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Find cheap flights from Des Moines to South America from $434

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Thu 5/23
Thu 5/30

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Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Bogotá
Bogotá2 stops$434
Cartagena
Cartagena2 stops$515
Santiago
Santiago1 stop$863
Quito
Quito1 stop$595
Guayaquil
Guayaquil2 stops$678
Barranquilla
Barranquilla2 stops$434
Belo Horizonte
Belo Horizonte2 stops$1,109

Good to know

Low season

October

High season

December

Cheapest flight

$434
Best time to beat the crowds but there is an average 15% increase in price.
Most popular time to fly with an average 31% increase in price.
Flight from Des Moines to Barranquilla

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to Des Moines with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South America

  • Morning departure is around 24% cheaper than an evening flight, on average*.
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 3 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 11028 reviews
8.2boarding
8.6crew
7.5food
7.9comfort
8.0entertainment
Airline reviews

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

2.0 MediocreMarisol, Apr 2024DFW - ATL
Read more about Delta reviews

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive. I also upgraded to comfort + , I didn’t feel it was worth it. There was no benefit

On my way home I had a layover. The flight from ATL to CLT was amended 5x while I was waiting. I could have driven home sooner. Overall from Dallas, Tx to Charlotte, NC I started my trip at 4:30pm, I didn’t get home until past midnight. I know things happen, but 5x to make me run back and forth in an airport from different terminals is excessive.

They did a fine job. Can't wait to use Delta in the future.

There was a loud squeaky sound the whole time we were flying.

Had a broken tray in business class. Crew just shrugged it off.

Seat back monitors and outlets were dead and not working.

Everything was great except for the seat. The backrest would not stay in the upright position.

I usually have a positive experience with Delta. Complimentary upgrades are always nice!

Flight delayed about 2 hrs so it made it a VERY late night

The crew, food, and entertainment were all good. But my screen had some sort of bug where if I turned it off, it would turn back on after 2-5 minutes. At full brightness. It made it very hard to get any shut-eye on the overnight flight. Also, the older Boeing plane, while nicely cared for (and no doors fell off 😅👏) doesn't have the nice air quality of newer planes. So I felt a bit greasy by the time we landed in Sweden.

Flight delayed from Cape Town to Washington then got diverted to miami and in miami we had to fend for ourselves , im still trying to get to Shreveport now

delay several times and wait extra long to board. no entertainment service because there are problem for some rows. always encounter some delays for the last flight of the day.

I just wrote a text which was supposed to be for the flight from Denver to spokane not Frankfurt to Denver.

On time every leg of the journey and exceptional staff at counter, gate, and on board. I haven’t travelled in US for a long time and was genuinely surprised how pleasant this was.

Hated every minute of it. This flight should have only taken 1.5hrs but was delayed over 10hours. Now I am being told I cannot be compensated or refunded my ticket price or extra leg room, which I purchased but did not receive, because the airline is throwing the blame on the 3rd party I purchased tickets through and 3rd party putting the blame on airline. No one wants to help. They received their money and that's all they care about. Im going on 3 days of still trying to get to my final destination, had to cancel car rental, car insurance and hotel. Currently staying in airport until hotels open up. Thank you Lufthansa, Kayak, Underpricer and United for making this trip the worst ever.

The delays (5 hrs) were a comedy of errors, and the multiple safety issues encountered were very concerning.

flight delays, staff only communicating when pushed, food service lasting a grand total of 7 minutes, stuck in seat from 45mins into flight until landing

Crew was great and did their best to make us comfortable and captain came out at the beginning to announce why the flight was delayed, weather situation up ahead, and kept us updated throughout the flight.

the flight from Tampa departed with a delay. The food on board was poor, usually on international airlines alcoholic beverages are offered free of charge , but here it was for a fee, the cutlery was wooden, there were no hot drinks (tea, coffee). Unfortunately, I didn't take pictures of the portions of food, but it wouldn't have been enough for a child either.And in the future, I will try not to use the services of this airline

they made me check my carryon. There was space in the overhead bins.

It was spectacular. I had basic Economy and was given so much space and their seats lean back so far. Staff was superb, food was superb, everything was superb, Finnair is Fantastic.

Those seats were way too narrow. I had the middle seat, one person was a very skinny person and we still couldn’t avoid touching each other anytime one of us moved. The other person was larger and we were basically sitting in each others lap the entire flight. There was zero entertainment. The flight was long enough to justify tvs, but no. Gotta sit there in your infant seat and twiddle your thumbs.

The Flight attendant had an attitude and didn't allow anyone any time to prepare for landing despite being absent throughout the entire trip

Flight boarded without pilots. Sat on plane for 3 hrs. after over an hour late boarding. Plane never took off. Had to deplane near midnight. Line for rebooking was 3 hours + long. I had to leave.

The flight was great but board was a nightmare. The gate was changed 4 times during the layover period

The experience was great and much better than the flight going out. of course I was in first class but the service was excellent

Cold air blew constantly on my legs almost making me numb.

Ac was broken so we deplaned, waited 2 hours, taxiing for takeoff they said the plane would not fly so we went back to the gate and got a new plane which took another hour. In all a 4 hour delay for an 80 min flight.

Missed the flight because of them and up geting a rental car

Delayd flight out of atl as always miss my conection in dfw no flight untill next day

Book cheap flights from Des Moines to South America

Recent round-trip flight deals

9/28Sat
2 stopsDelta
52h 00mDSM-BAQ
10/2Wed
2 stopsDelta
13h 07mBAQ-DSM
$434
9/28Sat
2 stopsDelta
30h 41mDSM-BAQ
10/2Wed
2 stopsDelta
29h 47mBAQ-DSM
$441
5/9Thu
1 stop
15h 42mDSM-UIO
5/10Fri
1 stop
11h 50mUIO-DSM
$595
5/9Thu
1 stopDelta
9h 20mDSM-UIO
5/10Fri
2 stopsDelta
11h 36mUIO-DSM
$600
9/28Sat
1 stopAmerican Airlines
29h 19mDSM-BAQ
10/2Wed
2 stopsAmerican Airlines
31h 35mBAQ-DSM
$644
7/14Sun
2 stopsAmerican Airlines
41h 19mDSM-BAQ
7/21Sun
2 stopsAmerican Airlines
53h 55mBAQ-DSM
$647
9/16Mon
2 stopsAmerican Airlines
17h 42mDSM-GYE
9/20Fri
2 stopsAmerican Airlines
15h 08mGYE-DSM
$678
7/14Sun
3 stops
27h 23mDSM-BAQ
7/21Sun
3 stops
23h 44mBAQ-DSM
$713
9/6Fri
1 stopUnited Airlines
12h 45mDSM-GRU
9/11Wed
2 stopsUnited Airlines
18h 27mGRU-DSM
$1,042
9/4Wed
1 stopUnited Airlines
14h 35mDSM-GRU
9/10Tue
1 stopUnited Airlines
18h 29mGRU-DSM
$1,073

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Recent one-way flight deals

9/18Wed
3 stopsAmerican Airlines
23h 55mDSM-CNF
$642
9/18Wed
2 stopsDelta
18h 31mDSM-CNF
$643
5/12Sun
2 stopsUnited Airlines
43h 53mDSM-GRU
$761
5/12Sun
1 stopDelta
15h 45mDSM-GRU
$777
5/11Sat
2 stopsDelta
24h 05mDSM-CNF
$830
5/11Sat
3 stopsAmerican Airlines
23h 33mDSM-CNF
$833

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Last minute flights from Des Moines to South America

Last minute flight, train and bus deals

4/27Sat
multi-stopUnited Airlines
23h 30mDSM-GRU
5/4Sat
multi-stopUnited Airlines
14h 14mGRU-DSM
$1,613
4/27Sat
multi-stopAmerican Airlines
20h 45mDSM-GRU
5/4Sat
multi-stopAmerican Airlines
25h 02mGRU-DSM
$1,614
4/27Sat
multi-stopAmerican Airlines
17h 47mDSM-GRU
5/4Sat
multi-stopAmerican Airlines
25h 02mGRU-DSM
$1,616
4/27Sat
multi-stop
44h 33mDSM-GRU
5/4Sat
multi-stop
27h 51mGRU-DSM
$1,995
4/27Sat
multi-stop
44h 33mDSM-GRU
5/3Fri
multi-stop
34h 01mGRU-DSM
$2,008

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Des Moines - South America Flights

Departure:

Des Moines (DSM)United States

Return flight deals:

South America - Des Moines

Cabin classes: