DSM - EYW

$255 Find Cheap Flights from Des Moines to Key West - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Cheapest round-trip
$299
Typical prices: $378-$570
Allegiant Air
Tue 11/27Mon 12/3
DSM - EYW • 1 stop
Cheapest one-way
$244
Typical prices: $338-$386
Multiple Airlines
Wed 2/28
DSM - EYW • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Key West. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
July
Cheapest • 19% price drop
February
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Tampa St. Petersburg (PIE)
Cheapest • Avg $409 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 6h 01m (one-way)
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Key West!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Key West (DSM-EYW)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Key West

Fri, Nov 27 - Thu, Dec 3
Allegiant Air Logo
11:01 am - 3:09 pmDSM  Des Moines-EYW Key West
27h 08m1 stop Tampa St. Petersburg
Allegiant Air Logo
7:22 pm - 2:10 pmEYW  Key West-DSM Des Moines
19h 48m1 stop Orlando Sanford Intl
$299Allegiant Air
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
12:59 pm - 11:20 amDSM  Des Moines-EYW Key West
21h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
4:40 pm - 4:46 pmEYW  Key West-DSM Des Moines
25h 06m2 stops Tampa St. Petersburg Fort Lauderdale
$302Multiple Airlines
Fri, Nov 27 - Thu, Dec 3
Multiple Airlines Logo
11:01 am - 3:09 pmDSM  Des Moines-EYW Key West
27h 08m1 stop Tampa St. Petersburg
Multiple Airlines Logo
10:59 am - 9:50 amEYW  Key West-DSM Des Moines
23h 51m2 stops Orlando Nashville Intl
$317Multiple Airlines
Sat, Dec 5 - Wed, Dec 9
American Airlines Logo
7:30 am - 5:21 pmDSM  Des Moines-EYW Key West
8h 51m1 stop Charlotte Douglas
American Airlines Logo
5:50 pm - 11:30 pmEYW  Key West-DSM Des Moines
6h 40m1 stop Charlotte Douglas
$339American Airlines
Wed, Apr 7 - Wed, Apr 14
American Airlines Logo
2:02 pm - 10:36 pmDSM  Des Moines-EYW Key West
7h 34m1 stop Charlotte Douglas
American Airlines Logo
8:05 am - 1:11 pmEYW  Key West-DSM Des Moines
6h 06m1 stop Charlotte Douglas
$339American Airlines
Wed, Nov 25 - Wed, Dec 2
Delta Logo
11:36 am - 8:00 pmDSM  Des Moines-EYW Key West
7h 24m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$339Delta
Sat, Dec 5 - Wed, Dec 9
Delta Logo
11:38 am - 8:01 pmDSM  Des Moines-EYW Key West
7h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$339Delta
Sat, Dec 5 - Wed, Dec 9
American Airlines Logo
7:30 am - 5:21 pmDSM  Des Moines-EYW Key West
8h 51m1 stop Charlotte Douglas
American Airlines Logo
5:50 pm - 11:30 pmEYW  Key West-DSM Des Moines
6h 40m1 stop Charlotte Douglas
$339American Airlines
Tue, Mar 16 - Tue, Mar 23
United Airlines Logo
6:15 am - 5:07 pmDSM  Des Moines-EYW Key West
9h 52m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
4:45 pm - 10:33 pmEYW  Key West-DSM Des Moines
6h 48m1 stop Houston George Bush Intcntl
$344United Airlines
Thu, Dec 17 - Sun, Dec 20
United Airlines Logo
9:27 am - 5:11 pmDSM  Des Moines-EYW Key West
6h 44m1 stop Chicago O'Hare Intl
United Airlines Logo
4:04 pm - 11:17 pmEYW  Key West-DSM Des Moines
8h 13m1 stop Chicago O'Hare Intl
$359United Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Key West flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Des Moines to Key West?

Round-trip flights from Des Moines to Key West typically range from $378 to $570. The lowest price found in the past 5 days was $299, on Allegiant Air.

What's the cheapest day of the week to fly from Des Moines to Key West?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Des Moines to Key West. It’s 5% cheaper than the average day, while Sunday is the most expensive, with prices 35% higher.

What’s the cheapest month to fly from Des Moines to Key West?

•July is the cheapest month to fly from Des Moines to Key West at $378 round-trip.
•May ($948) and February ($609) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 150% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Des Moines to Key West flights

Low season

August

Cheapest flight

$244
Beat the crowds with an average 52% drop in travelers.
The most popular month to fly with an average 77% increase in travelers.
One-way flight from Des Moines to Key West

When to book flights from Des Moines to Key West

Are your dates flexible? Find out the best times to travel from Des Moines to Key West based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Key West flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Des Moines to Key West?

    Only Economy Class is available on flights from Des Moines to Key West.

  • How long is a flight from Des Moines to Key West?

    A nonstop flight from Des Moines to Key West takes 00m, covering 1,357 miles.

  • Do I need a passport to fly from Des Moines to Key West?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Des Moines to Key West flight?

    Round-trip flights from Des Moines to Key West range from $378 to $570, with an average of $464 over the past 12 months. Anything below $378 counts as a good deal.

  • How are flight prices from Des Moines to Key West looking right now?

    One-way fares from Des Moines to Key West are currently lower than usual. Average one-way flight prices are about $328, which is 15% below the typical average for this route.

  • What car rental options are available at Key West Airport (EYW)?

    Key West Airport (EYW) hosts 5 major car rental companies, with daily rates averaging $67 for economy cars. Top options include:

    • Dollar
    • Hertz
    • Budget
    • Enterprise Rent-A-Car
    • Alamo

  • Which airports can I use when flying from Des Moines to Key West?

    Flights from Des Moines to Key West usually depart from Des Moines (DSM) and arrive at Key West (EYW).

  • Which airports do connecting flights from Des Moines to Key West pass through?

    One-stop flights from Des Moines to Key West most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 34% of one-stop connections
    • Charlotte Douglas (CLT) - 32% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 28% of one-stop connections
    • Tampa St. Petersburg (PIE) - 3% of one-stop connections

  • Can I save money by using flexible dates for flights from Des Moines to Key West?

    Yes. Flexible dates can save you up to 30% on flights from Des Moines to Key West. Saturday is the cheapest departure day at $444 round-trip on average, while Sunday is the most expensive at $629, a difference of $185.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Des Moines to Key West?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 6h 01m, compared with 6h 18m via Charlotte Douglas (CLT) and 6h 20m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Des Moines and Key West?

    Key West is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Key West?

    Some of the most popular sights in Key West are Duval Street, Key West Historic District and Mallory Square. These are among the most viewed places in Key West on KAYAK.

Your guide to booking Des Moines to Key West flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Sunday. On this route, Saturday flights average $444, about $185 less than Sunday fares (29% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Key West trip for July. Fares historically average $378 round-trip in that month - typically $570 less than the most expensive month, which is May (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Key West Airport.

    • Parrot Key Hotel & Villas
    • Margaritaville Beach House Key West
    • Havana Cabana at Key West

More options for your flight from Des Moines to Key West

Complete your trip to Key West with a hotel stay or car rental

Car rentals in Key West
Hotels in Key West
Vacations in Key West