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Flight Deals
Book Cheap Des Moines to the Cayman Islands Plane Tickets
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to the Cayman Islands that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Recent round-trip flight deals from Des Moines to the Cayman Islands
Sun, Dec 20 - Fri, Dec 25
3:45 pm - 12:35 pmDSM Des Moines-GCM George Town Owen Roberts Intl
19h 50m2 stops Phoenix Sky Harbor Intl Orlando
1:30 pm - 10:05 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 35m2 stops Orlando Chicago Midway
$638Southwest
Sat, Apr 24 - Thu, Apr 29
5:35 pm - 12:10 pmDSM Des Moines-GCM George Town Owen Roberts Intl
18h 35m2 stops Denver Intl Orlando
1:05 pm - 11:50 pmGCM George Town Owen Roberts Intl-DSM Des Moines
10h 45m2 stops Orlando Chicago Midway
$638Southwest
Wed, Feb 3 - Wed, Feb 10
7:57 pm - 11:48 amDSM Des Moines-GCM George Town Owen Roberts Intl
14h 51m2 stops Chicago O'Hare Intl Miami
12:59 pm - 11:22 pmGCM George Town Owen Roberts Intl-DSM Des Moines
11h 23m1 stop Charlotte Douglas
$687American Airlines
Wed, Feb 3 - Wed, Feb 10
4:56 pm - 11:48 amDSM Des Moines-GCM George Town Owen Roberts Intl
17h 52m2 stops Dallas/Fort Worth Miami
12:48 pm - 11:33 pmGCM George Town Owen Roberts Intl-DSM Des Moines
11h 45m2 stops Miami Washington, D.C. Reagan-National
$687American Airlines
Sat, Apr 24 - Thu, Apr 29
5:45 am - 1:05 pmDSM Des Moines-GCM George Town Owen Roberts Intl
7h 20m1 stop Atlanta Hartsfield-Jackson
1:25 pm - 10:29 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 04m1 stop Atlanta Hartsfield-Jackson
$722Delta
Sat, Jan 30 - Sat, Feb 6
6:15 am - 4:35 pmDSM Des Moines-GCM George Town Owen Roberts Intl
9h 20m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
2:55 pm - 11:14 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 19m1 stop Chicago O'Hare Intl
$722United Airlines
Sat, Dec 19 - Thu, Dec 24
6:42 pm - 4:05 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 23m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
2:55 pm - 9:23 pmGCM George Town Owen Roberts Intl-DSM Des Moines
7h 28m1 stop Chicago O'Hare Intl
$722United Airlines
Thu, Dec 17 - Tue, Dec 22
6:16 pm - 12:11 pmDSM Des Moines-GCM George Town Owen Roberts Intl
16h 55m1 stop Charlotte Douglas
3:30 pm - 11:58 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 28m1 stop Charlotte Douglas
$722American Airlines
Fri, Dec 18 - Wed, Dec 23
5:40 pm - 3:20 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 40m2 stops Denver Intl Baltimore/Washington
1:30 pm - 11:35 pmGCM George Town Owen Roberts Intl-DSM Des Moines
11h 05m2 stops Orlando Chicago Midway
$822Southwest
Fri, Nov 13 - Sat, Nov 14
5:30 am - 12:25 pmDSM Des Moines-GCM George Town Owen Roberts Intl
5h 55m1 stop Atlanta Hartsfield-Jackson
2:08 pm - 10:35 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 27m1 stop Atlanta Hartsfield-Jackson
$982Delta
Recent one-way flight deals from Des Moines to the Cayman Islands
Fri, Dec 18
5:40 pm - 3:20 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 40m2 stops Denver Intl Baltimore/Washington
$337Southwest
Sat, Dec 19
6:42 pm - 4:35 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 53m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$364United Airlines
Fri, Dec 18
6:00 am - 4:00 pmDSM Des Moines-GCM George Town Owen Roberts Intl
9h 00m1 stop Houston George Bush Intcntl
$381United Airlines
Sat, Dec 19
6:42 pm - 1:45 pmDSM Des Moines-GCM George Town Owen Roberts Intl
18h 03m1 stop Chicago O'Hare Intl
$501United Airlines
Sat, Dec 19
12:39 pm - 11:35 amDSM Des Moines-GCM George Town Owen Roberts Intl
21h 56m3 stops Nashville Intl Denver Intl Miami
$587Multiple Airlines
Fri, Dec 18
9:35 pm - 5:20 pmDSM Des Moines-GCM George Town Owen Roberts Intl
42h 45m3 stops Las Vegas Harry Reid Intl Atlanta Hartsfield-Jackson Tampa
$672Multiple Airlines
Recent last minute flight deals from Des Moines to the Cayman Islands
Sat, Nov 7 - Sat, Nov 14
6:00 am - 7:53 pmDSM Des Moines-GCM George Town Owen Roberts Intl
12h 53m2 stops Washington, D.C. Reagan-National Miami
3:45 pm - 12:26 amGCM George Town Owen Roberts Intl-DSM Des Moines
9h 41m2 stops Miami Chicago O'Hare Intl
$946American Airlines
Sat, Nov 7 - Sat, Nov 14
6:00 am - 7:53 pmDSM Des Moines-GCM George Town Owen Roberts Intl
12h 53m2 stops Washington, D.C. Reagan-National Miami
3:30 pm - 11:36 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 06m1 stop Dallas/Fort Worth
$946American Airlines
Sat, Nov 7 - Sat, Nov 14
7:30 am - 11:23 amDSM Des Moines-GCM George Town Owen Roberts Intl
26h 53m1 stop Charlotte Douglas
3:30 pm - 11:36 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 06m1 stop Dallas/Fort Worth
$960American Airlines
Mon, Nov 9 - Sat, Nov 14
6:52 pm - 12:25 pmDSM Des Moines-GCM George Town Owen Roberts Intl
16h 33m1 stop Atlanta Hartsfield-Jackson
2:08 pm - 10:35 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 27m1 stop Atlanta Hartsfield-Jackson
$982Delta
Mon, Nov 9 - Fri, Nov 13
6:52 pm - 12:25 pmDSM Des Moines-GCM George Town Owen Roberts Intl
16h 33m1 stop Atlanta Hartsfield-Jackson
1:40 pm - 10:35 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 55m1 stop Atlanta Hartsfield-Jackson
$982Delta
Sat, Nov 7 - Sat, Nov 14
5:39 am - 12:40 pmDSM Des Moines-GCM George Town Owen Roberts Intl
6h 01m1 stop Atlanta Hartsfield-Jackson
2:08 pm - 10:35 pmGCM George Town Owen Roberts Intl-DSM Des Moines
9h 27m1 stop Atlanta Hartsfield-Jackson
$982Delta
Sat, Nov 7 - Sat, Nov 14
6:00 am - 7:53 pmDSM Des Moines-GCM George Town Owen Roberts Intl
12h 53m2 stops Washington, D.C. Reagan-National Miami
3:45 pm - 12:26 amGCM George Town Owen Roberts Intl-DSM Des Moines
9h 41m2 stops Miami Chicago O'Hare Intl
$986American Airlines
Sun, Nov 8 - Sun, Nov 15
6:45 pm - 4:30 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 45m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
5:45 pm - 7:16 pmGCM George Town Owen Roberts Intl-DSM Des Moines
26h 31m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,076United Airlines
Mon, Nov 9 - Sun, Nov 15
6:45 pm - 4:30 pmDSM Des Moines-GCM George Town Owen Roberts Intl
20h 45m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
5:45 pm - 10:59 pmGCM George Town Owen Roberts Intl-DSM Des Moines
30h 14m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,076United Airlines
Mon, Nov 9 - Sun, Nov 15
8:00 am - 4:30 pmDSM Des Moines-GCM George Town Owen Roberts Intl
7h 30m1 stop Houston George Bush Intcntl
5:45 pm - 7:16 pmGCM George Town Owen Roberts Intl-DSM Des Moines
26h 31m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,076United Airlines
Booking Insights
Price, demand and travel trends for Des Moines to the Cayman Islands flights
Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.
Prices
Airlines
More
What are the cheapest fares from Des Moines to the Cayman Islands right now?
The cheapest fare from Des Moines to the Cayman Islands in the last week was $638 round-trip, to George Town Owen Roberts Intl (GCM).
Which airport in the Cayman Islands is the cheapest to fly to from Des Moines?
All flights from Des Moines to the Cayman Islands arrive at George Town Owen Roberts Intl (GCM). On average, round-trip fares are around $801.
What are the cheapest airlines to fly with from Des Moines to the Cayman Islands?
Fares reflect aggregated pricing data and may not include every trip type.
Looking at KAYAK data from the last 12 months, the cheapest airlines to fly with from Des Moines to the Cayman Islands are:
• American Airlines (avg. price $768)
• United Airlines (avg. price $769)
• JetBlue (avg. price $845)
• Delta (avg. price $855)
What's the most popular airline to fly with from Des Moines to the Cayman Islands?
Drawing on KAYAK data from the past three months, the most popular airlines to fly with from Des Moines to the Cayman Islands are:
• American Airlines
• Delta
• United Airlines
What are the most popular flight destinations in the Cayman Islands?
George Town is the most popular flight destination in the Cayman Islands, based on KAYAK data from the past 3 months.
Key details for Des Moines to the Cayman Islands flights
Low season | August |
|---|---|
High season | May |
Cheapest flight | $337 |
Your Des Moines to the Cayman Islands flight questions, answered
Find helpful answers about this route, including flight times, airports, airlines and booking tips.
Your guide to booking Des Moines to the Cayman Islands flights
Get tips on when to book, when to fly and what to know before your trip.Reviews of the top 3 airlines serving from Des Moines to the Cayman Islands
7.8
DeltaOverall score based on 8696 reviews
8.5Crew
8.1Boarding
7.2Food
7.8Entertainment
7.8Comfort
Airline reviews
I used by Skymiles to upgrade to First so that I could comfortably work using my laptop. But WiFi was intermittent and unavailable for long periods. I feel like I wasted 70,000 miles :(
2.0 MediocreJames, Nov 2026
I used by Skymiles to upgrade to First so that I could comfortably work using my laptop. But WiFi was intermittent and unavailable for long periods. I feel like I wasted 70,000 miles :(
Great as one can be for a one connection 6 hour flight
Packed flight and not sure why dinner service would start at midnight while passengers we’re trying to sleep
The gate attendant was not clear w message on flight delays.
Chairs don’t recline and the ones that do recline, barely do recline. It was most uncomfortable flight i ever been on.
Good but not on par when compared with foreign flag carriers.
Good service but not on par when compared to foreign flag carriers.
Mechanical delay of 2 hours without telling us Canadians of the potential compensation for this delay. As this caused 2 out of three people in our travelling party to miss their connecting flights until the next day.
Travelling with 2 others for work. Delta asked to check their carry ons due to the fullness of the plane. This was all good until the next leg of the flight. One of the 3 had their carry on checked through to the final destination but their passport on in their checked bag. Which they could not get to and he was not allowed on to the plane. Even though Delta had to retrieve his bag, because he was not allowed on. So they got his bag and he was in the terminal, but even when the flight was delayed, due to mechanical issues, he was not allowed to come onto the plane. Since the delay was nearly 2 hours, he was finally allowed back on the plane.
I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.
Terrible boarding - 4 flights boarded from the same gate. Chaos there; long ramps to the plane.
Flight delay in lax which delayed our connecting flight to Copenhagen. Was placed on standby the following day and got delayed again at Scandinavian air. Bad bad counter service at ar Canada in Toronto by the name of Camilla who said that she was doing us a courtesy for even finding a earlier flight for us after we the customer are the ones being inconvenient by the cancellation of our flight. Btw, we are going on a tour. Air Canada is the worse
The flight itself was ok, but one member of the crew was miserable
Fine except from Chicago to moline three different gate changes and flight times
The food could have been better and the entertainment could have better movies or streaming.
1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding
It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.
Very rough getting into denver. my kid threw up it was so rough.
Liked that we left on time for each flight. Snacks not the best, but we're okay.
I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.
Fine. No announcement for Concierge Key to board. Not a big issue just pointing it out.
Totally uninformed of the situation. Not yet sure about compensation. Highly disappointed.
The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.
The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.
In flight connectivity (via T-Mobile) was often not working.
Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.
It was exactly what I expected, actually arriving sooner than scheduled.
Flight left more than 5 hours late. American's policy did not allow flight to be fueled or bags to be loaded due to intermittent lightning. We were on the plane for hours before having to deplane. They then changed the departure time to an earlier than expected time. We re-boarded and had to wait another 1.5 hours on the plane before it finally took off. Flight crew did not serve any food or drinks while airborne.
Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.
Delayed, missed connecting flight, ground crew double charged for international charges, were super rude and told me to just”deal with it” when I complained. Horrible airline, very frustrating.
More options for your flight from Des Moines to the Cayman Islands
Complete your trip to the Cayman Islands with a hotel stay or car rental
Information on your arrival and departure airports
Cabin class types available on flights to the Cayman Islands
Cabin classes available on flights to the Cayman Islands. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights from other airports in Des Moines to the Cayman Islands
Flights from all airports in Des Moines to the Cayman Islands. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to other popular destinations
The most popular flights on KAYAK according to clicks in the last 2 weeks. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.