$318 Find Cheap Flights from Charleston to Panama - Compare and Save

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Price, demand and travel trends for Charleston to Panama flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Are flights from Charleston to Panama cheaper or more expensive than last year?

Fares from Charleston to Panama are running about 15% higher than they were around this time last year, averaging $615 round-trip.

What are the cheapest fares from Charleston to Panama right now?

The cheapest fare from Charleston to Panama in the last week was $672 round-trip, to Panama City Tocumen Intl (PTY).

What’s the cheapest month to fly from Charleston to Panama?

March is the cheapest time of year to fly, with average fares of $487. Prices are highest in August, when average flight costs increase to around $1,075.

Which airport in Panama is the cheapest to fly to from Charleston?

All flights from Charleston to Panama arrive at Panama City Tocumen Intl (PTY). On average, round-trip fares are around $644.

What’s the cheapest day to fly from Charleston to Panama?

Tuesday tends to be the cheapest day to fly from Charleston to Panama, while Sunday is the most expensive. Fares run about 25% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Charleston to Panama?

Data from the past 12 months shows it's cheapest to fly to Panama during the morning with average prices of $644. The afternoon is the most expensive time to fly, with average prices of $1,418.

Key details for Charleston to Panama flights

Low season

July

Cheapest flight

$318
Beat the crowds with an average 34% drop in travelers.
The most popular month to fly with an average 53% increase in travelers.
One-way flight from Charleston to Panama City

Your Charleston to Panama flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Charleston to Panama?

    Fares from Charleston to Panama are around their usual level right now. A round-trip under $563 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Charleston to Panama?

    Over the past 12 months, round-trip fares from Charleston to Panama have ranged from $563 to $802.

  • What airlines fly nonstop from Charleston to Panama?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Charleston to Panama. One-stop options include American Airlines and Delta.

  • Which cabin classes are available on flights from Charleston to Panama?

    On flights from Charleston to Panama you can book Economy Class or Business Class.

  • What are some popular landmarks in Panama?

    KAYAK travelers' favorite landmarks in Panama include:

    • ATLAPA Conventions Center
    • Panama Old Cathedral
    • Veneto Casino
    • Ancon Hill

Your guide to booking Charleston to Panama flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for March when flights are typically cheapest and avoid August when prices are at their highest.
  • Flying on Tuesday is usually the cheapest. Flights on Sunday cost about 25% more on average, so being flexible with your travel dates could help you save.
  • Start your trip in Panama City, which is the most popular destination in Panama. From there, it's easy to continue on to other popular destinations such as Bocas del Toro, Río Hato and Boquete.

Reviews of the top 3 airlines serving from Charleston to Panama

 
Need help choosing which airline to fly with from Charleston to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8692 reviews
7.8Comfort
7.2Food
7.8Entertainment
8.1Boarding
8.5Crew
Airline reviews

Be on time. No issues with weather etc. entirely on airline.

2.0 MediocreDaniel, Oct 2026
Read more Delta reviews

Be on time. No issues with weather etc. entirely on airline.

Two of the flight attendants were cranky and seemed like they didn’t want to be there. Not up to normal Delta standards. And our bags didn’t make flight to Italy from Amsterdam resulting in having to make a trip back to airport which cost me 75 euros.

Delta staff was exceptionally helpful and considerate. However, the first two of three flight legs were delayed making connections tentative and stressful.

This wasn't my experience with Delta. It was just the Pegasus flight. Seats were very hard. Staff was kinda rough. Not very nice. Charged me for snacks. For a 4 hour flight I would've expected more.

I had a flight cancel and had it rerouted. When the rerouted they put me at a window seat instead of an isle. It was hard sitting by the window because the couple with masks on were making out. I get motion sickness which is why I need to have the isle seat.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The plane was old with small storage areas that had problems closing/latching and not enough storage for everyone, and worn, damaged seats. Service was great but feel a little unsafe on such well used planes.

I just can’t understand why are you sell to many tickets ???? We had to wait 2 hours before 13 people from our flight take money and go to next day flight!

The only real hiccups in the flight were things beyond Delta’s control - turbulence which delayed food service and a departure delay caused by some VIP plane which stopped all departures and landings for 30 minutes - and was never explained to us by the crew. Otherwise good flight. I would fly Delta again.

The plane was frigid, and leaked water from the ceiling all over me and my seat.

Even through the flight was delayed due to storms near IAH The flight was great! The crew was so hospitable and professional

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

United Airlines is my preferred airlines and I am thankful for Gary who also help support me on the phone to switch my flight literally last min.

The flight was on time. I generally don’t drink or eat on short flights and the seats were good and the flight attendants were friendly. That’s all I expect

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The food should improve! And The flight should leave on time and not make the traveler wait.

The attendant were friendly. I suggest you have a medical attendant on board every flight so that in case someone is sick , he/she will help them.

I completely missed my flight because the first leg was longer than planned. I had to sleep overnight in the airport because no accommodation was provided and then sent to Trinidad in the morning with an anticipated 7 hour layover before my flight to Georgetown which was now with Caribbean Airlines. I tried twice with customer service to see if they could put me on an earlier flight which had seats available but was told it wasn’t possible.

The flight and boarding were easy peasy. I was traveling with my 4-year-old, so a smooth boarding experience was especially appreciated. My only piece of feedback is really about where our gate was in O'Hare. They've shoved four gates into a tiny corner of the B terminal and there isn't early enough room or seating for everyone. Not United's problem, but did dent the overall experience.

I paid extra for a seat up front and at last minute was moved to the 2nd to last row - which I could have had for free. No reason and no refund. Really great customer service American

The first flight was delayed by an hour and a half, so we missed the second flight. They rebooked us on the later flight and I have to sit in the middle for more than 5 hours. Terrible experience. No more American Airlines.

Flight was fine, but not having WiFi was a major negative

I was trying to take 2 one and a half hour one way trips and I experienced almost 20 delays over the course of those two trips. Only a few of them were due to weather the rest was disorganization

Would have thought that they would gas up plane before everyone got on board

The flights were terribly delayed and then cancelled which forced us booking another night at the hotel. Very poor management from American Airlines

American switched my flight to a 5 hour layover then cancelled my whole reservation with no notice and refused refund. Won’t fly with them again.

We sat on runway for an 1 hour because they were short handed at key west airport was not fun

The WiFi and app don’t work as easily as other airlines

Late. Then next flight was an hour late due to mx.

More options for your flight from Charleston to Panama

Complete your trip to Panama with a hotel stay or car rental