$211 Find Cheap Flights from Des Moines to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South America departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$547
Bogotá
Bogotá1 stop$528
Santiago
Santiago1 stop$812
Cartagena
Cartagena2 stops$608
Quito
Quito2 stops$664
Guayaquil
Guayaquil2 stops$673
Barranquilla
Barranquilla1 stop$442
Belo Horizonte
Belo Horizonte2 stops$1,376
Lima
Lima2 stops$547
Bogotá
Bogotá1 stop$528
Santiago
Santiago1 stop$812
Cartagena
Cartagena2 stops$608
Quito
Quito2 stops$664
Guayaquil
Guayaquil2 stops$673
Barranquilla
Barranquilla1 stop$442
Belo Horizonte
Belo Horizonte2 stops$1,376

Book Cheap Des Moines to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South America

Tue, Mar 17 - Wed, Mar 25
Multiple Airlines Logo
1:23 pm - 1:44 pm
DSM
-
BAQ
24h 21m
1 stop
Multiple Airlines Logo
2:40 pm - 1:29 pm
BAQ
-
DSM
22h 49m
1 stop
$442Multiple Airlines
Tue, Mar 17 - Wed, Mar 25
Multiple Airlines Logo
1:23 pm - 6:55 am
DSM
-
BAQ
17h 32m
2 stops
Multiple Airlines Logo
2:40 pm - 1:29 pm
BAQ
-
DSM
22h 49m
1 stop
$453Multiple Airlines
Thu, Mar 19 - Thu, Mar 26
LATAM Airlines Logo
5:35 am - 11:32 pm
DSM
-
BAQ
17h 57m
2 stops
LATAM Airlines Logo
6:13 am - 10:48 am
BAQ
-
DSM
28h 35m
2 stops
$560LATAM Airlines
Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
7:27 pm - 2:25 pm
DSM
-
BAQ
18h 58m
2 stops
American Airlines Logo
1:30 pm - 11:56 pm
BAQ
-
DSM
10h 26m
1 stop
$568American Airlines
Mon, Mar 30 - Mon, Apr 6
American Airlines Logo
7:44 pm - 2:25 pm
DSM
-
BAQ
18h 41m
2 stops
American Airlines Logo
1:39 pm - 11:56 pm
BAQ
-
DSM
10h 17m
1 stop
$572American Airlines
Mon, Mar 30 - Mon, Apr 6
LATAM Airlines Logo
5:35 am - 1:15 pm
DSM
-
CTG
7h 40m
1 stop
LATAM Airlines Logo
2:30 pm - 10:48 am
CTG
-
DSM
20h 18m
1 stop
$661LATAM Airlines
Mon, Jun 1 - Mon, Jul 27
Delta Logo
11:49 am - 4:43 am
DSM
-
UIO
16h 54m
2 stops
Delta Logo
6:50 pm - 1:22 pm
UIO
-
DSM
18h 32m
2 stops
$664Delta
Thu, May 28 - Tue, Jul 28
Delta Logo
11:49 am - 4:43 am
DSM
-
UIO
16h 54m
2 stops
Delta Logo
6:50 pm - 2:07 pm
UIO
-
DSM
19h 17m
2 stops
$674Delta
Sat, Apr 11 - Tue, Apr 14
United Airlines Logo
6:20 am - 5:00 am
DSM
-
UIO
22h 40m
2 stops
United Airlines Logo
12:35 am - 2:25 pm
UIO
-
DSM
13h 50m
2 stops
$698United Airlines
Thu, May 28 - Sun, Jul 26
United Airlines Logo
6:20 am - 11:25 pm
DSM
-
UIO
17h 05m
1 stop
United Airlines Logo
7:25 am - 10:31 pm
UIO
-
DSM
15h 06m
1 stop
$707United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South America flights

Get data-powered insights and trends into flights from Des Moines to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to South America were found on LATAM Airlines ($560) and American Airlines ($560).

Good to know

Low seasonSeptember
Cheapest flight$211
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Des Moines to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Des Moines to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to South America

 
Need help choosing which airline to fly with from Des Moines to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8203 reviews
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
7.9Comfort
Airline reviews

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

10.0 ExcellentSharon, Feb 2026
TPA - ATL
Read more Delta reviews

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Smallest leg room I've ever had on a plane.

They took all carry-on luggage from Groups 6 -9 - I was group 5 and waiting in line to board - they made me check my luggage too. That then went to baggage claim and delayed departure from the airport. There was overhead room in my seating area - Delta over reacted. Also, had a gentleman next to me that took up 1/2 my seat.

Excellent!!! Aeromexico is a great airline. What was not that good is the service provided by Kayak. It is never clear and not easy to manage.

Flight delay was frustrating, also you cannot checkin online without delta app, web browser check-in throw errors

The gate agent was most helpful in getting me on to fly standby. I greatly appreciate it.

bulkhead seat had very little legroom - even in bsiness class.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Sorry I didn't realize I was writing a review for each leg. Please see my previous review - it applies to the entire flight, not just a single leg.

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Do not like the size of the overhead bin. I think staff should monitor the size of suitcases that are being carried on by passengers to ensure they meet the size requirement.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Flight delayed. WiFi connectivity very poor if not existant. Last minute arrival forced me to run to catch my connection.

Both of my flights arrived early and check in process was smooth

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

Short flight, but no drink/snack service. The flights both going and coming were delayed.

Much better than Spirit. I was please by the easy fast check in and boarding

Check-in and in-flight staff were better than average. The seat was a fair size but too hard and not enough padding. The cushion/pillow provided is poor (thin and seems to be disposable ,it provides no effective cushioning or support). Food was OK-ish but no choice of inflight snacks and no easy place to get drinks other than water (I could ask for juice by intruding into the staff area at the back of the plane) Entertainment was very good actually. Overall better than I expected from a US-based airline (sorry!) but compared to ANA or Singapore it was so-so. (I live in Japan so they are my comparative airlines)

Everything was on time Will use united again for sure

Didn't get a seat assignment until the last minute even though i picked a seat.

American has been able to implement an algorithm that makes it possible for nearly every one of my evening flights to be late. Congratulations!

I was on a small regional flight from Detroit to Philadelphia. When we landed the outside cruise needed to turn something off with the engine, which took quite a long time. Then, when they allowed us to get off the plane it was outside. They took their time, unloading all the luggage and waited till they unloaded all the luggage before they brought it over to us. It was 9 o’clock at night freezing cold out, and there was no proactive hustle to try to get people their luggage. It was really one of the worst experiences I think I’ve ever had with American until a manager came over. I don’t think they were going to even consider pulling the luggage over to the people that had been waiting outside for at least 10 minutes in the freezing cold.

The flight was fine, once we got underway. It was more than hour delayed

Beverage service was not good. Also just one service in 5 hr 30 min flight. No ask fir water ir anything beside one time beverage service.

Waited for oxygen tanks for 30 minutes after boarding was complete.

The seats are too uncomfortable for anyone over 5ft 8in. I'm 5'10" with a back and hip issue and I was in pai for the full duration of the flight.

The flight was on time/early, attentive crew, and everything overall went smoothly. Disappointed that WIFI was not working for the flight.

One day, I do so hope for a gluten free snack! Seems like with the rest of the world FINALLY figuring out what gluten free is, American Airlines would too. Fingers crossed!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

Everything you need to know for your flight to South America

Information on your arrival and departure airports