$166 Find Cheap Flights from Sioux Falls to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Sioux Falls to South Carolina departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Sioux Falls to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Sioux Falls to South Carolina, as well as popular online travel agencies
Travelers love KAYAK
41.299.237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Sioux Falls to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$279
Myrtle Beach
Myrtle Beach1 stop$251
Greenville
Greenville1 stop$251
Charlotte
Charlotte1 stop$251
Charleston
Charleston1 stop$279
Myrtle Beach
Myrtle Beach1 stop$251
Greenville
Greenville1 stop$251
Charlotte
Charlotte1 stop$251

Book Cheap Sioux Falls to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Sioux Falls to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Sioux Falls to South Carolina

Sat, May 2 - Wed, May 6
United Airlines Logo
7:30 am - 2:18 pm
FSD
-
MYR
5h 48m
1 stop
United Airlines Logo
3:14 pm - 9:47 pm
MYR
-
FSD
7h 33m
1 stop
$251United Airlines
Tue, Mar 31 - Wed, Apr 8
United Airlines Logo
1:43 pm - 10:59 pm
FSD
-
CLT
8h 16m
1 stop
United Airlines Logo
5:23 pm - 9:49 pm
CLT
-
FSD
5h 26m
1 stop
$251United Airlines
Tue, Mar 10 - Tue, Mar 17
American Airlines Logo
1:22 pm - 8:39 pm
FSD
-
CLT
6h 17m
1 stop
American Airlines Logo
7:48 am - 11:38 am
CLT
-
FSD
4h 50m
1 stop
$252American Airlines
Tue, Mar 31 - Wed, Apr 8
Delta Logo
8:00 am - 6:20 pm
FSD
-
CLT
9h 20m
2 stops
Delta Logo
6:18 am - 10:21 am
CLT
-
FSD
5h 03m
1 stop
$266Delta
Wed, May 6 - Sat, May 9
American Airlines Logo
1:41 pm - 11:57 pm
FSD
-
MYR
9h 16m
2 stops
American Airlines Logo
4:52 pm - 10:03 pm
MYR
-
FSD
6h 11m
1 stop
$270American Airlines
Wed, Jul 22 - Wed, Jul 29
Delta Logo
10:58 am - 6:58 pm
FSD
-
CLT
7h 00m
1 stop
Delta Logo
4:55 pm - 10:46 pm
CLT
-
FSD
6h 51m
1 stop
$279Delta
Sat, Apr 4 - Sat, Apr 11
American Airlines Logo
1:26 pm - 10:15 pm
FSD
-
SAV
7h 49m
1 stop
American Airlines Logo
5:40 am - 11:59 am
SAV
-
FSD
7h 19m
1 stop
$279American Airlines
Wed, Apr 22 - Tue, Apr 28
American Airlines Logo
3:17 pm - 10:59 pm
FSD
-
CHS
6h 42m
1 stop
American Airlines Logo
12:29 pm - 7:09 pm
CHS
-
FSD
7h 40m
1 stop
$279American Airlines
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
6:11 pm - 9:42 am
FSD
-
MYR
14h 31m
1 stop
Multiple Airlines Logo
10:00 am - 5:21 pm
MYR
-
FSD
8h 21m
1 stop
$317Multiple Airlines
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
6:11 pm - 5:48 pm
FSD
-
MYR
22h 37m
2 stops
Multiple Airlines Logo
10:00 am - 5:21 pm
MYR
-
FSD
8h 21m
1 stop
$357Multiple Airlines
Booking Insights

KAYAK's insights & trends for Sioux Falls to South Carolina flights

Get data-powered insights and trends into flights from Sioux Falls to South Carolina to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Sioux Falls to South Carolina?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Sioux Falls to South Carolina were found on United Airlines ($251) and Delta ($266).

Good to know

Low seasonFebruary
Cheapest flight$166
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from Sioux Falls to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Sioux Falls to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Sioux Falls to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Sioux Falls to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Sioux Falls to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Sioux Falls to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Sioux Falls to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Sioux Falls to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Sioux Falls to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Sioux Falls to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Sioux Falls to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Sioux Falls to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8187 reviews
7.2Food
7.9Comfort
8.1Boarding
7.8Entertainment
8.5Crew
Airline reviews

They took all carry-on luggage from Groups 6 -9 - I was group 5 and waiting in line to board - they made me check my luggage too. That then went to baggage claim and delayed departure from the airport. There was overhead room in my seating area - Delta over reacted. Also, had a gentleman next to me that took up 1/2 my seat.

4.0 OkayDuane, Feb 2026
ATL - FLL
Read more Delta reviews

They took all carry-on luggage from Groups 6 -9 - I was group 5 and waiting in line to board - they made me check my luggage too. That then went to baggage claim and delayed departure from the airport. There was overhead room in my seating area - Delta over reacted. Also, had a gentleman next to me that took up 1/2 my seat.

Flight delay was frustrating, also you cannot checkin online without delta app, web browser check-in throw errors

The gate agent was most helpful in getting me on to fly standby. I greatly appreciate it.

bulkhead seat had very little legroom - even in bsiness class.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Sorry I didn't realize I was writing a review for each leg. Please see my previous review - it applies to the entire flight, not just a single leg.

This is the first time I've been disappointed with Delta. I was called by Delta to see if I would volunteer to change flights since my original flight home was overbooked. I accepted. The modified booking only provided me a 35 minute layover - when you subtract the fact that boarding closes for a flight 15 minutes early, that gave me 20 minutes to run for one end of the airport to the other. I barely made it. On the 2.5 hour flight to Tampa, the crew repeatedly let us know over the intercom that they cannot serve drinks or snacks due to safety/turbulence. I would have accepted this reason if they did not CONTINUALLY SERVE DRINKS AND COOKED FOOD to First class. If safety is the excuse then the entire plane should be strapped in for safety. On top of this the air conditioning vents were not working correctly and the plane was uncomfortably warm. I love Delta and am a loyal Delta traveler, and I have never had an experience like this. I don't know if there's a disconnect between availability among third-party sites like KAYAK and the airlines or what, but when overbooking causes issues like this for travelers it should be reviewed and changes to the booking process should be made. I blame BOTH KAYAK and Delta for this terrible experience.

boarded at 5:30 pm, pushed away from gate at 6pm ... takeoff was not until ~6:45pm; disappointing

Smooth boarding, pleasant and professional lady checking us in. Crew service was excellent, again pleasant, but professional. Nice touch-down on landing! Thank you Delta. 💗

Originally, I was booked in economy. I paid several hundred additional dollars to upgrade to first class. Then I paid several more hundred dollars to change my flight to a slightly earlier flight. I asked if the changed flight would also seat me in first class, and I was told that it would. When I boarded the plane, however, I was seated in economy. So, I paid $500-600 more than I paid for my original ticket for an upgrade and a changed flight - received the changed flight (which was nice), but did not receive the upgrade. So, I was not completely satisfied.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Do not like the size of the overhead bin. I think staff should monitor the size of suitcases that are being carried on by passengers to ensure they meet the size requirement.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Flight delayed. WiFi connectivity very poor if not existant. Last minute arrival forced me to run to catch my connection.

Both of my flights arrived early and check in process was smooth

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

Short flight, but no drink/snack service. The flights both going and coming were delayed.

Much better than Spirit. I was please by the easy fast check in and boarding

Everything was on time Will use united again for sure

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

I was on a small regional flight from Detroit to Philadelphia. When we landed the outside cruise needed to turn something off with the engine, which took quite a long time. Then, when they allowed us to get off the plane it was outside. They took their time, unloading all the luggage and waited till they unloaded all the luggage before they brought it over to us. It was 9 o’clock at night freezing cold out, and there was no proactive hustle to try to get people their luggage. It was really one of the worst experiences I think I’ve ever had with American until a manager came over. I don’t think they were going to even consider pulling the luggage over to the people that had been waiting outside for at least 10 minutes in the freezing cold.

The flight was fine, once we got underway. It was more than hour delayed

Beverage service was not good. Also just one service in 5 hr 30 min flight. No ask fir water ir anything beside one time beverage service.

Waited for oxygen tanks for 30 minutes after boarding was complete.

The seats are too uncomfortable for anyone over 5ft 8in. I'm 5'10" with a back and hip issue and I was in pai for the full duration of the flight.

The flight was on time/early, attentive crew, and everything overall went smoothly. Disappointed that WIFI was not working for the flight.

One day, I do so hope for a gluten free snack! Seems like with the rest of the world FINALLY figuring out what gluten free is, American Airlines would too. Fingers crossed!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

Flight was on time and the meal and service were good.

Flight was delayed for 2 hours, then last minute the change to on time. The satélite location is far and a nightmare to get to.

Everything you need to know for your flight from Sioux Falls to South Carolina

Information on your arrival and departure airports