$320 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$654
Bogotá
Bogotá1 stop$441
Santiago
Santiago2 stops$909
Cartagena
Cartagena2 stops$623
Quito
Quito1 stop$661
Guayaquil
Guayaquil2 stops$702
Barranquilla
Barranquilla1 stop$416
Belo Horizonte
Belo Horizonte2 stops$1,392
Lima
Lima1 stop$654
Bogotá
Bogotá1 stop$441
Santiago
Santiago2 stops$909
Cartagena
Cartagena2 stops$623
Quito
Quito1 stop$661
Guayaquil
Guayaquil2 stops$702
Barranquilla
Barranquilla1 stop$416
Belo Horizonte
Belo Horizonte2 stops$1,392

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Thu, May 7 - Thu, May 14
Multiple Airlines Logo
7:45 am - 12:45 pm
DSM
-
BAQ
29h 00m
1 stop
Multiple Airlines Logo
1:40 pm - 10:57 pm
BAQ
-
DSM
33h 17m
2 stops
$416Multiple Airlines
Thu, May 7 - Thu, May 14
Multiple Airlines Logo
7:45 am - 12:45 pm
DSM
-
BAQ
29h 00m
1 stop
Multiple Airlines Logo
1:40 pm - 10:57 pm
BAQ
-
DSM
33h 17m
2 stops
$421Multiple Airlines
Fri, May 8 - Fri, May 15
American Airlines Logo
7:05 pm - 12:30 pm
DSM
-
BAQ
17h 25m
2 stops
American Airlines Logo
1:40 pm - 8:26 am
BAQ
-
DSM
18h 46m
2 stops
$612American Airlines
Thu, Sep 17 - Thu, Sep 24
American Airlines Logo
6:15 pm - 11:55 am
DSM
-
BAQ
17h 40m
2 stops
American Airlines Logo
2:15 pm - 8:07 am
BAQ
-
DSM
17h 52m
2 stops
$621American Airlines
Tue, Sep 1 - Mon, Oct 5
United Airlines Logo
3:00 pm - 11:25 pm
DSM
-
UIO
8h 25m
1 stop
United Airlines Logo
7:25 am - 10:30 pm
UIO
-
DSM
15h 05m
1 stop
$661United Airlines
Wed, May 27 - Thu, Jun 4
LATAM Airlines Logo
5:27 am - 4:43 am
DSM
-
UIO
23h 16m
2 stops
LATAM Airlines Logo
6:50 pm - 11:08 am
UIO
-
DSM
16h 18m
2 stops
$666LATAM Airlines
Wed, May 27 - Wed, Jun 3
LATAM Airlines Logo
2:33 pm - 6:59 pm
DSM
-
UIO
28h 26m
1 stop
LATAM Airlines Logo
12:59 am - 11:08 am
UIO
-
DSM
10h 09m
1 stop
$671LATAM Airlines
Fri, Jun 12 - Wed, Jul 15
Delta Logo
6:39 pm - 6:59 pm
DSM
-
UIO
24h 20m
1 stop
Delta Logo
6:50 pm - 5:53 pm
UIO
-
DSM
23h 03m
2 stops
$681Delta
Sun, Jun 14 - Tue, Jul 14
United Airlines Logo
6:20 am - 11:25 pm
DSM
-
UIO
17h 05m
1 stop
United Airlines Logo
7:25 am - 10:35 pm
UIO
-
DSM
15h 10m
1 stop
$683United Airlines
Fri, May 15 - Thu, May 21
Delta Logo
6:41 pm - 6:59 pm
DSM
-
UIO
24h 18m
1 stop
Delta Logo
12:59 am - 5:53 pm
UIO
-
DSM
16h 54m
1 stop
$687Delta
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to South America were found on American Airlines ($612) and Delta ($655).

Good to know

Cheapest flight$320
Flight from Des Moines to Santiago

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8357 reviews
7.2Food
8.1Boarding
7.8Entertainment
8.5Crew
7.9Comfort
Airline reviews

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

8.0 ExcellentLorna, Mar 2026
LAX - LIH
Read more Delta reviews

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I haven’t flown economy in over 20 years but it was not bad. Room by my feet for my bag and seat was roomy enough. Surprised in a good way.

The flight was delayed 90 minutes The Gate was wrong The Restroom on Aircraft was not clean There was a half used water bottle in my seat

Delta is always a wonderful experience. A clean plane and the crew is really friendly.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

Excellent service, I love the soft blush pink mood lighting on the 767-400ER during meal service. The overhead gasper vents on the 767-400ER were also very strong with a lot of airflow to keep me comfortable on my flight.

This was the worse experience. They delayed our flight twice and we still had to find another flight to get home sooner which was alos delayed. Also, the flight attendant named Ginny on DL9890 leaving at 4:13pm on 3/23/26 was extremely rude.

I love Delta the flight attendants were personable and the flight arrived 1/2 earlier thanks expected. All a plus. The gate agent was a bit flustered but even with that I still had a good experience. Her supervisor assisted me.

Got to fly my favorite plane, the Boeing 767-400ER, to Milan. The soft blush pink mood lighting during meal service was very beautiful and gorgeous. The service was top-notch, and our flights were on time. I highly recommend Delta.

I am still at the Airport! Delayed Delayed and Delyaed

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

the entire flight felt off. The crew seemed uninterested and disengaged. The food service was really bad - overcooked, bland, weird food service. They actually woke us up to serve chicken wraps in the middle of the night, after dinner and before breakfast. Made no sense. Ultimately, I was glad they did though, because the breakfast had been held for so long it was inedible. Eggs, potatoes, sausage - all disgusting. We were asked to "honor" the lavatories for premium customers and stay in our own cabin: this was also strange. So people in economy didn't pay enough to use the closest toilet to them??? It's a toilet. All in all, not the experience I have come to expect from United Airlines. The return flight from Paris to SFO was better, btw.

Smooth and easy boarding, comfortable for the entire 5 hour flight, and the seat back entertainment was great! I appreciated all the features, from location info and maps, movies, the ability to connect with Bluetooth headphones, and good selection of movies. Food was good, normal airline snacks (I didn’t purchase anything)

Overall, the flight was good. Lounge access should be with all business class tickets.

They promise free wi-fi prior to boarding and then once on board you are informed you have to purchase wifi even after being a mileagePlus member.

I've been flying American mostly, and it's been very frustrating. This united flight makes me realize maybe the issue isn't flying, but the airline. United was a significantly better experience. The plane was more comfortable, with a normal amount of leg room (vs the ridiculous reductions AA has made), more comfortable seats, screens to watch movies. It was a much better experience!

Awful. No counter attendants. No dinner offered due to delays.

Horrible service no Wi-Fi connection on both leg of the flight and they are refusing to fix bad service

3 hour delay…. Nearly 2 hours sitting on tarmac. Do better, United. Or at least have the sense to not say “we hope you enjoyed your flight with us” upon disembarking.

Flights were on time. Free Wifi on plane. Everything was well organized.

The flight changed gates multiple times and flight had to be delayed multiple times

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Tv screens and movie selection v good. Friendly staff. They were really worried about max capacity and room for carryons. That is never fun but i had no problem finding space when I boarded.

I was in last row so that is never great bc the person in front of me leaned his seat all the way back into me.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

My flight from LGA was cancelled and my rebooked flight from JFK was delayed numerous times. I will now be getting home after 2am.

Flight was delayed half hour before boarding, but when I checked flight aware the plane that would Pick us up had a delay of more than an hour. AA should let us know in advance to avoid waiting several hours in the airport

On the return flight, arriving in Denver we sat on the tarmac in Denver for over 20 minutes.

Typical AA - late by 90+ mn. Gate changed twice... Changed the departure time 6 times No explanation, no communication on reasons for delay I travel with AA twice a year... and it is consistently very poor.. I will continue to use AA only when i have to.

The flight attendant in business class was excellent! Professional, friendly and attentive.

Everything you need to know for your flight to South America

Information on your arrival and departure airports