$177 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$503
Bogotá
Bogotá1 stop$507
Santiago
Santiago2 stops$810
Cartagena
Cartagena1 stop$466
Quito
Quito2 stops$646
Guayaquil
Guayaquil1 stop$511
Barranquilla
Barranquilla1 stop$555
Belo Horizonte
Belo Horizonte2 stops$1,205
Lima
Lima2 stops$503
Bogotá
Bogotá1 stop$507
Santiago
Santiago2 stops$810
Cartagena
Cartagena1 stop$466
Quito
Quito2 stops$646
Guayaquil
Guayaquil1 stop$511
Barranquilla
Barranquilla1 stop$555
Belo Horizonte
Belo Horizonte2 stops$1,205

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sun, Apr 26 - Mon, May 4
Multiple Airlines Logo
8:30 am - 12:06 pm
DSM
-
CTG
27h 36m
1 stop
Multiple Airlines Logo
1:11 pm - 5:08 pm
CTG
-
DSM
51h 57m
2 stops
$466Multiple Airlines
Wed, Apr 15 - Tue, Apr 21
Multiple Airlines Logo
7:16 pm - 10:35 am
DSM
-
LIM
15h 19m
2 stops
Multiple Airlines Logo
3:05 am - 10:43 pm
LIM
-
DSM
19h 38m
2 stops
$503Multiple Airlines
Sun, Apr 26 - Mon, May 4
American Airlines Logo
8:03 pm - 12:09 pm
DSM
-
CTG
16h 06m
2 stops
American Airlines Logo
3:10 pm - 8:26 am
CTG
-
DSM
17h 16m
2 stops
$584American Airlines
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
2:16 pm - 12:09 pm
DSM
-
CTG
21h 53m
2 stops
American Airlines Logo
1:25 pm - 11:26 am
CTG
-
DSM
22h 01m
2 stops
$599American Airlines
Mon, Aug 17 - Wed, Dec 9
United Airlines Logo
5:00 am - 5:00 am
DSM
-
UIO
24h 00m
2 stops
United Airlines Logo
1:35 am - 2:20 pm
UIO
-
DSM
13h 45m
1 stop
$646United Airlines
Tue, May 26 - Tue, Jun 2
LATAM Airlines Logo
5:27 am - 6:59 pm
DSM
-
UIO
13h 32m
1 stop
LATAM Airlines Logo
12:59 am - 5:54 pm
UIO
-
DSM
16h 55m
1 stop
$659LATAM Airlines
Wed, May 27 - Thu, Jun 4
Delta Logo
5:27 am - 4:43 am
DSM
-
UIO
23h 16m
2 stops
Delta Logo
6:50 pm - 12:24 pm
UIO
-
DSM
17h 34m
2 stops
$666Delta
Fri, May 1 - Sat, Aug 22
Delta Logo
6:31 pm - 6:59 pm
DSM
-
UIO
24h 28m
1 stop
Delta Logo
6:50 pm - 1:22 pm
UIO
-
DSM
18h 32m
2 stops
$671Delta
Wed, Aug 19 - Wed, Aug 26
LATAM Airlines Logo
6:30 pm - 11:00 pm
DSM
-
UIO
28h 30m
2 stops
LATAM Airlines Logo
6:50 pm - 1:22 pm
UIO
-
DSM
18h 32m
2 stops
$675LATAM Airlines
Sat, Aug 15 - Tue, Aug 25
United Airlines Logo
3:24 pm - 5:00 am
DSM
-
UIO
13h 36m
2 stops
United Airlines Logo
7:25 am - 12:34 am
UIO
-
DSM
17h 09m
2 stops
$676United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to South America were found on American Airlines ($601) and United Airlines ($646).

Good to know

Low seasonSeptember
Cheapest flight$177
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Des Moines to Cartagena

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8258 reviews
8.1Boarding
7.8Entertainment
7.2Food
7.9Comfort
8.5Crew
Airline reviews

The flight went very well, but the flight attendants didn't serve and food or drinks other than 1st class due to rough air but to be honest it wasn't that bumpy and I felt that they could've at least offered water and coffee perhaps. Also serving 1st class only is a bad look. I've been in 1st class many times and I would've felt that if the turbulence was too rough for the main cabin, it would be too rough for 1st class too.

10.0 ExcellentGary, Mar 2026
LGA - DTW
Read more Delta reviews

The flight went very well, but the flight attendants didn't serve and food or drinks other than 1st class due to rough air but to be honest it wasn't that bumpy and I felt that they could've at least offered water and coffee perhaps. Also serving 1st class only is a bad look. I've been in 1st class many times and I would've felt that if the turbulence was too rough for the main cabin, it would be too rough for 1st class too.

There was an unruly family behind us that made the short flight miserable!!! The cabin crew did nothing to contain it.

My seatback screen didn’t work so that sucked because that’s what I was going to do on the plane.

Left a few minutes early. Got in 15 minutes early. Very attentive service on board. Very organized boarding.

The whole experience was excellent. As it most often is with Delta

Cabin was not pressurized properly. Several passengers had respiratory difficulties.

I was happy that I was able to get a last minute flight but unfortunately my seat was a middle seat. Even with Delta Comfort I wasn't comfortable

There’s not much to say about a one hour flight. This is a connection from LA to RNO that I missed the previous night due to a mechanical check delay on my originating flight from JFK to LAX. The short flight itself was fine. Instructions from the pilot and crew were per usual. The coffee was barely lukewarm, which possibly was purposeful so we would down it quickly. Bags were already on carousel upon reaching baggage claim, which was excellent.

Flight was warm for first few hours and quite rough

Seat was extremely hard which made even a short 1 hour 20 minute flight fairly uncomfortable.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

It’s always a great time flying with united airlines.

Good flight. Efficient boarding and competent flight crew. No problems until we arrived at our destination gate. We were early so there was an aircraft at the gate that had to move before we could pull in. Then, due to the type of aircraft we flew, the cabin door could not be opened until some luggage from the cargo bay was offloaded to preserve center of gravity characteristics. So, that further delayed deplaning. Despite being 20 minutes early on landing, we ended up being 5 to 10 minutes late after all the delays.

Everything went well except the turbulence what no one have a control of but pilot and crew handled very good!

There was no WiFi available, there were mechanical problems with the plane and we landed at C 124, then the gate was switched to A 26, then all the way back to C126! For a 75 yo woman traveling alone, this was a difficult journey, indeed!

This trip did not start off well. The inbound flight was delayed about 20 minutes. Then, after initial onboarding, the passengers had to deplane due to a mechanical problem. That took about 30 minutes to fix and be cleared. Then, reboarding was chaotic. It took a long time to sort passengers and two passengers on standby were ticketed but there was no seat. So, they had to deplane. One of the flight crew was trying to help passengers figure out a place to put their carry-on bags and that took more time. In the end, our scheduled 10:30 am departure did not actually take off until about 12:05 pm CST. The flight itself was long but we got to Houston. Some passengers missed their connecting flights and had to rebook. Not the best of flights I've had.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Terrible because it was cancelled due to volcanic ash clouds in Guatemala while all other airlines kept flying. Had to pay for a hotel to stay overnight in Houston and try to fly next day.

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

Flight delay for mechanical. Inbound arrived on time. No one said why mechanical delay.

Forced to check bags. Crew uninterested in collecting trash. Unclean seats.

why would I bother with this airline and pick seats when I am asked to move for a weight imbalance

Flight pulled out on time but sat on runway for 30 mins. It was extremely cold in the aircraft despite wearing a winter coat. Surprisingly they had a vegetarian meal but could have some better snack choices for a 8 hour flight.

We had a male flight attendant who was super attentive and wonderful! Very professional. I have both gluten and dairy intolerance, and was only able to get a gluten free part, and not the dairy free part of the meal. Easy to order ahead of time and I appreciate being able to do that.

Snow delayed boarding several times, which I understand happens. Issue I had was that after we did board, pilot told us we were going to roll out to be de-iced, then on our way. We were de-iced once, taxied to the tarmac and then stopped. Sat for another 30 minutes or so, the another de-icing. Then we rolled out to a parking spot, only to sit for another hour due to a traffic stop in DCA, which I'm confident they knew would happen before we boarded. Pilot gave no updates other than we had to hold, attendants did speak to the crew, but when asked, said the pilot would be updating us. We on the ground in the plane waiting for over 2 hours. They did communicate that bathrooms would be open, but no other news until we left. Would have been better to be up front about status.

Good crew and flight was on time. It’s a small plane with limited overhead luggage space. They said the overhead space was full and I had to check my bag. There was still space when I got on. Waiting for my checked luggage added 30 minutes to my trip. Not the end of the world but also not great.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

Delayed initially because they couldn’t print the flight details. Poor instruction on delay. When I got on the plane the flight attendant argued with me about whether my carry on would fit (it did, although she didn’t acknowledge that). No greeting (other than arguing with me) getting on or off the plane.

Everything you need to know for your flight to South America

Information on your arrival and departure airports