$374 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Flights Deals

Best South America Flight Deals from Des Moines

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima2 stops$587
Bogotá
Bogotá1 stop$501
Cartagena
Cartagena2 stops$632
Santiago
Santiago2 stops$804
Quito
Quito2 stops$639
Guayaquil
Guayaquil2 stops$766
Barranquilla
Barranquilla3 stops$628
Belo Horizonte
Belo Horizonte2 stops$858
Lima
Lima2 stops$587
Bogotá
Bogotá1 stop$501
Cartagena
Cartagena2 stops$632
Santiago
Santiago2 stops$804
Quito
Quito2 stops$639
Guayaquil
Guayaquil2 stops$766
Barranquilla
Barranquilla3 stops$628
Belo Horizonte
Belo Horizonte2 stops$858

Cheap Flights from Des Moines to South America

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.

Recent round-trip flight deals from Des Moines to South America

Recommended round-trip deals departing in the coming months from the most popular airlines that fly from Des Moines to South America.
Discover the best prices for you by selecting your travel dates on KAYAK.
 Logo
11:35 am - 12:35 amDSM-LIM
13h 00m2 stops
 Logo
2:50 am - 5:14 pmLIM-DSM
14h 24m2 stops
Sun, Aug 24 - Wed, Sep 3
 Logo
5:19 pm - 5:09 pmDSM-BAQ
47h 50m3 stops
 Logo
2:46 pm - 5:16 pmBAQ-DSM
26h 30m2 stops
Fri, Jun 13 - Fri, Jun 20
American Airlines Logo
7:00 am - 12:50 amDSM-UIO
17h 50m2 stops
American Airlines Logo
6:30 am - 12:06 amUIO-DSM
17h 36m2 stops
$639American Airlines
Find Deal
Wed, Jun 18 - Wed, Jul 2
American Airlines Logo
7:00 am - 12:50 amDSM-UIO
17h 50m2 stops
American Airlines Logo
6:30 am - 12:06 amUIO-DSM
17h 36m2 stops
$651American Airlines
Find Deal
Wed, Jun 18 - Wed, Jul 2
Delta Logo
5:40 am - 5:30 pmDSM-CTG
11h 50m2 stops
Delta Logo
2:30 pm - 11:03 pmCTG-DSM
8h 33m1 stop
$688Delta
Find Deal
Sat, Jun 14 - Sat, Jun 21
Delta Logo
11:04 am - 6:25 amDSM-LIM
19h 21m2 stops
Delta Logo
12:15 pm - 9:16 amLIM-DSM
21h 01m2 stops
$709Delta
Find Deal
Sun, Aug 24 - Thu, Sep 4
LATAM Airlines Logo
5:40 am - 8:15 pmDSM-LIM
14h 35m2 stops
LATAM Airlines Logo
11:20 pm - 10:14 amLIM-DSM
10h 54m1 stop
$733LATAM Airlines
Find Deal
Tue, Jul 15 - Tue, Aug 12
United Airlines Logo
2:57 pm - 11:25 pmDSM-UIO
8h 28m1 stop
United Airlines Logo
12:35 am - 2:17 pmUIO-DSM
13h 42m1 stop
$738United Airlines
Find Deal
Fri, Jul 4 - Mon, Aug 18
United Airlines Logo
3:01 pm - 11:37 pmDSM-GYE
32h 36m2 stops
United Airlines Logo
12:17 pm - 10:22 pmGYE-DSM
34h 05m2 stops
$766United Airlines
Find Deal
Sat, Jun 14 - Sat, Jun 21
LATAM Airlines Logo
2:20 pm - 7:05 pmDSM-UIO
28h 45m2 stops
LATAM Airlines Logo
11:20 pm - 10:14 amUIO-DSM
10h 54m1 stop
$797LATAM Airlines
Find Deal
Fri, Jul 4 - Tue, Aug 19
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KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to South America?

The average price of all round-trip flights from Des Moines to South America clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to South America on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Des Moines to South America. For your return ticket, we recommend flying on a Sunday and avoiding Wednesdays for the best deals.


Good to know

Low seasonApril
High seasonNovember
Cheapest flight$374
Best time to beat the crowds with an average 14% drop in price.
Most popular time to fly and prices are also 0% lower on average.
Flight from Des Moines to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $645 on average. Morning departures are around 35% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the evening, which is peak travel time and where the average cost of a ticket is $1,128.

Top 4 airlines serving from Des Moines to South America

Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7936 reviews
7.3Food
7.9Comfort
8.5Crew
7.9Entertainment
8.2Boarding
Airline reviews

Our bag was lost so that made unnecessary chaos On our trip

6.0 GoodBarbara, Apr 2025JFK - FCO
Read more Delta reviews

Our bag was lost so that made unnecessary chaos On our trip

Delta is my preferred airline. I've traveled with them for years. On time in most cases, good communication, easy to use app. Most planes are pretty nice. I was on a CRJ 700/900 however, which was pretty badly aged inside and needed a refresh. No infotainment, unreliable wifi, best to download before boarding or bring a book. Food choices are really just snacks on this flight, nice variety but about what you'd expect. Great staff and prompt in departure and early arrival too. Overall quite satisfied.

Crew was friendly Love the entertainment in the seat head rest.

Delta flight was on time, seats were comfortable, and crew was nice.

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Delayed take-off. Very small plane so very scary with lots of bumps during the flight. Would never fly Delta on short flights in small 80 seaters plane again! Felt relieved when landed.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

It was an overnight flight and I desperately needed coffee before we landed, but Delta does only one beverage service, and that is shortly after takeoff, not before landing at 5 am.

A little bumpy ride . No food was being provided due the the turbulence. That was ok it was a short flight to my standards.

Simply outstanding. Their new lounge for Delta One customers is a cut above the rest.

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

It was good, however the airplane was really cold. We received snacks and the crew was friendly.

Delta has an outstanding service. They are courteous and punctual most of the time. The flight departed a half hour late but we arrived 15 minutes early.

Although the flight is goof and the crew is good, the way the airline charges you for every service is ridiculous.

They didi not provide wheelchair though we had requested. We had to run around for 40 minutes and arrange it from the airport!

No entertainment but not expected. Unless you are referring to monitor that you can use. Then Al, was fine on all flights.

Friendly staff, It was the first flight out for our plane, so had to be deiced from the frost. Only delayed a few minutes,

Staff encountered friendly and helpful. Flight delayed 1 hour due to mechanical issue, but made it through Atlanta immkgration and security in plenty of time,

Basic experience, we were delayed causing less time to enjoy our destination and on the way back, we boarded when the flight should have been taking off.

reliable, relatively relaxed, helpful and kind staff and clean airplanes. No need for more.

Everything is good except the dinner and breakfast. The sandwich is very delicious. Toilet is clean, I only use one of them. Flight attendants are very nice. 👍👍

A bit rush for transit. Food and entertainment are not available

Boarding was a little difficult. The gate area at O'Hare was very small and crowded due to multiple gates in the area. Could not hear the intercom, so had to rely on signage to see when my group was boarding and the signage was blocked by passengers standing in the gate. Flight was great and we arrived in Montreal on time.

Multiple delays and not straight answer from the United team

For economy, it was very good. Staff was great, they even let some of us change seats for more leg room... Put an empty seat between us which was fantastic for a 12hr flight. Onboard entertainment was excellent, I think over 200 choices of movies/tv/etc The bad was the barely/nonfunctional wifi that cost either $16.99 or 1700 miles (full flight). It was atrocious... Definitely the worst of the last 3 long haul major airlines I was on the last few months.

Stewardess spilled orange juice on my clothes/seat no help no apology just threw napkins at me to clean the mess up. Not Happy.

Smooth flight. Boarding was chaotic. Could not hear the gate agent over the intercom. People were lined up in the wrong lines. Groups one and two were told to board through line one and group 3 through line 2. All very confusing. Once in the air, the flight was smooth. There was no entertainment option on this aircraft, even though it was a larger aircraft.

The plane pushed back from the gate on time. However, it stopped on the ramp, and we waited for over 20 minutes before the aircraft pulled back to the gate. Apparently, something of importance had to be removed from the aircraft by the gate agent. I found this to be odd. The delay was not significant, but I felt that whatever was on the aircraft that had to be taken off, should’ve been done before we pushed back from the gate.

I didn’t get on plane. Passport being processed by consulate with visa application. Tried to cancel through underpricer after purchasing cacelling for any reason. No dice, they are thieves.

Electric plugs didn't work. Entertainment system wasn't working

Several delays. Next flight was worse. Did not arrive home until 2am PT

Very helpful ground crew after an earlier flight delay and being rebooked on a different flight.

Everything about the flight was lovely…We left early, arrived early, cabin crew were efficient and helpful. Flight was easy and most pleasant.

First world problems, but still… We were seated in first class and asked for a cocktail on a very short, 50 minute flight. After our drink order was taken, a half hour went by, and we noticed that every other person in the small plane had been served except for us. We got up to ask about it, the drinks finally came, then were taken away three minutes later since the flight was so short. Really strange situation, on the other hand, we were in Utah.

We missed our flight. The boarding pass had the wrong gate and by the time we received the text from Kayak, our flight was already gone. I’ll never use Kayak again and will go direct to the airlines in the future.

Boarding took forever, the plane was cramped and cold, and the seatbelt song came on constantly throughout the red eye flight with a loud pre-recorded message playing each time

Cabin felt crammed Snacks are lame But crew was super efficient getting us out on time despite delay

Took off on time and successfully avoided weather that looked to be a problem along the way

There were five broken seats on the plane. The crew was very rude in telling people they had to get off the plane and get a flight the next day. No call for volunteers, but telling people they had to get off. One woman was flying with her elderly mother and daughter and was told she had to leave or all three had to leave. Fortunately, a volunteer offered to stay. The situation was handled poorly.

The flight to Tokyo AA61 took off about two hours late, but then had to turn back. By that time the crew had to be replaced. Then they kept promising to take off in an hour, then in 3, then switch to the next day.

Everything you need to know for your flight to South America

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