DSM - SCL

$583 Find Cheap Flights from Des Moines to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Santiago departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Des Moines to Santiago (DSM-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Santiago

Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
8:47 pm - 10:15 pmDSM-SCL
47h 28m3 stops
Multiple Airlines Logo
12:30 pm - 5:08 pmSCL-DSM
31h 38m3 stops
$707Multiple Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Delta Logo
2:13 pm - 7:40 amDSM-SCL
15h 27m1 stop
Delta Logo
11:10 pm - 1:28 pmSCL-DSM
17h 18m1 stop
$764Delta
Find Deal
Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
8:47 pm - 2:40 pmDSM-SCL
39h 53m3 stops
Multiple Airlines Logo
8:55 pm - 2:58 pmSCL-DSM
21h 03m2 stops
$766Multiple Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
United Airlines Logo
6:05 am - 7:50 amDSM-SCL
23h 45m1 stop
United Airlines Logo
10:45 pm - 12:14 pmSCL-DSM
16h 29m2 stops
$768United Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
8:47 pm - 10:15 pmDSM-SCL
47h 28m3 stops
Multiple Airlines Logo
8:55 pm - 2:55 pmSCL-DSM
21h 00m2 stops
$774Multiple Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
8:47 pm - 2:40 pmDSM-SCL
39h 53m3 stops
Multiple Airlines Logo
8:55 pm - 2:55 pmSCL-DSM
21h 00m2 stops
$775Multiple Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
United Airlines Logo
6:05 am - 7:50 amDSM-SCL
23h 45m1 stop
United Airlines Logo
10:45 pm - 2:11 pmSCL-DSM
18h 26m1 stop
$844United Airlines
Find Deal
Thu, Oct 30 - Wed, Nov 5
LATAM Airlines Logo
2:13 pm - 7:40 amDSM-SCL
15h 27m1 stop
LATAM Airlines Logo
12:20 am - 5:44 pmSCL-DSM
20h 24m2 stops
$871LATAM Airlines
Find Deal
Thu, Oct 30 - Wed, Nov 5
LATAM Airlines Logo
10:50 am - 6:25 amDSM-SCL
17h 35m2 stops
LATAM Airlines Logo
12:20 am - 5:44 pmSCL-DSM
20h 24m2 stops
$966LATAM Airlines
Find Deal
Fri, Dec 26 - Thu, Jan 8
American Airlines Logo
6:00 am - 7:55 amDSM-SCL
22h 55m1 stop
American Airlines Logo
11:15 pm - 2:56 pmSCL-DSM
18h 41m1 stop
$1,492American Airlines
Find Deal

Everything you should know

Top airlines
Delta
Cheapest • from $764 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Cheapest round-trip
$707
Multiple Airlines
Thu 10/30Thu 11/6
DSM - SCL • 3 stops
Cheapest one-way
$583
Delta
Fri 10/31
DSM - SCL • 1 stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
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Booking Insights

KAYAK's insights & trends for Des Moines to Santiago flights

Get data-powered insights and trends into flights from Des Moines to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Santiago were found on Delta ($764) and United Airlines ($768).

Find deals

Good to know

Low seasonNovember
Cheapest flight$583
Best time to beat the crowds with an average 33% drop in price.
Most popular time to fly with an average 49% increase in price.
Flight from Des Moines to Santiago

When to book flights from Des Moines to Santiago

Are your dates flexible? Find out the best times to travel from Des Moines to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Santiago

  • What is the cheapest flight from Des Moines to Santiago?

    In the last 3 days, the lowest price for a flight from Des Moines to Santiago was $583 for a one-way ticket and $707 for a round-trip.

  • Do I need a passport to fly between Des Moines and Santiago?

    Yes, you’ll need a passport to travel to Santiago from Des Moines.

  • Which airports will I be using when flying from Des Moines to Santiago?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Santiago, also known as Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Des Moines to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Santiago?

    SkyTeam, Star Alliance, and oneworld are the airline alliances operating flights between Des Moines and Santiago, with SkyTeam being the most commonly used for this route.

  • How does KAYAK find such low prices on flights from Des Moines to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1847 reviews
7.6Boarding
8.0Crew
6.7Food
7.4Comfort
7.0Entertainment
Airline reviews

The flight was late. Please do not delay next time.

6.0 GoodAnonymous, Aug 2025AUS - ATL
Read more LATAM Airlines reviews

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Lost ,y connection due to a mechanical delay, huge line to get new connection and vouchers

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

Wider seats, better seat cushions, (I felt like there was a board I was sitting on). I had the chicken to eat but It neither tasted nor looked like chicken. The fruit was good.

I was in the last row and they sent me to check in my luggage last minute after boarding. I had to go through the crowd.

Our flight was cancelled and it took them 5 hours to reschedule and the next morning they said we still didn’t have a new ticket.

Everything you need to know for your flight from Des Moines to Santiago

Information on your arrival and departure airports

Des Moines (DSM)
Santiago (SCL)

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