DSM - BRU

$435 Find Cheap Flights from Des Moines to Brussels - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$730
Air Canada
Wed 12/2Wed 12/9
DSM - BRU • 2 stops
Cheapest one-way
$435
Air Canada
Sat 9/5
DSM - BRU • 2 stops
Top airlines
Cheapest • from $730 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Brussels. You'll need at least 1 connection.
Insights
Insights
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Insights
Top layover airports
Cheapest • Avg $1,200 (round-trip)
Shortest trip • 12h 56m (one-way)
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Booking Insights
Flight Deals

Cheap Flights from Des Moines to Brussels (DSM-BRU)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Brussels that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Brussels

Wed, Dec 2 - Wed, Dec 9
Air Canada Logo
8:00 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
16h 50m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
10:00 am - 11:01 pmBRU  Brussels Bruxelles-National-DSM Des Moines
44h 01m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$730Air Canada
Wed, Dec 2 - Wed, Dec 9
Air Canada Logo
6:15 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 35m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
10:00 am - 9:17 pmBRU  Brussels Bruxelles-National-DSM Des Moines
42h 17m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$730Air Canada
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
3:15 pm - 1:15 pmDSM  Des Moines-BRU Brussels Bruxelles-National
15h 00m2 stops Chicago O'Hare Intl London Heathrow
United Airlines Logo
10:10 am - 11:01 pmBRU  Brussels Bruxelles-National-DSM Des Moines
19h 51m1 stop Chicago O'Hare Intl
$743United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
3:15 pm - 1:15 pmDSM  Des Moines-BRU Brussels Bruxelles-National
15h 00m2 stops Chicago O'Hare Intl London Heathrow
United Airlines Logo
10:10 am - 11:01 pmBRU  Brussels Bruxelles-National-DSM Des Moines
19h 51m1 stop Chicago O'Hare Intl
$744United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
8:00 am - 8:55 amDSM  Des Moines-BRU Brussels Bruxelles-National
17h 55m1 stop Chicago O'Hare Intl
United Airlines Logo
10:10 am - 9:17 pmBRU  Brussels Bruxelles-National-DSM Des Moines
18h 07m1 stop Chicago O'Hare Intl
$747United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
3:15 pm - 8:55 amDSM  Des Moines-BRU Brussels Bruxelles-National
10h 40m1 stop Chicago O'Hare Intl
United Airlines Logo
10:10 am - 7:25 pmBRU  Brussels Bruxelles-National-DSM Des Moines
16h 15m1 stop Chicago O'Hare Intl
$747United Airlines
Wed, Dec 2 - Wed, Dec 9
Multiple Airlines Logo
6:15 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 35m3 stops Chicago O'Hare Intl Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl
Multiple Airlines Logo
10:00 am - 9:17 pmBRU  Brussels Bruxelles-National-DSM Des Moines
18h 17m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$762Multiple Airlines
Wed, Dec 2 - Wed, Dec 9
Multiple Airlines Logo
8:00 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
16h 50m3 stops Chicago O'Hare Intl Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl
Multiple Airlines Logo
10:00 am - 11:01 pmBRU  Brussels Bruxelles-National-DSM Des Moines
20h 01m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$762Multiple Airlines
Wed, Dec 2 - Wed, Dec 9
Air Canada Logo
6:15 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 35m3 stops Chicago O'Hare Intl Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
7:00 am - 7:25 pmBRU  Brussels Bruxelles-National-DSM Des Moines
19h 25m3 stops Frankfurt am Main Toronto Pearson Intl Chicago O'Hare Intl
$773Air Canada
Tue, Sep 15 - Tue, Sep 22
Lufthansa Logo
1:23 pm - 11:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
15h 27m2 stops Chicago O'Hare Intl Frankfurt am Main
Lufthansa Logo
8:35 am - 5:28 pmBRU  Brussels Bruxelles-National-DSM Des Moines
15h 53m2 stops Frankfurt am Main Chicago O'Hare Intl
$952Lufthansa
Booking Insights

KAYAK's insights & trends for Des Moines to Brussels flights

Get data-powered insights and trends into flights from Des Moines to Brussels to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Brussels?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Des Moines to Brussels were found on Air Canada ($730) and United Airlines ($743).

Good to know

Cheapest flight

$435
Flight from Des Moines to Brussels

When to book flights from Des Moines to Brussels

Are your dates flexible? Find out the best times to travel from Des Moines to Brussels based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Des Moines to Brussels flights

  • What is the cheapest flight from Des Moines to Brussels Bruxelles-National Airport?

    In the last 5 days, the lowest price for a flight from Des Moines to Brussels Bruxelles-National Airport was $435 for a one-way ticket and $730 for a round-trip.

  • Do I need a passport to fly between Des Moines and Brussels?

    Yes

  • Which aircraft models fly most regularly from Des Moines to Brussels?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Brussels?

    Star Alliance is the only airline alliance operating flights between Des Moines and Brussels.

  • How does KAYAK find such low prices on flights from Des Moines to Brussels?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Brussels.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Brussels?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Brussels from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Brussels?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Brussels with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and BRU can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Brussels?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Brussels from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Brussels

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Brussels. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Brussels? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 10072 reviews
8.1Crew
7.7Boarding
7.1Entertainment
7.3Comfort
6.7Food
Airline reviews

We sat on the hot plane for ours with very conflicting messages. Some (most?) of this may be due to the flight control staff, but we were also repeatedly getting "we are leaving"/"we are not" messages. It was very uncomfortable

4.0 OkayAnonymous, Jul 2026
Read more United Airlines reviews

We sat on the hot plane for ours with very conflicting messages. Some (most?) of this may be due to the flight control staff, but we were also repeatedly getting "we are leaving"/"we are not" messages. It was very uncomfortable

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

WiFi didn’t exist , seats were super cramped, lights stayed on near my seat for a long time while others were dimmed, the food/trash/drink cart hit my shoulder at least a couple of times while moving, food options were down to just one option by the time it got to my row, the utensils were garbage (knife bent at a couple of places by the time I was done eating) the spoon was very flimsy plastic

I had enough leg room. The check in was smooth. Good food

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

The boarding timing needs to be improved. The flight was delayed again because it took way too long to board. I was already exhausted from sleeping at the airport and spending all day there due to delay from my previous flight that connected in Chicago.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

Kayak, the site I went through to book our flight, sent very unclear emails about flight changes. Kayak was incredibly unhelpful in their communications with me about this, promising to work on resolving the issue, and failing to do so. As a result, I needed to get a hotel in Brussels and am now in the process of trying to get reimbursed. On the other hand, the flight personnel in Brussels were very helpful, taking time to look into the issue and determine if they could help. I am very grateful for them and have no problems with the airline. For Kayak, however, I will never use it again and will never recommend it to anyone, and will even discourage people who consider going through that site. My worst experience ever....

Everything you need to know for your flight from Des Moines to Brussels

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