Find Deals on Flights from Chicago to Panama

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
Students
under 26
The price shown for each flight will be the average for all passengers including any infants.
Compare vs. KAYAK all | none
Browse Origins:
Browse Destinations:

Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from Chicago to Panama

(Round-trip)
Depart: Sat Jan 21 2017 Return: Tue Jan 24 2017 Trip spans 4 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Sat Feb 4 2017 Return: Tue Feb 7 2017 Trip spans 4 days
Copa Airlines
Copa Airlines
ORD
PTY
5h 23m
nonstop
PTY
ORD
5h 42m
nonstop
Depart: Thu May 18 2017 Return: Mon May 22 2017 Trip spans 5 days
Major Airline
Major Airline
ORD
PTY
17h 11m
2 stops
PTY
ORD
32h 30m
2 stops
Depart: Mon Jan 23 2017 Return: Mon Jan 30 2017 Trip spans 8 days
Delta
Delta
MDW
PTY
8h 39m
1 stop
PTY
MDW
11h 49m
1 stop
Depart: Sat Dec 24 2016 Return: Sat Dec 31 2016 Trip spans 8 days
Aeromexico
Aeromexico
ORD
PTY
16h 25m
1 stop
PTY
ORD
18h 17m
1 stop
Depart: Tue Feb 7 2017 Return: Tue Feb 14 2017 Trip spans 8 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Sat Mar 11 2017 Return: Mon Mar 20 2017 Trip spans 9 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Sat Jan 28 2017 Return: Sat Feb 4 2017 Trip spans 8 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Tue Mar 7 2017 Return: Tue Mar 14 2017 Trip spans 7 days
Copa Airlines
Copa Airlines
ORD
PTY
5h 18m
nonstop
PTY
ORD
5h 32m
nonstop
Depart: Tue Jun 6 2017 Return: Sat Jun 10 2017 Trip spans 5 days
Major Airline
Major Airline
ORD
PTY
32h 48m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Mon Feb 6 2017 Return: Sat Feb 18 2017 Trip spans 13 days
Delta
Delta
MDW
PTY
6h 51m
1 stop
PTY
MDW
9h 32m
1 stop
Depart: Sun Feb 26 2017 Return: Sat Mar 4 2017 Trip spans 7 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Tue Feb 7 2017 Return: Sun Feb 12 2017 Trip spans 6 days
Delta
Delta
MDW
PTY
8h 39m
1 stop
PTY
MDW
9h 09m
1 stop
Depart: Sun Feb 26 2017 Return: Sat Mar 4 2017 Trip spans 7 days
Delta
Delta
MDW
PTY
8h 26m
1 stop
PTY
MDW
9h 25m
1 stop
Depart: Sun Apr 2 2017 Return: Sat Apr 8 2017 Trip spans 7 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Tue Mar 21 2017 Return: Tue Apr 4 2017 Trip spans 15 days
Copa Airlines
Copa Airlines
ORD
PTY
5h 18m
nonstop
PTY
ORD
5h 32m
nonstop
Depart: Mon Mar 6 2017 Return: Sat Mar 11 2017 Trip spans 6 days
Delta
Delta
MDW
PTY
8h 26m
1 stop
PTY
MDW
9h 18m
1 stop
Depart: Thu Apr 20 2017 Return: Sat Apr 29 2017 Trip spans 10 days
Avianca
Avianca
ORD
PTY
17h 11m
2 stops
PTY
ORD
15h 30m
2 stops
Depart: Mon May 8 2017 Return: Mon May 15 2017 Trip spans 8 days
Delta
Delta
MDW
PTY
7h 45m
1 stop
PTY
MDW
8h 58m
1 stop
Depart: Wed Jan 18 2017 Return: Thu Jan 26 2017 Trip spans 9 days
Major Airline
Major Airline
ORD
PTY
5h 23m
nonstop
PTY
ORD
5h 42m
nonstop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

Airports
Origin

Chicago
only $335
only $478
Destination

Panama City
$335