$345 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$709
Bogotá
Bogotá1 stop$593
Santiago
Santiago2 stops$764
Cartagena
Cartagena2 stops$499
Quito
Quito2 stops$643
Guayaquil
Guayaquil2 stops$699
Barranquilla
Barranquilla2 stops$614
Belo Horizonte
Belo Horizonte2 stops$1,153
Lima
Lima2 stops$709
Bogotá
Bogotá1 stop$593
Santiago
Santiago2 stops$764
Cartagena
Cartagena2 stops$499
Quito
Quito2 stops$643
Guayaquil
Guayaquil2 stops$699
Barranquilla
Barranquilla2 stops$614
Belo Horizonte
Belo Horizonte2 stops$1,153

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Fri, Jan 16 - Tue, Jan 20
American Airlines Logo
4:00 pm - 3:30 pmDSM-CTG
22h 30m2 stops
American Airlines Logo
2:30 pm - 10:50 amCTG-DSM
21h 20m2 stops
$499American Airlines
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Sun, Jan 18 - Wed, Jan 21
United Airlines Logo
3:04 pm - 11:37 pmDSM-BAQ
31h 33m2 stops
United Airlines Logo
9:09 am - 10:30 pmBAQ-DSM
38h 21m2 stops
$614United Airlines
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Sun, Mar 8 - Thu, Mar 12
United Airlines Logo
7:15 am - 11:00 pmDSM-CTG
15h 45m2 stops
United Airlines Logo
6:25 am - 10:36 pmCTG-DSM
16h 11m2 stops
$619United Airlines
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Wed, Jan 14 - Wed, Jan 28
Multiple Airlines Logo
12:04 pm - 5:17 amDSM-UIO
16h 13m2 stops
Multiple Airlines Logo
11:45 pm - 10:41 amUIO-DSM
11h 56m1 stop
$643Multiple Airlines
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Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:45 am - 1:15 pmDSM-CTG
7h 30m1 stop
Delta Logo
5:05 am - 10:23 amCTG-DSM
29h 18m2 stops
$651Delta
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Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:15 pm - 1:15 pmDSM-CTG
20h 00m1 stop
Delta Logo
5:05 am - 10:23 amCTG-DSM
29h 18m2 stops
$652Delta
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Wed, Jan 14 - Wed, Jan 28
LATAM Airlines Logo
11:26 am - 9:35 pmDSM-UIO
9h 09m1 stop
LATAM Airlines Logo
11:45 pm - 10:41 amUIO-DSM
11h 56m1 stop
$682LATAM Airlines
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Sun, Jan 11 - Sat, Jan 24
Multiple Airlines Logo
2:58 pm - 8:05 pmDSM-UIO
28h 07m3 stops
Multiple Airlines Logo
3:05 pm - 10:09 pmUIO-DSM
32h 04m3 stops
$683Multiple Airlines
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Sun, Jan 11 - Sat, Jan 24
LATAM Airlines Logo
5:16 pm - 9:35 pmDSM-UIO
27h 19m1 stop
LATAM Airlines Logo
7:00 pm - 10:41 amUIO-DSM
16h 41m2 stops
$688LATAM Airlines
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Tue, Dec 30 - Tue, Jan 6
Lufthansa Logo
11:35 am - 11:10 amDSM-CNF
20h 35m2 stops
Lufthansa Logo
5:25 pm - 5:47 pmCNF-DSM
27h 22m2 stops
$1,749Lufthansa
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Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to South America?

The average price of all round-trip flights from Des Moines to South America clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South America on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to South America. For your return ticket, we recommend flying on a Sunday and avoiding Wednesdays for the best deals.

Good to know

Low seasonDecember
Cheapest flight$345
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly with an average 13% increase in price.
Flight from Des Moines to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $645 on average. Morning departures are around 35% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the evening, which is peak travel time and where the average cost of a ticket is $1,128.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8009 reviews
7.3Food
8.1Boarding
7.9Comfort
8.5Crew
7.9Entertainment
Airline reviews

Plenty of leg room, temperature was great and staff was excellent. Would do it more often.

10.0 ExcellentJacky, Nov 2025JFK - LHR
Read more Delta reviews

Plenty of leg room, temperature was great and staff was excellent. Would do it more often.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Flight delayed then cancelled. Misplaced luggage. Still do not have. Rented car 1100 mile drive. I had to buy some overnight Hotels clothes toiletries gas food at my expense. Still not home. Not sure where luggage is. Over 4 hours on hold to Felta

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Boarding was confusing with a delayed flight because there was no English translation

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Bought a ticket that included a bag and they still charged me to check it in, latam is the worst airline.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Seats in waiting area and on plane hard as rock. Fast internet on the flight was great! Crew was kind.

Starlink wifi on the Embraer E175 is an excellent experience. I was able to connect and work from IAD all the way to approach into BTV.

Older aircraft, no meal, only food was for purchase. Not impressed United.

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

Always wish for more healthy, gluten free options. We have to bring our own.

Having a long layover, I was very appreciative of the ability to stand by for an earlier flight. Other airlines like Delta have refused this to me in the past, just to be mean (because my ticket class wasn't high enough). United went out of their way to help me get to my destination early, which I really appreciated given that it was the third leg of a 24+ hour journey for me.

Other than a way way too cold cabinets for the entire flight, all was great

One bag is incorrect and not acceptable for an international flight. The food was not just good. I won't fly with them again.

Not pleasant trip cross country when the entertainment and WiFi system not working. No entertainment for entirety of route. Staff was rather nonchalant in that they dismissed the problem due to age of plane. It would have been nice to know this up front so I could have come prepared to read or download movies before boarding Coincidentally or not, there was a similar issue with the entertainment system on my previous flight I took on my fist leg of the trip. There are no seat TVs, so you must rely on the app when it works. United can do better. Also, what use it it to pay for boarding group 2 when half of the passengers are in the same line as you?

Plane boarded early a quickly, was mostly full. We left close to on time. And landed early.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Loved the crew . Absolutely no complaints. Except for luggage lost

Everything was good The connects, with no blame to crew. Or pilots. I understand they are short staffed. Everything went well for me. I'll be using you guys again in May if not sooner.

this plane was really old, had exit row seats and tray was in arm of seat so super uncomfortable to use. another seat they could t even use the tray it was broke. seat i. front of me had duct tape on it cause seat was ripped open... this plane should either be updated or retired.

We were very rushed by a staff member at the gate when transferring from American Airlines to Fijian. Then the plane stayed put for ages anyhow! The plane was delayed and my bag sent to San Francisco instead of Fiji

Baggage handling poor. Second time this has happened. My bag went to San Francisco instead of Fiji. No apology. Luckily Nadi airport staff are fantastic. My bag arrived in Fiji the next day.

Everything you need to know for your flight to South America

Information on your arrival and departure airports