DSM - SCL

$440 Find Cheap Flights from Des Moines to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Santiago departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$841
Typical prices: $1,190-$1,309
Multiple Airlines
Mon 3/2Mon 3/9
DSM - SCL • 1 stop
Cheapest one-way
$457
Delta
Fri 3/6
DSM - SCL • 2 stops
Top airlines
LATAM Airlines
Cheapest • from $845 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Santiago (DSM-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Santiago

Mon, Mar 2 - Mon, Mar 9
Multiple Airlines Logo
2:59 pm - 8:50 am
DSM
-
SCL
14h 51m
1 stop
Multiple Airlines Logo
9:45 pm - 2:18 pm
SCL
-
DSM
18h 33m
1 stop
$841Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
LATAM Airlines Logo
12:04 pm - 7:40 am
DSM
-
SCL
16h 36m
1 stop
LATAM Airlines Logo
10:10 pm - 10:48 am
SCL
-
DSM
14h 38m
1 stop
$845LATAM Airlines
Mon, Mar 2 - Wed, Mar 11
Multiple Airlines Logo
2:59 pm - 8:50 am
DSM
-
SCL
14h 51m
1 stop
Multiple Airlines Logo
9:45 pm - 1:23 pm
SCL
-
DSM
17h 38m
2 stops
$846Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
LATAM Airlines Logo
12:04 pm - 7:40 am
DSM
-
SCL
16h 36m
1 stop
LATAM Airlines Logo
11:25 pm - 4:33 pm
SCL
-
DSM
19h 08m
2 stops
$847LATAM Airlines
Mon, Mar 2 - Mon, Mar 9
LATAM Airlines Logo
5:24 am - 7:40 am
DSM
-
SCL
23h 16m
1 stop
LATAM Airlines Logo
10:10 pm - 10:48 am
SCL
-
DSM
14h 38m
1 stop
$851LATAM Airlines
Wed, Mar 4 - Wed, Mar 11
American Airlines Logo
1:38 pm - 9:30 am
DSM
-
SCL
16h 52m
2 stops
American Airlines Logo
9:20 pm - 1:18 pm
SCL
-
DSM
17h 58m
2 stops
$852American Airlines
Mon, Mar 2 - Mon, Mar 9
LATAM Airlines Logo
5:15 pm - 2:05 pm
DSM
-
SCL
17h 50m
2 stops
LATAM Airlines Logo
10:10 pm - 10:48 am
SCL
-
DSM
14h 38m
1 stop
$855LATAM Airlines
Mon, Mar 2 - Mon, Mar 9
Delta Logo
5:24 am - 7:40 am
DSM
-
SCL
23h 16m
1 stop
Delta Logo
6:35 pm - 4:33 pm
SCL
-
DSM
23h 58m
2 stops
$858Delta
Tue, Mar 3 - Mon, Mar 9
Avianca Logo
2:59 pm - 8:50 am
DSM
-
SCL
14h 51m
1 stop
Avianca Logo
9:45 pm - 1:23 pm
SCL
-
DSM
17h 38m
2 stops
$860Avianca
Sun, Mar 1 - Wed, Mar 11
United Airlines Logo
6:55 pm - 8:50 am
DSM
-
SCL
34h 55m
2 stops
United Airlines Logo
9:45 pm - 2:18 pm
SCL
-
DSM
18h 33m
1 stop
$863United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Santiago flights

Get data-powered insights and trends into flights from Des Moines to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Santiago were found on LATAM Airlines ($845) and American Airlines ($852).

Find deals

Good to know

Low seasonOctober
Cheapest flight$457
Best time to beat the crowds with an average 29% drop in price.
Most popular time to fly with an average 45% increase in price.
Flight from Des Moines to Santiago

When to book flights from Des Moines to Santiago

Are your dates flexible? Find out the best times to travel from Des Moines to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Santiago

  • What is the cheapest flight from Des Moines to Santiago?

    In the last 3 days, the lowest price for a flight from Des Moines to Santiago was $457 for a one-way ticket and $841 for a round-trip.

  • Do I need a passport to fly between Des Moines and Santiago?

    Yes, you’ll need a passport to travel to Santiago from Des Moines.

  • Which airports will I be using when flying from Des Moines to Santiago?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Santiago, also known as Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Des Moines to Santiago?

    We unfortunately don’t have that data for this specific route.

  • How does KAYAK find such low prices on flights from Des Moines to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1913 reviews
8.0Crew
7.0Entertainment
7.3Comfort
7.6Boarding
6.7Food
Airline reviews

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

8.0 ExcellentAnonymous, Jan 2026
BOG - ATL
Read more LATAM Airlines reviews

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Everything you need to know for your flight from Des Moines to Santiago

Information on your arrival and departure airports

Des Moines (DSM)
Santiago (SCL)