$350 Find Cheap Flights from Charleston to South America

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:35 pm - 10:05 pm
CRW
-
MDE
28h 30m
2 stops
United Airlines Logo
10:45 am - 5:00 pm
MDE
-
CRW
30h 15m
2 stops
$350United Airlines
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:35 pm - 10:05 pm
CRW
-
MDE
28h 30m
2 stops
United Airlines Logo
10:45 am - 5:00 pm
MDE
-
CRW
30h 15m
2 stops
$406United Airlines
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:35 pm - 10:05 pm
CRW
-
MDE
52h 30m
2 stops
United Airlines Logo
10:45 am - 5:00 pm
MDE
-
CRW
30h 15m
2 stops
$441United Airlines
Tue, Mar 17 - Sun, Mar 29
LATAM Airlines Logo
6:00 am - 9:20 pm
CRW
-
LIM
16h 20m
1 stop
LATAM Airlines Logo
10:50 am - 6:18 pm
LIM
-
CRW
30h 28m
2 stops
$615LATAM Airlines
Tue, Mar 17 - Sun, Mar 29
LATAM Airlines Logo
2:40 pm - 5:00 am
CRW
-
LIM
15h 20m
2 stops
LATAM Airlines Logo
10:50 am - 6:18 pm
LIM
-
CRW
30h 28m
2 stops
$620LATAM Airlines
Wed, May 13 - Wed, May 20
American Airlines Logo
6:00 am - 7:05 am
CRW
-
SCL
25h 05m
2 stops
American Airlines Logo
8:35 pm - 11:53 pm
SCL
-
CRW
27h 18m
2 stops
$863American Airlines
Sun, Mar 22 - Sun, Mar 29
American Airlines Logo
11:25 am - 4:10 am
CRW
-
LIM
17h 45m
2 stops
American Airlines Logo
11:45 pm - 10:43 pm
LIM
-
CRW
21h 58m
2 stops
$868American Airlines
Tue, Mar 17 - Sat, Mar 28
Delta Logo
10:59 am - 9:20 pm
CRW
-
LIM
11h 21m
1 stop
Delta Logo
12:10 am - 6:18 pm
LIM
-
CRW
17h 08m
2 stops
$875Delta
Wed, May 13 - Wed, May 20
Delta Logo
6:56 pm - 7:15 am
CRW
-
SCL
12h 19m
1 stop
Delta Logo
8:40 pm - 11:07 pm
SCL
-
CRW
26h 27m
1 stop
$885Delta
Mon, Apr 20 - Tue, Apr 28
GOL Logo
6:00 am - 8:30 pm
CRW
-
LIM
15h 30m
2 stops
GOL Logo
6:30 am - 9:30 pm
LIM
-
CRW
14h 00m
2 stops
$905GOL
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Charleston to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Charleston to South America were found on United Airlines ($350) and LATAM Airlines ($615).

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8159 reviews
7.8Entertainment
7.9Comfort
7.2Food
8.1Boarding
8.5Crew
Airline reviews

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

2.0 MediocreKeenan, Feb 2026
GEG - SEA
Read more Delta reviews

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

It was delayed but other than that it was great.

Got on the plane and sat there for an hour before departure.

Second flight in a row where the entertainment system is broken. 5 hour long flight with no entertainment and flight attendants did not seem interested in resolving the matter. Very shocked to be treated this poorly considering I paid for a first class experience and have Diamond Medallion status.

They double booked seats, the gate staff changed my ticket as I was boarding she went over to the computer and changed it without telling me. She messed up an entire three row section for me and others. Other travelers were outraged but the gate staff were so rude, so condescending saying it wasn't their problem to solve. I would rate this a zero if I could. Will not fly Delta again I'll stick with United and American.

It was nt delta. It was aeromexo. Service was awful. They served a very small drink and NO snack for a 3hr and 35min flight. Then for the first 30 min of the flight is was talk and talk over head interruption the movie/ show i picked to watch.

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

I was given middle seat on this flight and prior Boston to Seoul flight That is a problem for long flights, Kayak system did not give me a change to select my seats and assigned me middle seats regardless of my elevated status in Delta. This needs immediate attention.

I didn't take this flight. I changed the flight. Why am I getting surveys and notifications on flights that I change. Seems like a defect with Kayak.

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Everything you need to know for your flight to South America

Information on your arrival and departure airports