$308 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$561
Bogotá
Bogotá1 stop$544
Santiago
Santiago2 stops$950
Cartagena
Cartagena1 stop$396
Quito
Quito1 stop$661
Guayaquil
Guayaquil2 stops$718
Barranquilla
Barranquilla1 stop$425
Belo Horizonte
Belo Horizonte2 stops$1,064
Lima
Lima2 stops$561
Bogotá
Bogotá1 stop$544
Santiago
Santiago2 stops$950
Cartagena
Cartagena1 stop$396
Quito
Quito1 stop$661
Guayaquil
Guayaquil2 stops$718
Barranquilla
Barranquilla1 stop$425
Belo Horizonte
Belo Horizonte2 stops$1,064

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sun, May 17 - Fri, May 29
Multiple Airlines Logo
7:45 am - 12:06 pm
DSM
-
CTG
28h 21m
1 stop
Multiple Airlines Logo
1:11 pm - 11:24 pm
CTG
-
DSM
10h 13m
1 stop
$396Multiple Airlines
Sun, Apr 26 - Wed, May 6
Multiple Airlines Logo
8:30 am - 12:06 pm
DSM
-
CTG
27h 36m
1 stop
Multiple Airlines Logo
1:11 pm - 3:15 pm
CTG
-
DSM
26h 04m
1 stop
$399Multiple Airlines
Thu, Sep 17 - Thu, Sep 24
American Airlines Logo
4:13 pm - 11:55 am
DSM
-
BAQ
19h 42m
2 stops
American Airlines Logo
2:15 pm - 8:07 am
BAQ
-
DSM
17h 52m
2 stops
$621American Airlines
Sun, May 3 - Sun, May 10
American Airlines Logo
8:03 pm - 12:30 pm
DSM
-
BAQ
16h 27m
2 stops
American Airlines Logo
3:25 pm - 11:26 am
BAQ
-
DSM
20h 01m
2 stops
$632American Airlines
Thu, Sep 17 - Thu, Sep 24
LATAM Airlines Logo
2:15 pm - 9:10 pm
DSM
-
BAQ
30h 55m
3 stops
LATAM Airlines Logo
7:20 am - 10:26 pm
BAQ
-
DSM
15h 06m
3 stops
$644LATAM Airlines
Thu, Sep 17 - Thu, Sep 24
LATAM Airlines Logo
11:04 am - 9:10 pm
DSM
-
BAQ
34h 06m
2 stops
LATAM Airlines Logo
7:20 am - 10:26 pm
BAQ
-
DSM
15h 06m
3 stops
$646LATAM Airlines
Tue, Sep 1 - Mon, Oct 5
United Airlines Logo
3:00 pm - 11:25 pm
DSM
-
UIO
8h 25m
1 stop
United Airlines Logo
7:25 am - 10:30 pm
UIO
-
DSM
15h 05m
1 stop
$661United Airlines
Wed, May 27 - Wed, Jun 3
Delta Logo
11:57 am - 4:43 am
DSM
-
UIO
16h 46m
2 stops
Delta Logo
12:59 am - 11:08 am
UIO
-
DSM
10h 09m
1 stop
$666Delta
Sun, May 3 - Thu, May 7
United Airlines Logo
8:15 am - 11:38 pm
DSM
-
BAQ
15h 23m
2 stops
United Airlines Logo
9:13 am - 10:45 pm
BAQ
-
DSM
37h 32m
2 stops
$751United Airlines
Mon, May 4 - Mon, May 11
Delta Logo
5:45 am - 6:00 am
DSM
-
SCL
23h 15m
2 stops
Delta Logo
8:40 pm - 1:37 pm
SCL
-
DSM
17h 57m
1 stop
$1,008Delta
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to South America were found on American Airlines ($620) and Delta ($654).

Good to know

Cheapest flight$308
Flight from Des Moines to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8313 reviews
7.9Comfort
8.5Crew
7.8Entertainment
7.2Food
8.1Boarding
Airline reviews

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

10.0 ExcellentShirley, Mar 2026
LAX - ATL
Read more Delta reviews

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was cencaled due with the bad weather on Sunday the crew was poorly mistaken my luggage supposed depart with my flight instead I didn’t have my luggage for almost 3 days the website is poorly respond to my complain until I have someone to do it my connection smooth their not even respon or email me even the have my luggage

Delta needs to step its game up get a more reliable internet service. Internet service was non-existent for this flight.

Mechanical Delay of over an hour with multiple gate changes. Entertainment system down for rejuvenation.

This was a Latam operated flight. Seats seemed a bit narrow in business class. Older aircraft.

I had a flight cancel and had it rerouted. When the rerouted they put me at a window seat instead of an isle. It was hard sitting by the window because the couple with masks on were making out. I get motion sickness which is why I need to have the isle seat.

NEVER MADE THE FLIGHT BECAUSE DELTA SAID THEY CAN NOT

THEY FAILED ME AND I NEVER GOT ON THE FLIGHT BECAUSE IT WAS SO DELAYED! I ENDED UP HAVING TO PAY OUT OF POCKET FOR A HOTEL AND STAY IN NASHVILLE TO CATCH A FLIGHT FOR THE FOLLOWING DAY. DELTA IS POOR CUSTOMER SERVICE>

8 hours late and the plane smelled like urine, that smell in the morning when your child wet the bed in the night.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

The flight was late. Please do not delay next time.

Good quick flight on a small but comfortable plane. I'm 6'3 and had plenty of space.

Experience was great - no complaints. Took off on time, landed early. Got to the gate relatively quickly - took a little bit of extra time to deplane but nothing excessive.

Business class seats felt very cramped compared to other airlines.

Economy plus was so cramped I could not use my laptop. It was beyond bad.

OK, we were delayed and had to de plane and reboard.

United is one airline which regardless of how many separate United tickets in existence, if one flight breaks down, the airline will take care of all the flights.

Both our flights were delayed. Almost didn’t get in the second flight. Staff was rude to the bone.

Both my flight where delayed Had 25min to make it to my transfer flight

Everything was on time and service on the flight was great!

Wifi Bluetooth features for watching in flight movie was horrible. Screen kept blacking out no connection of sound although it said connected. Other than that smooth trip .

Rough flight No beverage service due to turbulence Bottom Seat cushion was non existent

Great experience. Good dinner and service. FA's were very nice and attentive.

It was great. Smooth flight, comfortable, left on time and landed on time.

Perhaps this is an airport issue, but being in a takeoff queue for over an hour in the taxiing lane is unacceptable. We will definitely be seeking alternative avenues for air travel in the future.

We hoarded. Then we deplaned. Then we waited for 10 hours in the MSP airport due to a wheel misfunction. We understand safety but communication between crew and airport staff was horrible. When we did finally board, we were rushed on and because we were waiting for a “fresh” pilot and crew, we sat in a roasting plane with no A/C for an hour. My question is why was this flight not cancelled right away when they knew this would be a huge issue OR, why did AA not get a substitute plane, considering this was already a full flight? To me, this appears to be a complete breakdown in leadership and utter systems failure. The compensation for completely disrupting travel plans for hundreds, which we paid dearly for, was measly. While we appreciated the lodging for the night, $12 in meal vouchers isn’t going to sustain anyone for over 12 hours. “We apologize; our hands are tied” is no longer an acceptable explanation. We are so completely turned off by this experience and will definitely seek alternative avenues when we need to fly.

Mostly good. The WiFi wasn’t working so that was not great.

I rated the experience "mediocre" because of the 2 hour delay in take off. This is the 4th flight from DFW on AA where there was a delay and in one of the instances (after 13 delays), the flight was cancelled. I understand weather but for the March 18th flight, there was no weather issue in Dallas or Detroit. I called Concierge Key and they were wonderful, booking me on a later flight in case my flight was cancelled. I have flown with American for many years and never has there been this consistent pattern of delays. Very disappointing.

They put me on an earlier and I got home sooner

Not good. One of my luggage is missing. And until now they can’t find it

Horrible experience upon landing. Probably more due to DCA utter incompetence than AA.

Everything you need to know for your flight to South America

Information on your arrival and departure airports