$341 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 21% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$767
Bogotá
Bogotá1 stop$622
Santiago
Santiago2 stops$1,276
Cartagena
Cartagena2 stops$658
Quito
Quito2 stops$716
Guayaquil
Guayaquil2 stops$956
Barranquilla
Barranquilla2 stops$656
Belo Horizonte
Belo Horizonte2 stops$1,426
Lima
Lima2 stops$767
Bogotá
Bogotá1 stop$622
Santiago
Santiago2 stops$1,276
Cartagena
Cartagena2 stops$658
Quito
Quito2 stops$716
Guayaquil
Guayaquil2 stops$956
Barranquilla
Barranquilla2 stops$656
Belo Horizonte
Belo Horizonte2 stops$1,426

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
1:41 pm - 12:34 pm
DSM
-
BAQ
22h 53m
2 stops
American Airlines Logo
1:34 pm - 12:24 pm
BAQ
-
DSM
22h 50m
2 stops
$656American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:46 am - 12:35 pm
DSM
-
CTG
29h 49m
1 stop
American Airlines Logo
3:15 pm - 9:56 am
CTG
-
DSM
18h 41m
2 stops
$658American Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
8:50 pm - 2:15 pm
DSM
-
CTG
17h 25m
2 stops
American Airlines Logo
1:35 pm - 12:24 pm
CTG
-
DSM
22h 49m
2 stops
$661American Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
6:15 am - 11:50 pm
DSM
-
BAQ
17h 35m
2 stops
United Airlines Logo
9:01 am - 2:16 pm
BAQ
-
DSM
29h 15m
3 stops
$712United Airlines
Fri, Sep 25 - Sat, Oct 3
Delta Logo
6:45 pm - 6:59 pm
DSM
-
UIO
24h 14m
1 stop
Delta Logo
12:59 am - 6:00 pm
UIO
-
DSM
17h 01m
1 stop
$717Delta
Thu, Oct 22 - Tue, Oct 27
United Airlines Logo
6:00 am - 11:25 pm
DSM
-
UIO
17h 25m
2 stops
United Airlines Logo
12:35 am - 12:30 pm
UIO
-
DSM
11h 55m
2 stops
$720United Airlines
Tue, Jul 14 - Fri, Jul 17
Copa Airlines Logo
3:24 pm - 12:25 pm
DSM
-
BAQ
21h 01m
2 stops
Copa Airlines Logo
9:04 am - 9:22 pm
BAQ
-
DSM
36h 18m
2 stops
$756Copa Airlines
Sat, Aug 1 - Sat, Aug 8
LATAM Airlines Logo
5:41 am - 1:12 pm
DSM
-
CTG
7h 31m
1 stop
LATAM Airlines Logo
2:30 pm - 2:09 pm
CTG
-
DSM
23h 39m
1 stop
$784LATAM Airlines
Sun, Oct 18 - Wed, Oct 21
LATAM Airlines Logo
5:45 am - 6:59 pm
DSM
-
UIO
13h 14m
1 stop
LATAM Airlines Logo
12:59 am - 5:42 pm
UIO
-
DSM
16h 43m
1 stop
$787LATAM Airlines
Wed, Sep 2 - Wed, Sep 16
Delta Logo
11:28 am - 9:45 am
DSM
-
EZE
20h 17m
1 stop
Delta Logo
8:10 pm - 10:46 am
EZE
-
DSM
16h 36m
1 stop
$1,106Delta
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South America is August, when tickets cost $489 (return) on average. On the other hand, the most expensive months are May and November, when the average cost of round-trip tickets is $995 and $867 respectively.

Good to know

Low seasonFebruary
Cheapest flight$341
Best time to beat the crowds with an average 40% drop in price.
Most popular time to fly with an average 48% increase in price.
Flight from Des Moines to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8423 reviews
7.8Entertainment
8.5Crew
8.1Boarding
7.8Comfort
7.2Food
Airline reviews

Flight got canceled 4 times, missed my connecting flight due to delays, have to wait to go home tomorrow

2.0 MediocreChelsea, Jun 2026
DAL - ATL
Read more Delta reviews

Flight got canceled 4 times, missed my connecting flight due to delays, have to wait to go home tomorrow

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Great experience nice pilot very soft and easy landing and take off

We sat on the runway for over an hour before departure. That was unwelcome.

Horrible. Faucet in sink not working, wifi not working. Didn’t bring food or snacks

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Flight attendants were great. Cheerful, upbeat and friendly. Jet, in particular, was fantastic.

I have Precheck. Flew HPN to DEN and return this past weekend. Delta didn't attach my Precheck number to this trip. So it was waiting in general line especially in Denver. Unavailable.

LATAM clearly does not have well-established policies re: luggage for international flights to Lima followed by domestic flights within Peru (in my case, from Lima to Cuzco). On the way in, they forced me to pay $50 in Lima to check my second carry on bag (the three bags were included in the fare from JFK to Lima). On the return trip, they told me at check in that I would have to pay $50 again at the gate (she said they couldn't accept the money at check in) Then, at the gate, they initially told me I would have to pay several hundred dollars to check the big bag through to JFK. I protested, and showed them a print out of an email saying the checked bag was included between LIM and JFK. Than a second woman showed up, and told me I wouldn't have to pay anything at all -- which was great news, of course -- but that means I was incorrectly charged the extra $50 on the incoming flight. Basically, just a mess. Also, their website is completely non-functional -- it was very cleear that all the airport staff knew the website was nonfunctional, too.

In flight from Miami to Anchorage, we were all on board ready to take off. Pilot decided to take on more fuel causing a delay. Once fueled, the pilot came back over the radio stating more delay due to VIP. These delays caused me to miss my connecting flight. I went to the Alaska Air counter for information. They flat out stated that it was ATCs fault that I missed my flight and booked me a flight the next day about 1300 . I believe if we had the fuel prior to getting on board we would not of been delayed and I would have taken off on time. Pilot was taken out of the equation. I think they should’ve taken responsibility for their pilots decision to top off his aircraft instead of waiting til the last moment. Enough said…

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Nothing I like, I missed this connection b/c of an earlier flight delay. I had to stay one more night and I paid out my own pocket. LATAM failed to send me to a safe and decent hotel.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Flight cancelled. Twice. And no communication. No gate agent. Went past boarding time and had to go and see email from AA. Airport communication was bad

I love the e fact that the staff communicated swiftly when my flight was delayed and gate number changed

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

Delayed and horrible communication and sat on flight for an hour before taking off

Flight was delayed three times and we had an international connecting flight which we would’ve missed but AA manage to find us a flight that allowed us to catch and we made our international flight. However, due to the flight change, I’m in Amman, Jordan missing all 4 bags. It’s been a nightmare. Been waiting since June 17 and today is June 20th. Still without luggage. Customer service wait times are two hours and I get disconnected while waiting. I’ll update when/if my luggage arrives. Every day is costing money in a hotel in Amman. I can’t continue my trip to Palestine until the luggage arrives. Then, I will be updating my review.

They did not offer coffee on a 7am flight…awful!!

Plane temperature was so hot that everyone on the plane was sweating. Departure gates changed 3 times in the hour before the flight. Internet service was so poor in the terminal that updates weren't always being received.

We had a mechanical delay which made us 90 minutes late (9:30 PM) then land and put into the penalty box because a plane was in our gate? What the hell! We should get priority.Damn American.

Check in for 5am flight at RDU was hampered by American check in counters being seriously understaffed , was told even supervisor called out. Took so long in line for special services check in that we missed our 5am departure even after arriving at 3:30am. Had to be rescheduled to later flight from Charlotte to St Thomas.

Delayed flight due to maintenance and I have had multiple delayed flights due to maintenance in the last month plus

Everything you need to know for your flight to South America

Information on your arrival and departure airports