DSM - EYW

$269 Find Cheap Flights from Des Moines to Key West

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Key West departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Key West

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Key West, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Key West, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$269
Typical prices: $400-$668
Delta
Sat 12/6Sat 12/13
DSM - EYW • 1 stop
Cheapest one-way
$329
Allegiant Air
Sat 11/15
DSM - EYW • 2 stops
Top airlines
Delta
Cheapest • from $269 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
April
Cheapest • 34% price drop
March
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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We hope you love your trip to Key West!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Key West (DSM-EYW)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Key West that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Key West

Sat, Dec 6 - Sat, Dec 13
Delta Logo
11:23 am - 8:06 pmDSM-EYW
7h 43m1 stop
Delta Logo
6:10 pm - 10:34 pmEYW-DSM
5h 24m1 stop
$269Delta
Find Deal
Fri, Dec 12 - Fri, Dec 19
American Airlines Logo
3:18 pm - 10:18 pmDSM-EYW
6h 00m1 stop
American Airlines Logo
6:32 pm - 11:50 pmEYW-DSM
6h 18m1 stop
$270American Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
American Airlines Logo
6:00 am - 3:46 pmDSM-EYW
8h 46m1 stop
American Airlines Logo
7:00 am - 3:35 pmEYW-DSM
9h 35m2 stops
$274American Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
American Airlines Logo
12:15 pm - 11:07 pmDSM-EYW
9h 52m2 stops
American Airlines Logo
2:36 pm - 11:45 pmEYW-DSM
10h 09m2 stops
$279American Airlines
Find Deal
Sat, Dec 13 - Sat, Dec 20
Allegiant Air Logo
10:38 am - 3:44 pmDSM-EYW
28h 06m1 stop
Allegiant Air Logo
3:36 pm - 11:32 pmEYW-DSM
8h 56m1 stop
$281Allegiant Air
Find Deal
Wed, Mar 25 - Wed, Apr 1
American Airlines Logo
6:56 am - 3:23 pmDSM-EYW
7h 27m1 stop
American Airlines Logo
3:08 pm - 9:53 pmEYW-DSM
7h 45m1 stop
$299American Airlines
Find Deal
Sat, Dec 13 - Sat, Dec 20
Allegiant Air Logo
11:00 am - 1:33 pmDSM-EYW
49h 33m2 stops
Allegiant Air Logo
3:36 pm - 11:32 pmEYW-DSM
8h 56m1 stop
$310Allegiant Air
Find Deal
Tue, Feb 17 - Tue, Feb 24
Delta Logo
11:04 am - 7:44 pmDSM-EYW
7h 40m1 stop
Delta Logo
6:00 pm - 10:28 pmEYW-DSM
5h 28m1 stop
$339Delta
Find Deal
Tue, Apr 21 - Thu, Apr 30
United Airlines Logo
8:00 am - 3:06 pmDSM-EYW
6h 06m1 stop
United Airlines Logo
7:00 am - 2:11 pmEYW-DSM
8h 11m1 stop
$349United Airlines
Find Deal
Sun, Apr 19 - Wed, Apr 29
United Airlines Logo
8:00 am - 3:06 pmDSM-EYW
6h 06m1 stop
United Airlines Logo
4:05 pm - 9:36 pmEYW-DSM
6h 31m1 stop
$379United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Des Moines to Key West flights

Get data-powered insights and trends into flights from Des Moines to Key West to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Key West?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Key West departing in December.

What is the cheapest month to fly from Des Moines to Key West?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Key West, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Key West is April, where tickets cost $293 (return) on average. On the other hand, the most expensive months are June and March, where the average cost of round-trip tickets is $588 and $571 respectively.

How far in advance should I book a flight from Des Moines to Key West?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Des Moines to Key West, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Des Moines to Key West, you should book around 1 week before departure. For the absolute cheapest price, our data suggests you should book 6 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$269
Best time to beat the crowds with an average 35% drop in price.
Most popular time to fly with an average 28% increase in price.
Flight from Des Moines to Key West

When to book flights from Des Moines to Key West

Are your dates flexible? Find out the best times to travel from Des Moines to Key West based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Key West

  • What is the cheapest flight from Des Moines to Key West?

    In the last 3 days, the lowest price for a flight from Des Moines to Key West was $329 for a one-way ticket and $269 for a round-trip.

  • Do I need a passport to fly between Des Moines and Key West?

    No

  • Which airports will I be using when flying from Des Moines to Key West?

    On your way to Key West, you’ll fly out from Des Moines. You’ll be landing at Key West.

  • Which aircraft models fly most regularly from Des Moines to Key West?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Key West?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between Des Moines and Key West, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Key West, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Key West are Delta and United Airlines. With an average price for the route of $475 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $503 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Key West?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Key West.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Key West?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Key West from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Key West?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Key West with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and EYW can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Key West?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Key West from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to Key West

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Key West. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Key West? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7992 reviews
8.5Crew
7.9Comfort
7.3Food
7.9Entertainment
8.2Boarding
Airline reviews

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

8.0 ExcellentJulie, Oct 2025LAX - SFO
Read more Delta reviews

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

The flight was an hour and a half late departing which was inconvenient

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

Movie selection was meh. Food was great. Crew as always great. I paid for premium because that’s the only way not to feel like a sardine. That’s how economy should be imo. Sadly passengers have to pay an extra $1000 to get what they should at base price but that’s all airlines. The airline industry in general treats passengers as cargo.

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

this crew didn't care much. bumping carts into seats more times than i care to remember

Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.

The person I bought the ticket for didn’t make the flight.

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

After boarding the plane in Chicago, the passengers were told that there was a technical problem with the plane. Passengers remained on the plane as they tried to fix the problem. After what was probably an hour passengers were told that there was a need to change planes as the problem was not solved. Passengers disembarked and boarded another plane. After taxing to the runway and waiting for takeoff, passengers were told that owing to the thunderstorm the flight was unable to take off but would try and reroute. After some time passengers were told there wasn't enough fuel for the new route and the plane had to return to the gate for additional fuel. after another log delay the flight got underway. On the plane there was food, drinks, ice or entertainment. We were a glass of water, which appeared rationed. Flight arrived about 5 hours late. The pilot was fantastic and communicated with the passengers throughout the ordeal.

The flight attendants were great, I joked with one I can’t remember her name, a blond, really sweet. I thought it was run well very professional. This was great i survived Spirit, I know for which I speak.

During booking, I kept trying submitting my payment from the Mexican website and it didn't work. After I had the idea to change it to the Canadian website, it worked but I had to be charged the equivalent of 50 CAD more. I received the clear instruction that I would only be able to check-in at the airport and that it was impossible to select a seat 24 hours before departure, that I had to pay 144 CAD to do so, although not only was I able to check-in 24 hours before departure, but I could have selected my seats for free then. All in all, I almost threw $200 out the window due to misleading information. Besides, the app kept crashing, the information to get to the gate on the app was inaccurate, my gate was switched and I was only informed once in the air (luckily I had noticed the departure pannel), I was not addressed in my language beforehand and even if I tried I was immediately answered in English (which meant the crew understood but didn't want to answer accordingly), there was only one snack & beverage service on my medium haul flight and no beverage service on my short haul flight. To be fair, the planes were comfortable, the crew apart from the language issue was helpful, dynamic and engaging, the plane was clean and the directions were clear and direct. United has a lot of potential to be one of my favourite airlines, but the devil is in the details and a lot of them missed the target.

Flight was timely, relatively comfortable, with decent entertainment and food served. Only problem encountered was with the free messaging which I highly appreciate, but it did not work from iphone to non-iphones.

Better WiFi. I cannot understand that in 2025, United is so behind on a technology that is now a necessity and still painfully unreliable, slow and keeps disconnecting.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Very good but wish they had the seat-back video screens for movies & games

Flight was delayed not sure why no explanation given and no apologies either. Otherwise the flight was fine

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

This flight never occurred because AA couldn’t get their act together.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

I liked how when I got on board how fast we ended up taking off but what I truly disliked was how uncomfortable the seats were. There was truly never a time that I could ever get comfortable during both of my flights. The seats could get away during shorter flights but flights 3 hour plus makes it hard to enjoy.

The crew was great and the flight was very smooth. Can’t really judge food since I did not get any because it costs money. The seat was comfortable for what we bought. Thanks!

Crew was great. No entertainment and food and beverage was for purchase only, even water

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

The plane had originated in Las Vegas at 6:30 in the morning and flew to Moline where we boarded. The flight left around 12:30 PM and there were no boxed snacks available and many of the alcoholic beverages were unavailable. I would find it hard to believe that that many of the passengers coming from Las Vegas at 6:30 in the morning, drank and ate that much of the items. I can only come to the conclusion that someone failed to stock the plane for the round-trip. This is a huge revenue failure for the airline and disappointment for the passengers. The flight crew did not seem happy to be there and did not engage with passengers. Allegiant you can do better.

They did not let my husband on the plane with our service animal at the last minute. Do NOT fly this airline with a service animal!

Tight! Seats are not designed for those of us who wear extra-large clothes.

The non-stop flight from Grand Rapids was excellent. I neither expected or needed a budget flight and Allegiant made the trip easy and for an affordable price, Arriving at the Mesa Airport (AZA) is a delight compared to the international airport. For our return flight, we were able to arrive 75 minutes before the flight, return the rental car, check our bag and make it to the gate in plenty of time. That would never happen at most airports.

Easiest flights I’ve ever taken. Plane was comfortable without overly crowded seating.

Terrible. Still have not received the refund from them. They sent it to some account that I don't even know. Spoke with costumer service and they are unable to help.

Everything you need to know for your flight from Des Moines to Key West

Information on your arrival and departure airports

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