$420 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$810
Bogotá
Bogotá1 stop$621
Santiago
Santiago2 stops$980
Cartagena
Cartagena2 stops$654
Quito
Quito2 stops$703
Guayaquil
Guayaquil2 stops$584
Barranquilla
Barranquilla2 stops$645
Belo Horizonte
Belo Horizonte2 stops$1,257
Lima
Lima2 stops$810
Bogotá
Bogotá1 stop$621
Santiago
Santiago2 stops$980
Cartagena
Cartagena2 stops$654
Quito
Quito2 stops$703
Guayaquil
Guayaquil2 stops$584
Barranquilla
Barranquilla2 stops$645
Belo Horizonte
Belo Horizonte2 stops$1,257

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sat, Jun 6 - Sat, Jun 13
American Airlines Logo
8:03 pm - 12:34 pm
DSM
-
BAQ
16h 31m
2 stops
American Airlines Logo
3:38 pm - 2:04 pm
BAQ
-
DSM
22h 26m
2 stops
$645American Airlines
Mon, Jul 13 - Mon, Jul 20
American Airlines Logo
8:06 pm - 2:13 pm
DSM
-
CTG
18h 07m
2 stops
American Airlines Logo
3:13 pm - 12:34 pm
CTG
-
DSM
21h 21m
2 stops
$654American Airlines
Thu, Oct 22 - Tue, Oct 27
United Airlines Logo
6:15 am - 11:25 pm
DSM
-
UIO
17h 10m
1 stop
United Airlines Logo
12:35 am - 2:11 pm
UIO
-
DSM
13h 36m
2 stops
$710United Airlines
Thu, Jun 11 - Thu, Jun 18
Multiple Airlines Logo
7:30 am - 7:02 pm
DSM
-
CTG
35h 32m
2 stops
Multiple Airlines Logo
1:12 pm - 5:54 pm
CTG
-
DSM
28h 42m
1 stop
$714Multiple Airlines
Thu, Oct 22 - Tue, Oct 27
United Airlines Logo
6:15 am - 11:25 pm
DSM
-
UIO
17h 10m
1 stop
United Airlines Logo
12:35 am - 10:30 pm
UIO
-
DSM
21h 55m
1 stop
$716United Airlines
Wed, May 27 - Thu, Jun 4
LATAM Airlines Logo
5:27 am - 6:59 pm
DSM
-
UIO
13h 32m
1 stop
LATAM Airlines Logo
6:50 pm - 11:08 am
UIO
-
DSM
16h 18m
2 stops
$734LATAM Airlines
Wed, May 27 - Wed, Jun 3
LATAM Airlines Logo
5:27 am - 6:59 pm
DSM
-
UIO
13h 32m
1 stop
LATAM Airlines Logo
12:59 am - 5:53 pm
UIO
-
DSM
16h 54m
1 stop
$743LATAM Airlines
Wed, May 27 - Thu, Jun 4
Delta Logo
1:04 pm - 4:43 am
DSM
-
UIO
15h 39m
2 stops
Delta Logo
6:50 pm - 11:08 am
UIO
-
DSM
16h 18m
2 stops
$748Delta
Wed, May 20 - Tue, May 26
Delta Logo
5:27 am - 6:59 pm
DSM
-
UIO
13h 32m
1 stop
Delta Logo
12:59 am - 10:32 pm
UIO
-
DSM
21h 33m
1 stop
$749Delta
Thu, May 14 - Sun, May 24
Multiple Airlines Logo
7:45 am - 4:43 am
DSM
-
UIO
20h 58m
1 stop
Multiple Airlines Logo
6:30 pm - 11:24 pm
UIO
-
DSM
28h 54m
2 stops
$760Multiple Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South America is February, when tickets cost $638 (return) on average. On the other hand, the most expensive months are June and March, when the average cost of round-trip tickets is $989 and $881 respectively.

Good to know

Low seasonOctober
Cheapest flight$334
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly with an average 40% increase in price.
Flight from Des Moines to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8467 reviews
7.2Food
7.9Comfort
7.8Entertainment
8.5Crew
8.1Boarding
Airline reviews

The agent at check in and at the gate were less than thrilled to be at work. I'm not a fan of Kayak's placement on the plane. I got put in the middle seat and none of my preferences were used.

4.0 OkayBradley, Apr 2026
RDU - ATL
Read more Delta reviews

The agent at check in and at the gate were less than thrilled to be at work. I'm not a fan of Kayak's placement on the plane. I got put in the middle seat and none of my preferences were used.

In ATL they have two sets of departure screens. Follow what is on your airline's departure board - the ATL Airport Authority departure board had completely incorrect details about the gate assignment for my flight, which would have made me miss boarding.

Flight was delayed it was hot while sitting on the plane, one engine was working on the plane until they had to do some jimmy rigging down the runway in order for the other engine to charge up. It was ridiculous

The flight was very good and the staff was very friendly and helpful!

The only thing I would say is we tried to get on a standby earlier flight, but with our fair we couldn’t. That seems senseless to leave with open seats..

Very easy to use and convenient, you can perform any action within the same portal

In a world of delays, Delta was on time both ways! Boarding was fast and efficient. Staff was friendly. AND wifi worked.

WiFi didn’t work. Flight delayed 3 hours Crew members were illiterate Seat lean back did not work.

Flight was delayed, we could have been notified earlier and in a consistent manner. App was not refreshing for another passenger to get the latest flight status. We could have stayed and waited at the hotel instead of waiting at the airport had we known the flight was going to delayed for more than 5 hours. The toilet is too tight, and needs to be cleaned more frequently (every hour). The entertainment screen froze, the touch screen not responding to touch. We were upgraded to comfort, it is more comfortable than regular economy seats.

Everything was great. The only issue is unfixable. Seats are too small. 😁🤪

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

The flight was late. Please do not delay next time.

Some crew were unfriendly or in some cases just straight up rude.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Was great in general, try to respect time and excuses when slight changes have been made, appreciated!

A long delay. Don't travel late in the day.

Super friendly with lots of drink options an entertainment. Friendly crew.

Standard flight with a drinks and a snack- overall very quick flight. The flight attendants were very strict, bordered on rude.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

United Airline crews were very friendly and very attentive. 12 hours flight was gone like in a shorter one.

Delayed - weather wasn't bad at either end. Also sat on tarmac in ORD.

Food was surprisingly delicious. Space in the seat is horrible when the seating front is reclined. Movie offerings were terrible. Crew was friendly and helpful.

I would like a refund for the extra cost the seat I paid for. An oversized person sat next to me and I couldn’t fit on my seat and had to move to another seat.

Boarding gate at LAX was too crowded—two gates next to one another

The flight was delayed about an hour for a maintenance specialist to approve the maintenance repair

This flight was delayed but it worked in my favor because my Atlanta to Dallas flight was delayed.

This was a hard flight. 3 delays out of OKC (1 on the Tarmac). Delay in Atlanta coming to Dallas. total travel time was the equivalent of driving from OKC to Atlanta.

Like: flights are on time, good boarding process Can improve: planes are old, improve entertainment and make space more comfortable

Had to wait for a gate for a long time, then waited on the run way for a long time before leaving. The actual flights part was good.

The airplane was an old model, the overhead didn’t have enough room for people’s items and made boarding and boarding disappointing and stressful. Crew allowed passengers to bring more than the permitted baggage sizes.

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

On time departure and early arrival. Flight attendant very nice.

Everything you need to know for your flight to South America

Information on your arrival and departure airports