$366 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$709
Bogotá
Bogotá2 stops$477
Santiago
Santiago1 stop$784
Cartagena
Cartagena1 stop$467
Quito
Quito2 stops$616
Guayaquil
Guayaquil2 stops$734
Barranquilla
Barranquilla2 stops$640
Belo Horizonte
Belo Horizonte2 stops$1,112
Lima
Lima1 stop$709
Bogotá
Bogotá2 stops$477
Santiago
Santiago1 stop$784
Cartagena
Cartagena1 stop$467
Quito
Quito2 stops$616
Guayaquil
Guayaquil2 stops$734
Barranquilla
Barranquilla2 stops$640
Belo Horizonte
Belo Horizonte2 stops$1,112

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Sun, Oct 26 - Sun, Nov 2
 Logo
10:41 am - 12:25 pmDSM-CTG
25h 44m1 stop
 Logo
2:32 pm - 12:53 pmCTG-DSM
23h 21m2 stops
Mon, Oct 6 - Thu, Oct 9
 Logo
8:00 am - 12:27 pmDSM-UIO
28h 27m2 stops
 Logo
5:15 pm - 2:50 pmUIO-DSM
21h 35m1 stop
Sun, Oct 26 - Sun, Nov 2
United Airlines Logo
6:05 am - 8:41 amDSM-CTG
26h 36m2 stops
United Airlines Logo
9:42 am - 10:20 pmCTG-DSM
37h 38m2 stops
$618United Airlines
Find Deal
Mon, Mar 9 - Thu, Mar 12
United Airlines Logo
3:00 pm - 8:41 amDSM-CTG
41h 41m2 stops
United Airlines Logo
5:55 pm - 10:30 pmCTG-DSM
28h 35m2 stops
$630United Airlines
Find Deal
Sun, Nov 2 - Thu, Nov 6
American Airlines Logo
6:40 pm - 1:26 pmDSM-CTG
17h 46m2 stops
American Airlines Logo
2:26 pm - 11:33 pmCTG-DSM
10h 07m1 stop
$642American Airlines
Find Deal
Mon, Mar 9 - Thu, Mar 12
Delta Logo
5:45 am - 1:15 pmDSM-CTG
7h 30m1 stop
Delta Logo
2:30 pm - 10:23 amCTG-DSM
19h 53m1 stop
$649Delta
Find Deal
Mon, Mar 9 - Thu, Mar 12
Delta Logo
5:45 am - 1:15 pmDSM-CTG
7h 30m1 stop
Delta Logo
5:05 am - 10:23 amCTG-DSM
29h 18m2 stops
$650Delta
Find Deal
Sun, Oct 26 - Sun, Nov 2
American Airlines Logo
6:44 am - 8:54 pmDSM-UIO
14h 10m2 stops
American Airlines Logo
8:27 am - 10:02 pmUIO-DSM
14h 35m2 stops
$754American Airlines
Find Deal
Sun, Oct 5 - Wed, Oct 8
LATAM Airlines Logo
6:30 pm - 7:12 pmDSM-UIO
24h 42m2 stops
LATAM Airlines Logo
7:09 am - 10:05 amUIO-DSM
26h 56m2 stops
$757LATAM Airlines
Find Deal
Sun, Oct 5 - Thu, Oct 9
LATAM Airlines Logo
6:30 pm - 11:20 pmDSM-UIO
28h 50m2 stops
LATAM Airlines Logo
9:01 am - 10:05 amUIO-DSM
25h 04m2 stops
$767LATAM Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to South America?

The average price of all round-trip flights from Des Moines to South America clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South America on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to South America. For your return ticket, we recommend flying on a Sunday and avoiding Wednesdays for the best deals.

Good to know

Low seasonFebruary
Cheapest flight$366
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 30% increase in price.
Flight from Des Moines to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $645 on average. Morning departures are around 35% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the evening, which is peak travel time and where the average cost of a ticket is $1,128.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7960 reviews
8.2Boarding
8.5Crew
7.9Entertainment
7.9Comfort
7.3Food
Airline reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

10.0 ExcellentAnonymous, Sep 2025CLT - BOS
Read more Delta reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

The food was terrible especially for a 15 hour international flight. The crew was unpleasant as well.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Quick check in. Everything went smooth. I don't know what can be done about airline food.

Crew was good. The reservation got mixed up and they didn't have my TSA number. I am also a Silver Medallion and wasn't able to use Sky Priority.

Delta made it easy, comfortable and timely. The crew was fantastic.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

Nothing special. The crew never went out of their way for anything.

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Boarding was confusing with a delayed flight because there was no English translation

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Bought a ticket that included a bag and they still charged me to check it in, latam is the worst airline.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

It’s a delta flight operated by LATAM. The whole ticket sale is a mess, delta changed my flight but didn’t update it in LATAM system, I couldn’t get my boarding pass, it took me hours to resolve this issue with delta. I had to change my travel plan. No apology from Delta even though it’s their fault.

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

Wider seats, better seat cushions, (I felt like there was a board I was sitting on). I had the chicken to eat but It neither tasted nor looked like chicken. The fruit was good.

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

Everything was good, except the seats in economy were so close together, you could barely get out when the seat in front of your was reclined. If the airlines keep jamming in more and more seats, it will become intolerable. I will look for another airline that considers customer comfort and does not keep adding more rows of seats for more profit.

The newer screen was super cool and had the option to watch many different shows or movies. Crew was polite and helpful. However again, many children screaming bloody murder and kicking my seat, and parents doing nothing about it as usual.

Flight was good and crew was super polite. However, there were around 5 kids screaming the WHOLE 2 hours. I understand kids have to come but parents need to do something to control their children. They make the experience terrible, especially after finishing 16 hour shifts at the hospital I needed some sleep, which I did not get.

IAD with the archaic people movers is just a place to be avoided.

Great service on board. Boarding a bit slow due to process. Food was pretty average.

Tastless food and too obvious lack of enthusiasm for service in the economy vesus business class

All of the United employees I interacted with were professional and courteous. The aircraft was clean, the food on the flight was good. No complaints here.

I had no checked baggage but was required to hand over carry on baggage at the door of the plane. There was a lot of overboard space in the plane and I was one of the last ones. I ran to get my carry on but it was gone. I was given back at the plane door in Toronto, so the wait was not as long as it would have been at the carousel.

Armrest controller on my seat 35D and nextbooennseat 35E did not work right. Hard to press buttons to recognize and 35D had constantnpressure either upmost down somit was nearly impossible to make selections. .

Given it’s a red-eye into Charolotte, we didn’t get any food. The survey does not include “N/A” so the rating will be skewed.

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

American airlines suck they delay the flights all the time made me sleep in an airport because my flight was delayed and I miss my connecting flight

There's nothing I liked about it. For first off I scheduled this trip two weeks in advance then they delayed my flight which messed up my whole trip. So I scheduled it for the following weekend thinking there won't be a delay and guess what as soon as I got to the airport we said in the airplane on the tarmac for an hour and a half. Not only was it delayed I missed my connecting flight meaning I had to stay the night at Dallas-Fort Worth airport sleeping on the floor. I will tell you this I will never fly American airlines ever again I have had nothing but horrible experience with them and I just throw money at them

The stewardess hit me with the food kart twice on the head and didn't say I'm sorry once. The same stewardess gave me a warm Apple Juice with No ice. The Flight was delayed for Departure 6 times, starting from 2:36pm, finally taking off 7:50pm. I was late picking up my child from the sitter by 3 hours.

Don’t know they cancelled the flight day before I was to leave. They sent a email at 9:00 pm at night saying they cancelled. That is the smooth way to say we don’t want your business! I think they didn’t have enough people booking so they cancelled the flight! It’s all about the money anymore there is no honesty in business.

Having to reschedule flights a day later, they loaded by luggage on the wrong plane from Little rock now I have to HOPE they deliver it to where im staying like they said would. International flight crew was very disgruntled and not very friendly.

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

It took way too long to diagnose and solve the problem of a broken crew member cabin seat. Though compensation for the volunteer who left the flight was very kind.

The entertainment package was vast and the selections were very current. Keep updating it was great.

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