$328 Find Cheap Flights from Des Moines to Grand Cayman

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Grand Cayman departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Grand Cayman

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Grand Cayman, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Grand Cayman, as well as popular online travel agencies
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Book Cheap Des Moines to Grand Cayman Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Grand Cayman that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Grand Cayman

Sat, Jun 20 - Mon, Jun 29
Multiple Airlines Logo
4:22 pm - 5:20 pm
DSM
-
GCM
24h 58m
1 stop
Multiple Airlines Logo
12:40 pm - 11:35 pm
GCM
-
DSM
10h 55m
1 stop
$622Multiple Airlines
Wed, Jul 8 - Sat, Jul 11
Multiple Airlines Logo
2:19 pm - 11:35 am
DSM
-
GCM
21h 16m
2 stops
Multiple Airlines Logo
11:25 am - 9:43 pm
GCM
-
DSM
10h 18m
1 stop
$633Multiple Airlines
Mon, Jul 6 - Sat, Jul 11
Multiple Airlines Logo
1:37 pm - 4:05 pm
DSM
-
GCM
26h 28m
2 stops
Multiple Airlines Logo
11:25 am - 9:43 pm
GCM
-
DSM
10h 18m
1 stop
$643Multiple Airlines
Fri, Jun 26 - Mon, Jun 29
Multiple Airlines Logo
5:05 pm - 4:05 pm
DSM
-
GCM
23h 00m
1 stop
Multiple Airlines Logo
12:40 pm - 11:35 pm
GCM
-
DSM
10h 55m
1 stop
$649Multiple Airlines
Sat, Jun 20 - Tue, Jun 30
Multiple Airlines Logo
4:22 pm - 5:20 pm
DSM
-
GCM
24h 58m
1 stop
Multiple Airlines Logo
11:30 am - 1:31 pm
GCM
-
DSM
26h 01m
2 stops
$670Multiple Airlines
Fri, May 29 - Wed, Jun 3
Southwest Logo
7:10 pm - 12:05 pm
DSM
-
GCM
16h 55m
2 stops
Southwest Logo
1:05 pm - 10:10 pm
GCM
-
DSM
9h 05m
2 stops
$672Southwest
Sun, Jul 5 - Wed, Jul 15
Delta Logo
5:35 am - 11:34 am
DSM
-
GCM
5h 59m
1 stop
Delta Logo
12:56 pm - 10:29 pm
GCM
-
DSM
9h 33m
1 stop
$681Delta
Mon, Jul 6 - Wed, Jul 15
Delta Logo
6:50 am - 11:31 am
DSM
-
GCM
28h 41m
2 stops
Delta Logo
12:56 pm - 9:45 am
GCM
-
DSM
20h 49m
2 stops
$686Delta
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
5:00 am - 4:11 pm
DSM
-
GCM
11h 11m
2 stops
American Airlines Logo
12:33 pm - 7:30 pm
GCM
-
DSM
6h 57m
1 stop
$691American Airlines
Thu, Jun 25 - Mon, Jun 29
Multiple Airlines Logo
6:00 am - 4:05 pm
DSM
-
GCM
34h 05m
2 stops
Multiple Airlines Logo
12:40 pm - 11:35 pm
GCM
-
DSM
10h 55m
1 stop
$697Multiple Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Grand Cayman flights

Get data-powered insights and trends into flights from Des Moines to Grand Cayman to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Des Moines to Grand Cayman?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $337, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Des Moines to Grand Cayman?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Grand Cayman, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Grand Cayman is December, when tickets cost $496 (return) on average. On the other hand, the most expensive months are April and May, when the average cost of round-trip tickets is $710 and $686 respectively.

Good to know

Low seasonMay
Cheapest flight$328
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 24% lower on average.
Flight from Des Moines to George Town

FAQs - booking Grand Cayman flights

  • How does KAYAK find such low prices on flights from Des Moines to Grand Cayman?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Grand Cayman.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Grand Cayman?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Grand Cayman is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Grand Cayman?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Grand Cayman with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Grand Cayman?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Grand Cayman up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to Grand Cayman

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Grand Cayman. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Grand Cayman? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8459 reviews
8.5Crew
7.2Food
7.8Entertainment
7.9Comfort
8.1Boarding
Airline reviews

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

10.0 ExcellentIrmara, May 2026
MCO - BOS
Read more Delta reviews

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

Seats in Delta Main are unbelievably close to the seat in front of. Hard to get a backpack under the seat.

The flight was operated by Latam. The aircraft had a technical issue and the flight was delayed for the next day. They grounded other passengers to get their airplane assigned to my flight. Most of he ground staff don't speak English (Orlando Airport), but were very polite.The crew on the other hand could speak English and Portuguese. On board service was good.

The agent at check in and at the gate were less than thrilled to be at work. I'm not a fan of Kayak's placement on the plane. I got put in the middle seat and none of my preferences were used.

In ATL they have two sets of departure screens. Follow what is on your airline's departure board - the ATL Airport Authority departure board had completely incorrect details about the gate assignment for my flight, which would have made me miss boarding.

Flight was delayed it was hot while sitting on the plane, one engine was working on the plane until they had to do some jimmy rigging down the runway in order for the other engine to charge up. It was ridiculous

The flight was very good and the staff was very friendly and helpful!

The only thing I would say is we tried to get on a standby earlier flight, but with our fair we couldn’t. That seems senseless to leave with open seats..

Very easy to use and convenient, you can perform any action within the same portal

In a world of delays, Delta was on time both ways! Boarding was fast and efficient. Staff was friendly. AND wifi worked.

O’hsre taxi and deboarding took 40 minutes. Needed 20 minutes extra time between connecting flights to avoid running through terminal.

Cree was organized and pleasant. Plane had good seating but as it’s a shuttle toilets hadn’t been thoroughly cleaned (eg. bins too full)

I liked that my son and I were reseated next to each other (we had different bookings). I liked that it was a directg flight and mostly on time. I liked that you provided pillows and blankets. Flight attendants were generally courteous. The messaging through wifi did not work well. The food was not good. Seats are very narrow and I felt slightly claustraphobic in the window seat.

Overall a good experience, but no wifi available for free or for purchase and we got wet from condensation or other water source during descent.

Some crew were unfriendly or in some cases just straight up rude.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Was great in general, try to respect time and excuses when slight changes have been made, appreciated!

A long delay. Don't travel late in the day.

Super friendly with lots of drink options an entertainment. Friendly crew.

Standard flight with a drinks and a snack- overall very quick flight. The flight attendants were very strict, bordered on rude.

Terrible, horrible, disappointing- without telling us they changed planes and moved and separated our seats to opposite sides - said they changed seats putting us together - got to airport to find no, they did not - we sat opposing sides of plane - food overly salty to inedible, never saw stewardess but once - it was terrible

not sure why you ask about food, I n3ver get food on flights except maybe cookies or pretzels. wifi was slow and in and out most of the flight not good.

The crew was very attentive through out the flight. Seats were comfortable, nice flight bag with pillow and blanket. Food was okay, since it was a overnight flight seemed to go by fast.

The flight attendant on my side of business class seemed like a novice and did not provide good service. Otherwise the flight was good and the entertainment system was very good. No free WiFi.

Cancelled BOYH legs of our flight home 30 min before initial boarding

Cancelled the flight half hour before boarding. Then cancelled the connecting flight too.

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

I would like a refund for the extra cost the seat I paid for. An oversized person sat next to me and I couldn’t fit on my seat and had to move to another seat.

Boarding gate at LAX was too crowded—two gates next to one another

The flight was delayed about an hour for a maintenance specialist to approve the maintenance repair

Everything you need to know for your flight to Grand Cayman

Information on your arrival and departure airports