DSM - SCL

$1,243 Find Cheap Flights from Des Moines to Santiago - Compare and Save

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Everything you should know

Cheapest round-trip
$1,243
Typical prices: $985-$1,415
LATAM Airlines
Mon 12/10Tue 12/25
DSM - SCL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Santiago. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
October
Cheapest • 16% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $764 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 14h 51m (one-way)
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Insights
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Flight Deals

Cheap Flights from Des Moines to Santiago (DSM-SCL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Santiago

Thu, Dec 10 - Fri, Dec 25
LATAM Airlines Logo
5:20 am - 7:40 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
23h 20m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
11:00 pm - 5:02 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
21h 02m1 stop Atlanta Hartsfield-Jackson
$1,243LATAM Airlines
Sat, Jan 2 - Sun, Feb 28
American Airlines Logo
4:25 pm - 9:20 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
13h 55m1 stop Miami
American Airlines Logo
11:45 pm - 6:55 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
22h 10m1 stop Dallas/Fort Worth
$1,248American Airlines
Sat, Jan 2 - Sun, Feb 28
American Airlines Logo
9:40 am - 8:00 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
19h 20m2 stops Chicago O'Hare Intl Dallas/Fort Worth
American Airlines Logo
10:15 pm - 1:32 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
18h 17m2 stops Miami Chicago O'Hare Intl
$1,252American Airlines
Thu, Dec 10 - Fri, Dec 25
American Airlines Logo
3:31 pm - 8:15 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
13h 44m1 stop Dallas/Fort Worth
American Airlines Logo
10:25 pm - 6:58 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
23h 33m2 stops Miami Dallas/Fort Worth
$1,267American Airlines
Fri, Dec 11 - Sat, Dec 26
LATAM Airlines Logo
6:53 pm - 7:30 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
33h 37m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado
LATAM Airlines Logo
8:25 pm - 10:53 amSCL  Santiago Arturo Merino Benitez-DSM Des Moines
17h 28m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,273LATAM Airlines
Fri, Dec 11 - Sat, Dec 26
LATAM Airlines Logo
2:58 pm - 3:00 pmDSM  Des Moines-SCL Santiago Arturo Merino Benitez
21h 02m3 stops Atlanta Hartsfield-Jackson Miami Buenos Aires Ministro Pistarini
LATAM Airlines Logo
8:25 pm - 5:31 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
24h 06m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,277LATAM Airlines
Thu, Dec 10 - Fri, Dec 25
LATAM Airlines Logo
6:53 pm - 9:40 pmDSM  Des Moines-SCL Santiago Arturo Merino Benitez
23h 47m3 stops Atlanta Hartsfield-Jackson Miami Punta Cana
LATAM Airlines Logo
8:40 am - 10:38 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
16h 58m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,310LATAM Airlines
Sat, Jan 2 - Sun, Feb 28
LATAM Airlines Logo
6:43 pm - 3:00 pmDSM  Des Moines-SCL Santiago Arturo Merino Benitez
41h 17m3 stops Atlanta Hartsfield-Jackson Miami Buenos Aires Ministro Pistarini
LATAM Airlines Logo
8:35 am - 10:18 amSCL  Santiago Arturo Merino Benitez-DSM Des Moines
28h 43m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson
$1,313LATAM Airlines
Thu, Dec 10 - Fri, Dec 25
American Airlines Logo
11:38 am - 9:15 amDSM  Des Moines-SCL Santiago Arturo Merino Benitez
18h 37m2 stops Charlotte Douglas Miami
American Airlines Logo
10:25 pm - 6:58 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
23h 33m2 stops Miami Dallas/Fort Worth
$1,324American Airlines
Sat, Jan 2 - Sun, Feb 28
LATAM Airlines Logo
6:43 pm - 3:00 pmDSM  Des Moines-SCL Santiago Arturo Merino Benitez
41h 17m3 stops Atlanta Hartsfield-Jackson Miami Buenos Aires Ministro Pistarini
LATAM Airlines Logo
11:10 pm - 10:29 pmSCL  Santiago Arturo Merino Benitez-DSM Des Moines
26h 19m2 stops Miami Atlanta Hartsfield-Jackson
$1,348LATAM Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Des Moines to Santiago?

Round-trip flights from Des Moines to Santiago typically range from $985 to $1,415. The lowest price found in the past 5 days was $1,243, on LATAM Airlines.

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Key details for Des Moines to Santiago flights

Cheapest flight

$1,243
The most popular month to fly with an average 56% increase in travelers.
Round-trip flight from Des Moines to Santiago

When to book flights from Des Moines to Santiago

Are your dates flexible? Find out the best times to travel from Des Moines to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Santiago flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Des Moines to Santiago?

    Only Economy Class is available on flights from Des Moines to Santiago.

  • How long is a flight from Des Moines to Santiago?

    A nonstop flight from Des Moines to Santiago takes 00m, covering 5,374 miles.

  • Do I need a passport to fly from Des Moines to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Des Moines to Santiago flight?

    Round-trip flights from Des Moines to Santiago range from $985 to $1,415, with an average of $1,169 over the past 12 months. Anything below $985 counts as a good deal.

  • Have flight prices from Des Moines to Santiago changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $1,243 to $3,599. That means the highest observed fare was about 3x higher than the lowest one.

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates averaging $36 for economy cars. Top options include:

    • Lucano
    • United Rent-A-Car
    • FlexWays
    • Rosselot
    • Alamo

  • Which airports can I use when flying from Des Moines to Santiago?

    Flights from Des Moines to Santiago usually depart from Des Moines (DSM) and arrive at Santiago Arturo Merino Benitez (SCL).

  • Which airports do connecting flights from Des Moines to Santiago pass through?

    Connecting flights from Des Moines to Santiago most commonly pass through:

    • Atlanta Hartsfield-Jackson (ATL) - 82% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 18% of one-stop connections

  • Can I save money by using flexible dates for flights from Des Moines to Santiago?

    Yes. Flexible dates can save you up to 36% on flights from Des Moines to Santiago. Monday is the cheapest departure day at $985 round-trip on average, while Saturday is the most expensive at $1,536, a difference of $551.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Des Moines to Santiago?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 14h 51m, compared with 16h 41m via Houston George Bush Intcntl (IAH).

  • What is the time difference between Des Moines and Santiago?

    Santiago is 3 hours ahead of Des Moines (Chile Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Espacio Riesco Convention and Exhibition Center and Costanera Center. These are among the most viewed places in Santiago on KAYAK.

Your guide to booking Des Moines to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Monday departure and avoid flying on Saturday. On this route, Monday flights average $985, about $551 less than Saturday fares (36% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Santiago trip for October. Fares historically average $985 round-trip in that month - typically $720 less than the most expensive month, which is May (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.

    • Holiday Inn Santiago - Airport Terminal By IHG

More options for your flight from Des Moines to Santiago

Complete your trip to Santiago with a hotel stay or car rental

Car rentals in Santiago
Hotels in Santiago
Vacations in Santiago