$480 Find Cheap Flights from Buffalo to Panama - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Flight Deals
Booking Insights
Flight Deals
Booking Insights

Price, demand and travel trends for Buffalo to Panama flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Buffalo to Panama right now?

The cheapest fare from Buffalo to Panama in the last week was $667 round-trip, to Panama City Tocumen Intl (PTY).

Which airport in Panama is the cheapest to fly to from Buffalo?

All flights from Buffalo to Panama arrive at Panama City Tocumen Intl (PTY). On average, round-trip fares are around $692.

What's the cheapest time of day to fly from Buffalo to Panama?

Data from the past 12 months shows it's cheapest to fly to Panama during the evening with average prices of $666. The morning is the most expensive time to fly, with average prices of $740.

Key details for Buffalo to Panama flights

Low season

October

Cheapest flight

$480
Beat the crowds with an average 87% drop in travelers.
The most popular month to fly with an average 40% increase in travelers.
One-way flight from Buffalo to Panama City

Your Buffalo to Panama flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Buffalo to Panama?

    Fares from Buffalo to Panama are around their usual level right now. A round-trip under $655 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Buffalo to Panama?

    Over the past 12 months, round-trip fares from Buffalo to Panama have ranged from $655 to $781.

  • What airlines fly nonstop from Buffalo to Panama?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Buffalo to Panama. One-stop options include:

    • Delta
    • American Airlines
    • United Airlines

  • Which cabin classes are available on flights from Buffalo to Panama?

    On flights from Buffalo to Panama you can book Economy Class or Business Class.

  • What are some popular landmarks in Panama?

    KAYAK travelers' favorite landmarks in Panama include:

    • ATLAPA Conventions Center
    • Panama Old Cathedral
    • Veneto Casino
    • Ancon Hill

Your guide to booking Buffalo to Panama flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for February when flights are typically cheapest and avoid August when prices are at their highest.
  • Flying on Thursday is usually the cheapest. Flights on Saturday cost about 31% more on average, so being flexible with your travel dates could help you save.
  • Start your trip in Panama City, which is the most popular destination in Panama. From there, it's easy to continue on to other popular destinations such as Bocas del Toro, Río Hato and Boquete.

Reviews of the top airline flying from Buffalo to Panama

 
Need help choosing which airline to fly with from Buffalo to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8692 reviews
8.5Crew
8.1Boarding
7.8Comfort
7.8Entertainment
7.2Food
Airline reviews

Wi-fi was out for the whole flight. I pay a premium to fly Delta because it has wifi and because it was out I didn’t get to work on anything I wanted to. I’ll have to make it up later this week by spending less time with my family.

6.0 GoodSusan, Oct 2026
Read more Delta reviews

Wi-fi was out for the whole flight. I pay a premium to fly Delta because it has wifi and because it was out I didn’t get to work on anything I wanted to. I’ll have to make it up later this week by spending less time with my family.

I just wish the boarding process/time to take off after boarding was quicker and more efficient. I also wish that the overhead luggage was managed better. almost every time i fly there is no space for carry ons and they are either checked or I end up having to store it several rows back from my seat. Delta should not offer carryons for all customers if there is not actually space for everyone

Flight was fine, it was on-time and was not cancelled which is very good. However the small cabin bag was forced check-in although once I entered into the flight there was lot of space which would have accomodated 10 such bags. Moreover this caused delay on arrival of my bag due to which I missed my booked cab and had to wait for another 20 minutes before the next taxi (Uber) arrived.

Only flew a short distance from Buffalo to New York City JFK SO it was okay

Delta seems to be getting worse. They are trying to take any comfort away from poorer people to make more money selling it to the rich. I paid for delta comfort and on my flight from Rome to jfk I had a tv that would go on and off automatically and literally no electrical outlets or usbs worked which was advertised in the price of the fare. The infotainment system wasn’t fully working. Luckily the movies worked and the plane was needing a lot of repairs. The jfk to Tampa flight they stuck me next to this really larger guy who was half in my seat and they should have made other accommodations for him because now you’re interfering with the fare class I paid for and act like I shouldn’t care because I didn’t pay for first class. I couldn’t even pull out my tray table because of this guy. The safety video tv screen you couldn’t even see it. It made me a little scared to fly delta anymore, because if these planes are this much in need of servicing, I have to wonder if the plane is going to make it to the destination.

Delayed departure, 30min. but arrived nearly on time. Crew was reassuring.

First, off the bat, the Delta gate attendant was rude, inattentive and gave us an attitude when we asked for clarification of our seats for this rebooked flight as we missed our connecting flight due to the delay from Berlin. Flight attendants were all but friendly, rushed through for water refills so you couldn’t even catch them to request more water. Snacks were just OK. Headphones for the movies were so bad that with the airplane noise, the volume of the movie wouldn’t go up enough to even understand the voices. I had to turn on CC to even know what was being said.

The baseline is to have everything happen as expected. That is what happened with the small exception that climate control in the aircraft sss not turned on when boarding started making the aircraft very hot. All in all great experience!

Cancelled my flight. Left me in airport for 12 hours. Rude gate attendants. Worst delta experience I’ve had. I hope they have a focus group and return to thinking about customer service.

Crew handling the boarding at the gates are quite aggressive with the passengers and must be given training/ refreshing courses to improve customer experience.

More options for your flight from Buffalo to Panama

Complete your trip to Panama with a hotel stay or car rental