DSM - SCL

$372 Find Cheap Flights from Des Moines to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Santiago departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Des Moines to Santiago (DSM-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Santiago

Thu, Dec 11 - Thu, Dec 18
American Airlines Logo
5:00 am - 7:45 amDSM-SCL
23h 45m1 stop
American Airlines Logo
10:25 pm - 11:58 pmSCL-DSM
28h 33m1 stop
$763American Airlines
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Thu, Dec 11 - Thu, Dec 18
United Airlines Logo
8:15 am - 8:50 amDSM-SCL
21h 35m1 stop
United Airlines Logo
10:45 pm - 2:19 pmSCL-DSM
18h 34m1 stop
$764United Airlines
Find Deal
Thu, Dec 11 - Thu, Dec 18
American Airlines Logo
2:08 pm - 8:55 amDSM-SCL
15h 47m2 stops
American Airlines Logo
11:15 pm - 3:08 pmSCL-DSM
18h 53m1 stop
$767American Airlines
Find Deal
Thu, Dec 11 - Thu, Dec 18
American Airlines Logo
12:57 pm - 8:55 amDSM-SCL
16h 58m2 stops
American Airlines Logo
11:15 pm - 6:05 pmSCL-DSM
21h 50m2 stops
$768American Airlines
Find Deal
Thu, Dec 11 - Thu, Dec 18
United Airlines Logo
8:15 am - 8:50 amDSM-SCL
21h 35m1 stop
United Airlines Logo
10:45 pm - 9:40 pmSCL-DSM
25h 55m2 stops
$769United Airlines
Find Deal
Thu, Dec 11 - Wed, Dec 17
Multiple Airlines Logo
2:56 pm - 1:24 amDSM-SCL
31h 28m3 stops
Multiple Airlines Logo
1:08 am - 10:36 pmSCL-DSM
24h 28m3 stops
$926Multiple Airlines
Find Deal
Thu, Dec 11 - Wed, Dec 17
Multiple Airlines Logo
2:56 pm - 5:14 amDSM-SCL
35h 18m3 stops
Multiple Airlines Logo
1:08 am - 10:36 pmSCL-DSM
24h 28m3 stops
$934Multiple Airlines
Find Deal
Thu, Dec 11 - Wed, Dec 17
LATAM Airlines Logo
2:16 pm - 2:30 pmDSM-SCL
21h 14m3 stops
LATAM Airlines Logo
4:35 am - 10:34 pmSCL-DSM
20h 59m2 stops
$938LATAM Airlines
Find Deal
Thu, Dec 11 - Thu, Dec 18
LATAM Airlines Logo
2:16 pm - 2:30 pmDSM-SCL
21h 14m3 stops
LATAM Airlines Logo
6:40 am - 10:34 pmSCL-DSM
18h 54m2 stops
$942LATAM Airlines
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Fri, Dec 12 - Fri, Dec 19
Delta Logo
2:16 pm - 7:40 amDSM-SCL
14h 24m1 stop
Delta Logo
11:10 pm - 5:15 pmSCL-DSM
21h 05m1 stop
$1,229Delta
Find Deal

Everything you should know

Top airlines
American Airlines
Cheapest • from $763 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Cheapest round-trip
$763
American Airlines
Thu 12/11Thu 12/18
DSM - SCL • 1 stop
Cheapest one-way
$372
Multiple Airlines
Sat 3/21
DSM - SCL • 2 stops
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Booking Insights

KAYAK's insights & trends for Des Moines to Santiago flights

Get data-powered insights and trends into flights from Des Moines to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Santiago were found on American Airlines ($763) and United Airlines ($764).

Which airlines fly non-stop between Des Moines and Santiago?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Des Moines to Santiago.

There is just one airline that flies from Des Moines to Santiago direct and that is LATAM Airlines. The best round-trip deal found from LATAM Airlines for the route is $814.

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Good to know

Low seasonOctober
Cheapest flight$372
Best time to beat the crowds with an average 28% drop in price.
Most popular time to fly with an average 55% increase in price.
Flight from Des Moines to Santiago

When to book flights from Des Moines to Santiago

Are your dates flexible? Find out the best times to travel from Des Moines to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Santiago

  • What is the cheapest flight from Des Moines to Santiago?

    In the last 3 days, the lowest price for a flight from Des Moines to Santiago was $372 for a one-way ticket and $763 for a round-trip.

  • Do I need a passport to fly between Des Moines and Santiago?

    Yes, you’ll need a passport to travel to Santiago from Des Moines.

  • Which airports will I be using when flying from Des Moines to Santiago?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Santiago, also known as Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Des Moines to Santiago?

    We unfortunately don’t have that data for this specific route.

  • How does KAYAK find such low prices on flights from Des Moines to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1871 reviews
7.5Boarding
7.0Entertainment
8.0Crew
7.3Comfort
6.7Food
Airline reviews

Poor, the airline was not able to help me move flights.

2.0 MediocreChristopher, Oct 2025SDU - BSB
Read more LATAM Airlines reviews

Poor, the airline was not able to help me move flights.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Lost ,y connection due to a mechanical delay, huge line to get new connection and vouchers

Everything you need to know for your flight from Des Moines to Santiago

Information on your arrival and departure airports

Des Moines (DSM)
Santiago (SCL)

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