$349 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$829
Bogotá
Bogotá1 stop$681
Santiago
Santiago1 stop$1,211
Cartagena
Cartagena2 stops$656
Quito
Quito1 stop$720
Guayaquil
Guayaquil2 stops$701
Barranquilla
Barranquilla2 stops$737
Belo Horizonte
Belo Horizonte2 stops$1,508
Lima
Lima2 stops$829
Bogotá
Bogotá1 stop$681
Santiago
Santiago1 stop$1,211
Cartagena
Cartagena2 stops$656
Quito
Quito1 stop$720
Guayaquil
Guayaquil2 stops$701
Barranquilla
Barranquilla2 stops$737
Belo Horizonte
Belo Horizonte2 stops$1,508

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sat, Aug 1 - Fri, Aug 14
American Airlines Logo
4:48 pm - 12:35 pm
DSM
-
CTG
19h 47m
2 stops
American Airlines Logo
3:15 pm - 1:25 pm
CTG
-
DSM
22h 10m
2 stops
$656American Airlines
Sat, Aug 1 - Fri, Aug 14
American Airlines Logo
7:13 pm - 12:35 pm
DSM
-
CTG
17h 22m
2 stops
American Airlines Logo
1:35 pm - 9:01 am
CTG
-
DSM
19h 26m
2 stops
$658American Airlines
Thu, Nov 12 - Sun, Dec 13
Delta Logo
2:15 pm - 1:40 am
DSM
-
GYE
34h 25m
2 stops
Delta Logo
5:00 pm - 4:04 pm
GYE
-
DSM
24h 04m
1 stop
$707Delta
Thu, Oct 22 - Tue, Oct 27
United Airlines Logo
6:00 am - 11:25 pm
DSM
-
UIO
17h 25m
1 stop
United Airlines Logo
12:35 am - 5:23 pm
UIO
-
DSM
16h 48m
2 stops
$720United Airlines
Thu, Oct 22 - Tue, Oct 27
United Airlines Logo
6:00 am - 11:25 pm
DSM
-
UIO
17h 25m
1 stop
United Airlines Logo
12:35 am - 10:25 pm
UIO
-
DSM
21h 50m
1 stop
$726United Airlines
Tue, Nov 3 - Fri, Dec 4
Delta Logo
2:15 pm - 1:40 am
DSM
-
GYE
34h 25m
2 stops
Delta Logo
5:00 pm - 9:24 am
GYE
-
DSM
17h 24m
2 stops
$734Delta
Wed, Dec 2 - Sun, Dec 6
Avianca Logo
3:15 pm - 3:30 pm
DSM
-
VVC
23h 15m
2 stops
Avianca Logo
4:00 pm - 9:17 pm
VVC
-
DSM
54h 17m
2 stops
$783Avianca
Sun, Oct 18 - Wed, Oct 21
LATAM Airlines Logo
5:45 am - 6:59 pm
DSM
-
UIO
13h 14m
1 stop
LATAM Airlines Logo
12:59 am - 5:42 pm
UIO
-
DSM
16h 43m
1 stop
$787LATAM Airlines
Tue, Nov 10 - Fri, Dec 11
Avianca Logo
3:15 pm - 9:15 am
DSM
-
GYE
17h 00m
2 stops
Avianca Logo
10:25 am - 9:17 pm
GYE
-
DSM
35h 52m
2 stops
$800Avianca
Sun, Oct 18 - Sat, Oct 24
LATAM Airlines Logo
6:30 pm - 10:00 pm
DSM
-
LIM
27h 30m
2 stops
LATAM Airlines Logo
1:30 pm - 10:18 am
LIM
-
DSM
20h 48m
2 stops
$838LATAM Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South America is August, when tickets cost $489 (return) on average. On the other hand, the most expensive months are May and November, when the average cost of round-trip tickets is $995 and $867 respectively.

Good to know

Low seasonFebruary
Cheapest flight$349
Best time to beat the crowds with an average 40% drop in price.
Most popular time to fly with an average 48% increase in price.
Flight from Des Moines to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8455 reviews
7.8Comfort
8.1Boarding
8.5Crew
7.8Entertainment
7.2Food
Airline reviews

It was as good as it could be. Flying is not a pleasant experience these days.

8.0 ExcellentMark, Jun 2026
LAX - ORD
Read more Delta reviews

It was as good as it could be. Flying is not a pleasant experience these days.

The plane was old and thus the seats were not good. No cushion left whatsoever, and it all was a bit worn out.

I was in Comfort and we didn’t get any drinks, chips or anything! First Class got full service on the flight and Comfort got nothing. Seat was horrible and uncomfortable

My flight was delayed by 4 hours in 30 minute increments. The gate agents were amazing but the communication was not. We were told that there was a maintenance issue but they didn't know what it was. That didn't inspire confidence. Then they said they found it and it was fixed and the pilot just needed to sign off. Then the pilot needed to talk to the other pilot from the arriving flight and we'd be fine. Then we were waiting for the pilot to call back. Then the maintenance issue wasn't fixed. Then they decided we were getting a new plane (why didn't they decide this earlier??). Fine. But then they announced we were changing gates AND terminals. And we were boarding in 20 minutes. So we all had to run to the new terminal gate. We could have taken off at that time, but we then had to wait for all the people who rebooked on a different flight to book this flight again. That took 30+ minutes because there was only one gate agent. When everyone ditched this flight, I saw it as an opportunity to upgrade to comfort. Delta, the greedy jerks they are, charged me $121. After their delay, their fault, their issues, couldn't even discount an upgrade. They only handed out $12 meal vouchers for the delay. I can't even get a snack from starbucks for that.

The crew was very inconsiderate and rude. My flight was scheduled to depart at 6:00am. I received a call from the crew at 5:40am, asking if I was going to make the flight because I was the only one that hasn't boarded yet and boarding ends at 5:50am. I let them know that I will be at the gate in a few minutes, before the 5:50am cutoff. When I arrived at the gate at 5:45am the gate was closed. Departing early on last minute notice without having all passengers on board is inconsiderate and unprofessional.

FA was a bit strange and dodgy not very characteristic of Delta

Not really a “Delta” problem but worth mentioning: Boarding was a difficult process. TSA seemed understaffed and Pre-Check took longer than regular TSA. The supervisor was frazzled and yelled at travelers. Once through TSA, we had to put our carry-ons through another x-ray machine. Then queue up to board with both boarding pass and ID. Then, when we got to the stairs on the tarmac, we had to show our boarding pass again. Maybe this is just normal for Kona since the terminal is outdoors (but still a “secured” area).

flight was delayed 4+ hours. there was really no understanding of why? weather? the last hour of delay was post boarding. pilot seat was broken. was that the real reason? nonetheless, long day of inconveniences.

Love me some Delta. One of the few airlines to recognize and support veterans. Easy boarding, flight was on time and arrived early and the flight attendants were excellent on this flight.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

I cancelled this flight 2 days before departure but I followed your texts and emails and IF you were correct this flight turned into a nightmare.

My flight was delayed twice. The first time because of “plane maintenance” and the second because the previous flight who supposedly “arrived early” took an obnoxiously long time to get off the plane. Total delay was over an hour for no reason. Not to mention your airline repeatedly changed our gate from one end of the terminal to the other. Not very happy about this experience. My previous flights with American haven’t had this many issues.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Delayed, missed connecting flight, ground crew double charged for international charges, were super rude and told me to just”deal with it” when I complained. Horrible airline, very frustrating.

Everything you need to know for your flight to South America

Information on your arrival and departure airports