$440 Find Cheap Flights from Des Moines to Chile

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Chile departing on 3/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Chile

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Chile

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Santiago
Santiago1 stop$845
Punta Arenas
Punta Arenas3 stops$1,272
Santiago
Santiago1 stop$845
Punta Arenas
Punta Arenas3 stops$1,272

Book Cheap Des Moines to Chile Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Chile that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Chile

Wed, Mar 4 - Wed, Mar 11
LATAM Airlines Logo
12:04 pm - 7:40 am
DSM
-
SCL
16h 36m
1 stop
LATAM Airlines Logo
10:10 pm - 10:48 am
SCL
-
DSM
14h 38m
1 stop
$845LATAM Airlines
Wed, Mar 4 - Wed, Mar 11
LATAM Airlines Logo
12:04 pm - 7:40 am
DSM
-
SCL
16h 36m
1 stop
LATAM Airlines Logo
11:25 pm - 4:33 pm
SCL
-
DSM
19h 08m
2 stops
$847LATAM Airlines
Mon, Mar 9 - Mon, Mar 16
American Airlines Logo
3:26 pm - 7:00 am
DSM
-
SCL
13h 34m
1 stop
American Airlines Logo
10:15 pm - 2:56 pm
SCL
-
DSM
18h 41m
1 stop
$850American Airlines
Wed, Mar 4 - Wed, Mar 11
American Airlines Logo
1:38 pm - 9:30 am
DSM
-
SCL
16h 52m
2 stops
American Airlines Logo
9:20 pm - 1:18 pm
SCL
-
DSM
17h 58m
2 stops
$852American Airlines
Mon, Mar 2 - Mon, Mar 9
Delta Logo
5:24 am - 7:40 am
DSM
-
SCL
23h 16m
1 stop
Delta Logo
6:35 pm - 4:33 pm
SCL
-
DSM
23h 58m
2 stops
$858Delta
Mon, Mar 9 - Mon, Mar 16
LATAM Airlines Logo
11:33 am - 2:10 pm
DSM
-
SCL
24h 37m
3 stops
LATAM Airlines Logo
10:10 pm - 10:48 am
SCL
-
DSM
14h 38m
1 stop
$863LATAM Airlines
Mon, Mar 9 - Mon, Mar 16
LATAM Airlines Logo
11:33 am - 2:10 pm
DSM
-
SCL
24h 37m
3 stops
LATAM Airlines Logo
11:25 pm - 4:33 pm
SCL
-
DSM
19h 08m
2 stops
$864LATAM Airlines
Sun, Mar 8 - Sat, Mar 14
LATAM Airlines Logo
5:20 pm - 2:10 pm
DSM
-
SCL
18h 50m
2 stops
LATAM Airlines Logo
12:20 am - 10:38 pm
SCL
-
DSM
24h 18m
2 stops
$888LATAM Airlines
Sun, Mar 8 - Sun, Mar 15
Multiple Airlines Logo
5:20 pm - 11:14 am
DSM
-
PUQ
39h 54m
3 stops
Multiple Airlines Logo
12:09 pm - 10:48 am
PUQ
-
DSM
24h 39m
3 stops
$1,272Multiple Airlines
Thu, Feb 19 - Wed, Feb 25
Iberia Logo
10:04 am - 7:56 am
DSM
-
PUQ
42h 52m
3 stops
Iberia Logo
4:36 am - 7:05 pm
PUQ
-
DSM
41h 29m
3 stops
$3,559Iberia
Booking Insights

KAYAK's insights & trends for Des Moines to Chile flights

Get data-powered insights and trends into flights from Des Moines to Chile to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Chile?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Chile were found on LATAM Airlines ($845) and American Airlines ($850).

Good to know

Low seasonOctober
Cheapest flight$440
Best time to beat the crowds with an average 29% drop in price.
Most popular time to fly with an average 45% increase in price.
Flight from Des Moines to Santiago

FAQs - booking Chile flights

  • How does KAYAK find such low prices on flights from Des Moines to Chile?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Chile.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Chile?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Chile is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Chile?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Chile with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Chile?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Chile up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Chile

 
Need help choosing which airline to fly with from Des Moines to Chile? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1913 reviews
7.3Comfort
7.6Boarding
7.0Entertainment
8.0Crew
6.7Food
Airline reviews

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

2.0 MediocreJess, Jan 2026
BSB - GRU
Read more LATAM Airlines reviews

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Everything you need to know for your flight from Des Moines to Chile

Information on your arrival and departure airports