DSM - EYW

$155 Find Cheap Flights from Des Moines to Key West - Compare and Save

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Everything you should know

Cheapest round-trip
$299
Typical prices: $373-$582
American Airlines
Sat 3/3Sat 3/10
DSM - EYW • 1 stop
Cheapest one-way
$155
Typical prices: $316-$386
Multiple Airlines
Thu 10/18
DSM - EYW • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Key West. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
July
Cheapest • 20% price drop
February
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Tampa St. Petersburg (PIE)
Cheapest • Avg $409 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 5h 56m (one-way)
Insights
Insights
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We hope you love your trip to Key West!
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Booking Insights
Flight Deals

Cheap Flights from Des Moines to Key West (DSM-EYW)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Key West

Wed, Mar 3 - Wed, Mar 10
American Airlines Logo
9:49 am - 4:54 pmDSM  Des Moines-EYW Key West
6h 05m1 stop Dallas/Fort Worth
American Airlines Logo
6:45 pm - 12:04 amEYW  Key West-DSM Des Moines
6h 19m1 stop Chicago O'Hare Intl
$299American Airlines
Sat, Dec 5 - Wed, Dec 9
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$299Delta
Fri, Dec 11 - Tue, Dec 15
American Airlines Logo
7:23 am - 4:32 pmDSM  Des Moines-EYW Key West
8h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
6:35 pm - 12:18 amEYW  Key West-DSM Des Moines
6h 43m1 stop Chicago O'Hare Intl
$339American Airlines
Fri, Dec 4 - Wed, Dec 9
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$339Delta
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
12:59 pm - 11:20 amDSM  Des Moines-EYW Key West
21h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
10:45 am - 4:46 pmEYW  Key West-DSM Des Moines
31h 01m2 stops Tampa Fort Lauderdale
$339Multiple Airlines
Sat, Dec 5 - Wed, Dec 9
Multiple Airlines Logo
12:59 pm - 11:20 amDSM  Des Moines-EYW Key West
21h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
10:45 am - 4:46 pmEYW  Key West-DSM Des Moines
31h 01m2 stops Tampa Fort Lauderdale
$339Multiple Airlines
Fri, Dec 11 - Tue, Dec 15
American Airlines Logo
7:23 am - 4:32 pmDSM  Des Moines-EYW Key West
8h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
6:35 pm - 12:18 amEYW  Key West-DSM Des Moines
6h 43m1 stop Chicago O'Hare Intl
$339American Airlines
Fri, Dec 4 - Wed, Dec 9
Delta Logo
11:35 am - 8:02 pmDSM  Des Moines-EYW Key West
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:06 pm - 10:38 pmEYW  Key West-DSM Des Moines
5h 32m1 stop Atlanta Hartsfield-Jackson
$339Delta
Wed, Mar 3 - Wed, Mar 10
United Airlines Logo
6:00 am - 4:36 pmDSM  Des Moines-EYW Key West
9h 36m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
4:00 pm - 9:17 pmEYW  Key West-DSM Des Moines
6h 17m1 stop Chicago O'Hare Intl
$349United Airlines
Sat, Oct 3 - Sat, Oct 10
United Airlines Logo
6:00 am - 3:24 pmDSM  Des Moines-EYW Key West
8h 24m1 stop Chicago O'Hare Intl
United Airlines Logo
4:20 pm - 9:23 pmEYW  Key West-DSM Des Moines
6h 03m1 stop Chicago O'Hare Intl
$432United Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Key West flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Des Moines to Key West with more confidence.

How much is a round-trip flight from Des Moines to Key West?

Round-trip flights from Des Moines to Key West start at $299. Prices are below average for this route right now, with typical round-trip fares ranging from $373 to $582. The lowest price found in the past 5 days was $299 on American Airlines.

What's the cheapest day of the week to fly from Des Moines to Key West?

Saturday is the cheapest day of the week to fly from Des Moines to Key West, it is 6% cheaper than the average day. Thursday is the most expensive day with flight prices 33% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Des Moines to Key West?

  • July is the cheapest month to fly from Des Moines to Key West at $378 round-trip.
  • February ($609) and December ($584) are the most expensive months.
  • The price difference between flying in the cheapest and most expensive months is 61% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Des Moines to Key West flights

Low season

August

Cheapest flight

$155
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly with an average 29% increase in price.
Flight from Des Moines to Key West

When to book flights from Des Moines to Key West

Are your dates flexible? Find out the best times to travel from Des Moines to Key West based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Key West flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Des Moines to Key West?

    Flights from Des Moines to Key West usually depart from Des Moines (DSM) and arrive at Key West (EYW).

  • What cabin classes can I book on flights from Des Moines to Key West?

    Two cabin classes are available on flights from Des Moines to Key West:

    • Economy Class
    • First Class

  • Which airports do connecting flights from Des Moines to Key West pass through?

    One-stop flights from Des Moines to Key West most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 38% of one-stop connections
    • Charlotte Douglas (CLT) - 36% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 21% of one-stop connections
    • Tampa St. Petersburg (PIE) - 3% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Des Moines to Key West?

    On the Des Moines to Key West route, being flexible with your departure day can save you up to 29%. Saturday is the cheapest day at $447 round-trip on average, while Thursday is the most expensive at $629: a $182 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • What popular places can I visit in Key West?

    Some of the most popular sights in Key West are Duval Street, Key West Historic District and Mallory Square. These are among the most viewed places in Key West on KAYAK.

  • How long is a flight from Des Moines to Key West?

    A nonstop flight from Des Moines to Key West takes 0h 00m, covering 1,357 miles.

  • Do I need a passport to fly from Des Moines to Key West?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Des Moines to Key West changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $299 to $2,310. That means the highest observed fare was about 8x higher than the lowest one.

  • How are flight prices from Des Moines to Key West looking right now?

    One-way fares from Des Moines to Key West are currently lower than usual. Average one-way flight prices are about $262, which is 29% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Des Moines to Key West?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 5h 56m, compared with 6h 10m via Charlotte Douglas (CLT) and 6h 24m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Des Moines and Key West?

    Key West is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Key West Airport (EYW)?

    Key West Airport (EYW) hosts 5 major car rental companies, with daily rates starting from around $29 for economy cars. Top options include:
    • Dollar
    • Hertz
    • Budget
    • Enterprise Rent-A-Car
    • Alamo

  • How much should I expect to pay for a Des Moines to Key West flight?

    Round-trip flights from Des Moines to Key West range from $373 to $582, with an average of $472 over the past 12 months. Anything below $373 counts as a good deal.

Your guide to booking Des Moines to Key West flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Saturday departure instead of Thursday. On this route, Saturday flights average $447 - about $182 less than Thursday (29% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Key West trip for July. Fares historically average $378 round-trip in that month - typically $231 less than the most expensive month, which is February (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Key West Airport.
    - Havana Cabana at Key West
    - Fairfield Inn & Suites by Marriott Key West at The Keys Collection
    - Parrot Key Hotel & Villas

More options for your flight from Des Moines to Key West

Complete your trip to Key West with a hotel stay or car rental

Car rentals in Key West
Hotels in Key West
Vacations in Key West