$299 Find Cheap Flights from Charleston to South America

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41.299.237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Thu, Feb 19 - Fri, Feb 27
American Airlines Logo
6:08 pm - 2:06 pm
CRW
-
MDE
19h 58m2 stops
American Airlines Logo
3:10 pm - 10:55 am
MDE
-
CRW
19h 45m2 stops
$299American Airlines
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:35 pm - 10:05 pm
CRW
-
MDE
52h 30m2 stops
United Airlines Logo
10:45 am - 8:38 pm
MDE
-
CRW
33h 53m2 stops
$361United Airlines
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:35 pm - 10:05 pm
CRW
-
MDE
28h 30m2 stops
United Airlines Logo
10:45 am - 8:38 pm
MDE
-
CRW
33h 53m2 stops
$400United Airlines
Thu, Feb 19 - Fri, Feb 27
Multiple Airlines Logo
2:43 pm - 1:55 pm
CRW
-
MDE
23h 12m1 stop
Multiple Airlines Logo
10:08 pm - 9:19 am
MDE
-
CRW
35h 11m2 stops
$485Multiple Airlines
Thu, Jan 22 - Sun, Jan 25
Multiple Airlines Logo
2:43 pm - 1:55 pm
CRW
-
MDE
23h 12m1 stop
Multiple Airlines Logo
10:45 pm - 7:24 pm
MDE
-
CRW
20h 39m2 stops
$617Multiple Airlines
Fri, Feb 20 - Thu, Feb 26
United Airlines Logo
5:35 pm - 11:55 pm
CRW
-
LIM
54h 20m2 stops
United Airlines Logo
1:50 am - 8:38 pm
LIM
-
CRW
42h 48m2 stops
$653United Airlines
Wed, May 13 - Wed, May 20
Delta Logo
6:40 pm - 7:15 am
CRW
-
SCL
12h 35m1 stop
Delta Logo
7:45 pm - 10:41 pm
SCL
-
CRW
26h 56m2 stops
$785Delta
Wed, May 13 - Wed, May 20
Delta Logo
11:00 am - 6:55 am
CRW
-
SCL
19h 55m2 stops
Delta Logo
11:25 pm - 10:41 pm
SCL
-
CRW
23h 16m2 stops
$790Delta
Thu, Feb 19 - Fri, Feb 27
GOL Logo
5:00 am - 9:10 pm
CRW
-
MDE
16h 10m2 stops
GOL Logo
3:10 pm - 10:55 am
MDE
-
CRW
19h 45m2 stops
$1,231GOL
Thu, Feb 19 - Fri, Feb 27
LATAM Airlines Logo
6:44 pm - 6:00 pm
CRW
-
MDE
23h 16m2 stops
LATAM Airlines Logo
12:30 pm - 10:21 am
MDE
-
CRW
21h 51m2 stops
$1,398LATAM Airlines
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines fly non-stop between Charleston and South America?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Charleston to South America.

There is just one airline that flies from Charleston to South America direct and that is Delta. The best round-trip deal found from Delta for the route is to Lima (LIM) and costs $594.

Which airlines provide the cheapest flights from Charleston to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Charleston to South America were found on American Airlines ($299) and United Airlines ($361).

Find deals

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8022 reviews
8.1Boarding
8.5Crew
7.9Comfort
7.2Food
7.8Entertainment
Airline reviews

Flight was late from Newark to Atlanta, I asked flight attendant to please let my family of 3 out first when we landed to Atlanta because we were late for our connecting flight to Quito. She didn't and we were late for 5 minutes we couldn't board the plane and spend hours trying to get another flight with customer service for the next day.

2.0 MediocreAnonymous, Jan 2026
EWR - ATL
Read more Delta reviews

Flight was late from Newark to Atlanta, I asked flight attendant to please let my family of 3 out first when we landed to Atlanta because we were late for our connecting flight to Quito. She didn't and we were late for 5 minutes we couldn't board the plane and spend hours trying to get another flight with customer service for the next day.

I really liked the legroom. I am 6’4”.a at For some reason our seats were not together and using the app to fix it didn’t work. Passengers were nice enough to move for us but you should absolutely ensure a parent sits with their child.

Late delayed flight delays boarding and delays leaving and delays on arrival too. Cramped plane no room no food.

DTW line is too long. The flights from DTW to BWI are always delayed for unknown reasons.

Delta canceled our flight and we had to scramble to find another airline to get home. Phoenix is not a delta hub so they didn’t have another plane. It would have been a red eye though Salt Lake City. Getting in at 5am. No bueno.

This flight was no comparison to our prior flight. I'm thinking it all has to do with the age of the aircraft.

This flight was a first class choice and left much to be desired. Seat backs on seats were falling apart and torn. Seats actually didn't come to a "full & upright position". Pull out table was sprung. Not any significant leg room. All in all we were on an obviously older plane and felt overcharged for what we received as first class.

A 12 hour flight during the day with one real meal service - are you kidding? Also the breakfast was one of the worst and not what was listed

Flight was delayed several times. At one point, they "pulled back" 15 minutes from the delayed boarding and sent a text saying we would board sooner than previously advised. The flight then was delayed again. And when we boarded, there was an unspecified technical issue which had us waiting in the plane for about an hour.

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

Everything you need to know for your flight to South America

Information on your arrival and departure airports

Charleston (CRW)