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DSM - SCL

$374 Find Cheap Flights from Des Moines to Santiago - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$1,153
Typical prices: $931-$1,823
LATAM Airlines
Fri 1/5Fri 3/2
DSM - SCL • 1 stop
Cheapest one-way
$374
Typical prices: $622-$790
Multiple Airlines
Fri 10/19
DSM - SCL • 3 stops
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Santiago. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
January
Cheapest • 33% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $764 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 14h 35m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Des Moines to Santiago (DSM-SCL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Santiago

Tue, Jan 5 - Tue, Mar 2
LATAM Airlines Logo
11:04 am - 6:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
16h 36m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
11:10 pm - 4:27 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
20h 17m1 stop Atlanta Hartsfield-Jackson
$1,153LATAM Airlines
Mon, Dec 14 - Wed, Dec 23
LATAM Airlines Logo
5:20 am - 6:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
22h 20m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
6:30 pm - 12:41 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
45h 11m2 stops Sao Paulo Guarulhos Intl Atlanta Hartsfield-Jackson
$1,157LATAM Airlines
Tue, Jan 5 - Tue, Mar 2
LATAM Airlines Logo
11:04 am - 6:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
16h 36m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
8:40 am - 10:29 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
16h 49m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,158LATAM Airlines
Thu, Nov 12 - Thu, Nov 19
American Airlines Logo
11:28 am - 8:45 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
18h 17m2 stops Charlotte Douglas Miami
American Airlines Logo
10:30 pm - 2:35 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
19h 05m2 stops Miami Dallas/Fort Worth
$1,160American Airlines
Thu, Nov 12 - Thu, Nov 19
LATAM Airlines Logo
2:59 pm - 7:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
13h 41m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
11:10 pm - 10:44 amSCL  Santiago Arturo Merino Benitez-DSM Des Moines
14h 34m1 stop Atlanta Hartsfield-Jackson
$1,162LATAM Airlines
Tue, Jan 5 - Tue, Mar 2
LATAM Airlines Logo
11:04 am - 7:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
17h 36m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
8:35 am - 10:18 amSCL  Santiago Arturo Merino Benitez-DSM Des Moines
28h 43m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson
$1,162LATAM Airlines
Thu, Nov 12 - Wed, Nov 18
LATAM Airlines Logo
2:59 pm - 7:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
13h 41m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
12:48 am - 6:07 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
20h 19m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson
$1,162LATAM Airlines
Sun, Nov 15 - Sun, Nov 22
American Airlines Logo
5:00 am - 8:45 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
24h 45m1 stop Miami
American Airlines Logo
10:30 pm - 11:44 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
28h 14m1 stop Miami
$1,164American Airlines
Sun, Nov 15 - Sun, Nov 22
American Airlines Logo
5:00 am - 8:45 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
24h 45m1 stop Miami
American Airlines Logo
10:30 pm - 11:44 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
28h 14m1 stop Miami
$1,166American Airlines
Tue, Jan 5 - Tue, Mar 2
LATAM Airlines Logo
5:15 pm - 7:55 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
35h 40m3 stops Atlanta Hartsfield-Jackson Miami Punta Cana
LATAM Airlines Logo
8:35 am - 4:27 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
34h 52m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson
$1,167LATAM Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Des Moines to Santiago?

Round-trip flights from Des Moines to Santiago typically range from $931 to $1,823. The lowest price found in the past 5 days was $1,153, on LATAM Airlines.

What's the cheapest day of the week to fly from Des Moines to Santiago?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Des Moines to Santiago. It’s 40% cheaper than the average day, while Monday is the most expensive, with prices 38% higher.

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Key details for Des Moines to Santiago flights

Low season

August

Cheapest flight

$374
One-way flight from Des Moines to Santiago

When to book flights from Des Moines to Santiago

Are your dates flexible? Find out the best times to travel from Des Moines to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Santiago flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Des Moines to Santiago?

    Only Economy Class is available on flights from Des Moines to Santiago.

  • How long is a flight from Des Moines to Santiago?

    A nonstop flight from Des Moines to Santiago takes 00m, covering 5,374 miles.

  • Do I need a passport to fly from Des Moines to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Des Moines to Santiago flight?

    Round-trip flights from Des Moines to Santiago range from $931 to $1,823, with an average of $1,350 over the past 12 months. Anything below $931 counts as a good deal.

  • Have flight prices from Des Moines to Santiago changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $1,153 to $1,675. That means the highest observed fare was about 45% higher than the lowest one.

  • How are flight prices from Des Moines to Santiago looking right now?

    One-way fares from Des Moines to Santiago are currently lower than usual. Average one-way flight prices are about $634, which is 20% below the typical average for this route.

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates starting from around $6 for economy cars. Top options include:

    • Lucano
    • United Rent-A-Car
    • Rosselot
    • FlexWays
    • Alamo

  • Which airports can I use when flying from Des Moines to Santiago?

    Flights from Des Moines to Santiago usually depart from Des Moines (DSM) and arrive at Santiago Arturo Merino Benitez (SCL).

  • Which airports do connecting flights from Des Moines to Santiago pass through?

    One-stop flights from Des Moines to Santiago most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 73% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 18% of one-stop connections
    • Dallas/Fort Worth (DFW) - 9% of one-stop connections

  • Can I save money by using flexible dates for flights from Des Moines to Santiago?

    Yes. Flexible dates can save you up to 57% on flights from Des Moines to Santiago. Thursday is the cheapest departure day at $814 round-trip on average, while Monday is the most expensive at $1,875, a difference of $1,061.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Des Moines to Santiago?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 14h 35m, compared with 15h 14m via Dallas/Fort Worth (DFW) and 16h 41m via Houston George Bush Intcntl (IAH).

  • What is the time difference between Des Moines and Santiago?

    Santiago is 2 hours ahead of Des Moines (Chile Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Costanera Center and Espacio Riesco Convention and Exhibition Center. These are among the most viewed places in Santiago on KAYAK.

Your guide to booking Des Moines to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Thursday departure and avoid flying on Monday. On this route, Thursday flights average $814, about $1,061 less than Monday fares (57% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Santiago trip for January. Fares historically average $906 round-trip in that month - typically $969 less than the most expensive month, which is December (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.

    • Holiday Inn Santiago - Airport Terminal By IHG

More options for your flight from Des Moines to Santiago

Complete your trip to Santiago with a hotel stay or car rental

Car rentals in Santiago
Hotels in Santiago
Vacations in Santiago