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Find cheap flights from Des Moines to Florida Keys from $59

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Florida Keys departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
sam. 5/25
sam. 6/1

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Best Florida Keys Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Miami
Miami1 stop$159
Key West
Key West1 stop$246

Good to know

Low season

August

High season

January

Cheapest flight

$59
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Des Moines to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Des Moines to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Florida Keys from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Florida Keys with an airline and back to Des Moines with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Florida Keys from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to Florida Keys

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: Miami $217 one-way - $447 round-trip

Top 5 airlines serving from Des Moines to Florida Keys

 
Need help choosing which airline to fly with from Des Moines to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10975 reviews
8.2boarding
8.0entertainment
7.9comfort
8.6crew
7.4food
Airline reviews

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

4.0 OkayAndrew, Apr 2024RDU - MCO
Read more about Delta reviews

Horrible. This was not first class. This was a connecting flight whi h was late. My original flight never came. I hated the fact that delta gave me a connecting flight from New York to Orlando Florida. No meals and the television screens were not working. There wasn't even any power to charge your phones. This is NOT FIRST CLASS DELTA!!! Do better next time!

They did a fine job. Can't wait to use Delta in the future.

Seat back monitors and outlets were dead and not working.

The experience was good and the flight departed on time and landed early

The flight was delayed but we got to our final destination.

public website still broken for years randomly blocking browsers with privacy options active after loading a page maybe once. check-in on laptop was almost impossible but eventually randomly worked. had to print pass at airport since couldn't get back in to load digital pass on mobile firefox or chrome. red eye flight so smooth onboarding, plenty of room to spread out, easy offboarding. onboard wifi instructions mention vpn can cause problems connecting but fails to also mention private dns. no printed or built in menu list, seems weird to require personal device to point at qr code link for menu which does not even allow direct ordering. people with health condition risk related dietary restrictions trying to avoid for example cholesterol and sugar are left guessing what they can order either way without nutritional info highlights (cranberry juice was minute maid cocktail with as much suger as typical can of soda). tap to pay wasn't working and always seems sketchy to manually enter card info. good movie variety, so limited tv was okay.

Boarding super slow with people allowed to linger in aisles

There were choices for the snacks. Good choices and tasty lunch and breakfast as well.

First time travel in economy and the worst experience I ever had ! Shame on paying 600 dollars to be in a tuna can ! Service was terrible no even water no even class no even matters your flight attendants were lazy and sloppy very bad experience! After all these years traveling in first and once I try this cause I need to go to a destination for an emergency wow shame on you !

Everything was smooth and easy to fly. No complains and a lot of thanks!

The net issue I had was with the gate agent. We had added a carryon to our boarding pass when we checked bags. When I got to the boarding gate the agent was rude asking why I had a backpack - I said I added it - even had an orange tag on it. She ripped my tag off and swung her monitor around to show me how she was right- saying it isn’t wasn’t listed - only a checked bag. I explained again that I wasn’t sure what the issue was but I wouldn’t have an orange tag if I hadn’t added it. Then she finally checked my husband’s boarding pass and found that the agent at checkin had added my carryon to his boarding pass instead of mine. She sent me on my way without my orange tag. Was a bit embarrassing for me the tone she used with me assuming I was trying to get away with something.

Gate agent asked if I could switch seats so a family could sit together. Agent moved me to a seat in the front of the plane, no charge. It was easy. The agent did a great job.

Great seat space. However food and drink prices outrageous. Jabbing to pay for a carry on bag or stuck paying at the gate too much.

Every Allegiant Air flight I've ever taken has been delayed. This flight was delayed a full 2 hours. It was excuse after excuse after excuse. It was a flight from southern Florida. They made us board the plane on time, but made us wait for 2 hours on the tarmac. Because the engines were kept shut off, so was the air conditioning. One can only imagine how hot the air was in the cabin over those 2 hours on the tarmac, while in the hot Florida sun. Just terrible.

Actually, for the price, I'm willing to put up with a little discomfort (upright chairs) and at times inconveniences (like any airline), lack of entertainment (I can bring my own). My flight was non stop and smooth. I would fly this route again.

The flight was delayed 6 hours and we were only offered an $8 food credit. My husband stood in line to get the credit for 45 minutes and when he got close to the end of the line the computers went down.

Worst ever! Flight cancelled supposedly for weather even though we k ow of many others who flew into Bangor same time no problem. At the airport there was no customer service at all just refund and no possibility of rebook for 3-4 days. Aweful won’t fly with them again!!

It’s a budget airline so adjust expectations accordingly. Nothing is without a fee but such is necessary for tickets to remain so affordable.

No complaints. It’s a budget airline so can’t expect any frills.

My TSA number was missing from my ticket which shouldn’t have happened since it’s in my file. The on board flight attendant who was a male, did not want to help me put my luggage in the overhead bin and made a very rude comment and was very unpleasant. The good… the woman who fixed my ticket with the TSA number was excellent and I had extra legroom which was perfect.

So so. Terrible aircraft choice for that leg of the flight.

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

Flight delayed from Cape Town to Washington then got diverted to miami and in miami we had to fend for ourselves , im still trying to get to Shreveport now

delay several times and wait extra long to board. no entertainment service because there are problem for some rows. always encounter some delays for the last flight of the day.

I just wrote a text which was supposed to be for the flight from Denver to spokane not Frankfurt to Denver.

On time every leg of the journey and exceptional staff at counter, gate, and on board. I haven’t travelled in US for a long time and was genuinely surprised how pleasant this was.

The delays (5 hrs) were a comedy of errors, and the multiple safety issues encountered were very concerning.

flight delays, staff only communicating when pushed, food service lasting a grand total of 7 minutes, stuck in seat from 45mins into flight until landing

Crew was great and did their best to make us comfortable and captain came out at the beginning to announce why the flight was delayed, weather situation up ahead, and kept us updated throughout the flight.

I liked everything about the flight. The service was excellent!

It was a good flight. Of course it was full, but it went well.

We sat on the plane for 1 hour because the airline was short handed could not be unloading.

We are gluten free, there were not any available complimentary gluten free options.

Flight delayed 3 times. We were directed to go to a gate across from our gate. The plane wasn't there yet so we had to wait for it to arrive, then deplane everyone and then wait again for the plane to be cleaned. After 45 minuites we were allowed on the plane. The first plane had mechanical issues. The 2nd plane must have had bathroom issues because we did not have any food service whatsoever. No snack or beverage. That made for a long time not to have anything considering that we had just made it to the original gate and we had no time to stop to get food or a drink. Then we didn't want to leave the gate to get food because we wouldn't know how much longer the delay would be. Then the next gate change. Had we been told that the total time would have been aprox 45 min later we would have left to get food and a beverage. We had to wait again for the okay to the pilot to take off so we were on the runway for another 20 min. Overall, we were delayed over 2 hours which felt like 4 hours.

Lots of weather delays that were poorly communicated and managed. I get there are weather delays but they didn’t make it clear what was happening or comfortable on the plane

Me and my husband experienced very bad in American Airlines. We missed our flight going to Doha. The American Airlines was delayed we arrived already 10:27pm. Supposed to be 9:40 pm. So what they did they rebooked our flight and they gave us a hotel. When we arrived at the hotel the front desk said it was fully booked already. Oh my gosh! I said why did you accept the booking if it's fully booked. The guy said that's American Airlines they just book even it's already full. That's 2am already, we have nothing to do so, we decided to go another hotel. We pay the room, food and taxi. Pls give an action on this matter. Refund our expenses and give us more compensation. Not only our room, food, taxi but also our efforts, tiredness looking for a room that can accommodate us.

Horrible. Flight was delayed and very bumpy. I was super unhappy

No meal on a cross country flight? SFO-MiA is pretty much the definition of a coast to coast flight. No meal provided. Sky high wi-fi rates too. Stop nickel and diming your customers.

Absolutely filthy flight and not equipped for a trans US

Overall okay. Ipgrades ate worthless anymore. Wish I’d not been so loyal To them for so many years. Platinum many years. Gold for life. Usually 20th-30th on upgrade list.

I purchased a carry on bag online…was supposed to cost $72 but after a whole slew of bs charges, the total was over $175.00. Because of these hidden charges, I will not even consider flying Frontier ever again. It’s just not worth the hassle. I’m scratching this company off my list forever.

Flight delayed 3 times, resulting in late arrival, rental car place gave car away resulting in increased BS charges because I was late. Frontier blows.

It was impossible to change a carry-on for a checked bag after the initial selection. The flight was delayed 14 hours "to allow for a late arriving aircraft." The seats were shockingly uncomfortable. This was only the second time I've seen seats that didn't recline in an airline. The first was in an East Bloc airline before the fall if the Iron Curtain.

First time flying Frontier, I am not sure the Ala Carte menu of options is for me.

I liked getting off the plane. Everything else was well below standards. Not even offering a bag of peanuts for free for a 4 hours flight is ridiculous.

There was no wifi, there was no usb charger on the planes Frontier lowered the weight limit on suitcases from 50 to 40 pounds Frontier now charges for a seat...really? If i don't pay for a basic seat, do i stand the whole flight? Frontier now charges for the carry on, just like for the checked suitcase The bundle pricing is way over priced.

Bought seats on the flight and they were supposed to be 2 and a jumpseat. Plane clearly changed and it was a regular 3 seat row. Asked for a refund and was denied. If I wanted to sit next to someone else I wouldn't have bought the seats..

Flying frontier reminded me of flying with my family in the 80’s in all of the worst ways possible. From poor customer service to little to no technology. The plane was dirty old and also stuck in the 80’s. From their seatbelts to not having anywhere to charge our phones the seats and the equipment I wasn’t sure if I was being punked or thrown back in time. Needless to say I don’t see myself flying frontier ever again.

Everything was on time and smoothly run. All employees appeared happy and enjoying their job. The delay in take-off was unrelated to anything in Frontier’s control. I wish there were a caffeine-fee, sugar free soda drink option besides water. There are multiple zero sugar caffeine free options.

Everything was on time and smoothly run. All employees appeared happy and enjoying their job. The delay in take-off was unrelated to anything in Frontier’s control.

Book cheap flights from Des Moines to Florida Keys

Recent round-trip flight deals

5/18sam.
1 stopFrontier
7h 27mDSM-MIA
5/25sam.
1 stopFrontier
8h 03mMIA-DSM
$159
5/8mer.
1 stopFrontier
13h 35mDSM-MIA
5/18sam.
1 stopFrontier
13h 53mMIA-DSM
$197
6/1sam.
1 stopFrontier
24h 50mDSM-MIA
6/6jeu.
1 stopFrontier
7h 09mMIA-DSM
$198
5/28mar.
1 stopDelta
5h 35mDSM-MIA
5/30jeu.
1 stopDelta
5h 46mMIA-DSM
$237
5/29mer.
1 stopAmerican Airlines
6h 09mDSM-EYW
6/4mar.
1 stopAmerican Airlines
5h 32mEYW-DSM
$246
5/29mer.
2 stopsAmerican Airlines
10h 21mDSM-EYW
6/4mar.
1 stopAmerican Airlines
5h 32mEYW-DSM
$251
5/22mer.
1 stopDelta
5h 35mDSM-MIA
5/31ven.
1 stopDelta
6h 18mMIA-DSM
$257
5/7mar.
1 stopUnited Airlines
6h 25mDSM-MIA
5/26dim.
1 stopUnited Airlines
8h 13mMIA-DSM
$302
5/6lun.
1 stopUnited Airlines
6h 25mDSM-MIA
5/8mer.
1 stopUnited Airlines
6h 30mMIA-DSM
$380
7/8lun.
2 stops
19h 07mDSM-MIA
7/13sam.
2 stops
26h 56mMIA-DSM
$531

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Recent one-way flight deals

5/18sam.
1 stopFrontier
7h 27mDSM-MIA
$59
5/25sam.
1 stopFrontier
7h 12mDSM-MIA
$101
5/6lun.
1 stopFrontier
12h 57mDSM-MIA
$105
5/14mar.
1 stopDelta
7h 47mDSM-MIA
$108
9/20ven.
1 stopFrontier
26h 20mDSM-MIA
$120
5/6lun.
1 stopAmerican Airlines
5h 35mDSM-MIA
$148
8/5lun.
1 stopFrontier
7h 27mDSM-MIA
$219
5/18sam.
2 stopsUnited Airlines
17h 50mDSM-MIA
$248
5/14mar.
2 stopsUnited Airlines
15h 13mDSM-MIA
$269
5/18sam.
nonstopAmerican Airlines
3h 18mDSM-MIA
$297

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Last minute flights from Des Moines to Florida Keys

Last minute flight, train and bus deals

4/27sam.
multi-stopFrontier
13h 50mDSM-MIA
5/3ven.
multi-stopFrontier
16h 59mMIA-DSM
$217
4/27sam.
multi-stopFrontier
13h 50mDSM-MIA
5/3ven.
multi-stopFrontier
16h 59mMIA-DSM
$227
4/29lun.
multi-stopDelta
7h 32mDSM-MIA
5/1mer.
multi-stopDelta
6h 26mMIA-DSM
$328
4/29lun.
multi-stopDelta
6h 36mDSM-EYW
5/1mer.
multi-stopDelta
6h 35mEYW-DSM
$418
4/29lun.
multi-stopDelta
12h 00mDSM-EYW
5/1mer.
multi-stopDelta
5h 12mEYW-DSM
$423
4/26ven.
multi-stopAmerican Airlines
6h 25mDSM-EYW
4/29lun.
multi-stopAmerican Airlines
6h 30mEYW-DSM
$455
4/27sam.
multi-stopAmerican Airlines
5h 10mDSM-EYW
4/30mar.
multi-stopAmerican Airlines
8h 47mEYW-DSM
$456
4/26ven.
multi-stopAmerican Airlines
11h 37mDSM-EYW
4/29lun.
multi-stopAmerican Airlines
6h 30mEYW-DSM
$460
4/29lun.
multi-stopUnited Airlines
6h 03mDSM-EYW
5/1mer.
multi-stopUnited Airlines
6h 40mEYW-DSM
$498
4/26ven.
multi-stopUnited Airlines
6h 26mDSM-MIA
4/29lun.
multi-stopUnited Airlines
6h 30mMIA-DSM
$530

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Des Moines - Florida Keys Flights

Departure:

Des Moines (DSM)United States

Cabin classes:

$463
$633
$167
$48