for grand daughter’s graduation .

So overall the flight was just average and nothing special. They overbooked some of the flights and they ended up running out of overhead storage space so we had to check our carry-ons which wasn't terrible but we were inconvenienced because of the second connecting flight with a long layover we couldn't get our bags until the final destination. Most of the flight attendants were pretty good and overall the meals were not that great because the chicken was dry and overcooked. They also didn't provide butter or any kind of spread with the bread which is cheap and concerning. The American airlines staff at the check-in counter was kind of unprofessional because this lady just started singing in the middle of checking us in and that's weird. The worst part of the flights was the terrible conditions of the bathrooms which were unclean and did not have toilet paper or toilet tissue available which is kind of insane for a 14-hour and 8 and 1/2 hour flight.

Requested early boarding to disinfect seat, tray table, etc. before general boarding. Instructed to board after wheelchair passengers. Waited on jet bridge behind 12 wheelchair passengers. Stopped immediately after entering plane to wait for gate agent in rear of plane cleaning a seat that was wet, got to my row and found both seats adjacent to mine already occupied, with the lack of room making it impossible for me to clean my own space and defeating the purpose of my boarding early. Cleaned the armrests and tray table as best I could.

Seat bottom cushions are not good. I’m 165# & they hurt my butt. Plenty of legroom.

The wifi experience is awful. I had to try again and again, taking over 30 minutes, to connect to the wifi. I had to watch the same two ads over and over until I was finally successful. Once connected, it was anything but "high speed" and disconnected at least three times during the flight.

Fine. Nothing to write home about. The plane left on time, and arrived on time.

I was downgraded from first class to coach due to an airplane change. They pulled me out of line and I was the very last person to board the plane stuck in the middle seat with no overhead place to put my carry-.on. Very poor customer service.

Seat comfort was poor (no lumbar or lower back support).

The airplane seats were spacious and comfortable, and the flight attendants were friendly and attentive. The food was delicious like never before. The blankets and toiletries were thoughtfully provided. The captain's navigation was steady and reliable. In short, having flown with Starlux, I won't consider any other airline next time.

STOP MAKING THE SEATING SO CRAMPED. WE NEED A PASSENGER BILL OF RIGHTS!

Everything you need to know for your flight to South America

Information on your arrival and departure airports