$367 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima3 stops$751
Bogotá
Bogotá2 stops$544
Santiago
Santiago1 stop$866
Cartagena
Cartagena2 stops$605
Quito
Quito2 stops$643
Guayaquil
Guayaquil2 stops$699
Barranquilla
Barranquilla1 stop$514
Belo Horizonte
Belo Horizonte2 stops$1,153
Lima
Lima3 stops$751
Bogotá
Bogotá2 stops$544
Santiago
Santiago1 stop$866
Cartagena
Cartagena2 stops$605
Quito
Quito2 stops$643
Guayaquil
Guayaquil2 stops$699
Barranquilla
Barranquilla1 stop$514
Belo Horizonte
Belo Horizonte2 stops$1,153

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sun, Feb 8 - Wed, Feb 11
Multiple Airlines Logo
2:58 pm - 2:41 pmDSM-BAQ
22h 43m1 stop
Multiple Airlines Logo
3:36 pm - 2:42 pmBAQ-DSM
24h 06m2 stops
$514Multiple Airlines
Find Deal
Sun, Feb 8 - Wed, Feb 11
Multiple Airlines Logo
4:30 pm - 2:41 pmDSM-BAQ
21h 11m2 stops
Multiple Airlines Logo
9:44 pm - 11:12 pmBAQ-DSM
26h 28m3 stops
$553Multiple Airlines
Find Deal
Fri, Jan 16 - Tue, Jan 20
American Airlines Logo
4:00 pm - 3:30 pmDSM-CTG
22h 30m2 stops
American Airlines Logo
4:30 pm - 3:15 pmCTG-DSM
23h 45m2 stops
$605American Airlines
Find Deal
Fri, Jan 16 - Tue, Jan 20
American Airlines Logo
4:00 pm - 1:30 pmDSM-CTG
20h 30m2 stops
American Airlines Logo
2:30 pm - 11:29 pmCTG-DSM
9h 59m1 stop
$617American Airlines
Find Deal
Mon, Mar 9 - Fri, Mar 13
United Airlines Logo
7:15 am - 11:36 pmDSM-BAQ
16h 21m2 stops
United Airlines Logo
9:08 am - 10:36 pmBAQ-DSM
13h 28m2 stops
$618United Airlines
Find Deal
Sun, Mar 8 - Thu, Mar 12
United Airlines Logo
7:15 am - 11:00 pmDSM-CTG
15h 45m2 stops
United Airlines Logo
9:42 am - 10:36 pmCTG-DSM
36h 54m2 stops
$619United Airlines
Find Deal
Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:45 am - 1:15 pmDSM-CTG
7h 30m1 stop
Delta Logo
5:05 am - 10:23 amCTG-DSM
29h 18m2 stops
$651Delta
Find Deal
Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:15 pm - 1:15 pmDSM-CTG
20h 00m1 stop
Delta Logo
4:35 am - 10:23 amCTG-DSM
29h 48m2 stops
$652Delta
Find Deal
Wed, Jan 14 - Wed, Jan 28
LATAM Airlines Logo
5:16 pm - 9:35 pmDSM-UIO
27h 19m1 stop
LATAM Airlines Logo
11:45 pm - 10:41 amUIO-DSM
11h 56m1 stop
$668LATAM Airlines
Find Deal
Fri, Jan 16 - Tue, Jan 20
LATAM Airlines Logo
5:16 pm - 2:17 pmDSM-CTG
20h 01m1 stop
LATAM Airlines Logo
3:32 pm - 10:31 pmCTG-DSM
7h 59m1 stop
$735LATAM Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to South America?

The average price of all round-trip flights from Des Moines to South America clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South America on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to South America. For your return ticket, we recommend flying on a Sunday and avoiding Wednesdays for the best deals.

Good to know

Low seasonOctober
Cheapest flight$367
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 52% increase in price.
Flight from Des Moines to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $645 on average. Morning departures are around 35% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the evening, which is peak travel time and where the average cost of a ticket is $1,128.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8004 reviews
8.5Crew
7.9Entertainment
8.2Boarding
7.9Comfort
7.3Food
Airline reviews

I truly love flying with Delta. They have always treated me with the upmost respect

10.0 ExcellentMAYRA, Nov 2025JFK - MIA
Read more Delta reviews

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

The aircraft interior is old and tired on this aircraft. The entertainment system never worked despite the crews attempt to reset the system.

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

Old plane and old configuration/seats but still comfortable for a morning flight

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Boarding was confusing with a delayed flight because there was no English translation

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Bought a ticket that included a bag and they still charged me to check it in, latam is the worst airline.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Premium Plus is a really good idea for longer flights

7 hours delayed due to operational issues on United’s end. Basically laziness.

Short flight but an "eager to help" crew made the journey more enjoyable!

Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.

The person I bought the ticket for didn’t make the flight.

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

After boarding the plane in Chicago, the passengers were told that there was a technical problem with the plane. Passengers remained on the plane as they tried to fix the problem. After what was probably an hour passengers were told that there was a need to change planes as the problem was not solved. Passengers disembarked and boarded another plane. After taxing to the runway and waiting for takeoff, passengers were told that owing to the thunderstorm the flight was unable to take off but would try and reroute. After some time passengers were told there wasn't enough fuel for the new route and the plane had to return to the gate for additional fuel. after another log delay the flight got underway. On the plane there was food, drinks, ice or entertainment. We were a glass of water, which appeared rationed. Flight arrived about 5 hours late. The pilot was fantastic and communicated with the passengers throughout the ordeal.

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

We loved the steward on the plane. He made the night enjoyable

I enjoyed the extra leg room compared to other airlines. The first stewards made my daughter’s birthday special by giving her an extra snack. Then the last one coming home from Chicago to Appleton made our night really enjoyable Thanks for making our trip enjoyable

The flight was smooth, the pilot kept us informed about delays and we arrived more of less on time

Flight delay was communicated before leaving for airport which caused it to be a non-event. Great flight and crew!

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Everything you need to know for your flight to South America

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.