$230 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$484
Bogotá
Bogotá1 stop$528
Santiago
Santiago1 stop$812
Cartagena
Cartagena1 stop$462
Quito
Quito2 stops$664
Guayaquil
Guayaquil2 stops$675
Barranquilla
Barranquilla2 stops$601
Belo Horizonte
Belo Horizonte2 stops$1,308
Lima
Lima2 stops$484
Bogotá
Bogotá1 stop$528
Santiago
Santiago1 stop$812
Cartagena
Cartagena1 stop$462
Quito
Quito2 stops$664
Guayaquil
Guayaquil2 stops$675
Barranquilla
Barranquilla2 stops$601
Belo Horizonte
Belo Horizonte2 stops$1,308

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Thu, Apr 2 - Thu, Apr 9
Multiple Airlines Logo
3:21 pm - 12:06 pm
DSM
-
CTG
20h 45m
1 stop
Multiple Airlines Logo
1:14 pm - 10:06 pm
CTG
-
DSM
8h 52m
1 stop
$462Multiple Airlines
Tue, Mar 31 - Mon, Apr 6
Multiple Airlines Logo
8:20 am - 3:30 am
DSM
-
LIM
19h 10m
2 stops
Multiple Airlines Logo
3:05 am - 10:43 pm
LIM
-
DSM
19h 38m
2 stops
$484Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
3:26 pm - 2:25 pm
DSM
-
BAQ
22h 59m
2 stops
American Airlines Logo
1:40 pm - 8:26 am
BAQ
-
DSM
18h 46m
2 stops
$601American Airlines
Wed, Apr 1 - Wed, Apr 8
American Airlines Logo
7:00 am - 2:15 pm
DSM
-
CTG
7h 15m
1 stop
American Airlines Logo
1:25 pm - 10:26 am
CTG
-
DSM
21h 01m
2 stops
$603American Airlines
Wed, Apr 1 - Wed, Apr 8
Delta Logo
5:35 am - 1:15 pm
DSM
-
CTG
7h 40m
1 stop
Delta Logo
2:30 pm - 10:38 pm
CTG
-
DSM
8h 08m
1 stop
$627Delta
Mon, Aug 17 - Sat, Dec 12
United Airlines Logo
3:15 pm - 5:00 am
DSM
-
UIO
13h 45m
2 stops
United Airlines Logo
8:00 am - 10:51 pm
UIO
-
DSM
15h 51m
2 stops
$664United Airlines
Wed, Apr 1 - Tue, Apr 7
United Airlines Logo
6:20 am - 11:25 pm
DSM
-
UIO
17h 05m
2 stops
United Airlines Logo
12:35 am - 9:27 pm
UIO
-
DSM
20h 52m
2 stops
$685United Airlines
Wed, Apr 1 - Tue, Apr 7
Delta Logo
5:35 am - 6:59 pm
DSM
-
UIO
13h 24m
1 stop
Delta Logo
12:59 am - 4:33 pm
UIO
-
DSM
15h 34m
1 stop
$712Delta
Tue, May 26 - Tue, Jun 9
LATAM Airlines Logo
2:33 pm - 5:00 am
DSM
-
LIM
14h 27m
1 stop
LATAM Airlines Logo
12:15 am - 5:42 pm
LIM
-
DSM
17h 27m
2 stops
$730LATAM Airlines
Fri, May 29 - Tue, Jun 9
LATAM Airlines Logo
5:29 am - 9:35 pm
DSM
-
LIM
16h 06m
2 stops
LATAM Airlines Logo
12:15 am - 5:42 pm
LIM
-
DSM
17h 27m
2 stops
$750LATAM Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to South America were found on American Airlines ($601) and United Airlines ($664).

Good to know

Low seasonSeptember
Cheapest flight$230
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Des Moines to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8212 reviews
7.8Entertainment
7.9Comfort
8.1Boarding
8.5Crew
7.2Food
Airline reviews

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

10.0 ExcellentGrace, Feb 2026
LAX - JFK
Read more Delta reviews

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

First flight out and was 85 minutes delayed. Notification came out way too late

Delta flights recently are always delayed AND at jfk tney get the gates further away (need To walk 20’ to get to them/all the way at the end of the terminal). Not sure whats happening but price doesnt match experience!

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Good experience and the flight landed early. There was no food I had or entertainment.

Flight was delayed and no reasons provided. After the passengers were boarded, the crew made announcement that the captain has jot arrived and he would take another 15 mins. All passengers patiently sat until the captain came and started. Terrible experience!

Flight was delayed. No information on why it was delayed. After we boarded the flight, , the crew made announcement that the captain hs not arrived and he will take 15 mins more to arrive. Passengers were just sitting patiently for the captain to arrive and start, Terrible experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

As great a red-eye flight as red-eye flights can be.

Once boarding started it was pretty quick. Food was inedible; cold and salty..

Entertainment kept turning itself off. Gave up on watching a movie.

Both the WIFI and entertainment did not work for 2.5h

The crew made our experience extremely bad. They were rude and didn’t have anything for kids.

Very old flight - time to retire it for newer airplanes

2+ hours delayed Outlet in row 12 did not work Tv monitors did not work Lights kept off the entire flight for at 5pm-7pm flight

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Do not like the size of the overhead bin. I think staff should monitor the size of suitcases that are being carried on by passengers to ensure they meet the size requirement.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

No Snacks or Entertainment. The flight was short, snacks should still be given.

We lost a day of our vacation because AA did not get the plane to the gate on time. Even though the gate attendant was very clear that it was not weather related, AA would do nothing because there was some snow that day. They basically said the gate attendant was wrong even though she was on the front line of the situation and they were not.

See prior comment about how Kayak mishandled my reservation and delayed my arrival by 6 hours.

American Airlines was great and worked very hard to change my ticket so I could get an earlier, direct flight back to Dallas. However, I was informed that Kayak made mistakes with my itinerary and classified my ticket as desiring to be on the earlier flight instead of taking the necessary step of calling AA to get me on the standby list. This ended up keeping me from being added to the standby list and delayed me getting home by 6 hours. I am happy to discuss this further with Kayak so they can correct their procedures so this won't happen again.

The flight was fine. It's the satellite terminal that supports American eagle flights is what sucks. There is only one food option and everything there is way overpriced. I mean I know it's airport pricing, but it's even crazier than that. I bought a sandwich in a plastic container for $18.

Overall it was a good flight. Because we traveled on a Saturday we were upgraded to FC since my wife and I are both Executive Platinum. The only areas for improvement we noted are better snack assortment and perhaps a little nicer plane as American is flying some older planes now. Everything else on this flight was excellent, which is frankly not the norm for American since we have had multiple issues on prior AA flights.

The smell from the bathroom kept wafting through the cabin. It made people sick.

The flight was really crowded. Flight attendants were just ok.

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

Didn't get a seat assignment until the last minute even though i picked a seat.

Everything you need to know for your flight to South America

Information on your arrival and departure airports