- Argentina (Español)
- Australia (English)
- Österreich (Deutsch)
- Belgique (Français)
- België (Nederlands)
- Bolivia (Español)
- Brasil (Português)
- Canada (English)
- Canada (Français)
- Chile (Español)
- Colombia (Español)
- Costa Rica (Español)
- Česká republika (Čeština)
- Danmark (Dansk)
- Deutschland (Deutsch)
- Germany (English)
- Ecuador (Español)
- El Salvador (Español)
- España (Español)
- Espanya (Català)
- France (Français)
- Ελλάδα (Ελληνική)
- Guatemala (Español)
- Honduras (Español)
- Hong Kong (English)
- 香港 (中文)
- India (English)
- Indonesia (Bahasa Indonesia)
- Indonesia (English)
- Ireland (English)
- Israel (English)
- ישראל (עִבְרִית)
- Italia (Italiano)
- 日本 (日本語)
- Malaysia (English)
- Malaysia (Melayu)
- México (Español)
- Nederland (Nederlands)
- New Zealand (English)
- Nicaragua (Español)
- Norge (Norsk)
- Panamá (Español)
- Paraguay (Español)
- Perú (Español)
- Philippines (English)
- Polska (Polski)
- Portugal (Português)
- Puerto Rico (Español)
- República Dominicana (Español)
- România (Română)
- المملكة العربية السعودية (العَرَبِيَّة)
- Saudi Arabia (English)
- Suisse (Français)
- Schweiz (Deutsch)
- Singapore (English)
- South Africa (English)
- 대한민국 (한국어)
- Suomi (Suomi)
- Sverige (Svenska)
- 台灣 (中文)
- ประเทศไทย (ภาษาไทย)
- Thailand (English)
- Türkiye (Türkçe)
- Україна (Українська)
- United Arab Emirates (English)
- United Kingdom (English)
- United States (English)
- Estados Unidos (Español)
- Uruguay (Español)
- Venezuela (Español)
- Vietnam (English)
- Việt Nam (Việt)

Cheap Flights from Des Moines to South America
Cheapest round-trip prices found by our users on KAYAK in the last 5 daysBook Cheap Des Moines to South America Plane Tickets
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Cheap flights from Des Moines to South America with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.
Sat, Apr 10 - Sat, Apr 24
6:45 pm - 8:55 amDSM Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
14h 10m2 stops Chicago O'Hare Intl Bogotá El Dorado
10:05 am - 10:20 amGYE Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
24h 15m2 stops Bogotá El Dorado Chicago O'Hare Intl
$732Multiple Airlines
Sat, Oct 31 - Sat, Nov 7
3:01 pm - 2:34 pmDSM Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
23h 33m2 stops Washington, D.C. Reagan-National Miami
6:00 am - 11:26 pmGYE Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
18h 26m2 stops Miami Charlotte Douglas
$867American Airlines
Tue, Nov 24 - Tue, Dec 1
7:11 am - 9:17 pmDSM Des Moines-MDE Medellín Jose Maria Cordova Intl
13h 06m2 stops Chicago O'Hare Intl Miami
7:30 am - 6:54 pmMDE Medellín Jose Maria Cordova Intl-DSM Des Moines
12h 24m2 stops Miami Chicago O'Hare Intl
$875American Airlines
Tue, Nov 24 - Tue, Dec 1
7:11 am - 9:17 pmDSM Des Moines-MDE Medellín Jose Maria Cordova Intl
13h 06m2 stops Chicago O'Hare Intl Miami
7:30 am - 11:44 pmMDE Medellín Jose Maria Cordova Intl-DSM Des Moines
17h 14m1 stop Miami
$875American Airlines
Mon, Nov 9 - Thu, Nov 12
3:01 pm - 11:00 pmDSM Des Moines-CTG Cartagena Rafael Nunez
30h 59m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
6:25 am - 2:20 pmCTG Cartagena Rafael Nunez-DSM Des Moines
32h 55m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$879United Airlines
Thu, Nov 19 - Mon, Nov 30
11:36 am - 9:25 pmDSM Des Moines-UIO Quito Mariscal Sucr
8h 49m1 stop Atlanta Hartsfield-Jackson
12:55 am - 6:06 pmUIO Quito Mariscal Sucr-DSM Des Moines
18h 11m1 stop Atlanta Hartsfield-Jackson
$881LATAM Airlines
Fri, Nov 27 - Thu, Dec 3
8:00 am - 12:30 amDSM Des Moines-UIO Quito Mariscal Sucr
15h 30m1 stop Houston George Bush Intcntl
1:35 am - 2:15 pmUIO Quito Mariscal Sucr-DSM Des Moines
13h 40m1 stop Houston George Bush Intcntl
$893United Airlines
Mon, Mar 8 - Tue, Mar 16
11:04 am - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
16h 56m1 stop Atlanta Hartsfield-Jackson
12:15 am - 10:29 pmLIM Lima J Chavez Intl-DSM Des Moines
22h 14m2 stops Miami Atlanta Hartsfield-Jackson
$970Delta
Wed, Mar 10 - Fri, Mar 19
5:15 pm - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
10h 45m1 stop Atlanta Hartsfield-Jackson
9:00 am - 10:18 amLIM Lima J Chavez Intl-DSM Des Moines
25h 18m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson
$1,008LATAM Airlines
Fri, Nov 20 - Mon, Nov 30
7:55 pm - 9:25 pmDSM Des Moines-UIO Quito Mariscal Sucr
24h 30m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
12:55 am - 9:31 pmUIO Quito Mariscal Sucr-DSM Des Moines
21h 36m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$1,035Delta
Fri, Jan 1
5:30 am - 8:44 pmDSM Des Moines-CTG Cartagena Rafael Nunez
14h 14m2 stops Chicago O'Hare Intl Miami
$312American Airlines
Sun, Nov 29
7:16 pm - 3:34 pmDSM Des Moines-CTG Cartagena Rafael Nunez
19h 18m2 stops Dallas/Fort Worth Miami
$337American Airlines
Sun, Nov 29
5:30 am - 9:10 pmDSM Des Moines-CTG Cartagena Rafael Nunez
14h 40m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado
$363Delta
Wed, Oct 28
6:43 pm - 9:00 amDSM Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
14h 17m2 stops Chicago O'Hare Intl Bogotá El Dorado
$404Multiple Airlines
Fri, Jan 1
5:00 am - 8:44 pmDSM Des Moines-CTG Cartagena Rafael Nunez
14h 44m1 stop Miami
$411American Airlines
Tue, Oct 27
6:45 pm - 1:10 amDSM Des Moines-UIO Quito Mariscal Sucr
30h 25m2 stops Chicago O'Hare Intl Bogotá El Dorado
$422Avianca
Thu, Oct 29
6:00 am - 9:25 pmDSM Des Moines-UIO Quito Mariscal Sucr
15h 25m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson
$515Delta
Sun, Oct 25
5:35 am - 9:25 pmDSM Des Moines-UIO Quito Mariscal Sucr
15h 50m1 stop Atlanta Hartsfield-Jackson
$515Delta
Tue, Dec 22
11:34 am - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
16h 26m1 stop Atlanta Hartsfield-Jackson
$803LATAM Airlines
Thu, Dec 24
1:40 pm - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
14h 20m1 stop Atlanta Hartsfield-Jackson
$813LATAM Airlines
Thu, Oct 15 - Mon, Oct 19
7:42 pm - 12:35 pmDSM Des Moines-CTG Cartagena Rafael Nunez
16h 53m2 stops Dallas/Fort Worth Miami
1:35 pm - 9:15 amCTG Cartagena Rafael Nunez-DSM Des Moines
19h 40m2 stops Miami Dallas/Fort Worth
$1,031American Airlines
Sun, Oct 18 - Sat, Oct 24
6:54 pm - 9:40 pmDSM Des Moines-LIM Lima J Chavez Intl
26h 46m2 stops Atlanta Hartsfield-Jackson Miami
1:30 pm - 10:42 amLIM Lima J Chavez Intl-DSM Des Moines
21h 12m2 stops Miami Atlanta Hartsfield-Jackson
$1,355LATAM Airlines
Sun, Oct 18 - Sat, Oct 24
5:35 am - 9:55 pmDSM Des Moines-LIM Lima J Chavez Intl
16h 20m1 stop Atlanta Hartsfield-Jackson
8:15 am - 10:33 pmLIM Lima J Chavez Intl-DSM Des Moines
14h 18m2 stops Miami Atlanta Hartsfield-Jackson
$1,358LATAM Airlines
Sun, Oct 18 - Sat, Oct 24
6:54 pm - 9:40 pmDSM Des Moines-LIM Lima J Chavez Intl
26h 46m2 stops Atlanta Hartsfield-Jackson Miami
1:30 pm - 10:42 amLIM Lima J Chavez Intl-DSM Des Moines
21h 12m2 stops Miami Atlanta Hartsfield-Jackson
$1,370LATAM Airlines
Sun, Oct 18 - Fri, Oct 23
3:03 pm - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
13h 57m1 stop Atlanta Hartsfield-Jackson
12:05 am - 10:42 amLIM Lima J Chavez Intl-DSM Des Moines
10h 37m1 stop Atlanta Hartsfield-Jackson
$1,370LATAM Airlines
Sun, Oct 18 - Sat, Oct 24
5:35 am - 9:55 pmDSM Des Moines-LIM Lima J Chavez Intl
16h 20m1 stop Atlanta Hartsfield-Jackson
1:30 pm - 2:09 pmLIM Lima J Chavez Intl-DSM Des Moines
24h 39m2 stops Miami Atlanta Hartsfield-Jackson
$1,386LATAM Airlines
Sun, Oct 18 - Sat, Oct 24
6:54 pm - 5:00 amDSM Des Moines-LIM Lima J Chavez Intl
10h 06m1 stop Atlanta Hartsfield-Jackson
8:15 am - 10:33 pmLIM Lima J Chavez Intl-DSM Des Moines
14h 18m2 stops Miami Atlanta Hartsfield-Jackson
$1,386LATAM Airlines
Sun, Oct 18 - Sat, Oct 24
11:22 am - 4:10 amDSM Des Moines-LIM Lima J Chavez Intl
16h 48m2 stops Charlotte Douglas Miami
6:30 am - 11:58 pmLIM Lima J Chavez Intl-DSM Des Moines
17h 28m2 stops Miami Charlotte Douglas
$1,402American Airlines
Sun, Oct 18 - Fri, Oct 23
5:35 am - 9:55 pmDSM Des Moines-LIM Lima J Chavez Intl
16h 20m1 stop Atlanta Hartsfield-Jackson
12:05 am - 10:42 amLIM Lima J Chavez Intl-DSM Des Moines
10h 37m1 stop Atlanta Hartsfield-Jackson
$1,416Delta
Thu, Oct 15 - Mon, Oct 19
6:00 am - 11:00 pmDSM Des Moines-CTG Cartagena Rafael Nunez
17h 00m3 stops Houston George Bush Intcntl Fort Lauderdale Panama City Tocumen Intl
6:20 am - 10:15 pmCTG Cartagena Rafael Nunez-DSM Des Moines
15h 55m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$7,303United Airlines
KAYAK's insights & trends for Des Moines to South America flights
Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.
Prices
Airlines
More
Good to know
Low season | December |
|---|---|
High season | July |
Cheapest flight | $312 |
FAQs - booking South America flights
Reviews of the top 3 airlines serving from Des Moines to South America
7.8
DeltaOverall score based on 8650 reviews
7.8Entertainment
7.8Comfort
8.1Boarding
7.2Food
8.5Crew
Airline reviews
On time, quick boarding, so nice of them to honor active and retired military with early boarding. Attendants were nice . Plane was clean. A bit crowded like all flights.
10.0 ExcellentCaroline, Oct 2026
On time, quick boarding, so nice of them to honor active and retired military with early boarding. Attendants were nice . Plane was clean. A bit crowded like all flights.
My bag was open when I got to Portland and all my clothes were wet and my parking pass was wet
Had to deplane 2 x due to problems with plane. Delayed over 6 hours ans was given a $12 food credit which barely oaud for anything and limited to wear incoukd redeem.
After boarding the plane had to wait an hour at the for the copilot to show up before we could depart
No beverage/snack service without any explanation or reason. Late boarding and delayed flight.
more room in seats, larger snacks, more comms with delays
There was overbooking that delayed boarding. Then an airport emergency lockdown that caused further delays in boarding. However the time was made up during flight and there was a minimal delay in landing. Everything else was excellent.
Very crowded and the economy seats were the smallest and with the least legroom I have ever experienced. Cabin staff were excellent although the food service was chaotic as they were being each person their food individually instead of from the wagon.
Delta is the best. It was all very easy and on time.
I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.
Abysmal overall. Delayed flight caused me to get in with an only 9 minute connection. No help from flight attendants or gate agents to try to make the connection. Second flight left 5 minutes early despite not having at least 10 people on it, including me. Rebooked 24 hours later. I asked four separate delta agents how to ensure my bag would get on the rebooked flight and all assured me it would be there. Landing in Rio right now, 24 hours late, and just got an alert that my bag didn’t make it. Horrible overall experience.
4 hour delay. So our flight schedule mass up. Your worker told me you should rebooking myself. I was very angry. Latam Airline always get the money more through any way. But They have no concern passenger.
Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.
Deleted flight made me loose my connection flight now stuck in Atlanta for a day
Apart of Sky miles delta. And they go everywhere in Brazil
We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing
I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money
Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.
The flight was late. Please do not delay next time.
I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.
Cabin was bone dry, no humidity whatsoever, and pretty warm; and beverage service didn't start for at least an hour. I had to go to the back for water and the FAs tried telling me it was always this way for all Miami flights, which is complete nonsense. Avoid the MAX8 like the plague.
We did not fly on American Airlines from Chicago to London. We were rebooked on British Airways (by American Airlines) and our luggage was left behind. A full day delay and lost luggage.
Business class flight attendant was very good. But our flight was delayed two hours for a “mechanical” bathroom issue that literally took 5 minutes to fix. Our plane landed early from its previous flight but still waited for a mechanic to show up to fix an obvious minor issue for almost three hours. This caused us to miss our connecting flight. They put us up in a Days Inn that was 17 miles away from the airport that took a half hour of driving just to get to and this was at 11pm at night. Then when we finally got back on a plane after a full day delay they left our luggage back in the airport. This was an international flight, so no luggage or belongings after flying 8 hours to a different country. We will NEVER fly American Airlines again.
The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.
The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.
In flight connectivity (via T-Mobile) was often not working.
Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.
It was exactly what I expected, actually arriving sooner than scheduled.
Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.
Delayed, missed connecting flight, ground crew double charged for international charges, were super rude and told me to just”deal with it” when I complained. Horrible airline, very frustrating.
More options for your flight to South America
Complete your trip to South America with a hotel stay or car rental
Information on your arrival and departure airports
Cabin class types available on flights to Des Moines
Cabin classes available on flights to South America. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights from domestic origins to Des Moines
Flights from all regions of Des Moines to South America. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to other popular destinations
The most popular flights on KAYAK according to clicks in the last 2 weeks. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to popular destinations in South America
Flights to Argentinafrom $1,276
Flights to Boliviafrom $4,755
Flights to Brazilfrom $1,178
Flights to Chilefrom $1,103
Flights to Colombiafrom $950
Flights to Ecuadorfrom $928
Flights to Perufrom $935