$296 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$747
Bogotá
Bogotá1 stop$620
Santiago
Santiago2 stops$947
Cartagena
Cartagena2 stops$537
Quito
Quito1 stop$691
Guayaquil
Guayaquil2 stops$778
Barranquilla
Barranquilla2 stops$621
Belo Horizonte
Belo Horizonte2 stops$1,276
Lima
Lima2 stops$747
Bogotá
Bogotá1 stop$620
Santiago
Santiago2 stops$947
Cartagena
Cartagena2 stops$537
Quito
Quito1 stop$691
Guayaquil
Guayaquil2 stops$778
Barranquilla
Barranquilla2 stops$621
Belo Horizonte
Belo Horizonte2 stops$1,276

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sun, Jul 12 - Mon, Jul 20
American Airlines Logo
8:50 pm - 12:35 pm
DSM
-
CTG
15h 45m
2 stops
American Airlines Logo
3:17 pm - 1:05 pm
CTG
-
DSM
21h 48m
2 stops
$537American Airlines
Thu, Jul 23 - Thu, Jul 30
American Airlines Logo
7:03 pm - 12:35 pm
DSM
-
CTG
17h 32m
2 stops
American Airlines Logo
1:35 pm - 8:32 am
CTG
-
DSM
18h 57m
2 stops
$607American Airlines
Mon, Jul 13 - Tue, Jul 21
Delta Logo
6:37 pm - 1:09 pm
DSM
-
CTG
18h 32m
1 stop
Delta Logo
2:30 pm - 10:29 pm
CTG
-
DSM
7h 59m
1 stop
$618Delta
Mon, Jul 13 - Tue, Jul 21
Delta Logo
6:37 pm - 1:09 pm
DSM
-
CTG
18h 32m
1 stop
Delta Logo
2:30 pm - 9:45 am
CTG
-
DSM
19h 15m
2 stops
$623Delta
Tue, Aug 25 - Wed, Sep 2
LATAM Airlines Logo
5:40 am - 7:05 pm
DSM
-
UIO
13h 25m
2 stops
LATAM Airlines Logo
9:00 am - 10:37 pm
UIO
-
DSM
13h 37m
2 stops
$696LATAM Airlines
Thu, Oct 22 - Wed, Oct 28
LATAM Airlines Logo
5:45 am - 11:00 pm
DSM
-
UIO
17h 15m
2 stops
LATAM Airlines Logo
11:55 pm - 10:18 am
UIO
-
DSM
10h 23m
1 stop
$715LATAM Airlines
Sat, Aug 8 - Fri, Aug 21
United Airlines Logo
6:20 am - 11:25 pm
DSM
-
UIO
17h 05m
1 stop
United Airlines Logo
12:35 am - 2:16 pm
UIO
-
DSM
13h 41m
2 stops
$721United Airlines
Sun, Oct 18 - Sat, Oct 24
Avianca Logo
6:55 pm - 10:35 am
DSM
-
LIM
15h 40m
2 stops
Avianca Logo
5:35 pm - 12:40 am
LIM
-
DSM
31h 05m
2 stops
$747Avianca
Sun, Oct 18 - Sat, Oct 24
Avianca Logo
6:55 pm - 10:35 am
DSM
-
LIM
15h 40m
2 stops
Avianca Logo
5:35 pm - 12:40 am
LIM
-
DSM
31h 05m
2 stops
$784Avianca
Mon, Oct 19 - Thu, Oct 22
United Airlines Logo
6:00 am - 11:00 pm
DSM
-
CTG
17h 00m
2 stops
United Airlines Logo
9:45 am - 10:15 pm
CTG
-
DSM
36h 30m
2 stops
$812United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South America is February, when tickets cost $638 (return) on average. On the other hand, the most expensive months are May and June, when the average cost of round-trip tickets is $1,558 and $1,283 respectively.

Good to know

Low seasonMay
Cheapest flight$296
Best time to beat the crowds but there is an average 59% increase in price.
Most popular time to fly with an average 47% increase in price.
Flight from Des Moines to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8396 reviews
7.2Food
8.1Boarding
8.5Crew
7.8Comfort
7.8Entertainment
Airline reviews

Only beverages were offered to first class and I thought the flight attendant could have also served the Delta Comfort as well instead of sitting down and staring at her phone and walking past all of us to the back of the plane to charge her phone more. There was a complete lack of turbulence and was safe enough for flights attendant to walk around in the front of the plane, collect trash and serve a few people water and turn off the seat belt light. Also didn’t enforce people putting their seats into the upright position and allowed two passengers to remain reclined during landing. They seemed out to lunch completely. Usually my experience on Delta is much better.

4.0 OkayMichelle, Jun 2026
ATL - PIT
Read more Delta reviews

Only beverages were offered to first class and I thought the flight attendant could have also served the Delta Comfort as well instead of sitting down and staring at her phone and walking past all of us to the back of the plane to charge her phone more. There was a complete lack of turbulence and was safe enough for flights attendant to walk around in the front of the plane, collect trash and serve a few people water and turn off the seat belt light. Also didn’t enforce people putting their seats into the upright position and allowed two passengers to remain reclined during landing. They seemed out to lunch completely. Usually my experience on Delta is much better.

Long story short, it was one of the better flight experiences I've had in some time when compared with other airlines.

Flight was great! This flight from Atlanta was even better than when I paid for Comfort from SNA to Atlanta.

Connection flights should be spaced out farther because too close I missed my connection.

Definitely a southern flavor. Cordiality was evident even though no drinks or snacks were served.

On time! There were plenty of airport employees who were able to keep us moving in the right direction. The crew on the plane were professional.

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Average seat comfort, a drink and chips were provided, early boarding because we checked a carryon at the gate was nice. Ticket pricing shenanigans, including fees to pick a seat, check a bag, and get food onboard - evidence the industry is reinvigorating last century’s strategies- destroys the experience before one ever arrives at the airport. It’s difficult to recognize any value or sustain loyalty in the end-to-end process making air travel more drudgery than pleasure.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

I paid for a confirmed upgraded aisle seat and was moved to a center seat in the back of the plane at the last minute.

Smooth travel. Immediate update prior flight delay so I can arrange myself properly without too rush.

Everything was the best it could be. Crew found me with pre- ordered food. Excellent experience!

Improve the food offerings and cabin seating. My wife would prefer to fly another airline, even with a connection for a more comfortable trip. A 737-8 should not be scheduled for a 6 hour segment, which turned into 7.5 hours due to the origin ground delay.

Packed flight, which makes it tough on crew and boarding staff (and the customers of course). But this was great boarding, clear instructions, etc. Traveling on the weekends are always fraught with danger as you have families and less frequent flyers thus more confusion. But this flight went as planned.

Destroyed my suitcase. Tired of talking about it. Cancelling my unite mileage plus account.

Read the fine print. This was my flight home. I booked my flight for the quickest way home. Had a carry-on and a personal item. Same as my outbound flight. Apparently I needed to pre-pay extra for my carry-on. When I checked in, I was told that I had to check it. I said I’ll pay for it, and was told that this wasn’t an option anymore. They said I still had to pay $50 to check my carry-on. I told them I’ll pay whatever to just carry it in as intended. I was not allowed, so eventually I paid $50 to check my carry-on under a plane that was half full, with overhead compartments that were even less full. My white carry-on suitcase was practically destroyed getting from Idaho falls to Denver to Orange County. The low price air fair was a bait and switch. Got me to the gate, made me pay extra, then didn’t even allow me to pay for a carry on. Not to mention that I paid the $8 for WiFi that didn’t work. All to get my suitcase destroyed. I don’t think I’m going to even keep my Untied mileage plus membership and card. Apparently, membership does not have its privileges for this one.

The flight was delayed, they didn’t even have water for the toilets or for drinks

Even through the flight was delayed due to storms near IAH The flight was great! The crew was so hospitable and professional

I flew from Santa Fe to Denver to catch a flight to London and the transfer of my luggage on arrival at Denver to the London flight worked perfectly. The crew on the ground and on board for the London flight were so friendly and efficient.

The flight attendants were extremely sourly and borderline rude. I did not feel appreciated as an AA customer once.

The flight back to Dallas was delayed, which has happened to me several times with American Airlines. There was no announcement, no update sent out, no compensation offered for the inconvenience.

It wa sort of on time; the cab was left with some trash

Our flight from JFK to Madrid was delayed. We had to go from one side of the Madrid airport (Terminal 4s to the far end of terminal 4 - Gate K98) to our gate in less than 30 minutes. Put passport control and security/baggage check and that’s very hard unless you’re Usain Bolt. I called Iberia Airlines and the telephone customer service told me that I was going to have to pay to re-book. Luckily the help desk in the airport (who was dealing with dozens of people from the same JFK-Madrid flight) did not charge us extra to reschedule to a flight 8 hours later. They also gave us a voucher for breakfast and lunch. Glad the actual person at the airport had some actual sense.

As always, most AA flights that we fly are almost ALWAYS delayed and that too multiple times. Very frustrating

Boarding was smooth and seamless and the flight was without incident.

For an long range economy flight I feel more space and more meal options need to be offered for flights over 5 hours

Our flight was repeatedly delayed for maintenance problems: scheduled for 9.30am, eventually delayed to 7pm! Very very inconvenient! AA should have provided a substitute plane much earlier.. On the other hand, Customer Service crew in Charlotte helped us to reach NY (LGA) by late afternoon. Thank you Patricia!! The actual flight was quick and very comfortable. As always a. excellent, professional crew. [no food on a a short hop).

Take-off delayed an hour because of a missing flight officer, so,arrived in Charlotte lates causing many passengers to miss connections. Otherwise a very good flight, safe and comfortable, with an excellent professional crew.

Little time between flight from Dallas to flight to Gainesville. We chose this one, 43 minutes between, because the price for a connection with at least an hour between, was so much higher. Had to ask passengers on the Dallas flight to please allow us to deplane ahead of them. The economy passengers allowed this. We had to walk very fast to the next gate, 35 gates away. Thankfully all in the same terminal. Getting to the small Gainesville plane was a little confusing as you enter an area that is boarding many small planes at the same time. We stood in the wrong line for about 15 seconds before realizing it was not our Gainesville flight. Since I had boarded at this gate in the past, I knew to check the signs carefully so we weren’t lost. The first class seat experience was wonderful. I really enjoyed the upgrade. We were offered an alcohol drink as soon as we sat down. I got something different but it was a great gesture especially since we really had to hurry to make the flight. We had packed expecting we might miss this connection, but made it. Our luggage didn’t miss the flight. American Airlines delivered our bags to our home the next day. That was very convenient!

Everything you need to know for your flight to South America

Information on your arrival and departure airports